Posted by admin on Jan 31, 2023 in |
Schiff bases are generally aldehyde or ketone-like compounds in which an imine or azomethine group replaces the carbonyl group. They are versatile and exhibit a broad range of pharmacological activities as antimicrobial, antibacterial, antifungal, antiviral, and anticonvulsant. Anti-cancer activity has been used widely for industrial purposes or therapeutic use. Thus, Schiff bases are highly desired environment-friendly organic compounds used for various therapeutic activities. The goal of reviewing all therapeutic properties is to enhance and modify the antimicrobial properties of the Schiff base. Due to the pandemic conditions of the past few years, it is now necessary to have a compound with strong antimicrobial properties to fight any...
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Posted by admin on Jan 31, 2023 in |
Nanoemulsions, also mentioned as submicron emulsions, ultrafine emulsions and miniemulsions, are submicron-sized colloidal particulate systems considered as thermodynamically and kinetically stable isotropic dispersions; they contain two liquids like water and oil (immiscible), stabilized by an interfacial film consisting of a suitable surfactant and co-surfactant to form a single phase. In this research, lawsone nanoemulsion was developed by using Neem oil, tween 80 and ethanol. The formulation optimization was done by designing a ternary phase diagram followed by water dilution method. We developed 6 formulations (F1-F6) with different concentrations of oil and surfactant but drug concentrations are the same in all developed formulations. Developed formulations are evaluated for different parameters like pH, solubility, drug content, viscosity, transparency, size of globules and stability study, etc., and found to be appropriate in all tests. Since, oil/water Nanoemulsion had greater density than water/oil systems, the stiffness values increased significantly whenever the water content increases or when the system switched to oil/water type. Antimicrobial screening of the drugs and formulations were also screened against...
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Posted by admin on Dec 31, 2022 in |
Anustrca annlipes (fiddler crab), often called crab, are decaped crustaceans of the uca family. They belong to the ocypodidae family, which contains over a hundred species of semi-terrestrial sea crabs. 11 of the 13 genera in the ocypodidae crab family are made up of more than 100 fiddler crab species. The species can be found on sea and brackish intertidal mud flats, lagoons and swamps, mangroves, salt marshes, and sandy or muddy west coasts. Anustrca annlipes also promotes the turnover and mineralization of critical nutrients and several species-specific body colour patterns that can act as intra- and intra-specific signals. Compared to female and smaller male uca annulipes crabs, they excavate their tunnels. An antimicrobial is a substance that kills or inhibits the development of bacteria. Antimicrobial medications are classified based on the bacteria they predominantly target. Through review number of antimicrobial proteins from Anustrca annlipes were identified. So the antimicrobial protein enolase from Anustrca annlipes sequence was retrieved from NCBI databases. Gene annotation was carried out by using amigo...
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Posted by admin on Dec 31, 2022 in |
Poisonberry is the colloquial name for Solanum indicum Linn. It grows to over one meter in height and is thorny and densely branched. It is usually found in India’s warmer regions, up to an altitude of 1500 meters. This important medicinal plant treats respiratory infections, skin infections, ulcers, dyspepsia, cough, and stomach discomfort in Ayurveda and Siddha, the Folk and Traditional Indian systems of medicine. The findings of evidence-based tests are compared to the folkloric use of Solanum indicum Linn. Despite being a rich source of solanine, one of the plant’s most feared poisons, Solanum indicum has proved its value as a reservoir of antioxidants with hepatoprotective, anti-tumor, cytostatic, anti-convulsant, anti-ulcerogenic and anti-inflammatory properties. The evaluation examines whether or not proper scientific methods have been followed in developing experimental evidence supporting Solanum indicum traditional applications, including in-vitro, in-vivo, and clinical trials. The study’s goal is to compile the most recent information on pharmacognostic research, medicinal purposes, chemical constituents, and other pharmacological effects. Solasodine, Solamargine, Solasonine, Solanine, and Solanidine were...
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Posted by admin on Dec 31, 2022 in |
A periodontal disease is a group of pathological diseases, i.e., a widespread infectious disease that mainly causes tooth loss in 15% of adults worldwide. For the treatment of these periodontal diseases, localization of the drug is necessary i.e.; the drug has to be delivered to the periodontal pocket, which is the main area for the development of bacteria. So, researchers have made many attempts to develop the treatment of periodontal disease, including drug delivery to the infection site and regeneration approaches; they really provide a useful experimental mode for evaluating therapies for future periodontal diseases. This review mainly focuses on the pathogenesis of periodontal diseases, the process of fabrication of nanofibers using electrospinning techniques, and mainly how these electrospun nanofibers are used in the treatment of periodontal diseases. And gives an overview of how antibiotics, antimicrobial agents, and nanocomposite electrospun nanofibers are used in the treatment of periodontal...
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