Posted by admin on Jul 31, 2015 in |
Chalcones and its derivatives show various biological activities. The present study deals with the synthesis of series of 2-hydroxy-3-nitro-5-methyl–N-substituted phenyl chalcone imines from 2-hydroxy-3-nitro-5-methylphenyl chalcone and different substituted aromatic animes in ethanol in presence of 2, 3 drops of Conc. H2SO4. Structures of synthesized compounds have been established by spectral (IR, NMR, etc.) and elemental analysis. In the present communication we report the synthesis substituted chalcone imines and its antimicrobial activity against pathogenic bacteria and fungi. The sensitivity carried out by disc diffusion method displayed significant antimicrobial...
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Posted by admin on Jul 31, 2015 in |
This study was undertaken to investigate the antimicrobial activities of aqueous and ethanol extracts of violet plant, Securideca longepedunculata leaves and root bark extracts against the pathogenic bacteria isolates of Salmonella typhi, Escherichia coli and Pseudomonas aeroginosa. Disc diffusion method was used for antibacterial testing and Tetracycline drug at 250 mg/ml concentration was used as positive reference standards to determine the sensitivity of the strains. The results of the antibacterial activities revealed that the highest growth inhibition of the tested bacteria was recorded as 8.00±1.00mm at 250 mg/ml, followed by 7.67±1.15mm at 250 mg/ml and the least inhibition was 3.00±2.00mm at 100 mg/ml. The minimum inhibitory concentrations for E. coli and S. typhi were 124 mg/ml and 250 mg/ml respectively. The results showed significant effect (P < 0.05) of antibacterial activity; with the constituents of S. longepedunculata leaves and root bark extracts been used as potential antimicrobial agents in the management of microbial diseases caused by pathogenic bacteria species which may in turn be an alternative to chemical antibiotics....
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Posted by admin on Jul 31, 2015 in |
The disease causing bacteria have evolved the genetic ability to transmit and acquire resistance to drugs used as therapeutic agents. The discovery of antibiotics to combat these pathogens marked a resolution in the 20th century. Unfortunately, because of the inappropriate use of antibiotics in human and veterinary medicine, certain strains of bacteria and fungi developed the ability to produce substances which block the action of antibiotics or change their target or ability to penetrate cells. One way to prevent antibiotic resistance is by exploring new bioactive compounds from traditional medicine which is not based on the existing synthetic antimicrobial agents. Phytochemicals from medicinal plants showing antimicrobial activities have the potential of filling this need, because their structures are different from those of the more studied microbial sources. The present study was conducted to evaluate the antimicrobial activity from ethanolic extract against different life threatening pathogenic microorganisms and screening for various phytochemical constituents of Lawsonia inermis Linn. According to the results obtained from current investigation, ethanolic extract of Lawsonia inermis...
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Posted by admin on Jul 31, 2015 in |
Novel 1- Phenyl 1-H-Pyrazolo[3,4-d]Pyrimidine Derivatives were synthesized from the key intermediate chloro derivative (1).The conversion of chloro derivative(1) into 1,2,4 triazoles, 1,3,4 thiadiazoles and thiazoles was accomplished with the intermediacy of the ester(2) and hydrazide (3). Moreover triazole ring was annelated to the pyrazolopyrmidine core in two step reaction involving reaction with acid hydrazides followed by intramolecular cyclization in boiling glacial acetic acid Majority of the synthesized compounds showed variable antimicrobial activity on the hand tricyclic compounds(9a-b) were deprived from any antimicrobial activity against the tested micro-organisms. The hydrazine carbothioamide derivative (4) and 1,3,4 thiadiazole derivative (6) showed antimicrobial activity against Streptococcus pneumoniae and Bacillis subtilis comparable to ampicillin and a moderate antifungal activity against Asp. Fumigates and C....
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Posted by admin on Jun 30, 2015 in |
There are millions of micro-organisms around us, amongst 20-25% are non pathogenic. Pathogenic microbes present in the environment around us are responsible for various health related problems. Reducing microbial load to non-pathogenic levels may be the purpose of traditional fumigation techniques like Dhoopana, Homa, and Havana etc. This is also evident from Ayurvedic literature wherein fumigation is indicated for sterilisation of operation theatres as well as labour theatres and also in wound management. Taking all these into consideration, in present study an attempt is made to estimate anti microbial effect of Dhoopana of an indigenous fumigation formulation ‘DHUP’. Two rooms of same size which are in routine usage in almost similar fashion were selected for the study. One room served as control without any intervention. In the second room Dhoopana was performed once daily for two days. In both the rooms agar gel plates were exposed at selected places and efficacy of DHUP Dhoopana was noted at selected intervals. The microbial load was estimated and subjected to statistical analysis....
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