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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2015): 1.11 , ICV (2015): 90.24
Five-Year Projected Impact Factor: 2.60

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Volume 8 (2017) - Issue 9, September

Review Articles

 
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1.

COLEUS FORSKHOLII: PHYTOCHEMICAL AND PHARMACOLOGICAL PROFILE

Coleus forskohlii is an herb historically used in Ayurvedic medicine. Nowadays Coleus forskohlii is used as a fat burning supplement in various formulations and available in the Indian market. Forskolin the main constituent of this plant is used to treat allergies, skin conditions such as eczema and psoriasis, painful menstrual periods, irritable bowel syndrome (IBS), urinary tract infection (UTI)...

M. Bhowal *and D. M. Mehta

PES College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3599-18

3599-3618

420

314

2.

A REVIEW OF SPECTROPHOTOMETRIC DETERMINATION OF ANTIBIOTIC NORFLOXACIN

Norfloxacin is one of the 4-quinolone antibacterials and have many applications in veterinary and human medicine. It is extensively used antibiotic among fluoroquinolone antibiotics in both human and animal welfare. Therefore, the estimation and monitoring of norfloxacin in pharmaceutical preparations and effluents has become a topic of interest for researchers and industries. Existing methods req...

D. R. Shrivastava, A. Shrivastava and R. Patel*

Department of Chemistry, Government College Bhanpuri, Bastar, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3619-29

3619-3629

313

190

3.

A BRIEF REVIEW ON SYSTEMIC RETINOIDS

Retinoids are the derivatives of Vitamin A and have similar action to that of Vitamin A. Sources of Vitamin A such as eggs and meat are known to contain a chemical, retin-A which is known to be useful for treating various dermatological disorders. Tretinoin, a first generation retinoid was first used orally for the treatment of acne in 1940s. Topical tretinoin was later developed as a result of po...

A. Aryal* and S. Upreti

Department of Pharmacy Practice, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3630-39

3630-3639

335

159

4.

RESVERATROL, A POTENTIAL RADIOPROTECTIVE AGENT: A MINI REVIEW

It is well known ionizing radiations produce deleterious effects on humans. In spite of research efforts for the past several years, today we do not have a radio protective agent that meets all the prerequisites like produces no cumulative and irreversible toxicity, offers effective long term protection, possess a shelf life of 2-5 years and can be easily administered. In recent years, attention h...

D. Thekkekkara, B. Duraiswamy and M. J. Nanjan*

PG Studies and Research / TIFAC CORE, J.S.S. College of Pharmacy, (Off Campus, JSS University, Mysore), Ootacamund, The Nilgiris, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3640-48

3640-3648

291

137

5.

APPLICATION OF QUALITY BY DESIGN TO DIFFERENT ASPECTS OF PHARMACEUTICAL TECHNOLOGIES

Quality by Design [QbD] is a science based approach widely used in industry to continually monitor and improve the quality of product. It is a modern risk based strategic framework of all the aspects related to quality. ICH guidelines Q8 to Q11 summarizes all the different perspectives of quality by design system in required depth along with ways to implement it. This review in all focuses on the ...

D. M. Patwardhan*, S. S. Amrutkar, T. S. Kotwal and M. P. Wagh

15B, Sonali Apartment, Near Vijan Hospital, Vise Mala, College Road, Nasik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3649-62

3649-3662

263

142

6.

A COMPREHENSIVE REVIEW ON STANDARDIZATION OF HERBAL DRUGS

In recent years more people throughout world are turning to use medicinal plant products in healthcare system. Worldwide need of alternative medicine has resulted in growth of natural product markets and interest in traditional systems of medicine. Proper integration of modern scientific techniques and traditional knowledge is important. There is a growing focus on the importance of medicinal plan...

R. K. Bijauliya*, S. Alok and M. Kumar

Department of Pharmacognosy, Bundelkhand University, Jhansi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3663-77

3663-3677

140

85

7.

FACTS ON GENERIC DRUGS TO MEET OUT WORLDWIDE CHALLENGES FOR IMPLEMENTING GENERIC MEDICINE RELATED POLICIES OF HEALTH SCHEMES

Global market of generic drug has been propelled by new government initiatives to produce generic drugs and to promote the use of generic drugs; thus the use of generic pharmaceutical products represents over half of the total volume of pharmaceutical products used worldwide. India is the world’s largest exporter of cost effective generic medicines and leading Indian generic companies are genera...

P. Katiyar, P. Lakhani, S. Tutu, A. K. Sachan, R. K. Dixit and A. K. Gupta*

University Institute of Pharmacy, C.S.J.M. University, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3678-85

3678-3685

129

82

8.

