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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2015): 1.11 , ICV (2015): 90.24
Five-Year Projected Impact Factor: 2.60

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Volume 8 (2017) - Issue 6, June

Review Articles

 
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1.

CHEMISTRY AND BIOACTIVITY OF CINNAMALDEHYDE: A NATURAL MOLECULE OF MEDICINAL IMPORTANCE

Cinnamaldehyde is derived from the cinnamon essential oil (EO) having many biological and pharmacological significance. This review article explains the source, chemistry, physico-chemical characteristics of the molecule. The synthesis of its different analogous has been duly highlighted. The different applications narrating the various usage have been reported. It is expected that this review sha...

S. N. Ashakirin, M. Tripathy*, U. K. Patil and A. B. Abdul Majeed

Laboratory of Fundamentals of Pharmaceutics, Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Bandar Puncak Alam, Selangor, Malaysia

DOI: 10.13040/IJPSR.0975-8232.8(6).2333-40

2333-2340

489

448

2.

ADVANCES IN TB DRUG DEVELOPMENT: A NOTE ON DERIVATIVES OF ISONIAZID AND PYRAZINAMIDE

Tuberculosis (TB) remains one of the main causes of death from an infectious disease till date. Recent data shows that currently 9.6 million people are infected with TB. Over 95% of TB deaths occur in low- and middle-income countries and it is among the top 5 causes of death for women aged 15 to 44. TB is a leading killer of HIV-positive people and around 1 in 3HIV deaths was due to TB. Furthermor...

Ruchita, S. Nanda*, D. Pathak and A. Mathur

Department of Pharmaceutical Sciences, Maharishi Dayanand University, Rohtak, Haryana India

DOI: 10.13040/IJPSR.0975-8232.8(6).2341-59

2341-2359

343

306

3.

MORPHOLOGY, PHYTOCHEMISTRY AND PHARMACOLOGY OF SYZYGIUM CUMINI (LINN.) – AN OVERVIEW

Syzygium cumini (L.) is a widely used medicinal plant for the treatment of various ailments. The plant contains anthocyanins, glucoside, ellagic acid, isoquercetin, kaempferol, and myricetin as its chief active constituents. These active cons isoquercetin, kaempferol tituents impart multiple pharmacological activities to the plant which includes antidiabetic, anticancer, antioxidant, antibacterial...

R. K. Bijauliya*, S. Alok, Man Singh and S. B. Mishra

Department of Pharmacognosy, Bundelkhand University, Jhansi, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(6).2360-71

2360-2371

370

278

4.

A REVIEW OF IRANIAN MEDICINAL PLANTS WITH TERATOGENIC AND ABORTION-INDUCING SIDE EFFECTS

Compounds with teratogenic effects can cause genetic defects during pregnancy and subsequently lead to unwanted abortions. Unwanted abortions and postnatal genetic defects can impose economic and psychological burden on the community. This systematic review was conducted to report medicinal plants with teratogenic and abortion-inducing side effects that are used in Iran. To conduct this systematic...

T. Artimani, S. Shabanian *, S. Heidari-Soureshjani, M. Asadi-Samani, T. Luther

Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

DOI: 10.13040/IJPSR.0975-8232.8(6).2372-77

2372-2377

309

169

5.

SOLID DISPERSION: OVERVIEW OF THE TECHNOLOGY

Up to 40% of new chemical entities (NCEs) discovered today by the pharmaceutical industry through combinatorial chemistry and high through put screening are highly lipophilic or poorly water soluble compounds, so the number of such compounds has dramatically increased and the solubility behaviour of these drugs has become one of the most challenging aspects in formulation development. So amongst t...

K. Bashir Mir and N. Ahmed Khan*

Department of Pharmaceutical Sciences, University of Kashmir, Srinagar, Jammu and Kashmir, India

DOI: 10.13040/IJPSR.0975-8232.8(6).2378-87

2378-2387

259

176

6.

COMPARISON OF VARIOUS APPROACHES TO INCREASE THE GASTRIC RESIDENSE TIME

Oral drug delivery is the most preferred route for the various drug molecules among all other routes of drug delivery, because ease of administration which lead to better patient compliance. So, oral extended release drug delivery system becomes a very promising approach for those drugs that are given orally but having the shorter half-life and high dosing frequency. Extended release drug delivery...

