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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.137
Five-Year Projected Impact Factor: 1.83

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Volume 9 (2018) - Issue 8, August

Review Articles

 
Title
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1.

OBESITY AND ITS COMPLICATIONS: ROLE OF AUTOPHAGY

Obesity is the primary cause of metabolic syndrome (MS), further developing to atherosclerosis, hypertension, insulin resistance and diabetes in different individuals depending on their predisposed genetic background. Though adipose tissue acts as endocrine gland, as storage for energy reserve and insulation to vital organs but overloaded adipose tissue, turns inflammatory and induces systemic low...

S. Tripathi, S. Srivastava and Y. B. Tripathi *

Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3100-13

3100-3113

234

288

2.

SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS): A CONVENTIONAL AND ALTERNATIVE APPROACH TO IMPROVE ORAL BIOAVILABILITY

The oral delivery of hydrophobic drugs presents a major challenge because of the low aqueous solubility of such compounds. Self-emulsifying drug delivery systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds. SEDDS can be orally ...

V. Rajeshwar * and B. Shrivastava

Department of Pharmaceutics, School of Pharmaceutical Sciences, Jaipur National University, SADTM Campus, Jagatpura, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3114-27

3114-3127

162

175

3.

NIPAH: SILENTLY RISING INFECTION

Nipah virus infection (NiV) is a viral infection caused by the Nipah virus. Nipah virus provides one of the most striking examples of an emerging virus and illustrates many of the pathways leading from a wildlife reservoir to human infections. Prior to 1998 there had been no reports of a disease of wildlife, domestic animals or humans that would subsequently be considered infection with Nipah vi...

D. K. Chanchal *, S. Alok, M. Sabharwal, R. K. Bijauliya and S. Rashi

Society of Pharmaceutical Sciences and Research, Panchkula, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3128-35

3128-3135

161

146

4.

NANO THERANOSTICS – A BREAKTHROUGH IN CANCER DIAGNOSIS AND TREATMENT AND REGULATIONS OF NANO TECHNOLOGY PRODUCTS

An object with at least one characteristic dimension between 1 and 100 nm can be defined as “nanomaterial”. The unbelievable development of nanotechnology in the last 30 years has allowed the release of new and efficient synthetic routes towards the production and functionalization of different NPs, composed of a variety of materials including noble metals (e.g. gold and silver), semiconductor...

S. P. Medavenkata * and H. S. Akshatha

Department of Pharmaceutics, JSS College of Pharmacy, Jagadguru Sri Shivarathreeshwara University, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3136-49

3136-3149

143

97

5.

REVISITING ANCIENT THERAPEUTIC POTENTIAL OF AYURVEDIC BHASMA

With the advent of nanotechnology, it has become important to realize the immense potential of ayurvedic bhasma which had been there for centuries. The study of ayurvedic bhasma as nanomedicine is an important interdisciplinary research area in need of contributions from material science, chemistry, pharmacology, etc. Such a research will definitely help in the characterization and standardization...

A. Pareek and N. Bhatnagar *

Department of Chemistry, Manipal University Jaipur, Dehmikalan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3150-65

3150-3165

123

80

6.

FOUR MOST LIFE THREATENING UROGENITAL CANCER AND ITS MANAGEMENT

Now a day’s urogenital cancer is the life threatening disease in worldwide, among them most four life threatening urogenital cancers are kidney cancer, bladder cancer, prostate cancer and testicular cancer. Kidney cancer or renal cell carcinoma (also called adenocarcinoma) is a disease in which malignant cancer cells are found in the living of tubules (renal epithelium). The kidney cancer has th...

T. Chakraborty *, V. Saini, D. Govila and G. Singh

M. M. College of Pharmacy, Maharishi Markandeshwar Deemed to be University, Mullana, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3166-74

3166-3174

77

41

7.

PARALLEL ANALYSIS OF KIRANTHI WITH BIRTH ASPHYXIA AND NEONATAL HYPOXIC ISCHEMIC ENCEPHALOPATHY – A SIDDHA LITERATURE REVIEW

The traditional Siddha system of medicine has its origin in South India, and it deals with the well being of human race from neonates to Geriatrics. Presently there is an emerging increase in research and publications regarding the evaluation of traditional medicines primarily based on phytochemical, pharmacological, sophisticated instrumental analysis including various in vitro and in-vivo studie...

M. Rajantheran, K. Silllalee, R. J. Gladys * and J. Sriram

Department of Research Methodology, Velumailu Siddha Medical College, Sriperumbudur, Kancheepuram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3175-79

3175-3179

76

49

Research Articles

 
Title
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8.

ANTIPROLIFERATIVE EFFECT OF CRUDE PROTEINS EXTRACTED FROM MARINE CLAM DONAX VARIABILIS ON HUMAN CANCER CELL LINES

Marine environment is a huge reservoir of various important resources for new bioactive molecule discovery from marine organisms. The aim of this investigation is to evaluate the anti-proliferative potential of crude proteins extracted from different organs of Donax variabilis (gills, adductor muscles, mantle and whole tissue) on human Lung (A549), oral (KB3-1), breast (MCF-7) and colon (HT-29) ca...

G. J. Sahayanathan, S. Guha and A. Chinnasamy *

Department of Zoology, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3180-88

3180-3188

148

105

9.

EVALUATION OF THE POSSIBLE ANTIOXIDANT EFFECTS OF PEGANUM HARMALA AND GINKGO BILOBA IN AMELIORATING ALZHEIMER’S DISEASE IN RAT MODEL

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder leading to dementia in the elderly inhabitants. Increasing evidence advises that oxidative stress that is normally associated with aging is an obvious and early feature of AD and plays a role in its pathogenesis. The present study was designed to evaluate the possible neuroprotective activity of Ginkgo biloba (Gb...

