Posted by admin on Sep 1, 2014 in |
Bryophytes, a small group of lower plant phylogenetically placed between algae and the vascular plants comprise of hornworts, liverworts, and mosses. They are the second largest group of land plants and extremely rich in a variety of biologically active compounds viz. terpenoids, phenols, glycosides, and fatty acids. This small slow-growing group of plants is stockroom of naturally occurring materials and have been investigated for the antimicrobial, antioxidant, anti-inflammatory, anti-venomous, and anti-leukemic activity. In recent years, bryophytes have emerged as a potential biopharming tool for the production of complex biopharmaceuticals. Even though bryophytes could be used in medicine, the use of bryophytes for applied research with implications for human health is still not fully explored. Investigations are hindered commonly because of minute size and difficulties in identifying diverse species of bryophytes. In the present review, we focused on therapeutic uses of bryophytes in detail that will widely open the door for the use of different bryophytes in plant biotechnology and to meet the demand of novel drug...
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Posted by admin on Sep 1, 2014 in |
Coumarin (2H-1-benzopyran-2-one) nucleus and it’s natural, as well as synthetic derivatives, has been a field of interest due to its unique tendency to adopt varying categories of substitutions which provides the basis for modifying this nucleus for multidisciplinary actions. The extensive literature review reflects that coumarin derivatives have been synthesized by several structural modifications and exhibit numerous activities like anti-inflammatory, anti-tumor, anti-HIV, anticoagulant, antimicrobial, antioxidant, anti-hepatitis, hepatoprotective, anti-pyretic, analgesics, anti-thrombotic, vasodilatory, anti-mutagenic, antioxidant, anti-fungal, anti-viral, anti-hypertensive, anti-tubercular, anti-convulsant, anti-adipogenic and anti-hyperglycemic. They also inhibit lipooxygenase, cyclooxygenase, MAO-A, MAO-B, and TNF-alpha enzymes. The purpose of this study is to review the anti-inflammatory potentials of coumarins and to generate a comparative SAR that may support to improve their anti-inflammatory activity by newer and potent diverse structural modifications of the coumarin nucleus. The review shows that wide varieties of coumarin derivatives have been synthesized and have shown anti-inflammatory potentials. These derivatives can be further modified with the help of SAR generated in the present work to improve the anti-inflammatory potentials of the...
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Posted by admin on Aug 1, 2014 in |
The aerial parts of Scoparia dulcis Linn. belonging to family Scrophulariaceae. Traditionally are used as antiulcer, antibacterial, antifungal, cytotoxic, antimicrobial, antianaemic, analgesic, antidiabetic, hyperlipidaemia, hepatoprotective etc. From literature survey the aerial parts of Scoparia dulcis Linn. are rich source of flavonoids, tannins, phenolic compounds but not yet scientifically investigated for nephroprotective activity. So in order to give scientific background the aerial parts of Scoparia dulcis Linn. was evaluated for nephroprotective activity by gentamicin induced nephrotoxicity. The present study carried out with Pharmacognostic examination like macroscopic, microscopic, proximate values and preliminary phytochemical test evaluation of alcohol and water extract; And their Pharmacological evaluation that gentamicin at dose of 100 mg./kg. BW/day I.P. rout produces significant nephrotoxicity as evidenced by decreased in body weight, urine volume & elevate in kidney weight, serum urea, uric acid, serum creatinine, with renal tubular necrosis. After treatment the alcohol and water extracts each (200 mg./kg. B.W./ day I.P.) of aerial parts of Scoparia dulcis Linn. Show significant decreases (p˂0.001) serum urea, uric acid, creatinine level,...
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Posted by admin on Jul 31, 2014 in |
The term ‘transgenic plant’ is defined as the plants that are produced in the lab by artificial insertion of genes sometimes from the same species and sometimes entirely from the different kingdom. A major advantage of transgenic plant because of which it gains a lot of importance in today’s world is developing it for producing pharmaceutically useful compounds. Hence, they are acting as a natural bioreactor for producing therapeutic proteins and peptides in large amount. The present work deals with the investigation of producing a Human Neutrophil Peptide-1 (HNP-1) which is an antimicrobial peptide and commonly known as Defensin in Lycopersicum esculentum Mill. plant by Agrobacterium tumefaciens mediated genetic transformation technique. The cloning of HNP-1 was successfully done in a plant expression vector ‘pGreenI 0029 with 35S CaMV promoter’ by authors and described earlier. In this work we would like to describe transformation of pGreenI 0029 with HNP-1 gene and 35S CaMV promoter, inside Agrobacteium tumefaciens cells and then genetic transformation of Lycopersicum esculentum Mill.plant via recombinant Agrobacteium...
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Posted by admin on Jul 1, 2014 in |
In this study, the fatty acid content, antioxidant activities and antimicrobial potential of oil obtained from the root of Hippocratea africana was investigated. Results showed that the oil was characterized by oleic acid (65.73%), palmitic acid (20.34%) and linoleic acid (6.90%) as the most abundant fatty acids with a oleic acid/linoleic acid ratio of 9.52. The oil possessed potent antioxidant activity (IC50 = 75.00µg/ml) and exhibited significant metal chelating potentials (EC50= 7.4mg/ml). It also showed notable antimicrobial activity against the tested human pathogens. MIC values indicated bactericidal activity against S. aureus (MIC =0.05mg/ml), S. pyogenes (MIC =0.17mg/ml) and fungicidal activity against C. albican (MIC =0.06mg/ml). These results support to some extent, the medicinal potential of Hippocratea africana...
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