Anand D. Savkare * and Priyanak S. Pagar

MVP Samaj’s College of Pharmacy, Gangapur Road, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2388-95

2388-2395

118

75

7.

PHARMACEUTICAL SCIENCE BRINGS GENETICS AND IMMUNOLOGY TOGETHER TO EVOLVE A NEW DIMENSION IN TREATING CHILDHOOD CANCER: A REVIEW

Surgery, chemotherapy and radiation therapy has been the cornerstone of cancer management for decades. Since a decade or so, targeted therapies by way of Imatinib and Trastuzumab arrived that specifically target cancer cells and reply on specific molecular changes to identify them. These are in fact the standard treatment at present in several forms of cancer. But now in recent times, the fifth pi...

A. S. Singh* and M. Y. Tilawat

SVKM’S Narsee Monjee Institute of Management Studies, Babulde, Bank of Tapi River, Mumbai-Agra Road, Shirpur, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(6).2396-01

2396-2401

99

54

8.

PRESENCE AND SOURCE OF TOXIC HEAVY METALS IN CAMELLIA SINENSIS SHOOT

Tea has been considered as a health promoting drink & stimulant. Globally 4842.1 thousand tons tea consume annually. But due to change in soil characteristics, indiscriminate use of pesticide & fertilizer lead to accumulation of toxic heavy metal like Lead(Pb), Arsenic(As), Copper(Cu), Nickel(Ni) & Cadmium(Cd) in tea leafs & bud. Tea market in India is not well regulated, an abunda...

S. Jana, B. Mahanti and D. Sur *

Department of Pharmacology, Bharat Technology, Jaduberia, Uluberia, Howrah,West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2402-07

2402-2407

121

67

9.

TOPICAL LIPOSOMAL GEL: A REVIEW

Liposomes have been established as a promising novel drug delivery vehicle in several different basic sciences. Liposomes are microscopic spheres with an aqueous core surrounded by one or more outer shells consisting of lipids arranged in a bilayer configuration. Liposomes are acceptable superior carriers having ability to encapsulate hydrophilic and lipophilic drugs and protect them from degradat...

M. Kamra *, A. Diwan and S. Sardana

Hindu College of Pharmacy, Sonepat, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2408-14

2408-2414

132

62

10.

IRANIAN MEDICINAL PLANTS EFFECTIVE ON SEXUAL DISORDERS: A SYSTEMATIC REVIEW

Medicinal plants used in traditional medicine and various cultures can be valuable resources for discovering new drugs. This review was conducted to report Iranian medicinal plants effective on sexual dysfunction (sexual desire disorders, erectile dysfunction, and premature ejaculation). To conduct this systematic review, the search terms Sexual*, Aphrodisiacs, Erectile, and Libido* combined with ...

K. Solati, S. Heidari-Soureshjani, T. Luther and M. Asadi-Samani*

Shahrekord University of Medical Sciences, Shahrekord, Iran.

DOI: 10.13040/IJPSR.0975-8232.8(6).2415-20

2415-2420

136

78

Research Articles

 
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11.

DUAL STIMULI-RESPONSIVE POLY (N-ISOPROPYLACRYLAMIDE-co-ACRYLIC ACID) COPOLYMERS AND THEIR APPLICATIONS IN IBUPROFEN DELIVERY

A series of poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA)) nanoparticles with different contents of acrylic acid were synthesized via free radical polymerization route. Their pH- and thermo-responsive behaviors were investigated using 1H-NMR, FT-IR and SEM, dynamic light scattering, scanning calorimeter and zeta potential measurements. The results elucidated that the P(NIPAM-co-AA) e...

Xiao Qi Jin, Ji Hong Sun *, Shi Yang Bai and Xia Wu

Beijing Key Laboratory for Green Catalysis and Separation, Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing, P. R. China.

DOI: 10.13040/IJPSR.0975-8232.8(6).2421-32

2421-2432

259

155

12.

PHARMACOVIGILANCE SIGNALS DETECTION: BENZODIAZEPINES AND SKIN AND SUBCUTANEOUS TISSUE DISORDERS

Pharmacovigilance compiles and analyzes spontaneous adverse drug reactions (ADRs) notifications reports on pharmacovigilance databases. Benzodiazepines have been related to skin and subcutaneous tissue disorders ADRs (SSTD-ADRs); tetrazepam was withdrawn in 2013 because of these ADRs. We intended to locate possible associations between cutaneous ADRs and benzodiazepines marketed in USA; for that, ...