N. N. Osman *, K. H. Alanbari and H. A. Al-Shreef

Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.9(8).3189-98

3189-3198

145

101

10.

POLY (LACTIC-CO-GLYCOLIC ACID) BASED DOUBLE EMULSION NANOPARTICLE AS ACARRIER SYSTEM TO DELIVER GLUTATHIONE SUBLINGUALLY

The sublingual delivery of drugs represents a continuing challenge, as well as an opportunity. In this study, a poly (lactic-co-glycolic acid) (PLGA) based Water-in-Oil-in-Water (w/o/w) double emulsion of nanoparticles was developed as potential platform technology, to generate sustained drug release profile and maximize the bioavailability of the glutathione (GSH). Two-level full factorial design...

G. Chen and J. Wen *

School of Pharmacy, Faculty of Medical and Health Science, University of Auckland, New Zealand.

DOI: 10.13040/IJPSR.0975-8232.9(8).3199-09

3199-3209

117

85

11.

EVALUATION OF THE EFFICACY OF COMBINATION THERAPY OF AGOMELATINE, DULOXETINE AND SERTRALINE IN THE MANAGEMENT OF STRESS INDUCED DEPRESSION

There is unmet need in the treatment of stress induced depression on suggesting requirement of new therapeutic agent. A combination therapy of antidepressants sertraline (5 mg/kg), duloxetine (10 mg/kg) and agomelatine (8 mg/kg) are used in different combinations of doses by intra-peritoneal route. Swiss albino mice were used as an animal model for stress-induced depression; mice were divided into...

P. Indulkar * and K. Prabhavalkar

Department of Pharmacology, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Mithibai College Campus, Vile Parle (West), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3210-22

3210-3222

168

75

12.

SUN PROTECTIVE FORMULATION FROM CAROTENOIDS EXTRACTED FROM THERMOTOLERANT GENERA SYNECHOCYSTIS PEVALEKII

Naturally occurring safe and broad spectrum UV blockers are required now- a- days to protect oneself from the onslaught of UV radiations that are known to cause many skin related ailments. The commercial inorganic sunblockers like Zinc oxide and titanium di oxide and organic sunblockers like Avobenzone and Benzophenone are known to be unstable and also their safety is doubted. Aim of the present c...

P. A. Tendulkar, M. A. Surve and M. A. Deodhar *

Department of Botany, Kelkar Education Trust’s V. G. Vaze College of Arts, Science and Commerce, Mithagar Road, Mulund (E), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3223-34

3223-3234

110

73

13.

SUB-ACUTE CHLOROQUINE TOXICITY ON TESTIS OF SWISS ALBINO MICE AND ITS AMELIORATION BY CURCUMIN

The objective of the present study is to investigate the adverse effect of chloroquine (CQ) toxicity on reproductive tissues and its attenuation by curcumin. Chloroquine (CQ) has been used widely as an antimalarial drug due to its quick action on blood schizontocide of different malarial parasite species for prophylaxis and treatment of malaria. Thirty-six male mice were divided into six experimen...

K. R. Desai, P. B. Patel and Z. Siddiqui and H. N. Highland *

Department of Zoology, BMT & HG, School of Sciences, Gujarat University, Navrangpura, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3235-46

3235-3246

71

46

14.

QUERCETIN AMELIORATES OXIDATIVE STRESS, NEURAL DAMAGE OF BRAIN AND BEHAVIORAL IMPAIRMENT OF RAT WITH FLUORIDE EXPOSURE

Excess fluoride causing fluorosis, can enter in to brain, disturb oxidative status and induce neural damage. Quercetin, antioxidant flavonoid stabilizes oxidative milieu of brain by quenching free radicals. The present study aimed to report ameliorative effect of quercetin on NaF induced oxidative stress, histological alterations in the brain and behavioural changes of rats. Rats were divided into...

M. Nageshwar, K. Sudhakar and K. P. Reddy *

Department of Zoology, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3247-56

3247-3256

74

40

15.

THE SYNERGESTIC EFFECTS OF EDTA / ANTIBACTERIAL COMBINATIONS IN KLEBSIELLA PNEUMONAE INDUCED PNEUMONIA RAT MODEL

The study was conducted to evaluate the synergistic effect of EDTA with antibacterial (Ceftriaxone + Sulbactum) as a combinational therapy against antioxidant enzyme activity, lipid peroxidation level, some hematological and biochemical parameters in Klebsiella pneumoniae induced nosocomial pneumonia followed by histopathology of lungs tissue in experimental exposed Sprague Dayle (S.D) rats. Total...

A. Kumar *, A. Choudhary, N. Mansoori, V. Dwivedi and M. Chaudhary

Department of Neurosurgery, Dr. Ram Manohar Lohia Hospital, New Delhi, Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3257-63

3257-3263

84

38

16.

CARDIOPROTECTIVE EFFECT OF FULVIC ACID ON DOXORUBICIN INDUCED CARDIAC OXIDATIVE STRESS IN RATS

The aim of study was to evaluate cardioprotective activity of fulvic acid in doxorubicin induced cardiac toxicity. In current investigation, female/male Wistar rats were divided into five groups, normal, control, fulvic acid 100 mg/kg, fulvic acid 200 mg/kg, and fulvic acid 300 mg/kg. Doxorubicin 15 mg/kg was administered in six divided doses to all except normal group for 2 weeks. Fulvic acid was...

T. S. Shikalgar * and N. S. Naikwade

Department of Pharmacology, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3264-73

3264-3273

69

35

17.

