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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2015): 1.11 , ICV (2015): 90.24
Five-Year Projected Impact Factor: 2.60

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Volume 8 (2017) - Issue 3, March

Review Articles

 
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1.

REVIEW OF NATURAL PRODUCTS FROM MARINE ORGANISMS IN THE RED SEA

The marine environment is a rich source of both biological and chemical diversity. This diversity has been the source of unique chemical compounds with potential for drug development. In recent years, a significant number of novel metabolites with potent pharmacological properties have been discovered from the marine organisms. Specifically, the Red Sea is a natural source of these bioactive compo...

R. Abou El-Ezz , A. Ibrahim, E. Habib, A. wahba , H. Kamel, M. Afifi, H. Hassanean and S. Ahmed *

Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

DOI: 10.13040/IJPSR.0975-8232.8(3).940-74

940-974

851

741

2.

A REVIEW ON THE ROLE OF ASROCYTE ELEVATED GENE-1 IN CANCER

AEG-1 expression is known to elevate in diverse cancers, where it plays a primary role in activating multiple signaling pathways that drives copious oncogenic properties. The versatile role of AEG-1 in mediating oncogenesis was found to be cognate with numerous signaling cascades such as the activation of NF-κB/p65, Ha‑Ras, PI3K/Akt, ERK/MAPK, Wnt/β-catenin, AURKA and RNAi pathways. In additio...

G. Nithya, U. Devan, K. Mahesh Kumar and A. Antony Joseph Velanganni *

Molecular Oncology Laboratory, Department of Biochemistry, School of Life sciences, Bharathidasan University, Tiruchirappalli - 620024, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).975-84

975-984

597

409

3.

POTENTIAL BIOMEDICAL APPLICATIONS OF METALLIC NANOBIOMATERIALS: A REVIEW

Nanobiomaterials are very effective components for several biomedical and pharmaceutical studies. Among the metallic, organic, ceramic and polymeric nanomaterials, metallic nanomaterials have shown certain prominent biomedical applications. Enormous works have been done to synthesize, analyse and administer the metallic nanoparticles for various kinds of medical and therapeutic applications, durin...

B. Shivaramakrishnan *, B. Gurumurthy and A. Balasubramanian

Department of Pharmacology, JSS College of Pharmacy, Udhagamandalam, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.8(3).985-00

985-1000

702

418

4.

REVIEW ARTICLE ON PERMEATION ENHANCERS: A MAJOR BREAKTHROUGH IN DRUG DELIVERY TECHNOLOGY

The human skin serves as an impediment, a thermo regulator and prevents excessive loss of water from the internal organs. Various ways of transferring the drugs have been developed by modifying the barrier properties of the skin. Enhancement in skin penetration by hydration of the stratum corneum, or by use of chemical enhancers acting on the lipids and keratinized structures in the stratum corneu...

N. Roy, M. Agrawal, S. Chaudhary, V. Tirkey, A. Dhwaj and N. Mishra *

Department of Biomedical Engineering, Indian Institute of Information Technology, Devghat, Jhalwa, Allahabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1001-11

1001-1011

611

385

5.

UTILIZING MUCOADHESIVE POLYMERS FOR NASAL DRUG DELIVERY SYSTEM

Nasal drug delivery has been recognized as a promising route for delivery of therapeutic compounds including biopharmaceuticals. It has been demonstrated that absorption of drugs can enhanced by using absorption enhancers or increasing the drug residence time in the nasal cavity. Mucoadhesive polymers can serve both functions. The residence time in the nasal cavity is considerably increased for mi...

Rahul H. Kirange * and Ram B. Chaudhari

S. Zhaveri Pharmakem Pvt. Ltd., Kalyan - shilphata rd, Dombivli East, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1012-22

1012-1022

471

321

6.

GLUTATHIONE S-TRANSFERASES: A BRIEF ON CLASSIFICATION AND GSTM1-T1 ACTIVITY

The glutathione S-transferase (GST) isoenzyme superfamilies detoxify a wide-range of toxic chemicals and environmental substances are extensively expressed in mammalian tissues. Liver and pancreas are the sites where cytosolic Phase I and phase II biotransformation GSTs enzymes have characteristic expression. GSTs play a key role in the deactivation of reactive oxygen species (ROS) and the metabol...

Prem Chandra Suthar

Anthropological Survey of India, Western Regional Centre, Udaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.8(3).1023-27

1023-1027

170

65

Research Articles

 
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7.

IN-VITRO AND IN-VIVO EVALUATION OF GLYCERIN AS A SOLVENT FOR THE IONTOPHORETIC DELIVERY OF DIPHENHYDRAMINE HYDROCHLORIDE

Diphenhydramine hydrochloride (DPH) is an antihistamine used topically to relieve skin itching and, at higher doses, DPH also has the capability to induce local skin anesthesia. The present study investigates the possibility to deliver DPH via iontophoresis using a stainless steel electrode.  In-vitro iontophoresis was performed using 1% (w/v) DPH dissolved in glycerin (100%), deionized (DI) wate...

J. Mehta, M. Patel and G. Stagni *

Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy, Long Island University, 75 Dekalb Ave., Brooklyn, NY 11201, USA.

DOI: 10.13040/IJPSR.0975-8232.8(3).1028-37

1028-1037

484

385

8.

PREPARATION AND IN VITRO CHARACTERIZATION OF RESEALED ERYTHROCYTES CONTAINING TMR-DEXTRAN FOR DETERMINATION OF HEMOGLOBIN UPTAKE AND TRANSFER BY THE MALARIA PARASITE

The hemoglobin uptake and transport by the malaria parasite, Plasmodium falciparum are preferable targets for antimalarial drug development. There is a need for alternative approaches to investigate the endocytic process of live and intact cells under non-disruptive conditions as previous findings were mostly based on morphological analysis of thin-section electron micrographs. In the present stud...

N. H. Mohd-Zamri, N. J. Sinin and N. Abu-Bakar *

School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.8(3).1038-47

1038-1047

572

269

9.

AN ANTI-DIABETIC POLY-HERBAL MEDICINE PREPARED FROM EXTRACTS OF ANNONA STENOPHYLLA, CITRUS LIMON AND ZINGIBER OFFICINALE

Background: Diabetes poses a burden on the limited health care delivery system. Current pharmacological anti-diabetic agents cause undesirable side effects and are very expensive. Herbal remedies offer the potential for alternative treatment strategies. This study was therefore conducted in an effort to formulate a poly herbal medicine for management of diabetes. Methods: A stenophylla root bark w...

