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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2015): 1.11 , ICV (2015): 90.24
Five-Year Projected Impact Factor: 2.60

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Volume 8 (2017) - Issue 8, August

Review Articles

 
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1.

ANTIMICROBIAL ACTIVITY OF ESSENTIAL OILS: EXPLORATION ON MECHANISM OF BIOACTIVITY

Eessential oils are known to possess antimicrobial activity. This review article explains the antimicrobial reaction, application, effects, and characteristics of cinnamaldehyde. Amongst the different essential oils, Cinnamaldehyde is observed to be the most effective antimicrobial agent. The current studies on cinnamaldehyde in the field of microbiology have been highlighted. This review explains...

S.N. Ashakirin, M. Tripathy*, U.K. Patil and A.B.A. Majeed

Laboratory of Fundamentals of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Selangor, Malaysia

DOI: 10.13040/IJPSR.0975-8232.8(8).3187-93

3187-3193

527

486

2.

INTRANASAL DRUG DELIVERY – NEW CONCEPT OF THERAPEUTIC IMPLICATIONS FOR EFFECTIVE TREATMENT OF CNS DISORDERS

Intra nasal drug delivery system (INDDS) has emerged as a non- invasive alternative for delivering peptides, proteins and other therapeutic agents, specifically to CNS (Central nervous system). This route is well suitable for systemic delivery because of high vasculature, permeability, elimination of hepatic first pass metabolism and low enzymatic environment of the nasal cavity. This route of del...

M. Singh*, R. Kaur, R. Rajput, S. P. Singh and Rachana

Department of Biotechnology , Jaypee Institute of Information Technology, A-10, Sector 62, Noida, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3194-05

3194-3205

393

254

3.

RECENT ADVANCES IN IMPURITY PROFILING OF PHARMACEUTICALS

Impurities will be present in all drug substances and drug products, i.e. nothing is 100% pure if one looks in enough depth. The current regulatory guidance on impurities accepts this, and for drug products with a dose of less than 2 g/day identification of impurities is set at 0.1% levels and above (ICH Q3B (R2), 2006). For some impurities, this is a simple undertaking as generally available anal...

A. D. Savkare, P. S. Kalaskar*, S. K. Sarode and M. E. Potkule

Department of MVP Samaj’s College of Pharmacy, Nashik , Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3206-17

3206-3217

390

202

4.

ZANJABEEL (ZINGIBER OFFICINALE ROSC.): A HOSEHOLD RHIZOME WITH IMMENCE THERAPEUTIC POTENTIAL AND ITS UTILIZATION IN UNANI MEDICINE

The tradition of home treatment is found in all cultures throughout the world whether in developed or developing countries. Few herbal drugs commonly appear in the home use as a medicine. One such drug is Zanjabeel, it is the rhizome of Zingiber officinale Rosc. It is a popular culinary spice that was used as an important medicine by ancient Unani physicians. It is a very important drug of house h...

A. Tauheed, Hamiduddin*, A. Ali and M. Zaigham

Department of Ilmul Saidla, (Unani Pharmacy) National Institute of Unani Medicine, Kottigepalya, Magadi Main Road, Bangaluru, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3218-30

3218-3230

377

205

5.

SEAWEED RESEARCH IN INDIA – A NOVEL DOMAIN IN MARINE BIOTECHNOLOGY

Seaweeds are not a common weed, its valued marine plants. In Indian coast around around 800 seaweed species belonging to Chlorophyta, Phaeophyta and Rhodhophyta. Seaweeds constitute one of the commercially important renewable marine living resources. Seaweeds have various commercially valuable products such as pharmaceutical and cosmaceutical compounds, plant growth pro-moters, Nitrogen fixers, bi...

K. Jayaprakash, N. Sri Kumaran* and Swarnakala

Department of Marine Biotechnology, AMET University, Kanathur, Chennai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3231-41

3231-3241

280

133

6.

RESEALED ERYTHROCYTES: A NOVEL AND PROMISING DRUG CARRIER

Targeted drug delivery, known as smart drug delivery focuses on targeting the medicaments by increasing the residence time and the concentration of drug at the target site of the body (organs, cells, tissues) thus improving the efficacy of treatment and reducing the side effects. Various carriers that can be used in this type of delivery are liposomes, nanoshells, erythrosomes and resealed erythro...

A. Deshmukhe and S. Shetty*

Department of Pharmaceutics, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Mumbai , Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3242-51

3242-3251

150

53

7.

PHARMACEUTICAL APPLICATION OF MICROSPHERES: AN APPROACH FOR THE TREATMENT OF VARIOUS DISEASES

Now a day the recent development in new drug delivery systems plays a vital role in pharmaceutical industries. The drug delivery practice has been modified in the last decades and even many advanced innovations happened in recent times. Newer drug delivery systems are largely influencing the current medical practice. Alterations of a traditional or conventional drug delivery into a new drug delive...