B. Proy-Vega *, A. M. Blázquez, J. S. García Del Pozo, E. Nava and J. Jordán

Pharmacy Department, La Mancha-Centro Hospital, Avenida de la Constitución nº 3, Alcázar de San Juan, Ciudad Real, Spain

DOI: 10.13040/IJPSR.0975-8232.8(6).2433-42

2433-2442

238

148

13.

AMELIORATED SOLUBILITY AND DISSOLUTION RATE OF GLIMEPIRIDE BY CYCLODEXTRIN TERNARY COMPLEXES EMPLOYING AMINOACIDS

The purpose of the current investigation was to ameliorate the aqueous solubility and dissolution rate of an anti diabetic drug Glimepiride by cyclodextrin ternary complexes employing aminoacids. Initially, Glimepiride (GMP) binary complexes with β-Cyclodextrin (βCD) and Hydroxy propyl β-Cyclodextrin (HPβCD) were formulated by physical mixing, kneading, solvent evaporation and spray drying tec...

Md. Jafar *, A. Malpani and Md. Imran Khan

Department of Pharmaceutics, College of Clinical Pharmacy, University of Dammam, Dammam, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.8(6).1000-09

2443-2451

227

125

14.

MICROARRAY BASED IDENTIFICATION REVEALS ARTERIAL ANGIOTENSIN SYSTEM EXPRESSION IN HUMAN

Purpose: We studied by microarray analysis the tissue angiotensin system organization. We elucidated the expression of chymase, cathepsins D, G and angiotensin-converting enzyme (ACE), potentially involved in intraparietal angiotensin II formation and atheroma. Methods: mRNA gene expression was measured by an Affymetrix Gene Chip Human Gene 1.0 ST arrays (Affymetrix, Santa Clara, CA, USA) using RN...

Hanène Ayari* and Giampiero Bricca

Université Lyon1, INSERM, ERI22, EA 4173, Lyon, France

DOI: 10.13040/IJPSR.0975-8232.8(6).2452-57

2452-2457

211

100

15.

PREVENTIVE EFFECT OF HELIX ASPERSA CRUDE EXTRACT AGAINST CHEMO-INDUCED COLONIC DAMAGES IN RATS

The present work aimed to explore in vivo the effect of Helix Aspersa Crude Extract (HACE) on the chemo-induced damages occurred in rat colon specially on the histology of the crypts foci in liberkhun glands. The toxicity of HACE was evaluated with different HACE concentrations. With the concentration of 160 mg, animals showed the best gain weight, stayed normal and all animals survived. Therefore...

M. Kouachi, D. Naimi *, D. Djadouri and I. Bendahra

Higher National School of Biotechnology, Taoufik Khaznadar – nouveau pôle universitaire Ali Mendjli BP E66, Constantine - Algeria.

DOI: 10.13040/IJPSR.0975-8232.8(6).2458-68

2458-2468

263

144

16.

IMPACT OF DIFFERENT CARBON SUPPLEMENT ON EXTRACTION OF C-PHYCOCYANIN (C-PC) FOLLOWED BY POLY-β-HYDROXYBUTYRATE (PHB) FROM NOSTOC MUSCORUM

The extraction of poly-β-hydroxybutyrate (PHB) and C-phycocyanin (C-PC) from Nostoc muscorum revealed that PHB yield after C-PC extraction was not found differ significantly as without C-PC extraction. Under photoautotrophic growth condition, the test cyanobacterium accumulates PHB and C-PC with a maximum yield of 40 and 57 mg l-1 respectively at the stationary phase, i.e. on day 21 of incubation...

Vrijesh Kumar Yadav * and Vikash Kumar Yadav

Indian Institute of Technology, Kharagpur, 721302, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2469-76

2469-2476

128

53

17.

ANTICONVULSANT EVALUATION OF SOME NOVEL 1, 3-THIAZINE DERIVATIVES

In the present study, a series of novel biologically active 8-benzylidene-6-tert-butyl-4-phenyl- 5, 6, 7, 8-tetrahydro-benzo-1, 3-thiazin – 2 -imines (TB1-TB12) were synthesized and evaluated for their biological activities. Initially, 2,6-dibenzylidene-4-tert-butylcyclohexanones were synthesized by Claisen-Schmidt condensation of 4-tert-butylcyclohexanone with various aromatic aldehydes in the ...