W. Verengai, L. Chagonda, K. Chitindingu, A. Marume and T. Taderera *

School of Pharmacy, University of Zimbabwe, Mt Pleasant, Harare, Zimbabwe.

DOI: 10.13040/IJPSR.0975-8232.8(3).1048-55

1048-1055

504

324

10.

FORMULATION AND EVALUATION OF NOVEL ANTIAGING CREAM CONTAINING RAMBUTAN FRUITS EXTRACT

Skin aging is a complex process induced by constant exposure to ultraviolet (UV) irradiation and damages human skin. Rambutan (Nephelium lappaceum), a delicious tropical fruit that grow in Malaysia and spread widely in most Southeast Asian countries, have strong antioxidants properties due to the presence of ellagic acid, corilagin, geraniin, β-carotene and vitamin C. These compounds scavenge the...

Mahendran Sekar *, Pavitra Sivalinggam and Afzan Mahmad

Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur, Royal College of Medicine Perak, Ipoh, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.8(3).1056-65

1056-1065

558

315

11.

ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF VARIOUS BREAD FRUIT LEAVES (ARTOCARPUS ALTILIS (PARKINSON) FOSBERG)

Breadfruit (Artocarpus altilis (Parkinson) Fosberg) empirically has been used in certain communities in Indonesia as a traditional medicine. Biosynthesis process can change colour leaves of breadfruit from green leaves (GL), yellow leaves (YL), fallen yellow (FY), fallen dry (FD), and the process fermentation of green leaves become fermented green (FG). The purpose of this study was to determine w...

Hesti Riasari *, Maria Ulfah, Diki Prayugo and Nurul Annisa Komariah

College of Pharmacy Indonesia Jl. Soekarno-Hatta No.354 (Parakan Resik), Bandung, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.8(3).1066-73

1066-1073

528

417

12.

LIPID PROFILE VARIABLES AND PREDICTION OF THE SEVERITY OF CORONARY ARTERY DISEASE IN TUNISIAN TYPE 2 DIABETIC PATIENTS

DM is characterized by insulin resistance and dyslipidemia, in particular, high levels of total cholesterol, triglycerides and LDL, and low levels of HDL-C, wich confer increased risk for CAD. Our study aimed to evaluate lipid profile in type 2 diabetic (T2DM) patients with coronary artery disease (CAD) in Tunisian population. Plasma levels of lipid profile variables were determined in 148 CAD pat...

N. Bouzidi *, S. Sahli, L. Khlifi, H. Graiet, F. Maatouk, H. Gamra and S. Ferchichi

Biochemistry Laboratory, Faculty of Pharmacy, University of Monastir, Tunisia.

DOI: 10.13040/IJPSR.0975-8232.8(3).1074-80

1074-1080

158

63

13.

PHYTOCHEMICAL PROFILE OF SEQUOIA SEMPERVIRENS GROWN IN EGYPT

The immunomodulatory and antiulcerogenic activities of the chloroform, ethyl acetate and n-butanol fractions of Sequoia sempervirens (D. Don.)  leaves were investigated. The ethyl acetate fraction showed the best results regarding to a high significant increase of RAW 264.7 macrophage cells and reduction of ulcers number and severity compaered with Ranitidine. HPLC technique was used to investiga...

Kamilia F. Taha and Zeinab T. Abd El Shakour *

Laboratory of Phytochemistry, National Organization for Drug Control and Research, Cairo- Egypt.

DOI: 10.13040/IJPSR.0975-8232.8(3).1081-90

1081-1090

175

77

14.

HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DRUG RELEASE OF LEVODOPA AND CARBIDOPA IN ENTACAPONE, LEVODOPA AND CARBIDOPA TABLETS

In pharmaceutical industry, researchers aim at catering to the need of robust analytical methods for analysis of generic drug products. The paper deals with method of analysis of pharmaceutical formulation - Entacapone, Levodopa and Carbidopa tablets for the treatment of Parkinson’s disease.  The paper presents a simple and efficient HPLC method that has been developed for a multi component dru...

P. Bhatnagar *, D. Vyas, S. Kumar Sinha and A. Gajbhiye

Macleods Pharmaceuticals Limited, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1091-01

1091-1101

178

87

15.

CHRYSIN LOADED CHITOSAN NANOPARTICLE: FORMULATION AND IN-VITRO CHARACTERIZATION

Flavonoids are natural products widely distributed in plant kingdom that gained lot of importance due to variety of biological effects relevance to numerous healthcare. It has been chosen as a drug molecule and gained attention in the area of novel drug delivery system because of their disease preventing property and therapeutic expediency in multiple biological effects. Chrysin (C) is one of the ...

K. S. Sridevi Sangeetha *, S. Umamaheswari , C. U. Maheswara Reddy and S. Narayana Kalkura

Department of Pharmacology, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai Tamilnadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1102-09

1102-1109

222

75

16.

FORMULATION AND EVALUATION OF ARCHIMEDES BASED NOVEL FLOATING CAPSULE THROUGH FILM FORMATION AND RETENTION FOR DRUG DELIVERY OF LEVOFLOXACIN

The study objectives were to develop a unique expandable integrated floating film to be filled in capsule dosage form, which combines hydrophilic and hydrophobic polymers. The developed film was totally free from the concept of gas generating system or the low-density system, which floats merely due to Archimedes principle. A 32 full factorial design was used in the study with HPMC K100M (X1) and ...

Kauser Fatema *, Md. Ismail Mouzam, S. R. Shahi and Tauqeer Shaikh

Y. B. Chavan College of Pharmacy, Aurangabad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1110-23

1110-1123

144

46

17.

ANTIOXIDANT, ANTIMICROBIAL AND ANTIPROLIFERATIVE ACTIVITIES OF LEAF EXTRACTS OF THE INDIAN TRADITIONAL MEDICINAL PLANT WRIGHTIA ARBOREA

Introduction: Wrightia arborea (Apocynaceae) has been used in traditional medicine to treat ailments such as menstrual and renal complaints, snake-bites, tooth-ache and diarrhea. Objective: This study aimed to evaluate the phytochemical constituents, antioxidant, antimicrobial and antiproliferative activities of W. arborea leaf extracts. Materials and Methods: Total phenolic and flavonoid contents...

T. Lakshmipriya, T. Soumya , P. R. Jayasree and P. R. Manish Kumar *

Department of Biotechnology, University of Calicut, Malappuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1124-33

1124-1133

195

78

18.