ANALYSIS OF PROTEOMIC DIVERSITY AND CALCIUM BINDING PROTEIN(s) IN SEEDS OF HORSE GRAM (MACROTYLOMA UNIFLORUM) CULTIVARS FROM UTTARAKHAND

Proteomic study of Macrotyloma uniflorum is quite useful for exploration of its Calcium binding proteins (CBPs) and their antilithiasis character. CBPs play an important role in prevention of kidney stone formation. Considering this fact the study was design to identify CBPs in M. uniflorum. Total six samples were collected from different elevations of Uttarakhand. Total buffer soluble proteins of...

N. Sharma *, S. S. Bisht, S. Gupta, A. K. Panda and M. Rana

Department of Zoology, D.S.B. Campus, Kumaun University, Nainital, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3274-80

3274-3280

66

35

18.

CLINICAL EVALUATION OF A NEW FORMULATION OF 99mTc-TRODAT-1 FOR SPECT IMAGING IN PARKINSON PATIENTS AND VOLUNTEER SUBJECTS

This study was conducted to evaluate the clinical usefulness of new developed kit of 99mTc-TRODAT-1 to differentiate PD(Parkinson disease) from volunteer subjects. The 925-1111MBq (25-30 mCi) 99mTc-TRODAT-1 samples were reconstituted by boiling water bath method. Fourteen subjects (women = 6, men = 8, age range 24 - 72, mean = 54.4) have been participated in this approach. The control group includ...

S. M. Saadati, A. Kiasat, M. Mousavinia, F. Ahmadi, R. Ahadi, S. Rafie, B. Etesami, M. Erfani and A. Doroudi *

School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

DOI: 10.13040/IJPSR.0975-8232.9(8).3281-90

3281-3290

68

62

19.

EFFECT OF SILVER NANO PARTICLES SYNTHESIZED OF TRICHODESMA INDICUM AGAINST NAJA NAJA (COBRA) VENOM

Nanobiotechnology in contemporary society is novel and has enhanced utility for size, distribution and morphology determination of various biomolecules. To prepare nano particles the used metals are gold, silver, mercury and platinum for significant applications in electronics, magnetics, optoelectronics and information storage. For our study we selected the sliver, since it is widely been used fr...

B. Suman, B. Eswari, B. J. Divya, C. Pallavi, M. Venkataswamy, K. Kemparaj and K. Thyagaraju *

Department of Biochemistry, Sri Venkateswara University, Tirupathi, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3291-96

3291-3296

69

35

20.

A STABILITY INDICATING UPLC METHOD FOR SIMULTANEOUS DETERMINATION OF TENELIGLIPTIN HYDROBROMIDE HYDRATE AND METFORMIN HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM

A stability indicating UPLC method was developed and validated for the determination of Teneligliptin hydrobromide and Metformin hydrochloride in bulk and tablet dosage form. The method was carried out using Endoversil column (2.1 × 50 mm, 1.8 mm) with mobile phase consisting of 0.1% v/v ortho-phosphoric acid: acetonitrile (80: 20) under isocratic mode with an injection volume 1 µl and at flow r...

T. Neeraja, P. Sridevi *, K. Vinutha and M. B. Raju

Department of Pharmaceutical Analysis, Sri Venkateshwara College of Pharmacy, Madhapur, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3297-06

3297-3306

74

35

21.

FORMULATION, CHARACTERISATION AND IN-VITRO EVALUATION OF NOVEL IONICALLY CROSS LINKED CASEIN NANOPARTICLES FOR MEMANTINE HYDRO-CHLORIDE DELIVERY

The objective of the study was to fabricate protein nanoparticles for better controlled and targeting action of drug, which can also overcome the problems like multidose therapy, poor patient compliance and high cost associated with conventional formulations. Memantine HCl loaded casein nanoparticles (F1 to F6) were prepared by ionically cross-linked method. The formulated nanoparticles were evalu...

S. V. Rao *, M. Meherunnisa and K. Padmalatha

Department of Pharmaceutics, Vijaya Institute of Pharmaceutical Sciences for Women, Enikepadu, Vijayawada, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3307-16

3307-3316

66

42

22.

DEVELOPMENT AND OPTIMIZATION OF ORODISPERSIBLE TABLETS OF SEROTONIN HYDROCHLORIDE

The aim of the present work is to develop the formulation the orodispersible tablets of Serotonin hydrochloride. The tablets were prepared by direct compression technique using microcrystalline cellulose (MCC) as directly compressible diluents. Superdisintegrants such as Croscarmellulose sodium (CCS) Sodium starch glycolate (SSG) and Crospovidone were used. Method: Using different concentrations o...

P. S. Das * and P. Saha

Department of Pharmaceutics Pharmacy Institute, Noida Institute of Engineering and Technology, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3317-21

3317-3321

70

38

23.

IN-VITRO ANTIBACTERIAL AND CYTOTOXICITY EVALUATION OF SOME NOVEL TETRAZOLE DERIVATIVES

A series of tetrazol derivatives 1(a-c) and 2(a-c) were synthesized by Mannich base reaction. Synthesized compounds 1(a-c) and 2(a-c) were confirmed by IR, ¹H NMR, ¹³C NMR, mass spectral, and elemental analysis. Synthesized compounds 1(a-c) and 2(a-c) were screened for dental plaque bacteria and cytotoxicity activity. The compound 1b was highly active against Enterococcus feacalis in antibacter...

A. Ahamed, I. A. Arif, M. Moydeen, R. S. Kumar and A. Idhayadhulla *

Department of Chemistry, Nehru Memorial College, Puthanampatti, Tiruchirappalli , Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3322-27

3322-3327

63

41

24.

FORMULATION AND EVALUATION OF HYDRALAZINE HYDROCHLORIDE BUCCAL FILMS BY SOLVENT CASTING METHOD USING DIFFERENT POLYMERS FOR THE MANAGEMENT OF HYPERTENSION

The main aim of the study was to formulate the buccal films of most satisfactory formulation by in-vitro evaluation. The present investigation was done to formulate Hydralazine hydrochloride with an objective to improve therapeutic efficacy, Patient compliance. Hydralazine hydrochloride buccal films were developed by solvent casting method. Formulation H2, P4, S8, was best fitted to the in-vitro r...

