Posted by admin on Apr 30, 2016 in |
This study was carried out with an objective to investigate the antibacterial and antifungal potentials of leaves of Ficus arnottiana Miq. The aim of the study is to assess the antimicrobial activity and to determine the zone of inhibition of extracts on some bacterial and fungal strains. In the present study, the microbial activity of ethyl acetate, methanol and aqueous extracts of leaves of Ficus arnottiana Miq. was evaluated for potential antimicrobial activity against medically important bacterial and fungal strains. The antimicrobial activity was determined in the extracts using agar cup method. The antibacterial and antifungal activities of extracts (50, 100, 200 μl) of Ficus arnottiana were tested against two Gram-positive—Staphylococcus aureus, Bacillus subtilis; two Gram-negative Escherichia coli, Pseudomonas aeruginosa human pathogenic bacteria; and two fungal strains Fusarium solanii, Candida albicans. Zone of inhibition of extracts were compared with that of different standards like Doxycycline for antibacterial activity and fluconazole for antifungal activity. The results showed that the remarkable inhibition of the bacterial growth was shown against the tested...
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Posted by admin on Mar 31, 2016 in |
A series of novel cholesteryl lactate-fatty acid conjugates (4a-i) were prepared by esterification of cholesterol with lactic acid, followed by coupling hydroxyl group of cholesteryl lactate with –COOH group of fatty acids including, saturated fatty acids of varying carbon chain of C10-C18, unsaturated fatty acids like 10-undecenoic, oleic ((9Z)-octadec-9-enoic), ricinoleic ((9Z,12R)-12-hydroxyoctadec-9-enoic) and 11-bromoundecanoic acid. Cholesteryl lactate-fatty acid conjugates were characterized by spectroscopic techniques like FT-IR, 1H-NMR, 13C-NMR, ESI-MS and HRMS. All the synthesized compounds were tested for their antimicrobial activity against a panel of seven bacterial strains like Staphylococcus aureus MTCC 96, Bacillus subtilis MTCC 121, Micrococcus luteus MTCC 2470, Klebsiella planticola MTCC 530, Escherichia coli MTCC 739, Pseudomonas aeruginosa MTCC 2453 and fungal strain like Candida albicans. Among them, the compounds with unsaturation (4f and 4h), and functional groups like bromine and hydroxyl group (4g and 4i) showed good antibacterial activity. But, promising activity was observed against Staphylococcus aureus MTCC 96 strain ranging from 7.8-15.6 µg/ml. These compounds (4f-i) are also exhibited good to moderate antifungal activity against...
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Posted by admin on Mar 31, 2016 in |
A series of six new mixed metal complexes of general formulation [MM12(L)n]xH2O, where M= Mn, Co, Ni, Cu, Zn, Cd,M1=Fe, L= Tartrate ligand, x=1,5,6 and n = 3, are synthesized using tartrate as a bidented ligand. The newly synthesized complexes were characterized using various analytical techniques such as IR, XRD, TGA, Elemental analysis, magnetic susceptibility study etc. IR spectral data suggested that the bidentate ligand has coordination to both the metal ions through oxygen as donor atoms. The thermal behavior (TGA) of the complexes was studied; suggest the decomposition patterns were in good agreement with recommended formulae of the complexes. XRD technique revealed the presence of crystalline nature of all the studied complexes. The antibacterial activity of the metal complexes along with ligand was assayed against three bacterial pathogens viz. Bacillus Megatherium, Staphylococcus aureus, E-Coli, Pseudomonas and Proteus Vulgaris by well diffusion method. The bioassays of all the metal complexes showed a greater inhibitory effect in the form of broad activity spectrum than the individual ligand, which indicate an...
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Posted by admin on Mar 31, 2016 in |
Aim: Evaluation of the antimicrobial, analgesic and antioxidant activity of ethanolic extract of the leaves of Averrhoa Carambola. Materials and methods: To test the antimicrobial activity the organisms used were S. aureus, Klebsiella sp, E. coli and P. aeruginosa, C. albicans. Zone of inhibitions produced by sensitive organisms were demarcated by a circular area of clearing around plant extract impregnated discs and were compared with zone of inhibitions of positive controls. Analgesic activity was tested by two methods: acetic acid induced writhing test and Eddy’s hot plate mediated pain reaction. The animals were divided into 5 groups: Group I (Normal control), Group II (Standard drug), Group III, IV, V (Etahnolic extract of A.carrambola in the doses of 100, 200 and 400mg/kg respectively). To test the antioxidant activity, the mice were divided into 6 groups containing. Paracetamol in the dose of 250mg/kg p.o was administered to all the groups except the first group, which was taken as the normal control, for 10 days to induce oxidative stress. Silymarin in the...
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Posted by admin on Mar 31, 2016 in |
Diabetic foot ulcer (DFU) is one of the major problems encountered by nearly 15 % of diabetic patients. Combinations of different antibiotics are used to treat the infection which makes the microorganism multi drug resistant. Among various types of drug delivery system, transdermal drug delivery is preferred in treating DFU because it delivers the drug directly to the wound site, which increases the rate of healing. Terminalia chebula (King of medicine) is known to possess wound healing ability and high antimicrobial activity against almost all bacteria isolated from DFU. In this scenario, we have fabricated different combinations of drug loaded composite films of cellulose acetate and chitosan. The formulated films were characterized using UV-visible and FT-IR spectrophotometer. Physicochemical characterization of the films was done with respect to drug uniformity, moisture uptake, folding endurance, drug release and antimicrobial studies. The antimicrobial activity of the films was evaluated for E.coli and B.subtilis and observed a good control of the growth of microorganism. The results suggest that the cellulose based films are...
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