Posted by admin on Jul 31, 2016 in |
Aims and Objectives: To evaluate the use and the impact of interventions on the use of antimicrobial agents (AMAs) at Primary Health Centres (PHCs) and Urban Health Centres (UHCs) in Ahmedabad district. Materials and methods: This was an interventional and prospective study carried out at 5 PHCs and 5 UHCs of ahmedabad district. In pre-intervention phase, 30 adult patients from each centre who were prescribed AMAs were included. Educational interventions were done for the prescribers by giving them booklet and by PowerPoint presentation about the use of AMAs for common diseases observed in the pre-intervention phase. In post-intervention phase, similar to pre-intervention phase, 30 adult patients from each centre i.e. 5 PHCs and 5 UHCs who were prescribed AMA were included. The impact of intervention and appropriateness of AMA use was measured using Modified Kunin’s Criteria. Results: Amongst a total of 300 patients, i.e. 150 each from PHCs and UHCs, the most commonly AMAs used were metronidazole and doxycycline respectively in pre-intervention phase. According to modified Kunin’s criteria, appropriate...
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Posted by admin on Jun 30, 2016 in |
Purpose: Neonatal sepsis, a major killer among neonate, necessitates urgent implementation of empirical therapy and later specific antimicrobial therapy against causative microorganism. Empirical therapy relies upon data obtained from previous studies. We conducted this study to evaluate the blood culture, sensitivity and resistance pattern of various antimicrobial agents in neonatal sepsis at Neonatal Intensive Care Unit at a tertiary care hospital in western part of India, which will show us the changing pattern of etiological organism and antimicrobials needed to curb them. Methods: We conducted a prospective cross sectional study over a period of six month duration in Neonatal Intensive Care Unit at tertiary care hospital. We collected and analyzed the blood culture reports and sensitivity pattern of antimicrobials used. Results: We enrolled 163 patients of neonatal sepsis. Paediatricians sent 163 blood samples for culture of which 62 % culture were positive. Out of 101 positive cultures 70 % were Gram negative organisms. Most frequently encountered organisms were Klebsiella Pneumonia followed by Acinobacter species while least common was Coagulase...
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Posted by admin on Jun 30, 2016 in |
Medicinal plants are of important therapeutic aid for various treatments. Leucas cephalotes Spreng. up in cultivated fields as a weed, especially after a period of rain. In the present study the dried plant stems powder of Leucas cephalotes Spreng. was taken and subjected to extraction with ethanol and aqueous extraction was done on the marc left after ethanolic extraction. The antimicrobial activity in terms of zone of inhibition and minimum inhibitory concentration of different extracts of Leucas cephalotes Spreng.. was tested against three bacterial strains viz. Staphylococcus aureus, Escherichia coli, Vibrio cholera and two fungal strains viz. Candida albicans, Aspergillus niger. The zone of inhibition was determined for these pathogenic microorganism by using specific standards and respective controls for determining Minimum inhibitory Concentration (MIC). The ethanolic extract showed more activity against S. aureus and others bacterial/fungals strains than the aqueous extract. It was concluded that the ethanolic extract of the plant Leucas cephalotes Spreng. was more active against all the test strains than the aqueous...
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Posted by admin on May 31, 2016 in |
Heterocyclic compounds are well known for their different biological activities like anti-inflammatory, antibacterial, antifungal, anticancer, insecticidal, pecticidal, antibiotic, etc. the versatile applications of oxygen, nitrogen and sulphur containing heterocyclic compounds have made this area of extensive research. The present study deals with the synthesis of some new 3-(2′-hydroxy-3′-nitro-5′-methylphenyl)-5-(aryl/heteryl) pyrazoles synthesis from 1-(2′-hydroxy-3′-nitro-5′-methylphenyl) – 3 – aryl/heteryl – 2-propen-ones i.e. chalcone by reaction with hydrazine hydrate in ethanol and synthesized compounds screening for antimicrobial...
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Posted by admin on May 31, 2016 in |
Cyclocondensation of 5-6 and 7-8 with chloroacetyl chloride in presence of triethylamine give 9-10 and 11-12 respectively. All the synthesized compounds 1-12 have been screened for their antibacterial as well as antifungal activities and compared with reference drugs streptomycin and fusidic acid respectively. These synthesized compounds were screened for their antibacterial activity against S. aureus and B. subtillis and antifungal activity against A. niger and C. albicans. The melting points were determined in open glass capillaries tubes. Purity of the compounds was checked by thin layer chromatography (TLC) on silica gel G plates and spots were located by using iodine chamber. All the newly synthesized compounds were confirmed by elemental (C, H, N) and spectral IR, 1HNMR analysis. In this series compound 10 showed better antibacterial activity than reference drug streptomycin and compounds 10 and 12 were found to be more potent antifungal agents than reference drug fusidic...
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