THE ANTI-ARTHRITIC POTENTIAL OF BARBADOS NUT JATROPHA CURCAS LINN. (1753) LEAF EXTRACT IN BOVINE TYPE II COLLAGEN-INDUCED ARTHRITIS IN MALE ALBINO MICE MUS MUSCULUS

In the Philippines, about 11 million suffer from arthritis. Jatropha curcas is being widely used by traditional users for treating arthritis. The study evaluated the anti-arthritic claims of J. curcas leaf extract in male albino mice with collagen type II-induced arthritis by assessing two parameters; the reduction of paw thickness due to inflammation and analysis of histopathological parameters (...

G. L. L. See *, F. E. H. Saño, A. C. Monterroso and F. J. V. Arce

Robert Hoeppener Building, Nasipit Talamban, Cebu City, Philippines.

DOI: 10.13040/IJPSR.0975-8232.8(9).3686-95

3686-3695

102

57

Research Articles

 
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9.

EVALUATION OF ANTIBACTERIAL ACTIVITY AGAINST MULTIDRUG-RESISTANCE (MDR) BACTERIA AND ANTIOXIDANT EFFECTS OF THE ETHANOLIC EXTRACT AND FRACTIONS OF CHENOPODIUM ALBUM (SUB SP STRIATUM)

Chenopodium album (sub sp. striatum) is a folk and nutritious medicine belongs to Chenopodiaceae family and widely used as antimicrobial agent. The aim of this study is to evaluate the in vitro antibacterial potential against multidrug-resistance (MDR) bacteria isolated from clinical spicemens, antioxidant activity, total phenolic and total flavonoids content of crude ethanolic extract and nine di...

N. Khomarlou, P. Aberoomand-Azar *, A. P. Lashgari, A. Hakakian, R. Ranjbar and S. A. Ayatollahi

Science and Research Branch, Daneshgah Blvd, Simon Bulivar Blvd, Tehran, Iran.

DOI: 10.13040/IJPSR.0975-8232.8(9).3696-08

3696-3708

263

200

10.

SPECTROPHOTOMETRIC DETERMINATION OF MOLYBDENUM IN ENVIRONMENTAL AND FOOD SAMPLES USING SOLVENT EXTRACTION

2, 6-dithiol-4-methylphenol (DTMP) is proposed as an ana­ly­tical reagent for the extractive spectrophotometric determination of molybdenum (V). DTMP in the presence 2, 6- bis (N, N-dimethylaminomethyl)-4-methylphenol (AP) forms red colored complex with molyb­denum (V) in the pH range 4.8 - 5.8. The Beer’s law was applicable in the range 0.4-22μg mL−1. The dark red Mo-DTMP-AP complex shows...

K. A. Kuliev *, N. A. Verdizadeh, G. S. Suleymanova, R. A. Mamedova and S. A. Mamedova

Department of Analytical Chemistry, Azerbaijan State Pedagogical University, U. Gadjibekov Street 68 Baku, AZ 1000, Azerbaijan.

DOI: 10.13040/IJPSR.0975-8232.8(9).3709-18

3709-3718

206

134

11.

TOXICITY ASSESSMENT OF KEDROSTIS AFRICANA COGN: A MEDICINAL PLANT USED IN THE MANAGEMENT OF OBESITY IN SOUTH AFRICA USING BRINE SHRIMP (ARTEMIA SALINA LINN.) ASSAY

Baboon's Cucumber (Kedrostis africana (Linnaeus) Cogn is a monoecious caudiciform plant that belongs to Cucurbitaceae family. Baboon's Cucumber is used traditionally for the management of syphilis and obesity in South Africa. In the present study, we examined the hatchability and lethality of Baboon's Cucumber bulb extracts against brine shrimps. The tested samples were aqueous extract, acetone ex...

J. O. Unuofin, G. A. Otunola* and A. J. Afolayan

Medicinal Plants and Economic Development (MPED) Research Centre, Department of Botany, University of Fort Hare, Alice, South Africa.

DOI: 10.13040/IJPSR.0975-8232.8(9).3719-25

3719-3725

203

95

12.

EVALUATION OF ANTITUSSIVE AND EXPECTORANT POTENTIAL OF ZIZIPHUS MISTOL FRUITS (MISTOL)

Context: Ziziphus mistol (mistol) fruits and their derivate product (arrope) have been traditionally used as food and in folk medicine for the treatment of a wide variety of diseases including bronchopulmonary disorder. Objective: The objective of this study is to evaluate the antitussive and expectorant effects of Z. mistol ethanol extract (EE), aqueous extract (AE) and arrope (Ar). Materials and...

M. A. Reynoso, I. Y. Brodkiewics, J. Villagra, M. E. B. Coca, A. N. S. Riera and N. R. Vera *

Cátedra de Farmacoquímica, Inst. de Estudios Farmacológicos, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Ayacucho, Tucumán, Argentina.

DOI: 10.13040/IJPSR.0975-8232.8(9).3726-33

3726-3733

212

114

13.

SYNTHESIS, CHARACTERIZATION AND EVALUATION OF HEPATOCYTES REGENERATOR POTENTIALITY OF SOME NOVEL OXADIAZOLE DERIVATIVES FOLLOWED BY MOLECULAR DOCKING AGAINST NF-KB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases and improper immune development. The main objective of the present research work was the synthesis of N-(4-{[5-(substituted phenyl)-1,3,4...