FORMULATION AND OPTIMIZATION OF BUPROPION HCl MICROSPONGES BY 23 FACTORIAL DESIGN

The rationale of the present study was to formulate & optimize the floating Bupropion HCl microsponges by 23 factorial design. The concentration of ethyl cellulose (EC), polyvinyl alcohol (PVA) and Dichloromethane (DCM) were selected as independent variables. Floating lag time & % drug release were selected as independent variables. Factors, their levels (with values) were substituted in t...

P. Muralidhar, E. Bhargav and B. Srinath

Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research, K.R. Palli cross, Anantapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1134-44

1134-1144

173

82

19.

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF INDOLE DERIVATIVE BEARING THE PYRAZOLE MOIETY

Series of 1 of  1-[(3,5 diphenyl substituted ) -4,5-dihydro-1H-pyrazol-1-yl]-2-(3H-indol-3-yl) ethan-1-one (5a-5j)  derivatives were synthesized by the reaction between indole 3 acetic acid hydrazide and various chalcones (3a-3j). The Chalcones were prepared by Claisen-Schmidt condensation reaction in which substituted aromatic aldehydes was treated with simple acetophenone(aromatic ketones) in ...

Imaduddin Quazi *, V. Girija Sastry and Javed Akhtar Ansari

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, MESCO College of Pharmacy (Affiliated to Osmania University), Hyderabad, TS, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1145-52

1145-1152

158

52

20.

REPROTOXICITY AND GENOTOXICITY BY ARSENIC ENSUING TO MALE INFERTILITY IN MALE MUS MUSCULUS

Arsenic has become a major problem in arsenic contaminated areas today. Its consequences on human health have been increasing with an alarming rate. Apart from toxicological effects caused by arsenic accumulation in the body, it causes several disorders including male infertility. Arsenic has been implicated to expedite the generation of ROS and hence lipid per-oxidation leading to DNA damage, apo...

A. Nath, A. K. Anshu*, Priyanka, C. K. Singh, S. Behera and J. K. Singh

Research Institute, S. S. Hospital and Research Institute, Patna, Bihar, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1153-59

1153-1159

136

69

21.

EFFECT OF GYMNEMA SYLVESTRE ON THE PHARMACOKINETICS OF SITAGLIPTIN PHOSPHATE IN TYPE II DIABETES MELLITUS

Practising complementary and alternative medicinal therapy has become a boom worldwide. There is a dearth in communication between doctors and the patients regarding concomitant use of complementary medicines like ayurvedic churnas and other drugs of natural origin with allopathic drugs. This usage might magnify or oppose the effect of synthetic drug leading to interactions. Use of herbals along w...

S. R. Dhande *, D. V. Lokegaonkar and S. P. Bhutkar

Bharati Vidyapeeth’s College of Pharmacy, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1160-67

1160-1167

174

40

22.

EVALUATION OF CENTRAL AND PERIPHERAL ANALGESIC ACTIVITIES OF SOLANUM MELONGENA ETHANOLIC LEAF EXTRACT IN EXPERIMENTAL ANIMALS.

The aim of the study was to evaluate the central and peripheral analgesic activities of Solanum melongena ethanolic leaf extract in experimental animals. The Solanum melongena leaves were air dried at room temperature and were ground to a fine powder. Ethanolic extract was obtained by percolating the dried powder with 95% ethanol. Oral toxicity test was done according to OECD guidelines. For evalu...

M. Das *, K. Gohain and S. Das

Department of Pharmacology, Assam Medical College, Dibrugarh, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1168-72

1168-1172

145

74

23.

ANTI-DIABETIC AND HYPOLIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF ARISTOLOCHIA BRACTEOLATA ON STREPTOZOTOCIN INDUCED DIABETIC RAT MODEL

The objective of the present study was to evaluate the anti-diabetic and hypolipidemic activity of methanolic extract of whole plant of Aristolochia bracteolata (MEAB) against streptozotocin (STZ) induced diabetic rat model. Glibenclamide was used as standard drug. The MEAB was administered orally at a dose of 200 & 400 mg/kg bd. wt and blood glucose levels were determined on 0th, 7th, 14th, 2...

M. Ganga Raju * and T. Hema Sundar Reddy

Gokaraju Rangaraju College of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1173-77

1173-1177

181

84

24.

OPTIMIZATION OF TELMISARTAN TABLET FORMULATION BY 23 FACTORIAL DESIGN EMPLOYING βCD, PRIMOJEL AND TWEEN 80

The objective of the present study is optimization of telmisartan tablet formulation employing βCD, Primojel, and Tween 80 by 23 factorial design to achieve NLT 85% dissolution in 10 min. Eight telmisartan tablet formulations were prepared using selected combinations of the three factors as per 23 factorial design. Telmisartan tablets were prepared by direct compression method and were evaluated....

P. Lakshmanarao, K. P. R. Chowdary * and S.V.U.M. Prasad

Vikas Institute of Pharmaceutical Sciences, Rajahmundry, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(3).1178-83

1178-1183

168

44

25.

A STUDY OF ANTIBACTERIAL AND ANTIFUNGAL ACTIVITY OF THE LEAVES OF COLOCASIA ESCULENTA LINN.

Aim: The study was done to evaluate the antibacterial and antifungal activity of the leaves of Colocasia esculenta Linn. Materials and Methods: Fresh tender leaves of C.esculenta collected, air-dried at room temperature, grounded to a fine powder and extracted with ethanol. The antibacterial and antifungal activity of C.esculenta compared to standard antibiotics was assessed by disc diffusion meth...

Sarmistha Dutta * and Biswajit Aich

Department of Pharmacology, Gauhati Medical College and Hospital, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1184-87

1184-1187

233

102

26.

KNOWLEDGE TOWARDS DIGITAL LIBRARY AND INNOVATION IN PHARMACY PRACTICE

Pharmacy profession has responsibility for ensuring the safe, effective and rational use of medicines. Effective pharmacy practice requires an understanding of the social context which is practiced, innovative and informative. The aim of the study was to find out the Knowledge towards digital library and innovation in pharmacy practice by Questionnaire based Prospective study on pharmacy-medical p...

Abdulmohsen H. Alrohaimi, Md. Salahuddin Ansari *, Zafer Saad Al Shehri and Md. Sarfaraz Alam

Department of Pharmacy Practice, College of Pharmacy Aldawadmi, Shaqra University, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.8(3).1188-93

1188-1193

165

53

27.

PRELIMINARY PHYTOCHEMICAL SCREENING AND HPTLC FINGERPRINT PROFILE OF TRAGIA PLUKENETII

Herbal medicine is the oldest form of health care known to humanity and has been used in all cultures throughout history. The validation of these novel products needs powerful analytical devices tailored for the study of herbal extracts in order to assess composition and face their natural complexity as a resource. The last item is important and crucial for the capacity and utility of the analytic...