R. Bairam *, S. M. Muppavarapu, A. Basha Shaik and S. Kumar K.

Department of Pharmaceutical Chemistry, Center for Pharmaceutical Sciences, New IST, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana State, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2477-85

2477-2485

113

73

18.

SUPERCRITICAL CARBON DIOXIDE EXTRACTION OF MELATONIN FROM BRASSICA CAMPESTRIS: IN VITRO ANTIOXIDANT, HYPOCHOLESTEROLEMIC AND HYPOGLYCAEMIC ACTIVITIES OF THE EXTRACTS

Brassica campestris Linn. (yellow mustard), a common Indian condiment, possesses melatonin as an important antioxidant. Optimization of supercritical carbon dioxide extraction (SC-CO2) process parameters was conducted to obtain an extract having the best combination of yield of melatonin and maximum in vitro hypoglycaemic and hypocholesterolemic activities, along with a desirable balance of ω6 to...

S. Chakraborty and P. Bhattacharjee

Department of Food Technology and Biochemical Engineering, Jadavpur University, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2486-95

2486-2495

100

51

19.

BENEFICIAL EFFECTS OF MORINDA CITRIFOLIA LINN. (NONI) LEAF EXTRACT ON OBESITY, DYSLIPIDEMIA AND ADIPONECTINEMIA IN RATS WITH METABOLIC SYNDROME

Pharmacological activities have been reported for the fruit, leaf and root extracts of Morinda citrifolia L. (Noni); however, the plant has not been widely studied for its antidyslipidemic effects on obesity and metabolic syndrome (MS). Objective: to evaluate the effects of aqueous M. citrifolia leaf extract on obesity and adipose tissue cell dynamics associated with triacylglycerol and adiponecti...

Soto R. Ida, Q. C. Rodolfo, R. A. Jorge, X. R. Irving, L. R. Luicita, A. M. Isaac and A. A. Alfonso *

Escuela de Medicina, Universidad Cristóbal Colón. Boca del Río, Ver., C.P. 94271. México

DOI: 10.13040/IJPSR.0975-8232.8(6).2496-03

2496-2503

99

55

20.

IMMUNOHISTOCHEMICAL DETECTION OF CASPASE 8 EXPRESSION AND APOPTOTIC INDEX ACTIVITIES OF CALVATIA CRANIIFORMIS CRUDE EXTRACT IN BALB/C MICE INOCULATED WITH H22 CELLS

Objectives: To identify Immunomodulatory, apoptosis induction and anticancer activities of aqueous and alcoholic extracts of Calvatia craniiformis regarding the size of tumor mass and immunohistochemical detection of caspase 8 expressions   and apoptotic index in mice inoculated   with H22 mouse hepatocellular carcinoma cells as therapeutic experimental system for human hepatocellular carcinom...

I. H. Mohammed, G. Hamdan Jameel and A. Ibrahim Ali Al-Ezzy *

Department of Pathology, College of Veterinary Medicine, Diyala University, Iraq.

DOI: 10.13040/IJPSR.0975-8232.8(6).2504-15

2504-2515

97

53

21.

ENUMERATION OF ORGANCHLORINE, ORGANOPHOSPHATE AND SYNTHETIC PYRETHROIDS IN BEANS GROWN IN FIVE DISTRICTS OF KARNATAKA

Pesticide residues in food and crops are a direct result of application of pesticides to crops growing in the field. Large quantities of pesticides are being used to control various pests, which normally infest the economically important plants. Beans- grown across the country and provides an important source of income for the small and marginal farmers. Bean growing in five districts of Karnataka...

S. R. Ananda Gowda, H. L. Ramesh * and R. K. Somashekar

Department of Sericulture, Visveswarapura College of Science, K.R. Road, Bengaluru, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.8(6).2516-25

2516-2525

107

51

22.

BIOMIMETIC SYNTHESIS OF CdSe NANOPARTICLES WITH POTENTIAL BIOIMAGING APPLICATIONS

This study presents in vitro biomimetic synthesis of CdSe nanoparticles using the enzyme, NADPH dependent-Nitrate reductase purified from fungus, Fusarium oxysporum. The synthesis of CdSe nanoparticles was accomplished in the presence of a synthetic peptide having amino acid sequence (γ-Glu-Cys-Glu-Cys)-Gly, which acted as binding molecule. The nanoparticles were synthesized in the size range of ...