A. Bhaumik*and M. C. Eswaraiah

Department of Pharmaceutical Sciences, Assam down town University, Gandhi Nagar, Panikhaiti, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3734-50

3734-3750

221

116

14.

MOLECULAR DOCKING STUDIES OF NOVEL IMIDAZOLE ANALOGS AS HIV-1-RT INHIBITORS

Molecular docking studies of 102 newly designed N-substituted imidazoles was performed in the non nucleoside inhibitory binding pocket of reverse transcriptase enzyme of wild type as well as resistant strains of HIV-1 virus with PDB ID 1RT2, 1JLB, 3BGR and 1FK9 respectively by using Glide 5.0 to carry out a binding mode analysis of the designed imidazoles. Results generated from this study indicat...

R. Singh* and S. Ganguly

Department of Pharmaceutical Science and Technology, Birla Institute of Technology, Ranchi, Jharkhand, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3751-57

3751-3757

114

49

15.

EFFECT OF SINTERING CONDITION ON PHYSIO-CHEMICAL PARAMETERS AND DRUG RELEASE CHARACTERISTICS FROM POLYMERIC MATRIX TABLET OF ATENOLOL FOR CONTROLLED RELEASE

Sintering technique, a relatively new, convenient, economic process for making polymeric matrices for controlled release is described here. The objective of the present investigation was to prepare thermally sintered matrix tablets of Atenolol using Eudragit RS 100 as sintering polymer and to study the effect of thermal treatment on drug release; physiochemical properties of the prepared tablets. ...

C. Mohanty * and K.V. Subrahmanyam

Department of Pharmacy, St. Mary’s Group of Institutions, Deshmukhi (V), Pochampally (M), Behind Mount Opera, Nalgonda, Greater Hyderabad, Telengana, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3758-67

3758-3767

106

46

16.

SOLUBILITY IMPROVEMENT OF TELMISARTAN BY COCRYSTALLIZATION WITH CITRIC ACID

Crystal engineering of cocrystals promises a new approach for the development of suitable solid phase when the solubility of API is compromised. Cocrystals are an emerging solid-state form to change physicochemical and biopharmaceutical drug properties. A cocrystal is defined as a stoichiometric hydrogen-bonded complex in the solid state between the active drug species and a suitable coformer mole...

P. Arora*, A. Kaur, J. Haneef and R. Chadha

GHG Khalsa College of Pharmacy, Gurusar Sadhar, Ludhiana, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3768-75

3768-3775

167

95

17.

PREPARATION AND EVALUATION OF MUCOADHESIVE MICROSPHERE OF FLUOXETINE HCl

The aim of this research was to formulate and evaluate microspheres of Fluoxetine Hydrochloride. It is a selective inhibitor of serotonin reuptake type of drug used in the treatment of depression. It is practically soluble in water belongs to BCS class I with a bioavailability approximately 72%. Fluoxetine HCl mucoadhesive microspheres were prepared by using chitosan polymer and emulsion solvent e...

M.T. Deshmukh *and S. K. Mohite

Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3776-85

3776-3785

133

58

18.

MICROWAVE ASSISTED SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING AND ANTIMICROBIAL EVALUATION OF 4-NITROCINNAMIDE ANALOGUES

A series of novel 2-Benzamido-3-(4-nitrophenyl)-N’-(substituted) benzylidene-acrylohydrazide (4a-l) analogues were designed by incorporating the few pharmacophoric fragments to enhance the activity profile of molecules. Title compounds were synthesized by the microwave irradiation of α-Benzamido-(4-nitro)-cinnamahydrazide (3) reveals with aromatic/ heteroaromatic aldehydes under acidic conditio...

M. Soujanya *and G. Rajitha

Department of Pharmaceutical Chemistry, Gokula Krishna College of Pharmacy, JNTU Anantapur, SPSR Nellore, Sullurpet, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3786-94

3786-3794

104

48

19.

ANTI – INFLAMMATORY ACTIVITY OF EXTRACTS OF WOODFORDIA FRUTICOSA STEMS BARK IN ANIMAL MODELS

Inflammation is an inflammatory process where histamine, kinin, prostaglandins and slow release substances are produced in the tissue of the body to cause irritation or injury. It consist three phases, dilation and increased permeability of small blood vessels resulting in oedema and swelling, emigration of leucocytes from venules, capillaries and cellular infiltration, proliferation of fibroblast...

N. R. Beck* and K. P. Namdeo

S. L. T. Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3795-00

3795-3800

125

49

20.

ISOLATION, PURIFICATION AND CHARACTERIZATION OF ANTIBACTERIAL PROTEINS FROM INDUCED LARVAE OF ANTHEREAE MYLITTA DRURY (DABA TV)

Antibacterial proteins are evolutionarily ancient, effect or molecules of innate immune defense and are ubiquitously found in all kingdoms. The present study deals with the induction of antibacterial proteins in the haemolymph of Anthereae mylitta drury (Daba TV) by injecting non-pathogenic Pseudomonas DAS-01. Purified protein fraction obtained on ammonium sulphate precipitation followed by ion ex...