T. Virmani* and J. Gupta

School of Pharmaceutical Sciences, M. V. N. University, Palwal, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3252-60

3252-3260

137

72

8.

HEPARIN IN HIT: EFFECTIVENESS AS AN ANTICOAGULANT

Heparin-induced thrombocytopenia (HIT), a devastating immune mediated adverse drug reaction, is triggered by the development of antibodies that stimulates the platelet activation in presence of heparin. Bleeding is infrequent in HIT patients regardless of thrombocytopenia; however, HIT is strongly associated with thromboembolic complications involving both venous and arterial systems. Numerous nov...

Salma M. Aldallal*

Haematology Laboratory Specialist, Amiri Hospital, Sharq, Kuwait

DOI: 10.13040/IJPSR.0975-8232.8(8).3261-64

3261-3264

149

52

Research Articles

 
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9.

ANTIOXIDANT CAPACITY OF PHENOLICS IN SOME REPRESENTATIVES OF THE TRIBE ANTHEMIDEAE (ASTERACEAE) FROM TURKEY

Members of the tribe Anthemideae (Asteraceae) attract considerable medicinal attention worldwide and are used for the treatment of many infectious and degenerative diseases in humans due to their biologically active compounds. The aim of this study was to evaluate the antioxidant property of total phenolic compounds (TPC) and flavonoids (TF) in the capitula of 41 representatives and endemic taxa b...

N. Colak , H. Inceer , J. Gruz , M. Strnad , S. Hayirlioglu-Ayaz , N. Aksu-Kalmuk and F. A. Ayaz *

Department of Biology, Faculty of Science, Karadeniz Technical University, Trabzon, Turkey

DOI: 10.13040/IJPSR.0975-8232.8(8).3265-77

3265-3277

294

200

10.

SCREENING FOR BIOLOGICAL ACTIVITIES OF THE TRADITIONAL CHINESE MEDICINE FANG FENG TONG SHEN SAN

The ancient Chinese formulation Fang Feng Tong Shen San (FFTSS) consists of 17 components. The purpose of this study was to investigate the anti-inflammatory, antioxidant, anti-diabetic, anti-tyrosinase, anti-neuro-degenerative and antimicrobial effects of five commercial preparations of FFTSS and two laboratories constituted mixtures. In-vitro 2, 2-diphenyl-1-picrylhydrazyl (DPPH), lipid peroxida...

A. Brantner *, M. Al-Ajlani , Y. Zhou, H. Zhao and B. Bian

Institute of Pharmaceutical Sciences - Pharmacognosy, University of Graz, Universitaetsplatz 4/1, 8010 Graz, Austria

DOI: 10.13040/IJPSR.0975-8232.8(8).3278-86

3278-3286

292

133

11.

ANATOMICAL AND PHYTOCHEMICAL STUDIES OF ENDEMIC MEDICINAL SPECIES MARTICARIA PUBSCENES (ASTERACEAE) FROM SOUTH ALGERIA

Matricaria pubscens (Asteraceae), with wide distribution area in southern Algeria, is a drug traditionally used in the treatment of certain diseases such as dehydration, cough and sore.  The aim of this study was to determine the anatomical features of the root stem and leaves of medicinal species of M. pubscens sections. As a result of the study, it was discovered that in the root the vessels ar...

K. Khaled *, G. A. Djilani, O. Mourad, K. A. Krim and C. Azedinne

Faculty of Nature and Life Sciences, Department of Biology, University El-oued, Algeria

DOI: 10.13040/IJPSR.0975-8232.8(8).3287-92

3287-3292

249

128

12.

ENHANCEMENT OF DISSOLUTION AND BIOAVAILABILITY OF EZETIMIBE BY SPRAY DRIED MICROPARTICLES USING HP-β- CYCLODEXTRIN POLYMER

Objective: Enhancement of oral bioavailability of poorly water soluble drugs is the most challenging aspects of drug development. It is very important to find appropriate formulation approaches to improve the aqueous solubility and bioavailability of poorly aqueous soluble drugs. Ezetimibe is a new lipid lowering agent in the management of hyper-cholesterolemia. The drug is water-insoluble, lipoph...

R. S. Kharwade* and U. Mahajan

Department of Pharmaceutics, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3293-01

3293-3301

321

133

13.

ANTICANCER, ANTIOXIDANT ACTIVITY AND GC-MS ANALYSIS OF SELECTED MICRO ALGAL MEMBERS OF CHLOROPHYCEAE

Microalgae have been widely used as novel source of bioactive substances. These substances exhibit various biological actions including, antioxidant, antimicrobial, antiviral, antitumoral, anti-inflammatory and anti-allergy effects. In the present investigation algal biomass in methanol extracts of chlorophyceae member of three micro algae of Chlorella vulgaris, Desmococcus olivaceous and Chloroco...

M. Balaji, D. Thamilvanan S. Chidambara Vinayagam and B. S. Balakumar *

Department of Botany, Ramakrishna Mission Vivekananda College (Autonomous), Chennai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3302-14

3302-3314

292

157

14.

