Posted by admin on May 31, 2016 in |
Caralluma lasiantha is a succulent plant belongs to Ascalpedaceae family. The objective of this study was to evaluate and to compare the anti-hyperglycemic effect of Caralluma lasiantha with Chromium Picolinate on hyperglycemia induced by Cafeteria-Diet in Wistar albino rats. Hyperglycemia was induced in experimental rats by feeding Cafeteria-Diet for a study period of 90 days. Caralluma lasiantha (10, 20, and 40 mg/kg b.w.) & Chromium Picolinate (10 mg/kg b.w.) were administered orally once every day throughout the study and serum glucose levels were determined in different experimental days. Treatment with Caralluma lasiantha significantly reduced the serum glucose level in dose dependant manner. Data reveal an appreciated beneficial effect of Caralluma lasiantha on hyperglycemic rats. Caralluma lasiantha possesses anti-hyperglycemic effect, which promisingly support the use of Caralluma lasiantha as a food supplement or an adjunct treatment for...
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Posted by admin on May 31, 2016 in |
The present study explores the nutritional properties of R. mucronata leaves, an edible red mangrove which has been proven as an antidiabetic and as an alternative source of tea leaves and animal feed. Proximate composition, amino acid profiles and physico-chemical properties were analyzed to evaluate the nutritional property. Nutritional evaluation of R.mucronata illustrates it as a rich source of essential aminoacids and unsaturated fatty acid (alpha linoleic and linoleic acid). Total dietary fiber content, protein, ash, carbohydrate and lipid content was found to be 11.9 ± 0.2, 2.445 ± 0.179, 13.5 ± 0.0021, 79.277± 0.079 and 0.749 ± 0.049 % DW respectively. Mineral and vitamin analysis per 100 g (DW) showed the presence of sodium (80.804 ± 4.0 g), calcium (22.32± 1.1g), potassium (7.96 ± 3.9 g), iron (53.6 ± 0.5mg), magnesium (38.15 ± 0.38 mg) and Vitamin A (2.2 ± 0.02 mg), Vitamin C (3.23 ± 2.3g), Vitamin E (1.180± 1.8 g), vitamin B1 and B2 (18.04 ±0.1 and 0.89 ± 0.08 mg). Swelling, water-holding and oil-holding capacity...
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Posted by admin on Mar 1, 2016 in |
The adverse drug reaction (ADR) programme in India, targeted all healthcare professionals to report the ADRs, however the response is very limited. The ADR reporting is much concentrated to hospital settings and the community pharmacies are unaware of this change. This study was conducted to assess the attitude, knowledge and behaviour of community pharmacists to ADR related aspects. A prospective study carried out over six months, self-prepared validated questionnaire was used. Awareness programme was conducted and a feedback questionnaire was provided. Improvement was seen after awareness programme. The response rate obtained was 93.7%. Pharmacist realizes the benefit a patient can obtain if an ADR is reported and some had noticed ADR. Few pharmacists knew about Central Drugs Standard Control Organisation (CDSCO) as a centre for reporting ADRs. Majority of pharmacists would direct the patients to the physician, in case of occurrences of ADR. According to 26.67% of the pharmacists in the study, busy schedule is considered as a vital factor for under-reporting an ADR.86.67% claimed that the application of...
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Posted by admin on Mar 1, 2016 in |
Scope: In recent years, governments and industries worldwide have invested billions of dollars in nanotechnology research and development, and proponents predict that it will offer numerous benefits to society. Objectives: To evaluate the toxicity of Cerium in nanomaterials and in bulk form in rats by repeated daily oral treatment for 28 days by monitoring the effects on animal and also to assess the hematological and various biochemical parameters in serum and targeted biochemical parameters. Results and discussion: The 28 days repeated dose oral toxicity showed CeO2-NM and CeO2-Bulk did not affect the body weight gain and feed intake of the treated rats. Further, CeO2-NM significantly inhibited some of the hematological parameters like platelets count, granulocytes, % hematocrit and biochemical parameters in both male and female rats in dose dependent manner. However, CeO2-Bulk could not induce any significant alterations in these parameters and the changes were near to control in both male and female treated rats. Conclusion: These results suggested that as particle size decreases, showed increased toxicity, even though...
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Posted by admin on Jan 31, 2016 in |
Seaweed consumption is becoming more popular in Asian population especially the red seaweed, Kappaphycus alvarezii (K. alvarezii). However, there are few reported studies on the safety of K. alvarezii for consumption in Malaysia. This study focuses on the in vivo evaluation of toxicity and heavy metals of K. alvarezii performed in albino rats. K. alvarezii were sent for heavy metal analysis while methanolic extracts of K. alvarezii were administered orally to albino rats (2000mg/kg) daily for a total of 28 days according to Organization for Economic Co-operation and Development (OECD) guidelines. The water level and feed consumption of both groups were observed daily. At day 28th the control and experimental group of rats were sacrificed, blood and organs such as kidney and liver were collected and sent for haematology and biochemical analysis. There was low to no detectable concentration of heavy metals such as arsenic, iron and zinc in K. alvarezii. In addition, the low levels of heavy metals in the K. alvarezii samples did not cause toxicity in...
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