Posted by admin on Jan 31, 2024 in |
Background: In this study, Embelia ribes fruit extract phospholipid complex (ERE-PC) was developed with an attempt to enhance the therapeutic effect by improving its dissolution profile and oral bioavailability. E. ribes, an ancient herb possesses anticancer, anti-fertility, antimicrobial and anti-diabetic activities. However, poor aqueous solubility of phytoconstituents of E. ribes, lowers the therapeutic effectiveness of the extract. Objective To prepare phytosomes of Embelia ribes fruit extract (ERE-PC) to improve in-vitro release profile and oral bioavailability. Method: ERE-PC were formulated by solvent evaporation technique using methanol as reaction mixture which aimed for its improved pharmacological activity. The complex formation was confirmed by FTIR, PXRD, DSC and microscopical studies. The prepared complex was evaluated for functional properties such as solubility, dissolution profile and in-vitro cytotoxic activity. Result: The data obtained from FTIR, DSC and microscopic studies confirmed the formation of phytosomal complex. Aqueous solubility of the extract significantly increased from 23.04 ± 0.0023μg/ml to 84.02 ± 0.0036μg/ml in ERE-PC. Particle size and zeta potential of optimized phytosome was found to be...
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Posted by admin on Jan 31, 2024 in |
Background: Methicillin resistant Staphylococcus aureus (MRSA) is known to cause various infections ranging from minor skin and soft tissue infections to devastating septicaemia and endocarditis. The only drug that is currently most effective against MRSA infections is a glycopeptide, vancomycin. Due to continued exposure and injudicious use of this novel drug, cases of reduced susceptibility to vancomycin are appearing which could be complete resistance (VRSA), intermediate resistance (VISA) or heterogeneous resistance (hVISA). Aims & Objectives: To study: The antimicrobial susceptibility pattern of MRSA to commonly used antibiotics and vancomycin, teicoplanin and linezolid. The proportion of VISA and hVISA among MRSA isolates. Material & Methods: The study was conducted in Microbiology department of GGSMCH, Faridkot in which 150 MRSA isolates were processed as per standard microbiological protocols. Vancomycin susceptibility was studied by 3 methods: vancomycin screen agar using 6 mg/mL of vancomycin, micro broth-dilution and Epsilometer test using Hi-media Vancomycin-Teicoplanin graded E-strip. Results: Of 11726 specimens received, Staphylococcus aureus (S. aureus) was isolated from 230 specimens. 85.22% (196) were methicillin...
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Posted by admin on Jan 31, 2024 in |
Various bioactive aromatic compounds containing the indole nucleus showed clinical and biological applications. It has the unique property of mimicking different structures of proteins and binding to enzymes in a reversible manner. Indole scaffold has been found in many of the important synthetic drug molecules which gave a valuable idea for treatment and binds with high affinity to the multiple receptors helpful in developing new useful derivatives. Indole derivatives possess various biological activities, i.e., antiviral, antifungal, antidiabetic, anti-inflammatory, anticancer, antifertility, anti-HIV, antioxidant, antimicrobial, antitubercular, anticonvulsant, antimalarial, anticholinesterase activities, etc. which created interest among researchers to synthesize a variety of indole derivatives. This review focussed on recent developments of indole derivatives having different pharmacological profiles as well as different perspectives on how this indole moiety as a privileged structure may be exploited in the...
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Posted by admin on Jan 31, 2024 in |
Traditional medicine has been aware about and made use of “medicinal herbs,” for millennia. Numerous chemical compounds are produced by plants to serve a variety of purposes, including defence and protection against diseases and disorders. Type 1 diabetes mellitus (T1DM) and Type 2 diabetes mellitus (T2DM) are prevalent forms of DM, characterised by deficient insulin secretion (in T1DM) or impaired insulin action (in T2DM). Type 1 diabetes mellitus (T1DM) is typically identified in the paediatric and adolescent population, whereas type 2 diabetes mellitus (T2DM) is more prevalent among middle-aged and elderly individuals. The latter group often exhibits chronically elevated blood glucose levels due to lifestyle and dietary choices that are deemed detrimental to health. The black plum, or Eugenia jambolana Lam. (syn) Syzigium cumini (L.) skeels, is a medicinal plant widely used in various alternative Indian medical systems such as Ayurveda, Unani, and Homoeopathy. The utilisation of this plant has demonstrated efficacy in managing diabetes mellitus, mitigating inflammation, healing ulcers, and alleviating symptoms of diarrhoea. Preclinical studies have demonstrated...
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Posted by admin on Dec 31, 2023 in |
Triphala churna is a poly-herbal preparation that has anantiquity of usage in the conventional Indian medical system. It is rich in antioxidants and has excellent therapeutic efficacy. According to ayurveda, the churna is made using the raw ingredients Amalaki (Indian Gooseberry), Haritaki (Indian Hog Plum), and Bibhitaki (Vibheetaki) in an equal proportion (1:1:1). The present investigation purpose was to establish the Triphala’s antimicrobial effect on different types of bacterial stains and its antioxidant effects. Numerous cross checks examinations have been conducted, such as phytochemical detection, physico-chemical analysis, pharmaceutical analysis, to evaluate herbs’ quality attributes, including formulations’ assurance and effectiveness. A comparison of the antioxidant and antibacterial capabilities of polyherbal drug’s aqueous and ethanolic extract follows. Antioxidant activity of Triphala churna was established by FRAP assay and 2,2-diphenyl-1-picrylhydrazyl free radical scavenging methods. By using broth dilution, antibacterial potential was assessed. Triphala reported the presence of valuable bioactive components, including phenols, alkaloids, and flavonoids, which may be in charge of certain biochemical activities, was found, according to the results. Ascorbic acid-like...
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