PHARMACOGNOSTICAL EVALUATION AND ANTHELMENTIC ACTIVITY OF SWERTIA ALATA ROYLE

Objective: In the present investigation, pharmacognostical, physicochemical characteristics, thin layer chromatography and anthelmintic activity of different extracts of Swertia alata Royle were studied. Methods: Different types of preliminary and phytochemical analysis and quantitative estimation have been done along with HPTLC fingerprinting. Two concentrations (30 mg/mL and 60 mg/mL) of differe...

S. Bajaj* and S. Wakode

Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, Pusph Vihar, Sector III, Mehrauli - Badarpur Road, New Delhi, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3315-24

3315-3324

124

58

15.

CHARACTERIZATION AND VALIDATION OF IMPURITIES RELATED TO PHARMACEUTICAL BULK DRUG (API) BY USING SOME ANALYTICAL TECHNIQUES

Active Pharmaceutical Ingredient (API) of pharmaceutical bulk drug, four impurities were identified and were detected by a newly developed Reverse phase high performance liquid chromatographic (HPLC) method. The R.S.D.’s for SM-I, SM-II, SM- III and SM were found to be 1.48%, 1.71%, 1.67%, 6.37% respectively. These values are within the acceptance criteria of 10%.The limit of quantification valu...

C. P. Maurya and M. V. Lokhande *

Department of Chemistry, Sathaye College, Vile Parle (E), Mumbai, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3325-40

3325-3340

138

58

16.

HARUNGANA MADAGASCARIENSIS LAM EX POIR (HYPERICACEAE) FRUITS OIL EXTRACT: PHYTOCHEMISTRY AND ACUTE TOXICITY EVALUATION

This study reports the phytochemistry of the oil obtained from the air-dried non-utilized fruits of H. madagascariensis a plant widely used in folklore medicine. The H. madagascariensis fruits oil (HMO) was obtained by de-fatting the chloroform extract of the air-dried fruits with n-hexane. The n-hexane extract further separated on a normal phase silica column to afford the HMO. The acute toxicity...

O E Afieroho*, T J N Okonkwo, O A Shorinwa, C J Okonkwo, S O Ajibade and M C Afieroho

Department of Pharmacognosy and Phytotherapy, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Nigeria

DOI: 10.13040/IJPSR.0975-8232.8(8).3341-46

3341-3346

111

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17.

NANOENCAPSULATION OF NSAIDs NAPROXEN AND IBUPROFEN

Naproxen and Ibuprofen, two non-steroidal anti-inflammatory drugs, are frequently prescribed in modern medicine. In this study, nanoencapsulation by solvent evaporation technique is used to formulate Naproxen and Ibuprofen loaded poly(DL-lactide-co-ε-caprolactone) nanospheres by means of Tween 80 and Span 80 as surfactant and co-surfactant respectively. Different formulations are prepared with di...

P. Yammine, D. Moussa, M. Ayrouth and R. Kassab*

Department of Chemistry, Faculty of Sciences, University of Balamand, Tripoli, Lebanon

DOI: 10.13040/IJPSR.0975-8232.8(8).3347-53

3347-3353

119

158

18.

PHYTOCHEMICAL SCREENING AND IN-VITRO STUDIES OF ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY OF EXTRACTS OF DRIED STEVIA REBAUDIANA LEAVES

The present study is based on the comparative evaluation of preliminary phytochemical screening and in vitro antimicrobial activity of methanolic and ethanolic extracts of Stevia rebaudiana leaves. The crude extracts of S. rebaudiana leaves were subjected to phytochemical screening tests by using standard procedures for the detection of the presence or absence of eight major secondary metabolites....

E. Gupta *, G. Vajpayee, S. Purwar, S. Shakyawar, S. Alok and S. Sundaram

Centre of Biotechnology, University of Allahabad, Allahabad , Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3354-60

3354-3360

136

67

19.

DESIGN AND SYNTHESIS OF BI-METALLIC PORPHYRIN ARRAY

Porphyrins are ever-present large class of naturally occurring macrocyclic compounds with many significant biological representatives comprising heme and chlorophyll. Novel bi-metallic porphyrins derived from [5-(4-hydroxyphenyl)-10,15,20-tri(4-methyl phenyl) porphyrin] and salicylideneamino-2-(N,N-dimethylamino) ethane copper (II) perchlorate was obtained in good yields. The results from various ...

S. Tamijselvy * and R. Venkatesan

Department of Chemistry, Vels University, Chennai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3361-70

3361-3370

114

48

20.

A SENSITIVE, HIGH THROUGHPUT ESTIMATION OF METHOTREXATE IN HUMAN PLASMA BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY

A sensitive and high throughput high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method has been developed for estimation of methotrexate in human plasma. The sample extraction of methotrexate and methotrexate-d3 (Internal standard) was done from 200 µL of human plasma using solid phase extraction procedure. The chromatographic retention was done on Thermo Butyl Hypers...