M. Kalaivanan, L. Louis Jesudoss, A. Saravana Ganthi * and M. Padma Sorna Subramanian

Department of Botany, Rani Anna Govt. College for Women, Tirunelveli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1194-98

1194-1198

216

74

28.

ETHNOBOTANICAL AND FLORISTIC STUDY OF MEDICINAL PLANTS IN THE REGION OF OUED TLELALT, ALGERIA

An ethnobotanical study of medicinal plants was carried out in the region of Oued Tlelat. It was made in order to establish the catalog of medicinal plants and gather all information on the therapeutic uses practiced by the local population in the study area. The results have identified 59 species that are divided into 29 families of which three are the most dominant, especially Lamiaceae, Apiacea...

N. Bouredja *, N Messaoudi and K Benyamina

Department of living and Environment, Faculty SNV, University of Sciences and Technology, USTO-MB-Oran, Algeria

DOI: 10.13040/IJPSR.0975-8232.8(3).1199-04

1199-1204

191

51

29.

SYNTHESIS AND IN VITRO ANTIBACTERIAL ACTIVITY OF SOME PHENYL URENYL CHALCONES

Despite significant progress made in the treatment of infectious diseases, caused by bacteria and fungi, it remains a major worldwide health problem due to rapid development of resistance against the existing antimicrobial drugs. In the present investigation, a novel series of chalcones 2a–2h were synthesized by the clasein-schmidt condensation of various aldehydes with methyl ketone in the pres...

Himangini * and D. P. Pathak

Department of Chemistry, Delhi Institute of Pharmaceutical Science and Research, Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1205-09

1205-1209

172

53

30.

DESIGN AND DEVELOPMENT OF EMULSION-BASED CLEAR COMPLEXION SKIN WHITENING CREAM USING GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT AND VATERIA INDICA (WHITE DAMMAR) BARK EXTRACT BY SKIN MELANIN INHIBITORY PATHWAY

The objective of this study was to design and develop a skin lighting cream for improved skin whitening using herbal extracts from Glycyrrhiza glabra (Licorice) root and Vateria indica bark. The carrier cream base was developed by emulsion technique to deliver skin whitening property by holding the natural herbal actives such as G. glabra root extract and V. Indica bark extract as well as physical...

N. Kirubakaran *, Thiyagarajan , C. Mahendra, S. Varma, V. Kumar, V. Tripathi and Babu

Department of Personal Care Formulations, The Himalaya Drug Company, Makali, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1210-19

1210-1219

173

56

31.

STABILITY INDICATING RP – HPLC METHOD FOR COMBINATION OF AMBROXOL HYDROCHLORIDE AND CEFADROXIL MONOHYDRATE IN PHARMACEUTICAL FORMULATION

Reverse Phase - High performance liquid chromatographic (RP - HPLC) method was described for determination of Ambroxol Hydrochloride (AMB) and Cefadroxil Monohydrate (CEFXL). The chromatographic separation was achieved using mobile phase mixture of  Acetonitrile and 0.05 M Dihydrogen Phosphate Buffer (pH 3.0 adjusted with Ortho Phosphoric Acid Solution) in the ratio of 40:60 (%v/v) and Eclipse Pl...

J. A. Goswami * and N. J. Shah

Quality Assurance Department, School of Pharmacy, RK University, Rajkot, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.8(3).1220-28

1220-1228

176

76

32.

ANTIMYCOTICS IN CERTAIN TAXA OF EUPHORBIACEAE

There is a lot of thrust on utilization of bioactive chemicals from plant systems and their significant effect on microorganisms.  Ten species of plants of the family Euphorbiaceae have been used for our study they are, Croton bonpandianum, Euphorbia tirucalli, E. hirta, E. heterophylla,   Jatropha curcas, J. glandulifera, J. multifida, Phyllanthus amarus, Ricinus cummunis, Pedilanthus tithymal...

R. Vimala, B. R. Mrunalini, Mahuya De Ghosh * and T. M. Ramakrishna

Department of Chemistry, Indian Academy Degree College, Centre for Research and PG Studies, Bengaluru, Karnataka, India.

DOI: DOI: 10.13040/IJPSR.0975-8232.8(3).1229-34

1229-1234

231

53

33.

A STUDY ON THE ANTIMICROBIAL PROPERTY OF THE COTTON FABRIC IMPARTED WITH MICHAELIA CHAMPACA LEAF EXTRACT LOADED NANOPARTICLES

In the present work ethanol, methanol, ethyl acetate, chloroform and benzene extract of the Michaelia champaca leaves were screened for their antimicrobial activity.  The ethanolic extracts of M. champaca leaves were proved to have the maximum antimicrobial activity; thus the ethanolic leaf extract was selected and the nanoparticles were synthesized using ionic gelification method. The nanopartic...

R. Rajendran, R. Radhai *, R. Savitha, S. K. Sundaram, K. Kongarasi, C. Geethadevi and V. Rajalakshmi

PG and Research Department of Microbiology, PSG College of Arts and Science, Coimbatore, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1235-44

1235-1244

167

64

34.

STUDIES ON TREE BIOMASS FOR ASSESSING CARBON DENSITY IN TROPICAL FOREST ECOSYSTEM OF CENTRAL INDIA

The studies on tree biomass for assessing carbon density in tropical forest ecosystem of central India was undertaken during 2009-11 in forest area of eight districts [Jabalpur, Seoni, Balaghat, Narsinghpur, Mandla, Dindori, Shahdol and Umaria] at 30 adopted representative sites at varying latitudes and longitudes. The annual rainfall of their study area was 1000-1600 mm. The soils of the study si...

D. K. Hirankhede, Hardayal Khangar * and Shashi Alok

Department of Plant Physiology, Jawaharlal Nehru Krishi Vishwa Vidyalaya, Jabalpur Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(3).1245-48

1245-1248

172

45

35.

DRUG UTILIZATION PATTERN AMONG GERIATRIC PATIENTS IN A TERTIARY CARE TEACHING HOSPITAL

Objective: To evaluate drug utilization pattern among geriatric patients in outdoor as well as indoor departments of the hospital. Methods: Observational, prospective study was conducted from March 2014 to March 2015 among 600 geriatric patients; demographic details, education, occupation, diagnosis and drug details were recorded. The drugs were categorized by anatomical therapeutic classification...

U. S. Lalwani *, A. Pillai and K. G. Piparva

Department of Pharmacology - PDU Medical College, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1249-54

1249-1254

157

46

36.