Abu A. Ansary *, Imran Uddin and Muhammed I. Khan

Division of Biochemical Sciences, National Chemical Laboratory, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2526-32

2526-2532

105

74

23.

EFFECT OF LACTIC ACID BACTERIA ON BIOFILM FORMATION BY STREPTOCOCCUS MUTANS: AN IN VITRO STUDY

Dental biofilms are majorly developed by Streptococcus mutans, a cariogenic microorganism and are one of the major effects of glucosyltransferases (Gtf) produced by it. This study was conducted to determine the antagonistic potential of probiotic bacteria against S. mutans biofilm formation. We studied the anti-biofilm formation ability of three Lactobacillus species viz L. rhamnosus, L. acidophil...

A. Raj, P. Bhati and R. Bhadekar *

Department of Microbial Biotechnology, Rajiv Gandhi Institute of IT and Biotechnology, Bharati Vidyapeeth Deemed University, Pune – Satara Road, Katraj, Pune, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(6).2533-38

2533-2538

213

65

24.

DETERMINATION OF BIOACTIVE PHYTOCOMPONENTS FROM HYDROETHANOLIC EXTRACT OF ANNONA SQUAMOSA (LINN.) LEAF BY GC- MS

Annona squamosa Linn.commonly called as custard apple, is an edible tropical fruit belongs to the family Annonaceae, is said to show varied medicinal effects, including insecticide, antiovulatory and abortifacient. Hence the present investigation was carried out to determine the phytochemical composition of A. squamosa leaf extract using Gas Chromatography–Mass Spectrometry technique, while th...

S. Hemalatha, P. Amudha, N. Pushpa Bharathi and V. Vanitha *

Department of Biochemistry, School of Life sciences, Vels University, Chennai, Tamilnadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2539-44

2539-2544

94

59

25.

MORPHOMETRY OF THE THYROID GLAND IN DIFFERENT AGE GROUPS IN NORTH INDIAN POPULATION: A CADAVERIC STUDY

Aims and Objectives: The present study was conducted to find out morphometry of thyroid gland in different age groups. Material and Methods: The study was conducted on 60 human thyroid glands in the Department of Anatomy, Pt. B. D. Sharma, PGIMS, Rohtak in North Indian population. Results: In present study, mean length of right and left lobe of thyroid gland was found to be 29.88±7.03 mm and 29.4...

P. Malik *, S. K. Srivastava, S. K. Dhattarwal, U. Verma, R. Singroha, S. Yadav

Department of Anatomy, Pt. B.D. Sharma, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.8(6).2545-50

2545-2550

89

42

26.

EVALUATION OF ANTIDIABETIC POTENTIAL OF KANDELIA CANDEL AND RHIZOPHORA APICULATA- AN IN VITRO APPROACH

Objective of the present work was to evaluating the antidiabetic property of Kandelia candel and Rhizophora apiculata extracts by using in vitro assays. The serial exhaustive extraction was carried out with a series of solvents:  chloroform, ethyl acetate, methanol, ethanol and water with increasing polarity using Soxhlet apparatus. The concentrated and dried extracts were evaluated for antidiabe...

Arun Kashivishwanath Shettar and Ankala Basappa Vedamurthy *

PG Department of Studies in Biotechnology and Microbiology, Karnatak University, Dharwad, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2551-59

2551-2559

103

64

27.

ANXIOLYTIC AND MOTOR COORDINATION ACTIVITY OF HUPERZINE-A IN RATS

The aim of the present study was to evaluate the anxiolytic effects and motor coordination activity of Huperzine-A in rats. Wistar rats were treated orally with Huperzine-A (0.5, 1, 2 & 4 mg/kg) and diazepam (2 mg/kg p.o) as a standard anxiolytic drug then exposed to Elevated plus Maze (EPM) and Light Dark Box (LDB). The effects of the Huperzine-A on motor coordination were evaluated by actoph...

K. Jaswinder *, R. Singh, P. Singh, J. Kaur and H. Kaur

G.H.G. Khalsa College of Pharmacy, Gurusar Sadhar, Dist. Ludhiana Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2560-66

2560-2566

108

51

28.