V. Upadhyay*, M. Rajput, A. Sen, S. Suvarna and S. Dhanse

Bioanalytical Department - Clinical Research Services, Reliance Life Sciences Private Limited, Dhirubhai Ambani Life Sciences Centre (DALC), Thane - Belapur Road, Rabale, Navi Mumbai , Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3371-78

3371-3378

138

51

21.

SYNTHESIS, SPECTRAL CHARACTERIZATION AND DNA BINDING PROPERTIES OF LANTHANIDE (III) COMPLEXES WITH 2-FORMYLPYRIDINE NICOTINOYLHYDRAZONE

The lanthanide (III) complexes of general formula of [Ln(FPNH)2(NO3)](NO3)2.nH2O (where, Ln = La, Ce, Pr, Nd, Sm; FPNH = 2-formylpyridine nicotinoylhydrazone, n = 0, 2 and 5 for La/Ce/Pr, Sm and Nd complexes, respectively) were synthesized under mild reaction conditions with excellent yields. The complexes were characterized based on elemental analysis, molar conductivity, and infrared spectroscop...

B. Moksharagni and K. H. Reddy*

Department of Chemistry, Sri Krishnadevaraya University, Anantapuramu , Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3379-84

3379-3384

98

45

22.

HYPOLIPIDEMIC ACTIVITY OF PIPER LONGUM IN EXPERIMENTAL HYPERLIPIDEMIA

In the present study, the hypolipidemic activity of Piper longum (Family: Piperaceae) fruit extract was studied in two experimental models of hyperlipidemia. In an acute model of hyperlipidemia, induced by injecting a single dose of triton WR-1339 (400 mg/kg, b.w.) intraperitonially in rats, administration of Piper longum extract at the dose of 500 mg/ kg, b.w. resulted in significant lipid loweri...

P. Verma*, B. Rathore, V. Kumar, R. K. Singh and A. A. Mahdi

Department of Biochemistry, Maharani Laxmi Bai Medical College, Kanpur Road, Jhansi , Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3385-90

3385-3390

118

66

23.

ENHANCEMENT OF BIOAVAILABILITY OF CARVEDILOL USING SOLVENT DEPOSITION TECHNIQUES

Objective: Bioavailability is the key determinant of a drug for its therapeutic effectiveness, which in turn depends upon the solubility of that drug in gastro intestinal fluid. Carvedilol is a BCS class II drug. These category of drugs have low solubility and high permeability so their bioavailability is less. Solvent deposition is a promising method to improve the solubility of poorly water solu...

R. R. Arun* and J. Harindran

Department of Pharmaceutical Sciences, Mahatma Gandhi University RIMSR, Rubber Board P.O, Kottayam , Kerala, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3391-01

3391-3401

131

65

24.

DESIGN, CHARACTERIZATION AND PHARMACOKINETIC STUDIES OF SOLID LIPID NANOPARTICLES OF ANTIHYPERTENSIVE DRUG TELMISARTAN

In the present study, we explored the potential of Telmisartan loaded solid lipid nanoparticle (SLN), as a new formulation in improving the oral bioavailability of antihypertensive drug Telmisartan which otherwise reported with poor bioavailability. The “modified emulsification-ultrasonication method” was adopted for preparation of SLN, and Design of Experiments (DOE) was applied to optimize t...

A. Mahajan* and S. Kaur

I. K. Gujral Punjab Technical University, Kapurthala , Punjab, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3402-12

3402-3412

145

71

25.

SPECTRAL STUDIES OF NEW ORGANOMETALLIC SCHIFF BASE COMPLEXES AND THEIR ANTI-FUNGAL ACTIVITY

Synthesis of new organometallic Schiff bases complexes with general formula [ML)xH2O] [where M = Mn(II), Ni(II), Cu(II) Pd(II) and Pt(II), L=2,2'-{(1R,1'S)-1,1'Ferrocen-2,4-dien-1-yl-2,2'-diyl bis [(Z)methyl-ylidenenitrilo]}bis(3-iodophenol)] have been prepared and characterized by elemental analysis, magnetic susceptibility, Conductivity IR, UV-Visible, Mass spectra and TGA/DTA. Organometallic Sc...

K. George and M. V. Lokhande*

Department of Chemistry, Sathaye College, Vile Parle East, Mumbai , Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3413-20

3413-3420

137

52

26.

DESIGNING NATURAL AGONISTS FOR THYROID HORMONE RECEPTOR ALFA-1

Hypothyroidism is a common disorder of endocrine system in which the thyroid gland does not produce enough thyroid hormone. The most common cause of hypothyroidism is inflammation of the thyroid gland, which damages the gland’s cells. It can affect growth, cellular processes and many other body functions. As more damage accumulates, the risk of Hypothyroidism increases. In order to make an impac...