FORMULATION AND EVALUATION OF INDAPAMIDE SUSTAINED RELEASE MATRIX TABLETS

The study was undertaken with an aim to formulate anti-hypertensive agents as sustained release matrix tablets. The literature review showed that Indapamide is an anti hypertensive / diuretics in SR dosage form 50% of drug is released between 5-14hrs and 20-80ng/ml blood level is obtained for 24 hrs and SR form permits uniform and constant blood level after absorption of galenic form by oral route...

V. Rajesh Babu* and Syeda Rana Nikhat

Department of Pharmaceutics, MESCO College of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1255-59

1255-1259

160

58

37.

EVALUATION OF BRONCHIAL SMOOTH MUSCLE RELAXANT ACTIVITY OF FLUPIRTINE IN EXPERIMENTALLY INDUCED ASTHMA IN GUINEA PIGS

Objectives: The study aimed at evaluating the broncho-relaxant effect of the test drug Flupirtine in experimentally induced Asthma in Guinea pigs & compares its efficacy with the Standard. Materials and Methods: Guinea pigs of both sexes weighing around 350-400 gm were randomly divided into 3 groups of 6 animals each. Groups were categorised into Control, Standard and test groups. Animals serv...

Sabreen Bashir * and Md. Sibgatullah

Department of Pharmacology, JSS Medical College, Mysore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1260-63

1260-1263

148

37

38.

IDENTIFICATION OF POTENTIAL INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE BY VIRTUAL SCREENING AND DOCKING STUDIES

Understanding the mode of inhibition through the crystal structures of EGFR kinase domain complex with small molecule inhibitors provides us to search for potential ligands of EGFR. The binding mode analysis of pyridopyrimidine analog reveals that the presence of hydrogen bonds between the target protein amino acid Met 793 (i.e. the hinge region which is responsible for catalytic activity of the d...

S. Sugunakala and S. Selvaraj *

Department of Bioinformatics, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1264-74

1264-1274

149

40

39.

DESIGN AND CHARACTERIZATION OF PULSATILE DRUG DELIVERY SYSTSEM OF LERCANIDIPINE

The purpose of the present investigation is to formulate and evaluate Lercanidipine pulsatile drug delivery system by press coating method. The inner core tablets were prepared by using direct compression method by using cross-carmellose sodium (Ac-Di-Sol), sodium starch glycolate, crospovidone as super disintegrants. The drug polymer interaction was investigated by FTIR and their results directed...

Basu Venkateswara Reddy * and Kaluva Navaneetha

Department of Pharmaceutics, Santiram College of Pharmacy, Nandyal, Kurnool Dist, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1275-81

1275-1281

150

35

40.

ANTI-OXIDANT ACTIVITY OF AQUEOUS AND ORGANIC EXTRACTS FROM KENYAN RUELLIA PROSTRATA

Ruellia species belong to Acanthaceae family, and are perennial creepers with widespread medicinal uses including analgesic and anti-inflammatory activity. The objective of this study was to determine the qualitative phytochemical constituents and anti-oxidant activity of crude extracts from whole plant parts of Kenyan Ruellia species viz. Ruellia prostrata. Whole parts of the plants were collecte...

C. O. Wangia *, J. A. Orwa, F. W. Muregi, P. G. Kareru, K. Cheruiyot and J. Kibet

Department of Pharmacology, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya

DOI: 10.13040/IJPSR.0975-8232.8(3).1282-86

1282-1286

190

76

41.

EVALUATION OF WOUND HEALING ACTIVITY OF ZIZIPHUS XYLOPYRUS (RETZ) WILLD LEAVES EXTRACT IN WISTAR ALBINO RATS

Aim: The present study provides a scientific evaluation for the wound healing activity of methanolic extract of Ziziphus xylopyrus (Retz) Willd leaves (MEZX). Methods: Incision and excision wound models were used to evaluate the wound healing activity of MEZX on Wistar rats. In each model, animals were divided into four groups of 6 animals each. In both model, Group I was assigned as control (oint...

Talha Jawaid *, Mehnaz Kamal, Abha Kumari and Kuldeep Singh

Department of Pharmacology, Hygia Institute of Pharmaceutical Education and Research, Ghaila Road, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1287-93

1287-1293

164

56

42.

EVALUATION OF SERUM ADIPONECTIN AND ADIPOQ +45 T>G POLYMORPHISM WITH METABOLIC SYNDROME IN TUNISIAN POPULATION

Adiponectin has been schown to protect from insulin resistance, demonstrate anti-inflammatory and anti-atherosclerotic effects and be involved in the pathogenesis of metabolic syndrome (MS). We aimed to assess the  association between serum adiponectin concentration, insulin resistance and various risk factors of MS and to investigate the relationship between the single nucleotide polymorphism (S...

S. Sahli *, L. Khlifi, A. Jaballah, S. Khelil, N. Bouzidi, H. Chahed, S. Ferchichi and A. Miled

Biochemistry Laboratory CHU Farhat HACHED, Sousse, Tunisia.

DOI: 10.13040/IJPSR.0975-8232.8(3).1294-00

1294-1300

170

71

43.

DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR SIMULTANEOUS ESTIMATION OF DEXTROMETHORPHAN AND QUINIDINE BY RP-HPLC AND UV-SPECTROMETRY

Objectives of study: To develop and validate new, rapid, selective, precise, accurate and economical, isocratic RP-HPLC and UV spectrophotometric method for simultaneous estimation of Dextromethorphan and Quinidine in bulk and in tablet formulations. Methods: A RP-HPLC was developed for the simultaneous estimation of Dextromethorphan and Quinidine on Phenomenex C-8 column with the mobile phase of ...

K. Poornima *, Y. Madhusudan and K. P. Channabasavaraj

Department of Pharmaceutical Chemistry, PES College of Pharmacy, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1301-13

1301-1313

186

36

44.

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEW BENZOTHIAZOLE DERIVATIVES

Some new hydrazino group substituted benzothiazole derivatives have been synthesized and their characterization was done by IR, NMR and MASS spectral data. The antimicrobial activities of these synthesized compounds was done by cup-plate diffusion method in DMSO against some Gram positive and Gram negative bacteria. Some of synthesized derivatives exhibited potent activity when compared with stand...

G. J. Upadhaye * and A. J. Asnani

J. L. Chaturvedi College of Pharmacy, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1314-18

1314-1318

153

52

45.

