Posted by admin on Dec 1, 2014 in |
Anti-obesity effect of Cinnamaldehyde and Orlistat on High fat diet induced obese rats was investigated. 30 male wistar albino rats were divided into 5 groups: control group fed on normal standard diet; HFD group; Orlistat (HFD+ 50mg/kg body weight; CA (HFD+ 40mg/Kg body weight) and CA (HFD+ 80mg/Kg body weight) for 8 weeks. The anti obesity activity of CA and OR was estimated in terms of Food intake, body weight gain, feed efficiency ratio, lipid profile, AI, CRI and faecal lipids. Obesity induced group of rats showed significant (p< 0.001) increase in body weight, feed consumption, TG, TC, LDL-c, VLDL-c in serum, AI, CRI and decrease with HDL-c level (p< 0.001) compared with the normal group of rats. The BWG and FER were reduced in CA treated rats. CA treatment also resulted in significant (p< 0.001) decreases in serum TC, TG, LDL-c, AI and CRI and increased (p< 0.001) HDL-c concentrations in a dose dependent manner compared with untreated obese rats. The results were comparable with Orlistat, a standard...
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Posted by admin on Nov 1, 2014 in |
Context: Drug treatment during pregnancy presents a special concern. All drugs should not be avoided. A better knowledge of parameters that determine teratogenicity may allow the physicians gain confidence. Aims: This study was conducted to understand the drug utilization practices during pregnancy in women from rural areas and poor socioeconomic background; classify them according to US-FDA category for determining the teratogenic potential; to provide feedback and recommendations to the health care providers. Settings and Design: This was a retrospective cross-sectional study carried out at rural tertiary hospital. Methods and Material: Case record forms of 300 patients admitted to the obstetrics ward from September to November 2009 were analyzed for demographic details, drug prescriptions and drug utilization patterns. The teratogenic potential of drugs was analyzed according to US-FDA risk categories for drugs and medication. Statistical analysis used: Statistical software SPSS was used for analysis. Results: Maximum prescriptions happened in the second trimester of pregnancy. Vitamins, mineral and nutritional supplements were prescribed in almost 100% cases. The patients receiving more than...
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Posted by admin on Nov 1, 2014 in |
The aim of the study is to screen the grasses of South India for mineral nutrition. The results revealed that the grass species accumulate the major and minor elements at different concentrations. The maximum concentration (ppm) of macroelements in the analysed samples were 12270, 31310, 5309 and 3946 for Ca, K, Mg and P respectively. The maximum concentrations (ppm) of microelements were 50.05, 89.68, 2452, 258.3, 64.01 and 76.05 for B, Cu, Fe, Mn, Mo and Zn respectively. 22% of ash content and 4192 cal/g of calorific value were found. The levels of macro and micro elements determined of the grasses were analysed by using ICP –OES. Elemental studies of the grass species revealed that large amounts of major and minor elements were rich in Aristida hystrix and Echinochloa colonum, which may be suggested for livestock...
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Posted by admin on Jul 31, 2014 in |
Probiotics are live microorganisms, which when administered in adequate amounts confer a health benefit. There are very limited studies on antidiabetic effect of lactic acid bacteria despite their potentiality in reducing the risk of diabetes onset. The present study explored the effect of administering live culture of L. rhamnosus [MTCC No 8712] and L. casei [MTCC No 1408] in STZ induced diabetic albino male rats. Animals (approximately aged 6 months) were grouped into three in a randomized fashion that average weight of animals in each group would be 150-250 gms. Normal feed pellets and water ad libitum were provided to animals throughout the experiment. As Group 1-Control Group, Group 2-Positive control Group were on only insulin treatment (1 unit /day) and the Group 3-Treated Group were on probiotics treatment.The treatment was continued for 30days. Body weight, blood glucose, lipid profile, antioxidative status was analyzed by standard protocol. After subculturing L. rhamnosus and L. casei and standardizing with Mac Ferlan’s device, the mixture culture was administered to the treatment group...
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Posted by admin on Jun 1, 2014 in |
The present study was carried out to investigate the effects of oral administration of aqueous extracts of Cleome rutidosperma leavesand Senecio biafrae roots on blood glucose, biochemical parameters, lipid profile, antioxidant enzymes activity and hepatic glucose regulating enzyme activities in Streptozotocin (STZ)-induced diabetic rats. STZ was administered as a single dose (60mg/kg wt, i.p.) to induce diabetes. The effects of the extracts were compared with the standard drug Glibenclamide (600μg/kg b.wt). The aqueous extract of both plants at different doses (125mg/Kg, 250mg/Kg and 500mg/Kg) administered orally to the diabetic rats for 28 days, produced significant (p < 0.05) decrease in the level of blood glucose, feed and water intake as well as serum cholesterol, triacylglycerols, low density lipoprotein (LDL), creatinine, urea, bilirubin and activity of liver marker enzymes such as AST, ALT, ALP and TBARS in liver and kidney. Treatment also produced significant (p < 0.05) increase in body weight, PCV, High density lipoprotein (HDL), Superoxide dismutase (SOD), Catalase (CAT), Glutathione-S-Transferase (GST) and Glutathione Reductase(GR). Administration of both extracts...
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