S. Muthukumar * and R. S. Ganapathy

Faculty of Pharmacy, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3328-33

3328-3333

69

43

25.

BIOAVALIBILITY ENHANCEMENT OF RESVERATROL USING SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM DEVELOPED APPLYING CENTRAL COMPOSITE DESIGN

The objective of current study was to develop self-nanoemulsifying drug delivery systems using long-chain triglycerides of resveratrol to enhance its bioavailability. Solubility studies performed in different lipids, surfactants and cosurfactants. Phase diagrams constructed to select areas of nanoemulsion. SNEDDS formulation optimized using 33 central composite design (CCD) considering lipid (X1),...

Monika *, R. Garg and S. Sardana

NIET, Pharmacy Institute, Knowledge Park 2, Plot 19, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3334-46

3334-3346

66

50

26.

MEDICATION ADHERENCE AND HEALTH RELATED QUALITY OF LIFE IN ADULT PATIENTS SUFFERING FROM DIABETES MELLITUS TYPE 2 AND ITS ASSOCIATION WITH GLYCOSYLATED HEMOGLOBIN AND LIPIDS – A PROSPECTIVE STUDY AT TERTIARY CARE HOSPITAL

A prospective, cross sectional questionnaire-based study was carried out over a period of six months. All the diabetic patients aged 18 to 60 years in the Medicine department and diabetes clinic who are eligible for study were enrolled. In addition to a questionnaire on demography, exercise, and smoking status, we used a structured case record form to capture diabetes-related complications, durati...

H. Rajgadhi, V. Patel, B. Sabu and S. Malhotra *

Department of Pharmacology, Smt. NHL Municipal Medical College, Kocharab, Paldi, Ahmadabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3347-54

3347-3354

78

64

27.

DEVELOPMENT AND VALIDATION OF Q-ABSORBANCE RATIO SPECTROPHOTO-METRIC METHOD FOR SIMULTANEOUS ESTIMATION OF MANGIFERIN AND BERBERIN HCl IN BULK AND SYNTHETIC MIXTURE

There are so many promising plant based chemical constituents are present which act as alternative therapy for the control of diabetes. But due to lack of its proper quality control parameters they are not widely used. The US FDA patent is approved for fixed dosage combination of Mangiferin (MF) and Berberin HCl (BER) as antidiabetic herbal formulation. Absorbance ratio method uses the ratio of ab...

H. Padh, S. Parmar * and B. Patel

Department of Pharmaceutical Sciences, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3355-59

3355-3359

65

34

28.

FREE RADICAL SCAVANGING ACTIVITY OF RASASINDURA (RED SULPHIDE OF MERCURY)

The main aim of the study was to scientifically validate the free radical scavenging activity of classically prepared Rasasindura (Red sulphide of mercury). With this intention Rasasindura (Red sulphide of mercury) was subjected to the screening of free radical scavenging activity in rat’s liver homogenate with four parameters like lipid peroxidation (LPO), super oxide dismutase (SOD), catalase ...

V. B. Kupati * and P. G. Jadar

Department of Rasashastra and Bhaishajyakalpana, KAHER’S Shri B. M. Kankanawadi Ayurveda Mahavidyalaya, A Constituent Unit of KLE Academy of Higher Education and Research, Belgavi, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3360-66

3360-3366

87

29

29.

HEPATOPROTECTIVE ACTIVITY OF HYDROALCOHOLIC EXTRACT OF BOERHAAVIA DIFFUSA LINN. AGAINST D-GALACTOSAMINE INDUCED HEPATOTOXICITY IN MICE

Boerhaavia diffusa is a natural herb possesses potent diuretic, anticancer and antioxidation properties. This work was designed to investigate the effect of hydro alcoholic extract of Boerhaavia diffusa Linn. on hepatoprotective efficacy in D-galactosamine-intoxication in mice. Albino Mice divided into 5 groups each consisting of 6 animals. Group 1 served as vehicle control, Group 2 served as hepa...

G. Nalini *, Ajithadasaruna, N. Chidambaranathan and N. Jegan

Department of Pharmacology, K. M. College of Pharmacy, Uthangudi, Madurai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3367-72

3367-3372

72

33

30.

SENSITIVE SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF VITAMINS (C AND E)

A sensitive, simple, accurate and fast method for vitamin C and E determination in pure and drug formulations using spectrophotometric was developed. The developed method is based on the formation of the charge transfer complex via the reaction between vitamins and Fe+3 [FeNH4(SO4)2.12H2O] in the presence of K3Fe(CN)6 which lead the formation of a blue-greenish colored product that has a maximum a...

A. M. Saeed *, M. J. Hamzah and N. J. M. Ali

Department of Chemistry, College of Education for Pure Science, Diyala University, Iraq.

DOI: 10.13040/IJPSR.0975-8232.9(8).3373-77

3373-3377

83

35

31.

EVALUATION OF GLUCOSE SYRUP PRODUCED FROM CASSAVA HYDROLYZED WITH MALTED GRAINS (RICE, SORGHUM & MAIZE)

The crude malt obtained from the grains were hydrolyzed with cassava starch to obtain glucose syrup. 94.33% malt was produced from maize, rice had 84.46% malt, while sorghum had 84.97% malt. Glucose syrup yield was greatest using sorghum malt with percentage yield of 75.55%, 52.37% using rice malt, and while maize malt had 48.33 % syrup. Maize sample had highest malt yield but lowest glucose syrup...