L. Marepally*

Department of Zoology, Kakatiya University, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3801-07

3801-3807

123

45

21.

FORMULATION AND IN VITRO CHARACTERIZATION OF ANTICANCER DRUG LOADED SOLID LIPID NANOPARTICLES

The aim of the study was to prepare Temozolomide loaded solid lipid nanoparticles and evaluating loaded solid lipid nanoparticles. Temozolomide loaded solid lipid nanoparticles were prepared by micro emulsification method using different lipid (stearic acid) concentration keeping drug concentration unchanged, poloxamer 188 and cetyl alcohol as surfactant and co-surfactant. The prepared SLN were ch...

U. M. Bandi*, K. Philip, D. B. Reddy, A. Swaroopa, L. Prabakaran and G. Parthasarathy

R.R. College of Pharmacy, Guddadahalli, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3808-12

3808-3812

133

61

22.

EVALUATION OF IRON OXIDE NANOPARTICLES (NPs) ON AGING AND AGE RELATED METABOLISM AND PHYSIOLOGICAL CHANGES IN C. ELEGANS

In recent decades, advances in nanoscience have resulted the rapid development of many novel technological applications for nanoparticles (NPs) in various in Biomedical Sciences. Iron is essential for eukaryotic biochemistry and is an important element in several metabolic processes such as, carrier for oxygen transportation, cell respiration, synthesis of genetic material and protein synthesis. T...

S. Kumar, R. K. Singh, A. K. Aman*, J. Kumar and M. Kar

Aryabhatta Centre for Nanoscience and Nanotechnology, Aryabhatta Knowledge University, Patna, Bihar, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3813-16

3813-3816

141

66

23.

STABILITY INDICATING ASSAY AND ESTIMATION OF IRBESARTAN BY FIRST ORDER UV DERIVATIVE SPECTROPHOTOMETRY

Introduction: Irbesartan is chemically 2-butyl-3-({4-[2-(2H-1,2,3,4-tetrazol-5-yl) phenyl] phenyl} methyl) -1,3-diazaspiro [4.4] non-1-en-4-one. Irbesartan is an Angiotensin II receptor antagonist effective in the treatment of Hypertension.  It is also effective in the treatment of High blood pressure.  It is also effective when used alone or in combination with other drugs. Aims and Objectives:...

G. Kalyani*and B. Adjuad

Shri Rawatpura Sarkar, Institute of Pharmacy, Kumhari, Durg, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3817-21

3817-3821

131

56

24.

EFFECT OF COMBINED MIXTURE OF FOUR MINOR MILLETS ON BLOOD GLUCOSE, SERUM LIPIDS AND OXIDATIVE STRESS IN OVARIECTOMISED WISTAR ALBINO RATS AN ANIMAL MODEL FOR MENOPAUSAL COMPLICATIONS

Diabetes mellitus, coronary artery disease and oxidative stress are some of the important complications encountered by women during menopause due to decrease in estrogen levels. Food intake has a strong impact on menopausal women and a well balanced diet is important for good health and to combat some of the complications of menopause to certain extent. Minor millets has much health benefits and h...

K. C. Prabha* and S. Selvi

Department of Biochemistry, Bharathidasan College of Arts and Science, Ellispettai, Erode, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3822-29

3822-3829

111

44

25.

THE ASSOCIATION OF DIFFERENT FUNGAL SPECIES CAUSED EPIZOOTIC ULCERATIVE SYNDROME IN FRESH WATER FISH OF CHANNA PUNCTATUS FOUND IN HASANPARTHY LAKE, TELANGANA, INDIA

Murrels are very often affected by Epizootic Ulcerative Syndrome (EUS) and it causes huge loss to the capture and culture sector. The principal infectious agent of this infestation is a fungal species, Aphanomyces invadans. Different fungal species were isolated from EUS infected Channa punctatus fish from Hasanparthy Lake of Warangal, Telangana, India. Aspergillus flavus, Fusarium solani, Rhizoph...

P. K. Rao*

Department of Zoology, Kakatiya University, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3830-36

3830-3836

114

41

26.

CHARACTERIZATION OF ENDOGLIN GENE USING IN SILICO TOOLS

Diabetic retinopathy (DR) is a micro vascular disorder affecting the retina of the eye. Many genes have been identified for its pathogenesis. Endoglin (ENG) is one of the candidate gene involved in DR. Several literature studies helped us understand that the in vitro and in vivo studies of these candidate genes had demonstrated the role of a new gene called endoglin (ENG) capable of inhibiting ang...

V.G. Vidhya * and A. Bhaskar

Department of Biotechnology, Faculty of Science and Humanities, SRM University, Kattankulathur, Kancheepuram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3837-42

3837-3842

124

45

27.

