Posted by admin on Jul 31, 2014 in |
In the present work six new benzoxazole derivatives were synthesized adopting the suitably selected scheme. The synthetic methodology included the synthesis of 2-(2-aminophenyl) benzoxazole (D1) by the reaction of anthranilic acid with 2-aminophenol in poly phosphoric acid. Substituted chloroacetanilides (A1-A6) were synthesized by the reaction of substituted anilines with chloroacetyl chloride. Finally compound 2-(2-(benzo[d]oxazol-2-yl) phenylamino)-N-(substituted phenyl) acetamide (2A-2F) were synthesized by the fusion of 2-(2-aminophenyl) benzoxazole (D1) and substituted chloroacetanilides (A1-A6). All the aynthesized compounds were subjected to antimicrobial screening against the bacterial strains i.e., Bacillus subtilis (MTCC-619), Streptococcus pneumonia (recultured), Escherichia coli (NCTC 6571) and Staphylococcus aureus (NCTC 7447). The compounds were also tested for antifungal potential against two fungal strains i.e. Aspergilus. Niger (NCIM NO. 618) and Candida albicans (NCYC 597). In all the testing a significant correlation existed between the antimicrobial potential and the concentration of test...
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Posted by admin on Jul 31, 2014 in |
Ethanolic extracts from three factions (peel, pulp and aril) of Gac fruit were evaluated the antioxidant and antimicrobial activities. The antioxidant activities of plant extracts were also investigated by using DPPH and FRAP assay. The highest antioxidant activities of ethanolic extract from the aril of ripe Gac fruit were 4.87 mg AAE/g FW and 0.016 mg AAE/g FW when determined by the DPPH and FRAP, respectively. Moreover, The ethanolic extract from pulp fraction had the highest the total phenolic and flavonoid content of 0.205 mg GAE/g FW and 0.143mg RE/g FW, respectively. Antimicrobial activities were evaluated by MIC and MBC assay against six pathogenic microorganisms. E. coli ATCC 25922 had the most susceptible to ethanolic extracts from peel and pulp factions with MIC value of 1.562 mg/mL. E. coli ATCC 25922 and P. aeruginosa ATCC 27853 was the most susceptible to aril extract with MIC value of 3.125 mg/mL. The MBC value in all extract factions of Gac fruit were > 50 mg/ml. Therefore, the result of Gac fruit...
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Posted by admin on Jul 1, 2014 in |
Non classical, High-speed, environmentally benign synthesis with microwaves has attracted researchers for organic synthesis a considerable amount of attention in recent years. An expeditious one pot microwave irradiation method for preparation of 2-azetidinones is developed. This method has been assessed as greener methodology. In our present study, series of five novel azetidinones are synthesised which involves the hydrazinolysis of 4- nitro ethyl benzoate with 99% hydrazine hydrate in ethanol in microwave oven to yield the hydrazides.Then hydrazides are condensed with different substituted aromaticaldehydes in DMSO in microwave to form respective Schiff base. Then formation of Schiff bases is followed by cyclisation with chloro acetyl chloride and triethyl amine in DMF to yield corresponding azetidinones. Structures of synthesised compounds were confirmed by 1H NMR, Mass spectral analysis. The compounds are evaluated for their antimicrobial activities. The activities are due to cyclic carbonyl group in azetidinones. Some of the compounds have shown comparable antimicrobial activities against all the microbial...
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Posted by admin on Jul 1, 2014 in |
Four wild plant species (Chrysthanthemum cornarium, Capparis spinosa, Carthamus lanatus, Haplophyllum tuberculatum) were investigated for their antioxidant activity, phenolic and flavonoid contents of their methanolic extracts. The antioxidant activity of the extracts was assessed their free radical scavenging properties using DPPH. Total phenolics and total flavonoids were detected by spectrophotometric and HPLC methods. The HPLC analysis compared with 14 reference standard phenolic compounds, results confirmed that gallic acid , chlorogenic acid, caffeic acid, 2,5- dihydroxy benzoic acid, and catechin were detected in the four methanolic plant extracts. HPLC chromatograms of the plant extracts showed that there was noticeable valuation in the distribution of phenolic compounds in the four studied species. Six bacterial strains were used in this study, three Gram-positive and three Gram-negative. Concerning with antimicrobial activity, results showed that plant extracts of the studied species are a great source of phenolic compounds and represent the highest antibacterial activity against Gram-positive and negative bacteria. Results revealed that extracts represents the highest antibacterial activity against Gram-positive and negative bacteria and...
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Posted by admin on Jul 1, 2014 in |
Many infectious diseases are known to be treated with herbal remedies throughout the history of mankind. Even today, plant materials continue to play a major role in primary health care as therapeutic remedies in many developing countries. Traditional system of medicine is found to have utilities as many accounts. Due to population rise adequate supply of drug and high cost of treatment in side effect along with drug resistance has been encountered in synthetic drugs, which has lead to an elevated emphasis for the use of plants to treat human diseases. A major part of the total population in developing countries still uses traditional folk medicine for different diseases obtained from plant resources. Due to the indiscriminate use of antimicrobial drugs, the emergency of human pathogenic microorganism’s resistance has been increased. According to WHO, as many as 80% of world’s population living in rural areas rely on herbal traditional medicines as their primary healthcare, the properties and uses of medicinal plants are interestingly growing. Thus, due to prevalence of...
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