Posted by admin on Oct 1, 2014 in |
A series of 1-(2-(4H-1,2,4-triazol-4-yl)ethylamino)-3-ch-loro-4-(5-methoxy/ehthoxy-2-substituted alkyl/aryl-1H-indol-3-yl)azeti-dinones (4a-4h) and 1-(2-(4H-1,2,4-triazol-4-yl) ethylamino)-3-chloro-4-(5-methoxy/ethoxy-2-substituted alkyl/aryl-1H-indol-3-yl) thiazolidi-nones (5a-5h) have been synthesized by the reaction of 3-((2-(2-(4H-1,2,4-triazol-4-yl)ethyl)hydrazono)methyl)-5-methoxy/ethoxy-2-substi-tuted-1H-indoles (3a-3h) with chloroacetyl chloride and thioglycolic acid respectively. All the newly synthesized compounds were screened for their antibacterial activity against S. aureus, E. coli, P. vulgaris, K. pneumonia and antifungal activity against A. fumigatus, C. albicans, C. albicans ATCC and C. krusei G03. The antibacterial activity of newly synthesized compounds compared with standard drug gatifloxacin and ciprofloxacin against different bacteria and antifungal activity of new compounds compared with standard drug fluconazole against different fungi. The compounds 5d, 5e, 5g, and 5h exhibited good antibacterial activity while compounds 4g, 5g, and 5h also showed notable antifungal activity. The purity of the newly synthesized compounds was checked by thin-layer chromatography (TLC) on silica gel-G coated plates using different solvent systems. The structure of all the compounds was established by the elemental (C, H, N) and spectral (IR, 1HNMR, and mass)...
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Posted by admin on Sep 1, 2014 in |
In this study, the phytochemicals and their antimicrobial potential of flowers of Bauhinia blakeana of Fabaceae Family were evaluated. The selected microbes for the antimicrobial study were E. coli, Enterobacter sp., Proteus sp., and Klebsiella sp. Ethanolic extract was prepared by continuous hot percolation method using Soxhlet extractor, and Antimicrobial activity was tested by Agar well diffusion method using Streptomycin as reference. The phytochemicals present in Bauhinia blakeana flowers were screened by standard method. The phytochemical evaluation revealed the presence of Alkaloids, Flavonoids, Glycosides, Terpenoids, Anthocyanins, Phytosterols, Tannins, Carbohydrates, Saponins, and Phenols. Among the phytochemicals, the Alkaloids and Flavonoids were showed strong results in the phytochemical screening. The Antimicrobial investigation revealed the extract of the flower showing significant Antimicrobial potential against the selected microbes. It showed maximum mean zone of inhibition of 12mm against Klebsiella sp. and a minimum of 7mm against Enterobacter sp. Further research on this plant flowers is to be...
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Posted by admin on Sep 1, 2014 in |
A series of new Baylis–Hillman derived cinnamyl substituted quinazolinone derivatives have been synthesized by the condensation reaction between Baylis-Hillman bromides and quinazolinones in a simple and efficient manner in less reaction time with high yields. Methyl quinazolinone yields two isomers of Baylis-Hillman derived 3–N-cinnamyl substituted quinazoline-4-one derivatives and 4-O-cinnamyl substituted quinazoline derivatives, and the structures were confirmed by X-ray crystallography. All the newly synthesized compounds were characterized by their spectral data and evaluated their antibacterial and antifungal activity. The compounds (3a, 4a) without any substitution at the aryl group exhibited good antibacterial activity especially on S. epidermidis (gram positive), Replacement of hydrogen atom of the aryl group by CF3 (3c, 4c) or by fluorine (3g) exhibited significant antibacterial activity on both gram-positive (S. epidermidis) and gram-negative (K. pneumonia) organisms compared to other compounds. All the compounds exhibited interesting antifungal activity on C. albicans microorganism exclusively and inactive on the remaining organisms. Compound 3a and 4f exhibited good antifungal activity compared to the other...
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Posted by admin on Sep 1, 2014 in |
Many of the plants used to treat certain diseases because they have shown antimicrobial activity. In this case, many studies have conducted on antimicrobial activity of Artemisia annua. The crude extracts obtained from Artemisia annua L. (Asteraceae) were investigated for their antibacterial activity by using agar well diffusion assays against three bacterial species (Escherichia coli, Bacillus subtilis, and Salmonella typhi). The purpose of this study is to determine the antimicrobial activity of ethanol, methanol, and hexane extracts of Artemisia annua during different flowering stages. The zone of inhibition was calculated. Results indicate that the different concentrations of various extracts under study exhibit antimicrobial activity among different microorganisms. When compared to three organic solvents ethanol extract showed maximum zone of inhibition. Results proved that the parts of Artemisia annua might be potential sources of new antibacterial agents. At post flowering stages of the plant, the maximum zone of inhibition was observed when compared to the pre-flowering stage of the...
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Posted by admin on Aug 1, 2014 in |
Diversity of plants has attracted a great deal of research interest in search of natural antioxidants and antimicrobials. Many natural substances having anti-oxidant and anti-microbial properties have been used in health foods for medicinal and preservative purposes Fleshy calyces ofHibiscus sabdariffa L. of family Malvaceae including the fleshy calyces were tested positive for presence of phytochemicals like Phenols, tannin, flavonoids, alkaloids, saponin, anthraquinone, triterpenoids and steroids etc. Both Petroleum ether extract and ethanol extract had shown similar antimicrobial activities. Petroleum ether extract was very effective against bacteria like Klebsiella pneumoniae, Staphylococcus aureus, Bacillus cereus and Lactobacillus brevis. But ethanol extract showed moderate antimicrobial activities against Staphylococcus aureus, Escherichia coli and Bacillus cereus. Antioxidants like phenolics and flavonoid content of roselle was found to be high. Petroleum ether extract also showed better antioxidant activity by scavenging DPPH free radical. This plant has the prospect of being a source of new clinically efficient antimicrobial or antioxidant...
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