PHYTOCHEMICAL AND GC-MS ANALYSIS OF LEAF EXTRACTS OF PSEUDARTHRIA VISCIDA (LINN.) WEIGHT & ARN.

The present study elucidates the secondary metabolite profile of leaves of Pseudarthria viscida­, one of the main ingredient of dasamula in Ayurveda. Alkaloids, phenolic compounds and flavonoids were estimated in different solvent-extracts. Acetone extract of leaves showed highest content of phenols and flavonoids. The leaves are quite rich in alkaloids and is found to be 1.9   mg g-1. GC-MS an...

M. Rajina*, P. Ratheesh-Chandra and K. M. Khaleel

Research Centre in Botany, Sir Syed College, Taliparamba, Kannur University, Kannur, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3843-46

3843-3846

114

67

28.

RISK FACTORS ASSOCIATED WITH ADVERSE DRUG REACTIONS IN HOSPITALIZED PATIENTS

Background: Understanding the association of risk factors to adverse drug reactions is very important to all healthcare professionals for the development of appropriate preventive strategies for better health care. Objectives: To identify and evaluate the risk factors associated with adverse drug reactions developed in the hospitalized patients of different departments. Methods: A prospective-retr...

M. K. Mudigubba, Y. Rajashekarachari and S. Dahiya*

School of Pharmacy, Lingaya`s University, Nachauli, Jasana Road, Old Faridabad, Faridabad, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3847-54

3847-3854

123

59

29.

PHARMACOGNOSTICAL AND PHYSICOCHEMICAL EVALUATION OF CYNODON DACTYLON LINN. PERS. LEAF EXTRACT

From ancient time, plants serve as vast source for varied phyto-constituents exhibiting varied pharmacological property. Identifying such potential plants is of significance in medicine. So it becomes necessary to study the pharmacognostic characteristic and physicochemical parameters of the plant before they are use in the field of research and also in pharmaceutical formulations. Moreover it als...

S. M. Pawaskar* and K. C. Sasangan

Department of Biochemistry, K. J. Somaiya College of Science and Commerce, Vidyavihar, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3855-62

3855-3862

122

48

30.

BACTERICIDAL PROPERTY OF CLERODENDRUM PANICULATUM AND SARACA ASOKA AGAINST MULTIDRUG RESISTANT BACTERIA, RESTORING THE FAITH IN HERBAL MEDICINE

Bacterial pathogens are known to pester Mankind from times immemorial; even though significant efforts in getting rid of these harmful microbes have been made the results are very faint with only few organisms that have been eradicated, such as Small pox virus. But the efforts to eradicate bacterial diseases have shown no passable results as in case of viruses. This is due to the exceptional adapt...

G. Shruthi , M. P. Joyappa, S. Chandrashekhar, S. P. Kollur, M. N. N. Prasad, A. Prasad and C. Shivamallu*

Division of Bioinformatics and Biotechnology, Faculty of Life Sciences, Jagadguru Sri Shivarathreeshwara University, Mysore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3863-71

3863-3871

102

46

31.

FREE RADICAL SCAVENGING ACTIVITY OF FISH OIL – AN IN-VITRO STUDY

Aim and Objective: To evaluate the antioxidant property of fish oil by its free radical scavenging activity using three different antioxidant models. Materials and Methods: In vitro antioxidant activity of fish oil was evaluated by DPPH radical scavenging activity, lipid peroxidation, ABTS radical scavenging activity using olive oil as positive control. Different concentrations of the fish oil, 0....

N. L. H. B. I. Akmal and A. Roy*

Faculty of Pharmacology, Saveetha Dental College and Hospitals, Chennai , Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3872-75

3872-3875

115

50

32.

LOCALIZATION OF CONNEXIN 36 AND CALCITONIN GENE RELATED PEPTIDE AS A DETERMINANT OF NEUROPATHIC PAIN IN THE TRIGEMINAL GANGLION

The trigeminal ganglion consists of pseudounipolar neurons surrounded by satellite glial cells and processes innervating craniofacial region. The trigeminal ganglion consists of neurons which are of first order pseudounipolar carrying sensory pathway from the receptors from face, mouth, scalp and duramater. The gap junctions are trans-membrane proteins formed between the cell membranes of adjacent...

P. K. Sankaran *, R. Gunapriya, M. Kumaresan and G. Karthikeyan

Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3876-80

3876-3880

103

58

33.

MORPHOLOGICAL AND MORPHOMETRICAL STUDY OF CORONOID PROCESS IN HUMAN MANDIBLES

Background: The coronoid process of mandible is thin flat triangular process from the ramus of the mandible. This varies in the shapes and size. It gives attachment to two main muscles that is temporalis and masseter muscle. The coronoid process is the favourable donor site. A Coronoid process graft can be used for alveolar defects repair, orbital floor repair, maxillary augmentation, repair of no...