PHYTOSYNTHESIS OF SILVER NANOPARTICLES USING FRUIT EXTRACT OF LEEA INDICA (BURM. F.) MERR. AND THEIR ANTIMICROBIAL ACTIVITY

Green nanotechnology is gaining importance due to the elimination of harmful chemicals and provides a safe, environmental friendly and economic method for synthesis of nanoparticles. In the present investigation fruit extract of Leea indica (Burm.f.) Merr. was used for the synthesis of silver nanoparticles. Aqueous fruit extract were added to 1 mm silver nitrate solution by changing the colour of ...

Veena K. Rokhade and T.C. Taranath *

P. G. Department of Studies in Botany, Karnatak University, Dharwad, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1319-25

1319-1325

231

46

46.

ANTILITHIATIC ACTIVITY OF GREWIA ASIATICA IN MALE RATS

Lithiasis is the process of stone formation in the kidney, bladder, and/or urethra. Herbal drugs are reported to be effective in the treatment of urolithiasis with no side effects. Grewia asiatica is a plant commonly used as a traditional herbal medicine and possesses the wide range of pharmacological applications. The present study investigated the antilithiatic activity of an ethanolic leaf extr...

P. Veeresh Babu *, M. Vamsi Krishna, T. Ashwini and M. Ganga Raju

Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1326-35

1326-1335

136

40

47.

ANTI-DIABETIC, HYPOLIPIDEMIC AND HEPATO-RENAL PROTECTIVE EFFECT OF A NOVEL FERMENTED BEVERAGE FROM SYZYGIUM CUMINI STEM

In view of therapeutic values associated with Syzygium cumini and increasing consumer demand for functional foods, a non-conventional alcoholic beverage prepared from the stem of Syzygium cumini was evaluated for its efficacy against streptozotocin-induced diabetes mellitus in male wistar rats. The beverage was observed to be safe for consumption as it did not produce any anomalies in the biochemi...

Urvashi Swami, Praveen Rishi and Sanjeev Kumar Soni *

Department of Microbiology, Panjab University, Chandigarh, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1336-45

1336-1345

141

44

48.

PROTECTIVE EFFECT OF NYCTHANTHES ARBOR-TRISTIS ON SCOPOLAMINE INDUCED AMNESIA IN RATS “A BEHAVIOURAL AND BIOCHEMICAL APPROACH”

The hydroalcoholic extract of Nyctanthes arbor-tristis (HeNAT) leaf was prepared using Soxhlet apparatus. Memory impairment (amnesia) in male albino rats induced by scopolamine hydrochloride was recorded as transfer latency time (TLT) in EPM model; escape latency time (ELT) and time spent in Q4 target quadrant (TSTQ) in MWM model. Scopolamine markedly decreased the TLT over 2 min, ELT, TSTQ over 9...

Sonakshi Antal , Vrish Dhwaj Ashwlayan * and Anuj Kumar

Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut, India, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1346-55

1346-1355

139

40

49.

DEVELOPMENT OF THE PROCESSING STRATEGIES FOR THE PRODUCTION OF DAPTOMYCIN BY FREE AND IMMOBILIZED CELLS OF STREPTOMYCES ROSEOSPORUS USING NON-CONVENTIONAL SUPPORT MATRICES

The emergence of novel antibiotics against the upsurge of “Superbugs” is a breakthrough health intervention. Daptomycin has gained prominence as a novel antibiotic produced by Streptomyces roseosporus which has demonstrated a broad spectrum of activity in vitro against a wide range of aerobic and anaerobic gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and vancom...

Ipsita Chakravarty, Sukhendra Singh and Subir Kundu *

School of Biochemical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1356-62

1356-1362

166

38

50.

STUDY OF THE ENZYME-SUBSTRATE BY MOLECULAR MODELING INTERACTION; CASES OF THE DISEASE OF CANCER

This study was carried out with goal to predict the inhibition of Aurora Kinase B by a series of Oleocanthal by molecular modeling. During last year’s Kinases Aurora were emerged like one of the important targets of drug in several pharmaceutical companies and industries of research and it plays a main function in the regulation of the mitosis and the cytocinèse 1 and for this reason one inhibi...

Benmiloud Kamal, Meriem Merad, Mostefaoui Larbi and Said Ghalem *

Laboratory of Naturals Products and Bio actives-LASNABIO Faculty of Science, Department of Chemistry, University of Tlemcen, Tlemcen, Algeria.

DOI: 10.13040/IJPSR.0975-8232.8(3).1363-67

1363-1367

161

71

51.

PREVALENCE AND RISK FACTORS OF METABOLIC SYNDROME IN ADULT TUNISIAN PATIENTS

Background: Metabolic syndrome (MetS) is a cluster of diseases, including hypertension, obesity, dyslipidemia, and hyperglycemia. We therefore aimed to estimate MetS prevalence and to determine risk factors for MetS. Methods: In the present study, we recruited 209 adult Tunisian MetS patients (57 males and 152 females, mean age 58.9±10.7 years) matched by gender and ethnic origin to 193 healthy i...

J. Abir *, S. Sondes, E. Rania, K. Latifa, B. D. Mokhles, B. Nedia, B. Hadj Md Manel, K. Souhir, G. Hejer, F. Salima and M. Abdelhedi

Biochemistry Laboratory CHU Farhat HACHED, Sousse, Tunisia

DOI: 10.13040/IJPSR.0975-8232.8(3).1368-74

1368-1374

145

37

52.

ISOLATION AND CHARACTERISATION OF STIGMAST-5-EN-3-OL (β-SITOSTEROL) FROM CALOTROPIS PROCERA LATEX ETHYL ACETATE FRACTION FOR IMMUNOMODULATORY ACTIVITY

Aim of this study was to identify and characterise the bioactive principles from the latex of Calotropis procera which could influence cellular and humoral aspects of immune system which may influence immune disorders. Calotropis procera R.Br. (Asclepiadaceae), commonly known as milk weed or swallow-wort, is a medicinal plant widely used as a folk medicine in India. It exhibits a wide spectrum of ...

G. Parihar and N. Balekar *

IPS Academy, College of Pharmacy, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1375-80

1375-1380

158

74

53.

OBSTACLES TO PRACTICAL SKILL DEVELOPMENT AMONG STUDENTS IN KADUNA POLYTECHNIC, NIGERIA

There is no doubt that quite a number of obstacles are stumbling blocks to students’ practical skill acquisition. Such impediments could either be as a result of factors directly related to students, their lecturers or the institutions where the students are undergoing their training. This study identified the hindrances to practical skill development among the students in Kaduna Polytechnic, Ni...

