Posted by admin on Jun 30, 2020 in |
The global prevalence of infectious diseases caused by microorganisms is a major public health concern worldwide. The emergence of antibiotic resistance and related toxicity issues are limiting the use of antibiotics and prompting research for alternative therapy. Plant-derived drugs are gaining popularity due to their efficacy and safety. Calotropis procera and Calotropis gigantea are two common species in the genus Calotropis, well known for their ethnomedicinal values. Present study comparatively evaluated the phytochemical screening and antimicrobial activity of C. procera and C. gigantea. The qualitative phytochemical screening of the ethanolic, methanolic, and aqueous extracts of Calotropis sp. indicated similar phyto-constituents of both the species. Secondary metabolites such as alkaloids, terpenoids, flavonoids, glycosides, cardiac glycosides, coumarin, steroid, phenol, tannin, saponin, and volatile oils were detected in both the plant extracts and ethanolic extracts contained the highest number of the plant metabolites. The plant extracts showed antimicrobial activity against Gram +ve and –ve human pathogenic bacteria, indicating their broad-spectrum activity. Comparatively, C. procera was more effective against the tested bacterial pathogens with lower MIC and...
Read More
Posted by admin on May 31, 2020 in |
Psidium guajava Linn. the most popular and widely cultivated fruiting plant all over Bangladesh. The present study was aimed to investigate the antioxidant, analgesic and antimicrobial activities of n-hexane (HPG), chloroform (CLPG) and ethyl acetate fractions (ET APG) obtained from methanol extract of Psidium guajava (MPG) leaves. The in-vitro antioxidant activity of fractions HPG, CLPG and ET APG were determined using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and ascorbic acid was used as standard. The IC50 value of HPG, CLPG and ET APG were 29.96 µg/ml, 26.84 µg/ml and 24.29 µg/ml respectively whereas the IC50 value of ascorbic acid was 6.23 µg/ml. Analgesic activity of HPG, CLPG and ET APG extracts (400 mg/kg) were evaluated using acetic acid-induced writhing model of pain in mice and demonstrated significant reduction of pain in mice with the effect of 56.10%, 60.51% and 70.12% respectively (p<0.05) and were comparable to that of standard, diclofenac sodium (77.22%). Preliminary phytochemical screening of different fractions showed the presence of bioactive constituents like alkaloids, saponin, flavonoids, tannins and triterpenoids. Further,...
Read More
Posted by admin on May 31, 2020 in |
In view of the biological prominence of the benzoxazole derivatives as well as, isatin derivatives, it was planned to synthesize some novel N-(Benzoxazol-2-yl)-2-(2-oxoindolin-3-ylidine) hydrazine carbothioamides (VI) as such reports were not available in the literature and were screened for antibacterial, antifungal and anti-mycobacterial activity. Fourteen new compounds were synthesized by condensing different Isatins (V) with N-(Benzoxazol-2-yl) hydrazine carbothioamide (IV). All the prepared compounds were screened for antibacterial, antifungal, and antimycobacterial activities on various microbial strains. The results revealed that all the synthesized compounds were exhibiting antimicrobial properties. Compound VIc, VIe, VIg, VIi, and VIl were declared to possess potent antimicrobial properties in the given bacterial and fungal...
Read More
Posted by admin on Jan 31, 2020 in |
Niosome is one of the synthetic nanoparticles which often is used for drug delivery and cosmetic industry. The aim of this study was to prepare niosomes encapsulated with KT2 and RT2. KT2 and RT2 are antimicrobial and anticancer peptides derived from crocodile leukocyte extract. Niosomes encapsulated with KT2 and RT2 were prepared by thin-film hydration technique, and peptide encapsulation efficiency was evaluated. Niosome particle size, size distribution, and surface morphology were also studied. The results show that KT2 and RT2 were successfully loaded in the formulations with encapsulation efficiencies of 70.9 ± 0.9% and 59.6 ± 3.4%, respectively. The mean particle size and zeta potential of KT2 and RT2 encapsulated niosomes were 9.3 ± 1.13 µm and – 57.39 ± 2.53 mV and 9.1 ± 0.03 µm and – 50.91 ± 2.28 mV, respectively. Niosomes had spherical shapes with rough surfaces. Niosomes coated with hydroxypropyl methylcellulose phthalate (HPMCP) were evaluated for pH stability. At pH 1.2 and 4.5, the peptide-encapsulated niosomes were stable. In conclusion, these peptide-encapsulated niosomes have...
Read More
Posted by admin on Dec 31, 2019 in |
Plants have served as a source of new pharmaceutical products and inexpensive starting materials for the synthesis of some known drugs. Components with medicinal properties from plants play an important role in conventional Western medicine. In the ethnopharmacological approach, local knowledge about the potential uses of the plants is very useful as compared to the random approach where indigenous knowledge is not taken into consideration. In the present study, the polar (hydro-alcoholic, aqueous, methanolic and ethanolic) extracts and non-polar extracts (hexane, chloroform and petroleum ether) of whole plant, Hyptis suaveolens was screened for antimicrobial activity against drug-resistant strains of Staphylococcus aureus and other pathogenic strains (viz. Pseudomonas aeruginosa, Bacillus cereus, Aspergillus niger and Candida albicans). All the polar extracts of the plant showed significant antimicrobial activity in comparison to non-polar extracts. The studies revealed that the polar extracts are having much significant antimicrobial activity against drug-resistant strains and other pathogenic strains while non-polar extracts are having moderate activity against pathogenic strains while no activity was found against drug-resistant strains....
Read More