A. P. Gouthaman*, M. F. Yuvaraj, R. Dev, P. K. Sankaran, M. Z. Begum, M. Kumaresan and G. Raghunath

Department of Anatomy, Saveetha Medical College and Hospital - Thandalam Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3881-86

3881-3886

136

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34.

BIOSYNTHESIS OF COPPER OXIDE NANOPARTICLES USING CYANOBACTERIA SPIRULINA PLATENSIS AND ITS ANTIBACTERIAL ACTIVITY

Recently, biological synthesis of nanoparticles (NPs) has attracted attention because of the need to develop new cost-effective and efficient synthesis protocol. In this paper, we account for the use of cell-free extract of Spirulina platensis in the biosynthesis of copper oxide nanoparticles (CuO NPs) of dimensions 30 - 40 nm. The biosynthesised CuO NPs were confirmed visually by appearance of da...

S. Saran, G. Sharma, M. Kumar and M. I. Ali*

Department of Biosciences, Suresh Gyan Vihar University, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3887-92

3887-3892

105

45

35.

IN VITRO EVALUATION OF ANTIBACTERIAL ACTIVITY OF LEAF EXTRACTS OF BALLOTA NIGRA AGAINST FIVE BACTERIAL PATHOGENS

Ballota nigra (Lamiaceae) has been widely used as traditional medicine in many countries for the treatment of neuro-sedative, antidepressant, antioxidant, antibacterial, insecticidal, anticholinesterase and antifeedant effects. The main objective of this study is to evaluate the antibacterial activity of leaf extracts of Ballota nigra Linn. against five bacterial pathogens. The leaves were extract...

M. Nishandhini, T. Viswanathan, M. Radha*, P. R. Rathisre and J. Suganya

Department of Bioinformatics, School of Life Sciences, Vels University, Pallavaram, Chennai , Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3893-98

3893-3898

122

54

36.

ROLE OF EMBLICA OFFICINALIS IN MITIGATING THE SULPHUR DIOXIDE INDUCED TOXICITY IN RATTUS NORVEGICUS (BERKENHOUT)

SO2 is considered as one of the most poisonous and irritant gas because it alters the physiology, biochemistry and behaviour of the living individuals. In the present investigation the effect of oral administration of Emblica officinalis on serum electrolyte in SO2 exposed albino rats. The thirty albino rats were grouped in three sets - control set (1) were kept in control conditions, while, rats ...

M. Yadav*

Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B. R. Ambedkar University, Agra, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3899-03

3899-3903

106

43

37.

TRADITIONAL PHYTOTHERAPEUTIC USES IN PURBA MEDINIPUR, WEST BENGAL, INDIA

The traditional health care system has been significantly used from ancient time. The rural people of Purba Medinipur, West Bengal still continue to depend on indigenous plants to cure their different types of primary health treatment. The present study explore 79 plant species belong to 41 families are systematically used in traditional health care system. Information was collected by the structu...

A. Patra, A. K. Mondal *and D. Banerjee

Department of Botany and Forestry, Vidyasagar University, Midnapore, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3904-10

3904-3910

161

62

38.

A RETROSPECTIVE STUDY OF PRESCRIBING PATTERN FOR ACUTE RESPIRATORY INFECTIONS IN CHILDERN IN A TERTIARY CARE TEACHING HOSPITAL

Objective: To study prescribing pattern for acute respiratory infections in children attending outpatient department of Paediatrics, J.L.N. Hospital, Ajmer, Rajasthan. Material and Method: The study was carried out retrospectively by analyzing the copies of prescriptions of patients who had visited the O.P.D. of the paediatrics department of J.L.N. Hospital Ajmer. A total of 350 prescriptions havi...

S. Sankhla*, S. Kanwar and D. K. Mahawar

JLN Medical College, Ajmer, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3911-16

3911-3916

128

54

39.

COMPARATIVE EVALUATION OF PATIENT’S ACCEPTABILITY BETWEEN POLYETHER AND NON – EUGENOL BASED PERIODONTAL DRESSINGS – A RANDOMISED CONTROL CLINICAL TRIAL

Periodontal dressings were widely used after flap surgery to protect the surgical site since long. This study compared polyether urethane dimethacrylate resin based Barricaid dressing and non-eugenol based periodontal dressings in the perspective of pain, esthetics and patient acceptance using a randomized split-mouth study design. Fifteen patients coming to the Department of Periodontics at ITS D...

S. Garg*, S. A. Arora, S. Chhina, G. Puri, D. Bhardwaj and N. Kaur

ITS Dental College, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3917-22

3917-3922

107

65

40.

TO STUDY THE PRESCRIBING PATTERN OF ANALGESICS IN THE ORTHOPAEDIC IN PATIENT DEPARTMENT OF JAWAHARLAL NEHRU INSTITUTE OF MEDICAL SCIENCES (JNIMS) HOSPITAL, IMPHAL, MANIPUR, INDIA

The prescription pattern of analgesic was investigated for the months of June, July, August 2016 by studying 253 (143 male + 110 female) BHTs of in patients of the orthopaedic department. The data mainly age, sex, diagnosis and line of management available from BHTs was analysed in the form of percentage, average of variable. The generic name cost of treatment per patient and rationality of prescr...