M. E. Ojewumi *, O. A. Adeeyo, O. M. Akingbade, D. E. Babatunde, A. A. Ayoola, O. O. Awolu, E. O. Ojewumi and O. J. Omodara

Chemical Engineering Department, Covenant University, P.M.B 1023, Canaan Land, Ota, Ogun state, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.9(8).3378-87

3378-3387

63

31

32.

DESIGN OF CONTROLLED RELEASE NON-ERODIBLE POLYMERIC ATENOLOL MATRIX TABLET USING MICROWAVE OVEN-ASSISTED SINTERING TECHNIQUE

The objective of the present study was to evaluate the effect of microwave sintering condition on matrix formation and subsequent drug release from polymer matrix tablet for controlled release. The Atenolol floating SR matrix tablets were prepared by using tragacanth, sodium bicarbonate, Eudragit S-100 and citric acid was incorporated as a gas generating agents. Atenolol controlled release tablets...

S. Polshettiwar * and R. Hajare

Department of Pharmaceutics, Maharashtra Institute of Pharmacy, Kothrud, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3388-97

3388-3397

74

37

33.

DEVELOPMENT AND EVALUATION OF SOLID SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM OF POORLY SOLUBLE OLMESARTAN MEDOXOMIL BY USING ADSORPTION ON TO SOLID CARRIER TECHNIQUE

Olmesartan medoxomil (OLM) is an angiotensin II receptor blocker antihypertensive agent. It is a highly lipophilic (log p (octanol / water) 5.55), poorly water soluble drug with absolute bioavailability of 26%.The present work aimed at formulating a solid self Nano emulsifying drug delivery system (solid-SNEDDS) for Olmesartan medoxomil with the objective of improving the aqueous solubility, disso...

M. S. Reddy *, B. Rambabu and K. A. Vijetha

Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3398-07

3398-3407

67

33

34.

CLINICAL STUDY OF ASSESSMENT OF THERAPEUTIC POTENTIAL OF VACHADI GHRITA, A MEDICATED GHEE FORMULATION ON HEALTHY INDIVIDUAL’S COGNITION

: In traditional Ayurved, numbers of medicated ghee formulations are prescribed to regulate person’s cognitive functions. Vachadi ghrita [VG], a medicated ghee formulation is prescribed to maintain healthy process of intellect and memory. In recent experimental studies, positive action of VG on animal’s memory was proved. Thus to generate clinical evidence, the study was attempted to evaluate ...

M. Pawar * and P. Magdum

Department of Ayurvedic Pharmaceutics and Pharmacology, Bharati Vidyapeeth Deemed University College of Ayurved, Dhankawadi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3408-13

3408-3413

70

32

35.

CYTOTOXICITY AND IN-SILICO STUDIES OF ANETHOLE IN TRIPLE NEGATIVE BREAST CANCER CELLS

Triple negative breast cancer (TNBC) is a type of breast cancer in which receptors such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are absent. Triple-negative breast cancer is a high risk breast cancer that lacks the benefit of specific therapy that targets these receptors. In the present study, anethole an aromatic compound from star anise was expose...

S. Sumathi *, A. Poornima, D. Muthukumari and P. R. Padma

Department of Biochemistry, Biotechnology and Bioinformatics, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3414-19

3414-3419

79

38

36.

FORMULATION OF GEL KEFIR PRODUCT OF MILK FERMENTATION AND ANTIBACTERIAL ACTIVITY TESTS AGAINST PROPIONIBACTERIUM ACNES

Propionibacterium acnes is one of the bacteria that causes acne. One of the natural ingredients that potentially as anti acne is kefir. Kefir is a product of fermented milk with starter kefir grain. The fermented kefir is incorporated into the gel product for acne treatment. The purpose of this study was to formulate the fermented kefir in the gel product and to test the antibacterial activity aga...

S. Muhsinin *, W. M. Miftahussa’adah and G. Jafar

Bandung School of Pharmacy, Bandung, West Java, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.9(8).3420-26

3420-3426

63

40

37.

EVALUATION OF ANTIDEPRESSANT ACTIVITY OF LITSEA FLORIBUNDA (BL.) GAMBLE – LAURACEAE USING ANIMAL MODELS

The genus Litsea, is used in traditional and indigenous Indian and Chinese medicines for the treatment of diarrhoea, stomach ache, dyspepsia, gastroenteritis, diabetes, edema, arthritis etc. The objective of the present study was to evaluate the antidepressant activity of leaf and stem bark aqueous and ethanol extracts of L. floribunda (LF) as well as its interaction with conventional antidepressa...

M. Devika and M. S. Nalini *

Department of Studies in Botany, University of Mysore, Manasagangotri, Mysore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3427-32

3427-3432

61

28

38.

DESIGN AND IN-VITRO CHARACTERIZATION OF METADOXINE BUCCAL PATCHES USING BORASSUS FLABELLIFER FRUIT RESIN – A NOVEL MUCOADHESIVE POLYMER

In this study, an attempt was made to introduce a new mucoadhesive polymer - Borassus flabellifer fruit resin (BFR), especially for buccal drug delivery. The novel polymer, in combination with two other natural polymers (Pectin and Sodium alginate) and one synthetic polymer (PVA) were used to formulate buccal patches containing Metadoxine. Compatibility studies carried out with the help of FT-IR s...

V. Hariharshan * and M. G. Rao

Department of Pharmaceutics, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3433-43

3433-3443

126

35

39.

OPTIMIZATION AND DEVELOPMENT OF BIO SYNTHETIC SILVER NANO PARTICLES OF AZURIN- AN ANTI-CANCER AGENT FROM PSEUDOMONAS AERUGINOSA

The pretentious extract of Pseudomonas aeruginosa has shown promising anticancer activity. It contains a protein called Azurin. It has a molecular weight of 14 kDa. It is soluble in water. It is a type I copper-containing protein of cupredoxin family. In this work, Pseudomonas aeruginosa MTCC strain 647 was cultivated in modified Asparagine -proline broth. An attempt was done to isolate and purify...

