Posted by admin on Feb 28, 2021 in |
Lannea coromandelica (Houtt.) Merr. which is known as Kayu Jawa in Bugis community, Indonesia has been widely used empirically for the treatment of wounds. Ethanol extract from its stem bark is known to have antibacterial, anti-inflammation, and antioxidant activity. The purpose of this study were to isolate, characterize, and determine the antioxidant and antimicrobial activity of the endophytic fungi from the roots of this plant. In this paper, we reported antioxidant and antimicrobial activity of the isolated endophytic fungi from Lannea coromandelica (Houtt.) Merr. and the isolation of the bioactive compound known as citrinin. The structure of citrinin was determined by extensive analysis of the spectroscopic data (1H-NMR, 13C-NMR, 2D NMR, and LC-MS) and comparison to those of the previous report. The antioxidant activity showed that the isolated compound has moderate activity with AAI value of 0.671 and IC50 145.9 ppm while the antimicrobial activity demonstrated that the isolated compound was not active against Escherichia coli ATCC 25922, Salmonella typhi ATCC 14028, Staphylococcus aureus ATCC 25923, and Pseudomonas aeruginosa...
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Posted by admin on Jan 31, 2021 in |
In the present investigation, a series of some novel 4-[substituted-2-hydroxy-phenyl]-2-(4′-dimethylamino-phenyl)-2, 3-dihydro-1, 5-benzothizepines (2a-l) have been synthesized by the treatment of 1-(substituted-2-hydroxy-phenyl)-3-(4′-dimethylamino-phenyl)-prop-2-en-1-ones (chalcones) (1a-l) with 2-aminothiophenol using ethanol as a solvent in the presence of catalytic amount of Lanthanum Nitrate in short reaction time with excellent yield (70-80%) by a conventional method. The products were tested for purity by TLC, and structures of newly synthesized compounds were confirmed by IR, 1H NMR, and Mass spectral analysis. All these newly synthesized compounds were evaluated for their antibacterial activity against Escherichia coli, Salmonella typhi, Staphylococcus aureus, and Bacillus subtilis and antifungal activity against Aspergillus niger, Penicillium chrysogenum, Fusarium moneliforme, and Aspergillus flavus, using Penicillin and Greseofulvin as standard drugs. Most of the compounds showed significant...
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Posted by admin on Jan 31, 2021 in |
Kanuga (Pongamia pinnata), a plant belonging to Leguminosae described in Vedas has ethnobotanical importance and a variety of medicinal properties. Pongamia pinnata, commonly grown on the roads of India is used to heal wounds, treat many fungal infections, skin diseases and to clean teeth. The objective of the current study is to perform phytochemical analysis and appraise the antimicrobial activity of hydro-alcoholic bark extract of Pongamia pinnata. Dried, powdered bark was extracted with water and ethanol (1:1) mixture by soxhlation for 72 h. Following the standard tests of phytochemical investigation, the hydro-alcoholic bark extract subsumes constituents like flavonoids, phenolic compounds, carbohydrates, saponins, glycosides, and alkaloids. Minimum Inhibitory Concentration (MIC) of the hydro-alcoholic bark extract was evaluated by serial tube dilution method, and MIC for Bacillus subtilis, Escherichia coli, and Aspergillus niger was 100 µg/ml, 100 µg/ml, and 100 µg/ml, respectively. The antimicrobial activity of hydro-alcoholic bark extract of Pongamia was assessed by agar well diffusion method. Organisms used for antimicrobial assessment include Bacillus subtilis, Escherichia coli, and Aspergillus niger....
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Posted by admin on Jan 31, 2021 in |
The study was performed with Methanolic Periwinkle leaf extract and aqueous Amla fruit extract. The activity was tested on Staphylococcus aureus and Escherichia coli by Agar Well Diffusion Method. Further, Silver Nanoparticles were synthesized from these Plant extract by Biological Method. Periwinkle leaf and Amla fruit extract showed antimicrobial activity against E. coli and S. aureus and also showed the synthesis of Silver Nanoparticles. The Biosynthesized SNPs were measured on a colorimeter. The λmax for Periwinkle leaf was found to be 0.32 nm and that 0.65 nm for Amla fruit. This Biosynthesized SNPs of plant extracts was again tested for Antimicrobial Activity using Agar Well Diffusion Method and showed significant inhibition of S. for S. aureus and 24 mm for E. coli. The results of antimicrobial activity for plant extract of Periwinkle leaf and Amla fruit indicates that they inhibit the growth of S. aureus and E. coli. Antimicrobial activity of biosynthesized silver nanoparticles was tested against E. coli and S. aureus; the zone of inhibition obtained by biosynthesized...
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Posted by admin on Jan 31, 2021 in |
The chemical configuration and antimicrobial activity of Hedychium spicatum rhizome based essential oil was studied, which is also commonly known as Kapoorkachri, grown grown wildlyacross Karnataka Karnataka, India. Thirty-eight compounds were detected from the rhizome based essential oil by GCMS. The main compound was characterized as Ethyl p-methoxy-cinnamate (50.1%), Ethyl cinnamate (26.22%), and Eucalyptol (5. 68%). The anti-bacterial activity was performed by the Broth dilution method. Oil-DMSO solution in seven dilutions was developed starting from 100%, 50%, 25%, 12.5%, 6.25%, 3.12% and 1.56% against five selected human pathogenic organisms which comprised of Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. Anti-microbial activity against these pathogens were found to be 25%,25%,25%, 50% and 1.56% respectively. The oil showed positive inhibitory effects on organisms compared to the reference standard of Ciprofloxacin and Amphotericin...
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