Ibrahim Shittu Kailani *, Abbah Bala Gyallesu and Ali Mamman Yaro

Department of Education (Technical), Kaduna Polytechnic, Kaduna, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.8(3).1381-87

1381-1387

174

34

54.

BIOCHEMICAL STUDIES ON THE MICE HEART REGARDING LEAD ACETATE INDUCED OXIDATIVE STRESS

Lead is important heavy metal and due to widespread use in industry, it has become an important pollutant that exerts toxic effects on human health. Lifestyle factors (e.g. cigarette smoking), proximity to industrial areas, lead mines, lead based paints and leaded gasoline significantly contribute to lead pollution of the air, food, water and soil. Several antioxidant enzymes and molecules have be...

Sushma Sharma and Anita Thakur *

Department of Biosciences, Himachal Pradesh University, Shimla, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1388-92

1388-1392

182

70

55.

PHARMACOGNOSTICAL EVALUATION OF TRIBULUS TERRESTRIS L.

Objective: The present study was designed to evaluate the pharmacognostical and quality control parameters of Tribulus terrestris L. whole plant except fruits. Method: The plant was collected from the university campus and was got authenticated from NBPGR, Delhi. Various standardization parameters viz. loss on drying, ash values, extractives values, swelling index, foaming index etc. were determin...

S. Das, N. Vasudeva * and S. Sharma

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1393-00

1393-1400

166

39

56.

THERMAL AND STRUCTURAL PROPERTIES OF IRRADIATED SILVER/POLY (VINYL ALCOHOL) (Ag/PVA) NANOCOMPOSITES USING ARGON ION BEAM

Structural and thermal properties of silver/poly(vinyl alcohol) (Ag/PVA) nanocomposites  has been investigated as a function of Argon ion beam fluence. The XRD patterns (X-ray diffraction) showed the formation of the Ag/PVA in polymer structure and phase analysis with different sizes as a function of either ion beam fluence or Ag+ ion molar concentrations. The kinetic parameters for the thermal s...

Mahmmoud S. Abd-Elmonem * and Waheed M. Salem

National Organization for Drug Control and Research (NODCAR), Giza, Egypt.

DOI: 10.13040/IJPSR.0975-8232.8(3).1401-06

1401-1406

124

39

57.

FORMULATION AND EVALUATION OF PULSATILE DRUG DELIVERY SYSTEM CONTAINING DOMPERIDONE AND PARACETAMOL

The objective of the study to formulate and evaluate of pulsatile drug delivery containing combination of domperidone and paracetamol for the treatment of migraine which is used to deliver the drug at specific time as per pathophysiological need of the disease and improvement of therapeutic efficacy and patient compliance. Domperidone and paracetamol in the core tablet was formulated with differen...

A. Shajan , S. Banu, V. Peter *, S. Raju and C. Das

Department of Pharmaceutics, Nazareth College of Pharmacy, Othera, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1407-12

1407-1412

199

78

58.

MICROSPHERES OF DILTIAZEM HYDROCHLORIDE BY IONOTROPIC GELATION TECHNIQUE

Diltiazem hydrochloride is a calcium channel blocker used in various cardiac diseases. It is associated with problem of short biological half life leading to high dosage frequency. Therefore, to ensure the controlled drug delivery systems of diltiazem the alginate-chitosan microspheres were prepared by Ionotropic gelation technique and characterized.  The diltiazem hydrochloride SR microspheres w...

Dheeraj Varma Kalidindi

Department of Pharmaceutical Technology, Shri Vishnu College of Pharmacy, Bhimavaram, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1413-19

1413-1419

118

35

59.

ASSESSMENT OF BIOCHEMICAL PARAMETERS IN THE PATIENTS OF CORONARY ARTERY DISEASE WITH TYPE 2 DIABETES MELLITUS

Impaired carbohydrate and lipid metabolism with amplified oxidative stress are well recognized factors for Coronary artery disease (CAD) which is the major reason of mortality and morbidity all over world. The incident of CAD with type 2 diabetes mellitus (T2DM) is growing and they are predicted to be the biggest cause of death by 2020 in India. Therefore, the venture of the present study was to a...

Manisha Singh, Eqbal Anwer and Vishnu Kumar *

Department of Biochemistry, Era’s Lucknow Medical College & Hospital, Lucknow, UP, India

DOI: 10.13040/IJPSR.0975-8232.8(3).1420-26

1420-1426

125

36

60.

PHYTOCHEMICAL CONTENTS AND BIOLOGICAL PROPERTIES OF VERNONIA POLYANTHES LESS

Vernonia polyanthes Less. (Asteraceae) is a medicinal plant that has been broadly used in Brazil for the treatment of inflammation and cutaneous damages. The present study evaluated the phytochemical contents and the antioxidant and topical anti-inflammatory activities of the V. polyanthes branches. Dried and powdered of V. polyanthes branches were exhaustively extracted with ethanol by static mac...

M. M. Minateli, G. Del-Vechio-Vieira, C. H. Yamamoto, A. L. S. M. Araújo, M. P. Rodarte, M. S. Alves and O. V. Sousa *

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Rua José Lourenço Kelmer, s/n, Campus Universitário, Juiz de Fora, Minas Gerais, Brazil.

DOI: 10.13040/IJPSR.0975-8232.8(3).1427-36

1427-1436

107

47

61.

QSAR STUDIES OF PYRAZOLE DERIVATIVES CONTAINING THIOUREA AS TYROSINE KINASE INHIBITORS

A QSAR studies on pyrazole derivatives as specific anticancer agents was performed with 37 (32 training + 5 test) compounds. QSAR studies were performed using chemOffice 6.0 software supplied by Cambridge soft. The sketched structures were subjected to energy minimization and then used to calculate the physiochemical properties. The regression analysis was carried out using a computer program call...

Asheesh Singh * and P. K. Singour

Computational & Synthetic Chemistry Division, Department of Pharmaceutical Chemistry, VNS Institute of Pharmacy, Bhopal Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1437-40

1437-1440

120

38

62.

SERUM HEART TYPE FATTY ACID BINDING PROTEIN (H-FABP) LEVELS IN METABOLIC SYNDROME

Background: Metabolic syndrome (MetS) is a defined cluster of cardiometabolic abnormalities that increases an individual’s risk of type2 diabetes (T2D) and cardiovascular disease (CVD). Heart fatty acid binding protein (H-FABP) is a major cytoplasmic low-molecular weight protein and released into the circulation when the myocardium is injured. Previous studies have demonstrated that H-FABP is cl...