P. Neeraja *, T. Parthasarathy and M. Sudhakar

Department of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3444-48

3444-3448

58

29

40.

SYNTHESIS AND EVALUATION OF ANTI-PROLIFERATIVE ACTIVITY OF NOVEL THIAZOLIDINONE DERIVATIVES

A series of, 2-thioxo-4-thiazolidinone (rhodanine) and 2,4-thiazolidine-dinone derivatives were synthesized by reacting 4-thiazolidine-dione/rhodanine moieties with 2-(4-formylphenoxy)-N-substituted-phenyl-acetamide, in equimolar proportions. The authentication of synthesized compounds was done by FTIR, 1HNMR, and mass spectrophotometry. The derivatives, N-(phenyl) -2- {4-[ (4-oxo-2-thioxo-1, 3-th...

V. Somasekhar *, R. Udainiya and S. Kumar

Department of Pharmaceutical Chemistry, KLE College of Pharmacy, Rajajinagar, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3449-53

3449-3453

75

44

41.

CHEMOPREVENTIVE ACTIVITY OF QUININE SULFATE IN DMBA-CROTON OIL INDUCED SKIN CARCINOMA IN MICE

Cancer has emerged as a major health problem globally as a consequence to the increased longevity of the population, changing environment and life style. Chemoprevention is a new and promising strategy for reducing cancer burden. The present study was conducted to evaluate the potential of Quinine sulphate to prevent chemically induced skin cancer in mice. Cancer was induced on 2-stage skin carcin...

D. Jhanwar and J. Sharma *

Department of Zoology, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3454-62

3454-3462

64

34

42.

PHYTOCHEMICAL SCREENING AND IN-VITRO ANTICANCER ACTIVITY OF EXTRACTS OF TECTARIA CICUTARIA

The rhizome of Tectaria cicutaria has been used in Indian traditional medicine for the treatment of various disorders. Different extracts of the rhizomes of Tectaria cicutaria were subjected to phytochemical analysis, anti-microbial activity and in-vitro anticancer activity. The in-vitro anticancer activity was performed using Sulforhodamine B (SRB) assay against various cancer cell lines namely H...

K. Preeti * and J. Namdeo

Department of Pharmaceutics, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3463-68

3463-3468

64

39

43.

OXONE AND IODOBENZENE ARE USEFUL REACTION SYSTEM FOR SYNTHESIS OF 2-AMINOTHIAZOLE DERIVATIVES FROM EASILY AVAILABLE THIOUREA AND ALKYL / ARYL KETONES

A quick one step, innovative approach for the Synthesis of 2-aminothiazole derivatives from easily available thiourea and alkyl / aryl ketones with the help of Oxone and Iodobenzene reaction system has been developed in aqueous acetonitrile solution. The developed procedure is applicable to several types of substituted 2-aminothiazole derivatives to get the corresponding products. The developed me...

V. Bhosale, K. Sasane, D. Sasane, V. Kapase and L. Patil *

Department of Chemistry, Maharaja Jivajirao Shinde Arts, Science, Commerce College, Shrigondha, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3469-73

3469-3473

79

31

44.

CHARACTERIZATION AND QUANTIFICATION OF ETHYLHEXYLGLYCERIN

Ethylhexylglycerin is an alkyl glyceryl ether. This means that the ethyl hexyl group is bound to glycerin at one end by an ether linkage. it has been used as a common ingredient in bath products, body and hand products, cleansing products, deodorants, eye makeup, foundations, hair care products and suntan products. The compound is synthesized by esterfication of 2-Ethylhexanol and epichlorohydrin,...

R. Arla *, J. S. Rao and K. Koumaravelou

Department of Pharmacy, Prist University, Thanjavur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3474-79

3474-3479

58

24

45.

DRUG UTILISATION EVALUATION OF ANTI HYPERTENSIVE DRUGS IN CHRONIC KIDNEY DISEASE PATIENTS

Objective: To assess the drug utilization evaluation of antihypertensive agents in diabetic and non-diabetic patients with chronic kidney disease. Method: Retrospective observational study was conducted in inpatient Nephrology department of B.B.R. Hospital from Sep 2016 to Feb 2017 and 155 case records of patients diagnosed with CKD and HTN, above 18 yrs of age, belonging to both genders were coll...

V. Jyothirmayee *, P. Chandana, M. Ashwani, D. Mamatha, N. Deepthi and K. Madhav

Geethanjali College of Pharmacy, Cheeryal Village, Keesara Mandal, Medchal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3480-86

3480-3486

80

32

46.

ASSESSMENT OF THE PRESCRIPTION PATTERN OF ORAL HYPOGLYCEMIC DRUGS IN UNCOMPLICATED DIABETES MELLITUS PATIENTS AT TERTIARY CARE HOSPITAL

Aim and Objective: Drug utilization research help in identification of the clinical use of drugs in population and its impact on health care system and to evaluate the rational drug usage. To study prescription pattern, to evaluate the adherence to treatment guidelines in diabetic patients attending the medical outpatient department in a tertiary care teaching hospital. Drug utilization research h...

P. Bhavana *, V. S. Kumar, N. Divya, K. P. Pratheek and G. E. Rao

Nirmala College of Pharmacy, Mangalagiri, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3487-92

3487-3492

79

40

47.

FORMULATION, EVALUATION AND RADIOGRAPHIC STUDY OF STOMACH SPECIFIC FLOATING TABLETS CONTAINING VENLAFAXINE HYDROCHLORIDE FOR TREATMENT OF DEPRESSION

Depression is a chronic, recurring, and potentially life-threatening illness. The present work is to formulate floating tablets of Venlafaxine hydrochloride as this drug is used to treat depression. GIT absorption of Venlafaxine hydrochloride is poor due to low aqueous solubility. Thus, an attempt was made to enhance it gastric residence time that will improve its dissolution profile. The floating...

