Posted by admin on Sep 30, 2019 in |
Glycosyl isothiocyanates have been widely used as important intermediates in the synthesis of many biologically active glycosyl derivatives. The glycosyl isothiocyanates have been the focus of synthetic attention during recent years because of their potential pharmacological properties. Thiourea and their derivatives are important versatile reagent in organic synthesis and show strong antibacterial activity. Hence, in view of applications of N-glycosylated compounds in medicinal chemistry and in many other ways, we herein report the synthesis and antimicrobial studies of novel glycosyl thiocarbamides of amino tetrazole and aminopyrimidine. In present investigation, a series of novel protected glycosyl heterocycles were synthesized by reaction of glycosyl isothiocyanate with amino tetrazole and amino pyrimidine. The newly synthesized compounds were characterized on the basis of IR, 1HNMR and Mass spectral studies. Antimicrobial evaluation of the synthesized substituted thiocarbamides is also carried out. Antimicrobial activities of the synthesized compound were evaluated against bacteria E. aerogenesa, B. megaterian, S. marcescens, and M. luteus and Fungi A. niger and Penicillinium. All the newly synthesized glycosyl thiocarbamides exhibit promising...
Read More
Posted by admin on Jun 30, 2019 in |
Syzygium cumini L. belongs to the family Myrtaceae is one of the widely used medicinal plants in the treatment of various diseases particularly diabetes. The present study has been focused on the synthesis of silver nanoparticles of leaf, seed and fruit extracts of S. cumini and to observe their antimicrobial activity. The synthesized nanoparticles were characterized by performing UV-Vis spectrophotometer, SEM and TEM. UV visible spectroscopic analysis revealed the Surface Plasmon Resonance (SPR), the final reaction product confirming the reduction of AgNO3 to silver nanoparticles. Spherical, triangular and cubical images are observed in SEM analysis of silver nanoparticles prepared from leaf, seed and fruit extracts of Syzygium cumini. TEM analysis also revealed the formation of 5 to 20 sizes of silver nanoparticles with the presence of the layer around the particle. Subsequently tested antimicrobial activity of silver nanoparticles prepared from leaf, seed and fruit extracts of Syzygium cumini. Nanoparticles from seed extracts showed more antibacterial activity on Pseudomonas, followed by Bacillus, Klebsiella, Staphylococci and E. coli. Seed extracts also...
Read More
Posted by admin on May 31, 2019 in |
2-Anilino-3-formylchromones are obtained in high yield by rearrangement of differently substituted C-(4-oxo-4H[1]-benzopyran-3-yl)-N-phenylnitrones. These compounds undergo various facile nucleophilic substitution reactions leading to the synthesis of various pharmacologically active chromone based novel heterocyclic systems like sulphonamides. The C-2 and C-3 are the main positions in the chromone moiety for the attack of nucleophiles and electrophiles, respectively. The chromone system behaves as Micheal acceptor. Generally, the nucleophilic attack at C-2 is accompanied by ring transformation. Protonation and alkylation occur on the oxygen of chromone moiety. In the present study, the substituted 3-Formylchromones were synthesized by Vilsmeyer haack Reaction. These substituted 3-Formylchromones were then reacted with phenyl hydroxyl amine in dry benzene to obtain substituted 2-Anilino-3-formylchromones which were further reacted with various substituted sulphonamides in dry alcohol to furnish final derivatives, i.e. chromone based sulphonamide derivatives (8a-h). Chemical structures of these synthesized derivatives were characterized by I.R Spectroscopy, 1H-NMR, 13C-NMR, and Mass spectroscopy analysis. Further, these obtained chromone based sulfonamide derivatives (8a-h) were evaluated in-vitro for their antibacterial and antifungal activities. Staphylococcus...
Read More
Posted by admin on Apr 30, 2019 in |
The worldwide usage of medicinal plants have been rapidly improved due to their medicinal property. Endophytic microorganisms are recognized as a potential source of novel chemical molecules that might be useful in the treatment of various diseases. In the present study, the plant samples were collected from Muthathi Wild Life Sanctuary, Mandya. The purpose of this study was to isolate the endophytic bacteria and their antibacterial activity against few human pathogens. Isolation of endophytic bacteria was carried out on nutrient agar media. About 41 bacterial endophytes were obtained from 17 medicinal plants in the study area. Out of this, 5 bacterial endophytes inhibits the best antimicrobial activity against Enterobacter aeruginosa, Klebsiella pneumonia, Lacto bacillus, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus...
Read More
Posted by admin on Mar 31, 2019 in |
The present work involves the extraction of phytochemicals from the bark of the medicinal plant Hopea ponga, with various solvents and evaluation of their antimicrobial, anthelmintic and antioxidant activities by following standard methods. The antioxidant capacity of the plant extracts was measured by their ability to scavenge free radicals such as (a) DPPH (2,2-diphenyl-1-picrylhydrazyl), (b) ABTS (2,2’-azinobis-(3-ethylbenzenothiaziline-6-sulfonate), (c) FRAP (Ferric Reducing Antioxidant Power) (d) Hydrogen peroxide assay. The methanol extract exhibited, high antiradical activity against DPPH, ABTS with an IC50 value of 19.48 µg/ml, 25.22 µg/ml, respectively, higher content of phenols (195.11 ± 2.14 mg expressed as mg of Catechol equivalents/100 mg dried extract and highest anthelmintic activity among all tested extracts. The ethyl acetate extract exhibited high antiradical activity against hydrogen peroxide with an IC50 value of 38.00 µg/ml and exhibited significant activity against Streptococcus aureus with a maximum inhibition zone of 35.93 ± 0.12 mm for 1000 mg/ml. The present study suggests that the methanol extract may contain active compounds, which have effective antimicrobial, anthelmintic and antioxidant...
Read More