V. P. Sinoorkar, Y. N Joshi and B. B. Kudkyal*

Department of PG Studies and Research in Bioinformatics, Walchand Centre for Biotechnology, Walchand College of Arts and Science, Solapur, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3421-26

3421-3426

129

46

27.

DEVELOPMENT OF A NEW STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF METFORMIN HYDROCHLORIDE AND CANAGLIFLOZIN AND ITS VALIDATION AS PER ICH GUIDELINES

A new stability indicating RP HPLC method has been developed and validated for simultaneous estimation of Metformin Hydrochloride and Canagliflozin in bulk and dosage forms. The method involves separation on Kromasil C18 column (250mm x 4.6mm x5µm particle size). The optimized mobile phase consists of 0.1% OPA (pH 2.8) and Acetonitrile (45:55v/v) with a flow rate of 1ml/min and UV detection at 25...

V. Kommineni , K. P. R. Chowdary* and S. V. U. M. Prasad

Vikas Institute of Pharmaceutical Sciences, Near Airport, Rajahmundry, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3427-35

3427-3435

167

71

28.

FORMULATION AND IN-VITRO CHARACTERIZATION OF SELF MICROEMULSIFYING DRUG DELIVERY SYSTEMS OF RIVAROXABAN

The drug Rivaroxaban which was poorly soluble was selected for formulation of SMEDDS due to its poor aqueous solubility and its oral bioavailability which is 66%. Self micro emulsifying drug delivery system was developed to improve its solubility and bioavailability. Solubility of Rivaroxaban is determined in various oils, Surfactants, and co-surfactants by UV-Spectrophotometric method. Rivaroxaba...

M. S. Reddy*, S. Sowmya and S. M. F. Ul Haq

Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad ,Telangana, India

DOI: 10.13040/IJPSR.0975-8232.8(8). 3436-45

3436-3445

131

65

29.

STUDIES ON THE SYNTHESIS AND IN-VITRO ANTIMICROBIAL ACTIVITY EVALUATION OF SOME NOVEL β-LACTAMS CONTAINING SULFA DRUGS

The present study aims to synthesize 2-azetidinone derivatives; 4-(3-chloro-1-(4-substituted-phenyl)-4-oxoazetidin-2-yl)-2-methoxyphenyl-acetate (c1-c6) and 2-allyl-4-(3-chloro-1-(4-Substituted-phenyl)-4-oxoazetidin-2-yl)-6-methoxyphenyl4-methylbenzenesulfonate (d1-d6) by electrocyclisation of imines with chloroacetylchloride in the presence of triethyle - amine and 1, 4-dioxane. The synthesized c...

P. Deshmukh, P. K. Soni*, M. K. Ahirwar and A. K. Halve

School of Studies in Chemistry, Jiwaji University, Gwalior, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3446-51

3446-3451

128

64

30.

IDENTIFICATION OF HUMAN cAMP DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT INHIBITORS

Cyclic adenosine monophosphate (cAMP) dependent protein kinase plays a major role in cell signaling pathway. Over expression of extracellular cAMP dependent protein kinase catalytic subunit caused tumorgenesis in prostate. This protein may provide a base for the design of clinically applicable therapeutic strategies. In order to develop potential inhibitor of cAMP dependent protein kinase catalyti...

U. Khanam, B. K. Malik and B. Rathi*

Centre for Computational Biology and Bioinformatics, Amity Institute of Biotechnology, Amity University Noida, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3452-57

3452-3457

110

52

31.

FATTY ACID PROFILING IN DIPLOID (n = 12) AND TETRAPLOID CYTOTYPES (n = 24) OF PHYSALIS ANGULATA LINN. FROM RAJASTHAN BY GAS CHROMATOGRAPHY

Present paper reports the chemical constituents in the fatty acids obtained from the whole plant of diploid and tetraploid Physalis angulata Linn. collected from hot desert areas of Rajasthan. The fatty acid analysis was carried out by gas chromatography-flame ionization detector (GC-FID). Meiotic studies confirm the ploidy level of the plant. Diploid (n = 12) cytotype is reported from Udaipur dis...

Ramanpreet* and R. C. Gupta

Department of Botany, Punjabi University, Patiala, Punjab, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3458-62

3458-3462

102

50

32.

STUDIES ON THE DEVELOPMENT AND EVALUATION OF COLON SPECIFIC DRUG DELIVERY SYSTEM CONTAINING MEBEVERINE

The main aim of this study was to develop Mebeverine colon specific drug delivery system with increased stability of drug in stomach and small intestine. This stability of drug was achieved by coating of the drug core with Chitosan and Ethyl cellulose polymers by direct compression using tablet punching machine. Mebeverine was a drug whose therapeutic role is in the treatment of Irritable Bowel Sy...

M. Y. Begum*, C. Sirisha, G. P. Reddy and M. Sudhakar

Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad, Hyderabad, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3463-70

3463-3470

115

63

33.

SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF COPPER(II), COBALT(II) AND ZINC(II) COMPLEXES OF 6-METHOXY-3-FORMYLCHROMONE

A new series of Cu(II), Zn(II) and Co(II) complexes have been synthesized from 6-Methoxy-3-phenyliminomethyl-chromen-4-one, a Schiff base derived from 6-Methoxy-4-oxo-4H-chromene-3-carbaldehyde and aniline. The nature of bonding and the structure of the complexes have been deduced from IR, UV, 1H NMR spectroscopy. The biological activity of the ligand and metal complexes have been examined against...

S. Chahal, R. Kumar and S. Nain*

Department of Chemistry, Deenbandhu Chhotu Ram University of Science and Technology, Murthal, Sonepat, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3471-76

3471-3476

102

48

34.

AN INVESTIGATION OF ACOUSTIC, THERMODYNAMIC AND ANTIMICROBIAL ACTIVITY STUDY OF A DRUG IN A PEPTIDE

Peptides are recognized for being highly selective efficacious and at the same time, relatively safe and well tolerated. Consequently, there is an increased interest in peptides, in pharmaceutical research and development (R&D) and approximately 140 peptide therapeutics are currently being evaluated in clinical trials. Ultrasonic is an area of intense scientific and technological research, sci...

R. Padmavathy*, K. Dhanalakshmi, E. J. V. Rani and N. Radha

PG and Research Department of Physics, Seethalakshmi Ramaswami College, Tiruchirappalli , Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3477-83

3477-3483

119

50

35.

ISOLATION AND EVALUATION OF STARCH FROM MUSA PARADISIACA LINN. AS A BINDER IN TABLET

A hydrophilic polysaccharide become isolated from green fruit of Musa paradisiaca L. by the usage of wet milling procedure and distilled water extraction the use of sodium sulphite solution, accompanied by way of maceration, centrifugation and sedimentation. The isolated polysaccharides became characterised for physicochemical properties, viscosity and flow behaviour, scanning electron microscopy ...

S. Sandhan*, N. Thombre and S. Aher

MVP’s College of Pharmacy, Gangapur Road, Nashik, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3484-91

3484-3491

109

51

36.

ENVIRONMENTAL FRIENDLY WETCHEMICAL SYNTHESIS AND CHARACTERIZATION OF TRANSITION METAL DOPED PARTICLE

Transition metal doped zinc oxide particles were synthesized in aqueous phase adopting a low cost, easy and environmental friendly route. The precursors used in the preparation of Co doped ZnO (Zn0.95Co0.05O) and ZnO (Zn0.9oCo0.1O) by wet process are zinc acetate dehydrates cobalt chloride, sodium hydroxide, di-ethylene glycol and double distilled water. The doped ZnO particles were characterized ...

A. Gupta* and A. Pandey

Department of Chemistry, C.M.P. College, University of Allahabad, Allahabad, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3492-97

3492-3497

126

46

37.

SYNTHESIS OF NOVEL IMIDAZO [1, 2-a] PYRIDINE FOR THEIR POTENT ANTI-CONVULSANT ACTIVITY

Synthesis of a Derivatives of imidazo[1,2-a]pyridines with potent activity. Synthetic approaches allowing for variation of the 2-Amino Pyridines as well as other imidazopyridine substituents are outlined and resulting effects on anticonvulsant activity are highlighted. An experimental evaluation of anticonvulsant activity of synthesized Imidazo[1,2-a]pyridine derivatives by Maximal Electro Shock (...

V. Jain and N. Singh*

NRI Institute of Pharmacy, Raisen Road, Bhopal, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3498-02

3498-3502

103

51

38.

EXTRACTION AND CHARACTERIZATION OF GYMNEMAGENIN IN GYMNEMA SYLVESTRE LEAVES

The objective of the present investigation is to extract and characterize the active constituent, Gymnemagenin in Gymnema sylvestre leaves using various Chemical and Analytical techniques. Extraction of Gymnema sylvestre leaves powder is done by Continuous soxhlet extraction with 80% ethanol. Identification was done by various chemical tests and TLC. Characterization and quantification by HPLC met...

S. R. Nikhat *, A. R. Nath and V. R. Babu

MESCO College of Pharmacy, Mustaidpura Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3503-07

3503-3507

126

49

39.

STUDIES ON PHYTOCHEMICAL COMPOUNDS AND ANTIOXIDANT POTENTIAL OF AURICULARIA AURICULA-JUDAE

Auricularia auricula-judae is a precious colloid fungus, widely used as a food supplement and medicine in Southeast Asian countries. The hot water extract of Auricularia auricula-judae was investigated for antioxidant efficacy and also determined the amount of phytochemical components such as total phenols and flavonoids. Antioxidant activity was analysed by different in vitro assays namely, DPPH ...

B. Packialakshmi *, G. Sudha and M. Charumathy

Department of Biochemistry, Kongunadu Arts and Science College, Affiliated to Bharathiar University, Coimbatore, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3508-15

3508-3515

103

49

40.

