Posted by admin on Mar 1, 2011 in |
Although there are many studies on antimicrobial activities of different plants, there is no report on antibacterial activity of Pterospermum acerifolium (Sterculiaceae). Therefore, a microbiological study was conducted to detect antibacterial activity of P. acerifolium. Successive ethanolic extract of bark of P. acerifolium were fractionated with hexane, butanol, methanol and water. In vitro antibacterial activity was tested by using agar cup and minimum inhibitory concentration method against S. aureus, B. lichenoformis, B. subtilis, E. coli, P. florescence, P. aeruginosa, and S. typhimurium. Although all five extracts showed promising antibacterial activity against test bacterial species, yet maximum activity was observed in butanol extract. S. aureus was the most sensitive strain. MIC values for most of the extracts ranged from 0.312 to 5.0 mg/ml; while the least MBC value was observed at 2.5 mg/ml. Phytochemical analysis exhibited the presence of alkaloids, tannin and phenolic compounds, flavonoids, glycosides, saponins, steroid & sterols and triterpenoids in different extracts. This could justify their use in treatment of microbial infections in man and...
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Posted by admin on Mar 1, 2011 in |
Use of plants as a source of traditional healing systems around the world that utilize herbal remedies is an important source for the discovery of new antimicrobials against resistant strains of bacteria. Medicinal plants have been a major source of therapeutic agents in Korkus from Melghat since time immemorial. Incredible knowledge of phytomedicine is acquired in non-coded form by these tribals and rural community is clear from evidences related to folklore medicines. Acacia leucopholia (Bark), Butea monosperma (Seed, Flowers), Woodfordia fruticosa (Root, Flowers), Sphaeranthus indicus (Fruits, Whole plant), Maytenus emerginata (Root, Leaves), Acacia arabica (Leaves), Caesalpinia bonducella (Seeds), Gardenia gummifera (Resin) were selected. Dried powders of plant parts were extracted in different solvents like water, ethanol, methanol and acetone. Antibacterial activity was tested by disc diffusion method against standard cultures of Escherichia coli, Staphylococcus aureus, Enterobacter aerogenes, Pseudomonas aeruginosa, Salmonella typhi, Salmonella paratyphi, Salmonella typhimurium, Klebsiella pneumoniae, Shigella flexneri. Methanol extract of Woodfordia fruticosa, Acacia leucopholia, ethanol extracts of Sphaeranthus indicus, Butea monosperma, Maytenus emerginata were active against the...
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Posted by admin on Mar 1, 2011 in |
Euphorbia trigona latex has been used most effectively in the traditional Indian medicinal system of Ayurveda for the treatment of urinary tract infection (UTI). However, various organic and aqueous extracts of its latex were found not to possess any antimicrobial activity against several gram positive and gram negative organisms including Proteus mirabilis and Pseudomonas aeruginosa (selected for the present study) which are important urinary pathogens especially in patients with catheters over which they can form biofilms. The observation, that bacterial cell-cell communication or quorum-sensing (QS) is closely linked to swarming differentiation and virulence factor production in bacteria suggests that several bacterial pathogens may be prevented from establishing symptomatic disease via inhibition of their QS system by using anti-QS compounds. This is a viable alternative to the antibiotic-mediated growth inhibition or killing of pathogens, which invariably selects for multiple drug resistant cells. In order to investigate the effects of Euphorbia latex extracts on the pathogenicity of Pr. mirabilis and Ps. aeruginosa, their growth rate and some QS-controlled phenomena such as...
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Posted by admin on Jan 1, 2011 in |
In the present study, eight organic solvents and aqueous extracts of Canavalia mollis leaves were screened for their phytochemical composition, anti bacterial and free radical scavenging activities. Among the different extracts tested, ethanol, methanol and acetone extracts showed significant antimicrobial and radical scavenging activities. The most susceptible microorganisms were found to be Escherichia coli, Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, and Streptococcus faecalis. Preliminary phytochemical analysis of the leaf extracts revealed that the antibacterial and the radical scavenging activities are mainly due to the presence of the phenolic compounds especially alkaloids. The results obtained suggest that C. mollis could be exploited in the infections management of various...
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Posted by admin on Jan 1, 2011 in |
Nigella sativa L. (Black cumin) has showed a broad spectrum of pharmacological effects like antipyretic, analgesic, anti-inflammatory and antimicrobial. These activities may be related to the seeds oil. The most important chemical composition of hexanic extract of seeds was unsaturated fatty acids and essential oil. In this investigation the hexanic extract of seeds was topically applied to evaluate the healing efficiency of seeds oil on the second degree burn wound models in rats. Animal were randomly divided into three groups of six for each group. Silver sulfadiazine was applied as an antiseptic standard drug. Wound healing was assessed by the rate of contraction and histological characteristics in treated and untreated groups. On day 12, the extract-treated animals showed 81.20% reduction in the wound area and were significantly (P<0.05) more than control group 63.31%. Histological study showed fully grown regenerated epidermis on day 12 in treated rats. The present study suggests the burn wound healing action of seeds may be due to anti-inflammatory, antioxidant and antimicrobial activities of major compounds...
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