S. Kumar * and R. Mazumder

NKBR College of Pharmacy and Research Centre, Meerut Hapur Road, Meerut, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3493-00

3493-3500

60

29

48.

FORMULATION AND EVALUATION OF TRADITIONAL MEDICINE BASED HERBAL LOZENGES, JELLIES AND DISPERSIBLE TABLETS

Traditional medicine and herbal formulations have been used by mankind for the cure and treatment of various diseases and disorders. Since time immemorable natural sources have been used as medicines by the humans. As per Indian System of medicine, Ayurveda, Siddha, Unani plants are formulated in various types of dosage forms like churna, gutika, asavas, aristasavlehas, etc. Various formulations w...

D. M. Kannur *, S. S. Salunkhe, P. S. Godbole and S. P. Patil

Department of Pharmacognosy, SCES’s, Indira College of Pharmacy, Tathwade, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3501-05

3501-3505

71

34

49.

IN-VIVO STUDY OF ORODISPERSIBLE TABLET OF PRIMAQUINE

The main objective of the study is to evaluate orodispersible tablets of primaquine with different in-vivo parameters. Sharma P et al., (2015), in-vitro study was based on various evaluation parameters of orodispersible tablets of primaquine. From their study results, we have selected formula-6 of orodispersible tablets of primaquine for in-vivo study. Taste masking evaluation was performed on fiv...

P. Sharma * and M. Tailang

Department of Pharmaceutics, Shri Ram College of Pharmacy, Morena, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3506-10

3506-3510

77

43

50.

ISOLATION AND CHARACTERIZATION OF β-SITOSTEROL FROM METHANOLIC EXTRACT OF CORDIA DICHOTOMA LINN. BARK

Cordia dichotoma Linn. belonging the family Boraginaceae is locally called as Lasora in India. It is an important drug to cure diseases of the kidney, liver, spleen, heart and blood which attribute many medicinal properties in Ayurveda. The purpose of this study is to identify and characterize the bioactive principle from the bark of Cordia dichotoma Linn. Phytochemical screening methanolic extrac...

S. S. Ali *, C. Kala and N. A. Khan

Department of Pharmacology, Faculty of Pharmacy, IFTM University, Lodhipur Rajput, Moradabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3511-14

3511-3514

81

51

51.

ANTIMICROBIAL SUSCEPTIBILITY TEST ANALYSIS OF AEGLE MARMELOS BARK EXTRACTS

India is a land of medicinal flora, there are large numbers of plants with miraculous medicinal values has been used traditionally to cure several diseases from decades in Ayurveda. So the present study was designated to evaluate the antimicrobial activities of Aegle marmelos (bale) bark extracts. In this study different bark extracts were prepared using various solvents, further these extracts we...

R. Dahiya, R. C. Choudhary, R. S. Tomar and V. Shrivastava *

Amity Institute of Biotechnology, Amity University, Gwalior, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3515-18

3515-3518

70

30

52.

ANTI-INFLAMMATORY ACTIVITY OF METHANOLIC EXTRACT OF ROOTS OF RUMEX OBTUSIFOLIUS

Rumex obtusifolius belong to the family Polygonaceae, it is a common wayside weed and it has a good medicinal value. In the present study, the methanolic extract (sample named as R2) of roots of R. obtusifolius was used to examine the in-vitro and in-vivo anti-inflammatory activity using human red blood cell membrane stabilization method to measure the potential of the extract on human red blood c...

M. Singh * and M. C. Purohit

Department of Chemistry, H.N.B. Garhwal University (A Central University), B.G.R. Campus, Pauri, Srinagar Garhwal, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3519-22

3519-3522

80

31

53.

MEDICATION ERRORS IN EGYPTIAN CRITICALLY ILL PATIENTS WITH RENAL INSUFFICIENCY: AN ASSESSMENT OF THE NEED FOR OPTIMIZING CLINICAL PHARMACY SERVICE

Background: The limited evidence of the critical role of clinical pharmacists in Egyptian teaching hospitals led to the fact that critical care pharmacists' responsibilities are still focused on dispensing and drug distribution. Objective: Assess the important role of clinical pharmacy service activities in an Egyptian intensive care unit (ICU) by describing the impact of medication errors on clin...

N. S. Bazan *, E. A. Darweesh and A. El-Sherif

Department of Critical Care Medicine, Cairo University Hospitals, Egypt.

DOI: 10.13040/IJPSR.0975-8232.9(8).3523-29

3523-3529

75

34

54.

ACNE VULGARIS: AN INSIGHT

Context: Acne vulgaris, a very common malady of adolescents, is well known and easily recognized. Acne is a “polymorphic” disorder which exhibits series of widespread and diverse lesions. Four key factors have been identified in the etiology of acne: increased sebum production, follicular hyperkeratinization, colonization of the pilosebaceous unit with Propioni bacterium acnes and the producti...

S. V. Agravat * and A. Pillai

Department of Pharmacology, PDU Government Medical College, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3530-34

3530-3534

71

29

55.

FIXED HEXA-HELIX: AN AMENDED QUAD HELIX FOR A COMPLIANCE DRIVEN PEDIATRIC PATIENT- A INNOVATIVE CASE APPROACH

Introduction: Early treatment in growing patient is of value as the guidance of occlusion to normalcy can shorten the treatment time in mature patients. The removable appliance is commonly used by pediatric dentist to intercept malocclusion in such patients, but it brings a major drawback with it of being compliance dependent. Fixed appliance therapy is better accepted and has better wear complian...