PHYTOCHEMICAL SCREENING AND EVALUATION OF PHARMACOLOGICAL ACTIVITIES OF EULOPHIA NUDA LIND. TUBER EXTRACTS

Eulophia nuda Lind. belongs to family Orichidaceae and is a rare and endangered orchid. Present research work was carried out on tuber extracts of Eulophia nuda for the evaluation of antimicrobial activities and hepatoprotective. Preliminary phytochemical screening revealed presence of phytochemical constituents like alkaloids, flavonoids, steroids, glycosides (cardiac), tannins, saponins, carbohy...

V. P. Nagulwar*, M. Nandgave, M. S. Mahajan and S. A. Deshpande

Government College of Pharmacy, Kathora Naka, Amravati, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3516-23

3516-3523

124

52

41.

EVALUATION OF ANTIOXIDANT AND ANTIMICROBIAL ACTIVITY OF A MEDICINAL PLANT HYDROCOTYLE SIBTHORPIODES LAM., GROWN IN NE INDIA

The present study was conducted to evaluate the antioxidant and antibacterial activities of methanol and aqueous extracts of whole plant of Hydrocotyle sibthorpiodes Lam. Antioxidant activity was measured using reducing power, hydrogen peroxide and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assays. The antioxidant activity was expressed as percentage (%) of DPPH and H2O2 radical...

P. J. Handique and M. Garg*

Department of Biotechnology, Gauhati University, Guwahati, Assam, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3524-29

3524-3529

117

50

42.

PRELIMINARY PHYTOCHEMICAL SCREENING AND GC MS ANALYSIS OF CHLOROFORM EXTRACT OF KANDELIA CANDEL (L.) DRUCE

The aim of the present study is to screen the phytochemicals present in the leaf extract of Kandelia candel and further analysis of the bioactive components present in it by Gas chromatography - Mass spectrometry (GC-MS) analysis. Carbohydrates, proteins, amino acids, Saponins, flavonoids, terpenoids, glycosides, tannins, alkaloids, and phenols were present in the sample. The percentage yield of p...

T. K. Jasna*, P. R. Chandra and K. M. Khaleel

Department of PG Studies and Research in Botany, Sir Syed College, Taliparamba, Kannur, Taliparamba, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3530-33

3530-3533

112

53

43.

EVALUATION OF RATIONALITY IN PRESCRIBING FOR CARDIOVASCULAR DISORDERS IN INTENSIVE CARDIAC CARE UNIT: A PROSPECTIVE OBSERVATIONAL STUDY

Objective: To evaluate the prescribing pattern in patients admitted to intensive cardiac care unit, to evaluate direct cost of the treatment in patients admitted in intensive cardiac care unit, to evaluate the rationality of drugs prescribed and to prepare and submit therapeutic guideline for management of ACS. Method: This prospective observational study was carried out in ICCU for a period of te...

S. Sriram*, S. Balaji and G. Kwihangana

Department of Pharmacy Practice, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3534-40

3534-3540

127

54

44.

METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF PLERIXAFOR BY RP-HPLC METHOD IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORM

A simple, precise and accurate RP-HPLC method was developed for the determination of Plerixafor in bulk and pharmaceutical dosage forms. The estimation was carried out on Xterra RP 18 (4.6 x 250mm, 5µm) column using a mixture of Methanol: Water (50:50% v/v) as the mobile phase at a flow rate of 0.8ml/min, the detection was carried out at 215nm. The method was validated for linearity, accuracy, pr...

S. V. Saibaba* and P. S. Pandiyan

Department of Pharmacy, Mewar University, Chittorgarh, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3541-46

3541-3546

143

53

45.

THE INVESTIGATION ON TOTAL PHENOLIC CONTENT AND IN VITRO ANTIOXIDANT POTENTIAL OF DIFFERENT PLANT PARTS OF NYCTANTHES ARBOR-TRISTIS (NIGHT JASMINE)

Nyctanthes arbor-tristis (Paarijaat) is one of the important plants used in traditional medicines, mainly known for the medicinal properties of its flower and leaf. In this study, the four plant parts of Nyctanthes arbor-tristis were extracted sequentially with four solvents of decreasing polarity and investigated for antioxidant potential. The highest phenolic content was observed with flower, fo...

M. K. Thakur and P. Jaiswal*

Department of Botany, Environmental Science and Microbiology, Government Science College (Auto.), Jabalpur, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3547-51

3547-3551

105

56

46.

A STUDY TO ASSESS THE COST EFFECTIVENESS OF HOME BASED EDUCATION PROGRAMME AMONG CLIENTS WITH DIABETES MELLITUS (DM) AT SELECTED VILLAGES IN KANCHEEPURAM DISTRICT, TAMIL NADU, INDIA

Home based education among clients with diabetes mellitus (DM) by diabetes educator has been cost effective although some educational intervention have strong evidence on cost saving. This study aimed to assess the cost effectiveness of home based education programme on diabetic treatment among clients with diabetes mellitus.  Community based randomized controlled trial with experimental design w...