STUDY OF POTENTIAL TO INHIBIT HEMOZOIN FORMATION OF SOME NOVEL AMINOPROPANOLS

One of the factors responsible for malaria pathogenesis is the suppression of host immune responses. This suppression enhances parasitemia and diminishes the host immune response to malaria-expressed proteins and other pathogens. Hemozoin is a key metabolite associated with severe malaria anemia (SMA), immunosuppression, and cytokine dysfunction. Targeting of this pigment may be necessary in the d...

Priya Jain * and D. S. Bele

Pacific Academy of Higher Education and Research Society, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2567-72

2567-2572

95

46

29.

ANXIOLYTIC EFFECT OF ETHANOLIC EXTRACT OF FLOWERS OF CHRYSANTHEM INDICUM IN ALBINO MICE

Mental disorders are commonly occurring and often seriously impairing in many countries throughout the world. The total number of people suffering from anxiety or depression amount to 615 million, Close to 10% of the world’s population is affected. Chrysanthemum indicum is an ancient herbal medicine used as an anti-arthritic, anti-inflammatory and anti-anxiety in many Asian countries. The elevat...

D. Sheela *, V. Srinivasan and E. Sukumar

Department of Pharmacology, Saveetha Medical College and Hospital, Chennai, Tamilnadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2573-77

2573-2577

109

52

30.

PERFORMANCE OF ASSOCIATION RULES FOR DENGUE VIRUS TYPE1 AMINO ACIDS USING AN INTEGRATION OF TRANSACTION REDUCTION AND RANDOM SAMPLING (TRRS) ALGORITHM

Association rule mining is the recent research area in data mining. Frequent Itemset Mining techniques is one of the prominent techniques in pattern mining. In this system frequent itemset mining is used to find the frequent amino acids patterns in Dengue Virus Type1 data set. This system uses an integration of Transaction Reduction and Random Sampling (TRRS) approach to identify the frequent patt...

D. Kerana Hanirex *, K. P. Thooyamani and V. Khanaa

Bharath University,Chennai, Tamilnadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2578-87

2578-2587

98

48

31.

BIOSYNTHESIS OF SILVER NANO PARTICLES FROM LEUCAS ASPERA (WILLD.) LINK AND ITS ANTI-INFLAMMATORY POTENTIAL AGAINST CARRAGEEN INDUCED PAW EDEMA IN RATS

Synthesis of metal nanoparticles has become an important branch of nanotechnology and there is an increasing commercial demand for nanoparticles due to their wide applications. The present study was carried to synthesize silver nanoparticles (AgNPs) using the ethanolic extract of the Leucas aspera and evaluate its in-vitro anti inflammatory activity. The synthesis was done by using the ethanolic s...

N. Sri Kumaran*, R. Vijayaraj and Swarnakala

Department of Marine Biotechnology, AMET University, Kanathur, Chennai, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.8(6).2588-93

2588-2593

102

68

32.

ANTIMICROBIAL ACTIVITY OF ALTERNANTHERA BETTZICKIANA (REGEL) G. NICHOLSON AND ITS PHYTOCHEMICAL CONTENTS

The present investigation evaluates preliminary phytochemical screening and antimicrobial activity of aerial parts of Alternanthera bettzickiana (Regel) G. nicholson an edible green medicinal herb tested against various Gram positive, Gram negative bacteria and fungi. The plants were evaluated against two Gram positive bacterial species such as Staphylococcus aureus and Enterococcus faecalis; two ...

U. Arul Pamila* and S. Karpagam

Department of Botany, Queen Mary's College (Autonomous), Chennai, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.8(6).2594-99

2594-2599

180

64

33.

IN VITRO CYTOTOXICITY EVALUATION OF ESCITALOPRAM LOADED NANOPARTICLES AFTER EXPOSURE TO NEUROBLASTOMA CELL LINES

The aim of the present studies is to evaluate the cytotoxic effects of newly formulated polymeric nanoparticles (ETP NP’s) of Escitalopram oxalate (ETP) on NB41A3 cell lines. They were made by ionic gelation method with particle size range between 60 - 115nm, showing spherical morphology. Moreover, zeta potential of the same was recorded as -1.89 ± 0.052 mV and its permeability release showed 9...

R. Rajput, R. Kaur and M. Singh *

Department of Biotechnology, Jaypee Institute of Information Technology, Noida, India

DOI: 10.13040/IJPSR.0975-8232.8(6).2600-06

2600-2606

96

50

34.

