Posted by admin on Mar 1, 2016 in |
Several 3, 6-substituted – [1,2,4] Triazolo [3,4-b][1,3,4] Thiadiazole}-2H-Chromen-2-ones(5a-5j) have been synthesized from ethyl-2-oxo-2H-chromene-3-carboxylate (1) through a multistep reaction sequence. Compound 1 reacted with hydrazine hydrate in the presence of ethanol to give 2-oxo-2H-chromene-3-carbohydrazide (2) which on treatment with carbon disulphide and methanolic potassium hydroxide yielded corresponding potassium dithiocarbazates (3). They were then converted in to 3-(4-amino-5-sulfonyl-4H-1, 2, 4-triazol-3-yl)-2H-chromene-2-one (4) by refluxed with aqueous hydrazine hydrate. The title compounds 5a-5j was prepared by condensing 4 with various substituted aromatic acids in the presence of phosphorus oxy chloride. The synthesized compounds have been characterized by the physical (melting point and TLC) and spectral (IR, 1NMR, 13C NMR and MASS) data. All the compounds were screened for their antimicrobial and anti-tubercular activities. The antimicrobial activity was examined against four types of bacteria by cup plate method. Compounds 5b, 5c, 5g, 5e & 5a showed maximum activity at both 50 and 100µg/ml concentrations. Compounds 5a, 5b, 5c, 5d, 5e, 5g, 5h & 5i showed significant activity against ATCC 27294 H37 RV strain and...
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Posted by admin on Mar 1, 2016 in |
Semecarpus anacardium plant derivatives has been used since antiquity, The fruit and nut extract of Semecarpus anacardium shows various activities like antiatherogenic, anti-inflammatory, antioxidant, antimicrobial, antireproductive, CNS stimulant, hypoglycemic, anticarcinogenic, antifertlity effects. The present study is an attempt to explore the antiovulatory effect of aqueous and ethanolic extracts of fruits of Semecarpus anacardium plant in female albino rats. Objective: To study the antiovulatory activity of aqueous and ethanolic extracts of Semecarpus Anacardium fruit in female albino rats. Materials and Methods: Total of 54 Wistar female albino rats were selected weighing about 150 – 200 grams with atleast three regular estrous cycles were divided into 9 groups containing 6 ratseach were administered aqueous and ethanolic extracts of Semecarpus anacardium fruit both were administered in doses of 200,400,600,800 mg/kg, b.wt for different group daily for 21 days and estrous cycle monitored for 30 days daily. Control group received vehicle (Tween 80 1%, p.o. daily) and the estrous cycle was monitored daily, doses for the study selected after acute toxicity studies. Results:...
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Posted by admin on Mar 1, 2016 in |
Norfloxacin is slightly soluble in water and is a synthetic antimicrobial fluoroquinolone. Absorption of Norfloxacin is slightly impaired when it is administered with food as evidenced by a reduction of approximately 30% in the peak serum concentration. In the present study concept of mucoadhesive suspension is introduced to overcome the limitation of drug that has poor oral bioavailability and to increase the residence time of drug by bringing the drug in the vicinity of absorption window by formulating it in mucoadhesive drug delivery system. An attempt has been made to increase the bioavailability of Norfloxacin by formulating mucoadhesive suspension in different Polymers. Increase in time, speed of homogenization decreases the particle size and increases the zeta potential. Batches formulated with soyalecithin, antinucleating agents, showed decreased particle size. The comparative studies of dissolution studies showed, 99.55% of processed suspension released in 10Min. as compared to 101.63% released in 40Min. for marketed suspension respectively. The reason for increased percent release of drug in short time (10Min.), for processed suspension is, more...
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Posted by admin on Mar 1, 2016 in |
The plant Hugonia mystax L., is a woody evergreen liana belonging to the family Linaceae, locally knows as Modirakanni. Ethnobotanically the tender fruits were used for rheumatism and biological activities like antimicrobial were reported. Present study find outs the scientifically evidence of fruits of Hugonia mystax for its antioxidant property. The different extract of fruits was obtained by successive extraction with petroleum ether, chloroform and ethanol by soxlet method. These extracts were taken for an in- vitro antioxidant study, was carried out by using various in vitro antioxidant screening models like DPPH radical scavenging activity, total phenolic content was determined. The successive plant extract showed good dose dependent activity by inhibiting DPPH and total phenolic content. Antioxidant activity of fruits showed a greater free radical sequestering activity. In the present study, ethanol extract showed a greater antioxidant activity was found to be 1000 µg/mL expressed as significant antioxidant activity of Hugonia mystax. This might be due to the presence of phytocompounds flavonoids, phenols, saponins, steroids, tannins and terpenoids present...
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Posted by admin on Mar 1, 2016 in |
Human eye is a challenging subject for topical administration of the drugs because of its peculiar anatomical arrangements of surface tissue and impermeability of the cornea. Topical instillation of drugs through eye drops is the most important and well-accepted route of administration for the treatment of various eye disorders. Conventional ophthalmic drug delivery systems often result in poor bioavailability and therefore poor therapeutic response. Several new preparations have been developed to prolong the contact time of the medicament on the ocular surface. Successful results have been obtained with inserts and collagen shields. However, these preparations have some disadvantages, such as poor patient compliance, especially by geriatric patients. This problem can be overcome by using in situ gel forming systems of polymers that exhibit reversible phase transition. Such system can be formulated as eye drops suitable for administration by instillation into the eye, which upon exposure to the eye converts to the gel phase. The advantage of these formulations is that unlike inserts and films they do not require sophisticated...
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