T. Suseelal*, K. R. John, A. Moses, J. Premkumar, M. Logaraj and V. C. Amalraj

SRM College of Nursing, SRM University, Kattankulathur, Kancheepuram, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3552-56

3552-3556

132

45

47.

INCIDENCE OF DIURETICS INDUCED ADVERSE DRUG REACTIONS IN AN INTENSIVE CARDIAC CARE UNIT OF A TERTIARY CARE TEACHING HOSPITAL

Objective: The present study was conducted to assess the incidence, causality and severity of diuretic induced Adverse Drug Reactions (ADRs). Method: 92 patients admitted in the intensive cardiac care unit and prescribed with diuretics were included and data on demographics, past medical and medication history, allergies to food/drugs, laboratory parameters, diuretics prescribed, side effects and ...

S. Vikas, M. Ramesh, V. N. Rani *, P. Thennarasu and G. Kannan

Department of Pharmacy, Practice, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai , Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3557-62

3557-3562

136

65

48.

ANTIMICROBIAL ACTIVITY OF METHANOLIC EXTRACT OF BARK OF PRUNUS CORNUTA

Prunus cornuta (family Rosaceae) commonly known as ‘Himalayan Bird Cherry’, is a deciduous tree growing to 15 m (49ft 3in) at elevations of 2100-3500 meters. It is hardy to zone (Uttarakhand) 5. It is in flower in May, and the seeds ripen from July to October. The flowers are hermaphrodite and are pollinated by insects and birds. It can grow in semi-shade (light woodland) or no shade. It prefe...

M. C. Purohit, M. Singh*, R. Purohit and G. Kumar

Department of Chemistry, H. N. B Garhwal University (A Central University), B.G.R. Campus Pauri, Srinagar Garhwal, Uttarakhand, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3563-67

3563-3567

127

56

49.

COMPARISON OF 7 – DAY CONCOMITANT THERAPY REGIMEN VERSUS CLASSIC TRIPLE THERAPY REGIMEN IN HELICOBACTER PYLORI ERADICATION: A RANDOMIZED CLINICAL TRIAL

There are various treatment regimens including different antibiotics and antacid medications for eradicating Helicobacter pylori to compare the effectiveness of 7-day concomitant regime with classic triple regimen in eradicating H. pylori. In this randomized clinical trial, 206 dyspeptic patients proven H. pylori infection, attended to a gastrointestinal clinic in Khorramabad (west of Iran) were s...

M. Moradniani, Z. Mirbeik-Sabzevari, M. Bahmani, S. Azadbakht and S. Jaferian*, H. Sherkatolabbasieh, S. Shafizadeh and M. M. Roozbahany

Department of Internal Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran

DOI: 10.13040/IJPSR.0975-8232.8(8).3568-73

3568-3573

146

49

50.

SELF-REPORTED CHRONIC ILLNESSES AND USE OF PRESCRIPTION MEDICINES (PM) AMONG ELDERLY MALAYS- A COMMUNITY BASED STUDY

This study explored self-reported chronic illnesses and use of prescription medicines (PM) by elderly Malays in the community. The study was a population based cross sectional study conducted among 490 Malay subjects aged ≥ 60 years in the semi-urban and rural areas in Perak, Malaysia. The study was conducted using pre-validated questionnaires after getting informed consent from the study partic...

B. K. Mohanty *, O. Ali , S. Sugathan and C. R. Giriyappanavar

Unit of Pharmacology, Faculty of Medicine, University Kuala Lumpur Royal College of Medicine Perak (UniKL RCMP), No. 3 Jalan Greentown, Ipoh, Perak, Malaysia

DOI: 10.13040/IJPSR.0975-8232.8(8).3574-81

3574-3581

96

40

51.

PROTEIN INTERACTION NETWORK AND DRUG DISCOVERY

Protein conformation and dynamics are influenced by various factors, including binding of ligands, their physico-chemical properties, etc. Every conformational change is dictated by an array of events, as making and breaking of bonds or change in interaction of protein residues. The three dimensional structure of protein molecules are widely investigated, based on small world network approaches, w...

M. Suriyavathana* and M. Vidhya

Department of Biochemistry, Periyar University, Salem, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3582-90

3582-3590

136

59

52.

THE REDUCTION IN CORTISOL INDUCED STRESS MARKERS BY THE AQUEOUS EXTRACT OF CLERODENDRUM COLEBROOKIANUM

In the present competitive world, stress is a major cause for several health disorders– Hypertension, Cardiovascular disorders, Supressed Immunity and other conditions. Proper stress management takes on great importance given the wide range of bodily systems impacted by stress hormones. Cortisol – the “stress hormone” affects the liver by increasing several biochemical pathways. One of the...

K. G. Singh*, J. J Thangi, H. A. Ashwini and C. J. M. D'souza

Department of Chemistry , Mount Carmel College, Palace Road, Bangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.8(8).3591-98

3591-3598

123

69