O. Joychandra, J. Oinam, N. Debashree * and Losica

Department of Pharmacology, Jawaharlal Nehru Institute of Medical Sciences (JNIMS) Hospital, Imphal, Manipur India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3923-27

3923-3927

137

54

41.

PULSATILE DRUG DELIVERY OF CANDESARTAN CILEXETIL FOR CARDIOVASCULAR COMPLICATIONS

The aim of current investigation was to formulate and evaluate an oral time controlled drug delivery system to achieve timed release of Candesartan cilexetil for the treatment of cardiovascular complications. Blood pressure rises early in the morning which can leads to hypertension and congestive cardiac failure. Attempt has been made to develop a drug delivery which releases the drug based on cha...

A. Y. Kanugo*, N. I. Kochar and A. V. Chandewar

PRIST University, Vallam, Thanjavur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3928-35

3928-3935

115

53

42.

ENCAPSULATION OF REPAGLINIDE INTO EUDRAGIT RS MICROSPHERES AND MODULATION OF THEIR RELEASE CHARACTERISTICS BY USE OF SURFACTANTS

Microspheres containing Repaglinide was prepared by emulsion solvent evaporation technique using two types of surfactants Tween 80 (polysorbate 80) and Span 80 (Sorbitanmonooleate 80). The effect of change in the type and surfactant amount on the size and drug release from the microspheres was investigated. The release of Repaglinide from the microspheres exhibit diffusional characteristics and cl...

V. K. Yadav*, A. K. Rai and A. K. Ghosh

Department of Pharmacy, Prasad Institute of Technology, Jaunpur - 222002, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3936-47

3936-3947

107

55

43.

DEVELOPMENT AND EVALUATION OF SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM FOR TELMISARTAN

Self nano-emulsifying system drug delivery system (SNEDDS) is promising for drugs of BCS class II. The objective of present study to develop self nano-emulsifying drug delivery system for Lipophillic drug Telmisartan (antihypertensive drug), labrafil 1944, Kolliphor ELP: Span 80 (1:1) and PEG 400: Ethanol (1:1) was chosen as oil, Surfactant and Co-surfactant as they show higher solubility for Telm...

G. C. Soni * and S. K. Prajapati

Sri Vankateshwara University, Meerut, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).3948-61

3948-3961

118

69

44.

TUBERCULOSIS OF THE BREAST – DIAGNOSIS, MANAGEMENT, AND TREATMENT

Tuberculosis is caused by Mycobacterium tuberculosis and affects primarily the lungs. Breast tissue is remarkably resistant to tuberculosis. This is due to fact that it gives infertile environment for survival and multiplication of tubercle bacilli like skeletal muscle and spleen. The breast may become infected by variety of ways e.g. haematogenous, lymphatic, spread from contiguous structures, di...

N. A. Shibli*

Department of Surgery, Prince Mutaib Bin Abdulaziz Hospital, Sakaka, Aljouf Region, Saudi Arabia

DOI: 10.13040/IJPSR.0975-8232.8(9).3962-65

3962-3965

221

88

45.

POTENTIAL POSITIVE EFFECT OF ORAL PYRIDOXINE ALONE AND IN COMBINATION WITH MECLIZINE ON CIGARETTES SMOKING DURING TENDAYS’ TRIAL

Purpose: Several medications are currently available for trying smoking cessation, such as nicotine replacement therapy or antidepressants. This study investigates potential effect of Meclezine-B6 combination; and B6 tablets administrated orally for possibility of reducing number of cigarettes smoked per day during 10 days. Methods: Using placebo control study. In which adult smokers' volunteers w...

J. K. Hassan*

Department of Clinical Pharmacy, College of Pharmacy, University of Basrah, Iraq.

DOI: 10.13040/IJPSR.0975-8232.8(9).3966-70

3966-3970

100

55

46.

ASSESSING THE PREVALENCE OF DISABILITY AND ITS RELATIONSHIP WITH DEMOGRAPHIC CHARACTERISTICS OF THE ELDERLY IN ZAHEDAN CITY IN IRAN

Aging is among the phenomena more commonly discussed in world health in recent years. Disability is a good indicator to measure health status in the aging population. Accordingly, the primary objective of this study was to determine the prevalence of disability and its relationship with demographic characteristics of the elderly in Zahedan city in Iran in 2016. This is a cross-sectional descriptiv...

M. Salarzaei, A. Malekzadegan, M. R. Havasian, M. A. Zaare, M. B. and Z. Mahmoodi *

Department of Cardiology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran.

DOI: 10.13040/IJPSR.0975-8232.8(9).3971-77

3971-3977

105

51

47.

FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF DOUBLE LAYER TABLET OF SUSTAINED RELEASE (S.R.) FLURBIPROFEN AND IMMEDIATE RELEASE DOXYCYCLINE

Purpose: To formulate and characterize the bi-layer tablet of doxycycline immediate release and flurbiprofen sustained release. Method: Bi-layer tablets were formulated by wet granulation method. Ethyl cellulose and HPMC K 100 were used as polymer for sustained release layer. Five immediate release formulations were developed with varying excipients. Bi-layer tablets were evaluated by pre formulat...

N. Masood*, H. Naureen, N. Abbas, M. Adnan and M. H. Tariq

Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.

DOI: 10.13040/IJPSR.0975-8232.8(9).3978-85

3978-3985

249

59

48.

QUASI-EXPERIMENTAL STUDY OF THE EFFECT OF PATIENT COUNSELING ON QUALITY OF LIFE AMONG TUBERCULOSIS PATIENTS

Objectives: Tuberculosis (TB) remains one of the most substantial infectious causes of death in the world. Studies focusing on the quality of life (QOL) among TB patients are limited and the effect of counselling on patients QOL has not been well-studied. The aim of this study was to assess the effect of patient counselling on QOL among patients with Tuberculosis. Methods: A quasi-experimental stu...

K. Prabahar*, S. Vaishali, D. Praveen and N. Harikrishnan

Department of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, Kingdom of Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.8(9).3986-90

3986-3990

114

57

49.

THE RISK OF HYPERGLYCEMIA ASSOCIATED WITH THE USE OF PRESCRIBED MEDICATIONS

Hyperglycemia is a deleterious consequence of uncontrolled diabetes and an adverse effect of many common therapeutic drugs. Identification of drug-induced hyperglycemia is necessary for reducing morbidity or mortality associated with high blood glucose levels. The aim of the present study was to assess risk of unrecognized drug-induced hyperglycemia in patients admitted to King Abdulaziz Medical C...

W. Abdel-Razaq*, W. Ismail, A. Al Anazi and A. R. Alissa

King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, College of Pharmacy, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.8(9).3991-99

3991-3999

214

90

50.

HPTLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF OXYCLOZANIDE AND LEVAMISOLE HYDROCHLORIDE IN TABLET DOSAGE FORM

This paper describes a new, simple, precise, and accurate HPTLC method for simultaneous estimation of Oxyclozanide and Levamisole hydrochloride as the bulk drug and in tablet dosage forms. Chromatographic separation of the drugs was performed on aluminium plates pre-coated with silica gel 60 F254 as the stationary phase and the solvent system consisted of Toluene: acetone: ammonia (5:5:0.04 v/v/v)...

H. Panchal *and M. Patel

Department of Pharmacognosy, Anand Pharmacy College, Anand, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).4000-05

4000-4005

94

50

51.

DEVELOPMENT OF A POLYHERBAL CAPSULE FOR THE TREATMENT OF ASTHMA

A drug dosage form is very important in delivering the drug in proper dose in most appropriate form. The capsule shell is an excellent barrier to air, and it also has some other advantages such as being easy to swallow and tasteless, flexibility of formulation etc. The use of the hard gelatin capsule dosage form may perhaps be an alternative to overcome the problem, which the hygroscopicity of the...

A. Gupta*, S. K. Singh , R. P. Singh and S. Jain

Department of Pharmaceutical Sciences, Suresh Gyan Vihar University, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).4006-13

4006-4013

128

69

52.

GC-MS ANALYSIS, ANTIOXIDANT AND ANTIBACTERIAL ACTIVITY OF THE BROWN ALGAE, PADINA TETRASTROMATICA

Marine algae are one of the largest sources for biogenic compounds. They produce a wide variety of chemically active metabolites. They are found to possess significant antioxidant, and phytochemical activities. Macroalgae provides a great variety of metabolites and natural bioactive compounds with antimicrobial activity, such as polysaccharides, polyunsaturated fatty acids, phlorotannins and other...

M. U. Maheswari , A. Reena* and C. Sivaraj

PG and Research Department of Microbiology, Mohamed Sathak College of Arts and Science, No. 13, Medavakkam Road Sholinganallur, Chennai , Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).4014-20

4014-4020

120

51

53.

MICROWAVE IRRADIATED SYNTHESIS, BIOLOGICAL EVALUATION AND MOLECULAR DOCKING STUDIES OF 3-((SUBSTITUTED-BENZO[D]THIAZOL-2-YLAMINO)METHYL)-5-(PYRIDIN-4-YL)-1,3,4-OXADIAZOLE-2(3H)-THIONE

A series of new Mannich base derivatives were designed, synthesized by conventional and non-conventional microwave method, compared and evaluated for their antimicrobial and anti-mycobacterial activity. Structures of the newly synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR, 13C NMR and mass spectral studies. The bioactive assay showed that Mannich base derivativ...

V. M. Patel and N. B. Patel*

Department of Chemistry, Veer Narmad South Gujarat University, Surat, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.8(9).4021-33

4021-4033

97

52