R. Bhandari *, S. Thakur, P. Singhal, D. Chauhan, C. Jayam and T. Jain

Department of Pedodontics, H.P. Government Dental College, Shimla, Himachal Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3535-37

3535-3537

68

29

56.

FORMULATION AND DEVELOPMENT OF NOVEL AND STABLE DOSAGE FORMS OF LAMIVUDINE AND TENOFOVIR DISOPROXIL FUMARATE TABLETS BY WET GRANULATION TECHNIQUE

Antiretroviral drugs are medications used for treatment of infection caused by retroviruses, primarily HIV. Different classes of antiretroviral drugs act at different stages of the HIV life cycle. No individual antiretroviral drug has been demonstrated to suppress an HIV infection for prolong treatment. Antiretroviral drugs must be taken in combinations in order to have a lasting effect. Combinati...

C. S. Panchagnula *, N. B. Naware, S. S. Bhamre, K. D. Deo and S. Meenakshisunderam

Polygen Pharmaceuticals Inc., 41 - 17, Mercedes Way, Edgewood, New York, USA.

DOI: 10.13040/IJPSR.0975-8232.9(8).3538-42

3538-3542

75

37

57.

IN-VITRO AND EX-VIVO STUDIES ON THE ANTIOXIDANT, ANTI-INFLAMMATORY AND ANTIARTHRITIC PROPERTIES OF CAMELLIA SINENSIS, HIBISCUS ROSA SINENSIS, MATRICARIA CHAMOMILLA, ROSA SP., ZINGIBER OFFICINALE TEA EXTRACTS

The adverse effects of oxidative stress have been discussed widely in the present day. It is the main cause of protein denaturation, cardiovascular diseases, ageing, etc. Thus, the daily requirement of anti-oxidants has to be fulfilled through dietary sources. Inflammation is yet again another form of stress on the body. It is the major cause of multiple chronic disorders. It can lead to the forma...

K. G. Singh *, S. Sonia and N. Konsoor

Department of Biochemistry, Mount Carmel College, Autonomous, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3543-51

3543-3551

95

36

58.

STUDY OF ANTIDIABETIC EFFECT OF LEMONGRASS (CYMBOPOGON CITRATUS) AQUEOUS ROOTS AND FLOWER EXTRACTS ON ALBINO MICE

Dexamethasone drug induced the hyperglycemia in the Albino mice when intra-peritoneally administered at the dose of 10 mg/kg. Administration of dexamethasone raised the level of blood sugar in the mice. Administration of aqueous extract of C. citratus root and flower extract reduced the fasting and postprandial blood sugar levels, bringing them towards normal. We were observed anti-diabetic effect...

N. Abbas *, M. H. Al-Sueaadi, A. Rasheed and E. S. Ahmed

Department of Medicinal Chemistry, Qassim University, College of Pharmacy, Qassim, KSA.

DOI: 10.13040/IJPSR.0975-8232.9(8).3552-55

3552-3555

169

54

59.

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC AREA UNDER CURVE METHOD QUANTITATIVE ESTIMATION OF PIPERACILLIN

The kinetic of conjugated reactions of S-oxidation and perhydrolysis of Piperacillin (Pip) with potassium hydrogen peroxo-monosulfate in alkaline medium is studied by the increase of forming product light absorbance. A scheme of peroxoacid oxidation and perhydrolysis conjugated reactions of Piperacillin by means of hydrogen peroxomonosulfate is proposed. The procedure of the quantitative analysis ...

S. P. Karpova *, M. Y. Blazheyevskiy and O. O. Mozgova

Department of Physical and Colloid Chemistry, National University of Pharmacy, Pushkinska Street, Kharkiv, Ukraine.

DOI: 10.13040/IJPSR.0975-8232.9(8).3556-60

3556-3560

74

64

60.

DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR ESTIMATION OF CARBAMAZEPINE IN BULK DRUG AND FORMULATIONS

A new, simple, and rapid high-performance thin-layer chromatographic method was developed and validated for quantitative determination of Carbamazepine. Carbamazepine was chromatographed on silica gel 60 F254 TLC plate using Ethyl acetate: Methanol (9: 1 v/v) as mobile phase. Carbamazepine was quantified by densitometric analysis at 239 nm. The method was found to give compact spots for the drug. ...

S. B. Patil * and R. Y. Chaudhari

DCS’s Annasaheb Ramesh Amerax College of Pharmacy, Nagaon, Dhule, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3561-66

3561-3566

40

20

61.

THE VALUE OF DOXYCYCLINE IN ACETIC ACID INDUCE ULCERATIVE COLITIS IN RATS

Ulcerative colitis is an idiopathic chronic inflammatory disease of the colon for which a lot of treatment modalities are present, however, significant side effects are associated with them and there is a need for a search for other treatment options.  This study was aimed to investigate the therapeutic role of Doxycycline in experimentally induced colitis in rats. Animals were categorized into 5...

M. J. Manna *, A. Abu-Raghif and O. J. A. H. Al-Saree

College of Dentistry, Al-Mustansiriya University, Iraq.

DOI: 10.13040/IJPSR.0975-8232.9(8).3567-72

3567-3572

40

14

62.

CLINICAL EVALUATION OF T-AYU-HMTM IN THE MANAGEMENT OF SICKLE CELL ANEMIA

Sickle cell anemia is a hemoglobin disorder, which is an autosomal recessive type affects millions of children of underprivileged and tribal area every year. Because of its devastating complications sickle cell is considered a major health problem in India and the entire world. Since many years, majority of the tribal population in the South Gujarat region are suffering from this lifelong disorder...

A. M. Desai *, M. N. Saraf, C. Desai, H. Desai and M. Dalal

Dhanvantari Clinic, Ayurveda Health Care and Research Center, Vyara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(8).3573-78

3573-3578

5

6