J. Abir *, S. Sondes, E. Rania, K. Latifa, B. D. Mokhles, B. Nedia, B. H. Md. Manel, K. Souhir, G. Hejer, F. Salima and M. Abdelhedi

Biochemistry Laboratory CHU Farhat HACHED, Sousse, Tunisia.

DOI: 10.13040/IJPSR.0975-8232.8(3).1441-48

1441-1448

121

64

63.

CHEMICAL OXIDATION OF PHENYLEPHRINE BY USING CHLORAMINE-T IN ACID MEDIA: A KINETIC AND MECHANISTIC STUDY

The kinetics and mechanism of oxidation of Phenylephrine (PHE) by Chloramine-T (CAT) in acid media have been investigated by spectroscopic technique at the temperature of 298 K. It is found that the reaction is of first order with respect to PHE, fractional order with respect to CAT & inverse order with respect to H+. The reaction rate remained unchanged with the variation of ionic strength of...

M. S. Veena, M. K. Prashanth, B. K. Jayanna, K. Yogesh Kumar, Y. Arthoba Nayaka and H. B. Muralidhara

Centre for Incubation, Innovation, Research and Consultancy (CIIRC), Jyothy Institute of Technology, Thataguni, Kanakapura Road, Bengaluru, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.8(3).1449-58

1449-1458

144

32

64.

MITIGATING POTENTIAL OF ALLLIUM SATIVUM ON ARTESUNATE INDUCED RENAL TOXICITY IN MALE MICE

In recent times, the use of natural antioxidants as ameliorative agents has become the focus of basic research. Allium sativum (garlic) is one such agent which has been proven to have antibacterial, antiseptic, antifungal, antiparasitic, anticoagulant and antitumor properties. The present investigation deals with the ameliorative effects of Allium sativum on the induced renal toxicity of the antim...

K. R. Desai, D. K. Rajput, P. B. Patel, J. P. Pandit and H. N. Highland

Department of Zoology, BMT and HG, School of Sciences, Gujarat University, Navrangpura, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1459-68

1459-1468

167

64

65.

EMBRYOTOXICITY IN DANIO RERIO USING FOENICULUM VULGARE AND ITS ABORTIFACIENT ACTIVITY

Danio rerio is one of the best model organisms to study various kinds of disorders. Their genome is fully sequenced and they possess easily detectable developmental properties. The development of their embryo is quite rapid. This is important as the embryos are formed by external fertilization, are large and transparent. Abortifacient is a substance that induces abortion. It can be used in the for...

P. Venkatesh, S. Mukherjee, N. Santhi and G. Ramakrishna *

Durga Femto Technologies and Research (DFTR), Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1469-75

1469-1475

166

51

66.

CHARACTERIZATION OF ANTIOXIDANT AND CYTOTOXIC POTENTIAL OF METHANOLIC EXTRACTS OF DIFFERENT PARTS OF AEGLE MARMELOS (L.)

Aegle marmelos(L.), family rutaceae is highly reputed medicinal tree commonly known as the bael. All parts of the plant have medicinal properties and extensively used by the traditional medicine practitioners of Bangladesh in different health ailments like Diabetes, Diarrhea, Jaundice, typhoid. The present study was dedicated to investigate phytochemical and pharmacological properties of ripe frui...

N. Jahan Bristy, A. H. M. Nazmul Hasan *, Md. Nur Alam, T. B. Wahed, P. Roy and K. M. K. Alam

Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.8(3).1476-84

1476-1484

103

39

67.

HETEROLEPTIC MONONUCLEAR RUTHENIUM(II) COMPLEXES: SYNTHESIS, CHARACTERIZATION, DNA CLEAVAGE, ANTIOXIDANT AND CYTOTOXIC ACTIVITIES

Mononuclear ruthenium(II) complexes of the type [Ru(bpy)2(L)] (PF6)2, where L=4,5-bis(4-dimethyaminophenyl)-1H, 1 'H-2,2'-biimidazole (1) and 4,5-bis (4-fluorophenyl) - 1H, 1' H-2,2'-biimidazole (2) have been synthesized and characterized by elemental analyses and  spectroscopic techniques such as UV-visible, IR and ESI-MS. The redox behavior of the complexes has been studied by cyclic and differ...

M. Kiruthika and P. Dharmalingam *

Department of Chemistry, Urumu Dhanalakshmi College, Tiruchirappalli, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.8(3).1485-91

1485-1491

104

38

68.

COMPARATIVE EFFECTIVENESS OF SIMULATION BASED TEACHING VERSUS CONVENTIONAL TEACHING FOR UNDERGRADUATE STUDENTS OF SECOND PROFESSIONAL M.B.B.S IN EXPERIMENTAL PHARMACOLOGY

Aims: To evaluate and analyze effectiveness of animal simulation based teaching in pharmacology in comparison to conventional methods to undergraduate medical students. Methods: An interventional and comparative study was conducted among second professional MBBS students. All students were divided into two groups A and B. Four demonstrations of experimental pharmacology were demonstrated by conven...

Meena Atray *, Apruva Agrawal and Deepika Atray

Department of Pharmacology, Department of Microbiology, R.N.T. Medical College, Udaipur, Rajasthan, India

DOI: DOI: 10.13040/IJPSR.0975-8232.8(3).1492-97

1492-1497

97

32

69.

HEPATOPROTECTIVE POTENTIAL OF POLYHERBAL PREPARATION AGAINST CCl4-INDUCED LIVER TOXICITY IN RATS

Hepatoprotective activity of Polyherbal preparation against CCl4 ‑induced hepatic damage in rats was observed. The healthy control (normal), control, and standard drug Silymarin treated groups were also maintained for the comparison. The liver marker enzymes SGOT, SGPT, ALP and total Bilirubin were assessed in all the experimental groups. The changes in liver function parameters were significant...

Sarika Shrivastava * and Ritu Gilhotra

School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1498-03

1498-1503

181

39

70.

SYNTHESIS AND CHARACTERISATION OF MANGANESE(II) COMPLEXES WITH SEMICARBAZIDE AND THIOSEMICARBAZIDE BASED LIGANDS

Mn(II) complexes with four semicarbazide and thiosemicarbazide based ligands such as 2-formyl pyridine semicarbazone (L1), 2-formyl pyridine thiosemicarbazone (L2), 5-methyl 2-formyl pyridine semicarbazone (L3) and 5-methyl 2-formyl pyridine thiosemicarbazone (L4) have been synthesized and characterized. All the ligands were characterized by elemental analyses, IR, 1HNMR and mass spectral studies....

Ruchi Verma

Department of Education in Science and Mathematics, National Council of Education Research and Training, New Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.8(3).1504-13

1504-1513

175

57