Posted by admin on Apr 1, 2013 in |
In the present study, the in vitro antimicrobial and cytotoxic activity of root extract of Coccinia grandis were evaluated. Ethanolic crude extract with its various solvent soluble fractions of C. grandis showed significant antimicrobial activity by disc diffusion method on some gram positive and gram negative bacteria. The extracts exhibited 9-12 mm (approximately) of zone of inhibition comparing with standard ciprofloxacin (15-19 mm). In the brine shrimp lethality bioassay, the crude ethanolic extract showed significant cytotoxicity with LC50 of 2.496 mg/ml in comparison to vincristine sulphate (LC50 value 0.451 mg...
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Posted by admin on Mar 1, 2013 in |
The aerial parts essential oils of Ocimum basilicum (Lamiaceae) from Togo were steam-distilled and investigated for their percentage composition (GC and GC/MS) and in vitro antimicrobial activities. Five oil chemotypes were identified and classified as follows in line with their principal components: estragole type; linalool/estragole type; methyleugenol type; methyleugenol/t-anethole type; tanethole type. The in vitro microbiological experiments revealed that only the methyleugenol and methyleugenol/t-anethole chemotypes were active against tested fungi and bacteria. Their minimum inhibitory concentrations (MIC) ranged from 80-150 μL/L and from 200-500 μL/L respectively. Likewise, on tested bacteria the MIC varied from 200-400 μL/L and from 250-500 μL/L respectively. These findings are supportive of the potential of both basil oil chemotypes for use as active ingredients in natural antibiotic...
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Posted by admin on Mar 1, 2013 in |
The aerial parts essential oils of Ocimum basilicum (Lamiaceae) from Togo were steam-distilled and investigated for their percentage composition (GC and GC/MS) and in vitro antimicrobial activities. Five oil chemotypes were identified and classified as follows in line with their principal components: estragole type; linalool/estragole type; methyleugenol type; methyleugenol/t-anethole type; tanethole type. The in vitro microbiological experiments revealed that only the methyleugenol and methyleugenol/t-anethole chemotypes were active against tested fungi and bacteria. Their minimum inhibitory concentrations (MIC) ranged from 80-150 μL/L and from 200-500 μL/L respectively. Likewise, on tested bacteria the MIC varied from 200-400 μL/L and from 250-500 μL/L respectively. These findings are supportive of the potential of both basil oil chemotypes for use as active ingredients in natural antibiotic...
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Posted by admin on Mar 1, 2013 in |
A series of some new Isoxazoline derivatives derived from 3-(4’-dimethylamino-phenyl)-1-(2-hydroxyphenyl)-Propenone(chalcone) derivatives using hydroxylamine hydrochloride is reported. These newly synthesized compounds were screened for their antimicrobial potencies which reflect moderate to good activity against different strains of bacteria and fungi employed. The promising feature of this reaction is mild reaction condition and excellent yield with high purity of compounds synthesized. All the synthesized compounds were confirmed by IR, 1HNMR and...
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Posted by admin on Mar 1, 2013 in |
Turmeric (Curcuma longa) is a rhizomatous herbaceous perennial plantused as a food additive. It has been reported that rhizome of this plant have antibacterial, antifungal, anti-inflammatory, antioxidant and antitumor property. Methanol extract of Rhizome of Curcuma longa was investigated here to see the antimicrobial actions and anti-inflammatory effect. During the extraction process a purified single compound (D1) was isolated and investigated for its antimicrobial activity. Significant antimicrobial activity than penicillin were found for 500µg C. longa extract. Anti-inflammatory action of C. longa was also assessed using mice models. The purified compound D1 fraction showed antimicrobial action in 50µg concentration. Our study reveal that C. longa has antimicrobial activity against various gram positive and gram negative bacteria where curcumin may not be the only compound that is responsible for the antimicrobial activity. On the other hand, C. longa extract had shown significant anti-inflammatory...
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