COMPARATIVE EVALUATION OF THE EFFECT OF STANNOUS CHLORIDE (SnCl2) AND DIMETHYLTIN DICHLORIDE (DMTC) ON DIAZOTROPHIC GROWTH AND NITROGEN METABOLISM OF NOSTOC MUSCORUM

Stannous chloride (SnCl2), an inorganic salt and Dimethyltin dichloride (DMTC), the organic species were found to influence the survival and nitrogen assimilatory system of Nostoc muscorum. A difference in the survival fractions suggested for differential susceptibility of the strain to the toxic effects of the either tin species. Growth of the Nostoc muscorum cells, measured as a function of grad...

J. Singh *, Shikha and D. P. Singh

Department of Environmental Science, Bareilly College, Bareilly, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(6).2607-11

2607-2611

85

42

35.

DISTINCT ENERGIES OF CHOLESTEROL

Cholesterol is a waxy substance which is made in the body by the liver but is also found in some foods. It plays a vital role in how every cell works and is also needed to make Vitamin D, some hormones and bile for digestion. The concept of energy of a graph was introduced by I. Gutman in the year 1978. In this paper, we compute Siedel Energy, Maximum Degree Energy, Distance Energy, Harary Energy ...

M. R. Rajesh Kanna*, D. Soner Nandappa and R. Pradeep Kumar

Department of Mathematics, Maharani's Science College for Women, Mysore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.8(6).2612-18

2612-2618

93

45

36.

AMELIORATED ACTIVITY OF MURRAYA KOENIGII LEAVES CHLOROFORM EXTRACT (MKCE) AGAINST LEAD INDUCED HEPATIC DYSFUNCTIONS IN MICE

Lead is a well-known hepatotoxic and all-pervading heavy metal. Ingestion of lead induces structural dysfunctions, physiological distortion and biochemical impairment in the liver. The present study was aimed to ascertain the ameliorated effect of chloroform extract of Murraya leaves against the deleterious effects of lead on hepatic function parameters. Murraya koenigii Chloroform Extract (MKCE) ...

Rohan S. Phatak * and Somnath M. Matule

Directorate of Research, Krishna Institute of Medical Sciences Deemed University, Karad, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(6).2619-23

2619-2623

120

57

37.

FORMULATION AND EVALUATION OF LOSARTAN POTASSIUM BI-LAYER BUCCAL TABLET USING MUCOADHESIVE POLYMER

In the present study, an attempt was made to design and evaluate mucoadhesive bilayer tablet of losartan potassium (angiotensin II receptor antagonist), in order to overcome bioavailability problems, to reduce dose dependent side effects and frequency of administration. The losartan potassium mucoadhesive buccal tablet were prepared by wet granulation method using chitosan as a mucoadhesive polyme...

S. Z. Chemate and S. Bothe Priyanka *

Department of Pharmaceutics, PDVVPF’S College of Pharmacy, Vilad Ghat, Ahmednagar, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(6).2624-30

2624-2630

127

0

38.

MACROSCOPIC AND MICROSCOPIC EVALUATION OF ABRUS PRECATORIUS L. (GUNJA), SEEDS

The excessive exploitation of medicinal plants during recent years raises the issues regarding their quality, safety and efficacy. In this respect, there has been a rapid increase in the standardization of medicinal plants with therapeutic potential. In spite of the new techniques, identification and evaluation of plant drugs pharmacognostic study is more cheap and reliable. Abrus precatorius L. o...

S. Tabasum *, S. Khare and K. Jain

Department of Botany, Government Science and Commerce College Benazeer, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2631-35

2631-2635

99

47

39.

EFFECT OF ACIDIC, NEUTRAL AND BASIC pH ON SOLUBILITY AND PARTITION-COEFFICIENT OF BENZOIC ACID BETWEEN WATER-BENZENE SYSTEM

Solubilization is depends on solute-solvent interaction, dissociation of solute in solvent into ionic form, temperature, pressure, hydrogen bonding, dielectric constant, polarity and non-polarity of substance, pH, etc. Partition coefficient was determined in two immiscible solvents in aqueous and organic layer. Benzoic acid was selected for present study for its solubilization in different pH buff...

Gita Chaurasia

Department of Pharmaceutics, Siddhant College of Pharmacy, Sudumbare, Pune, Maharashtra India

DOI: 10.13040/IJPSR.0975-8232.8(6).2637-40

2637-2640

94

50

40.

EFFICACY OF GRIFFITHSIA PACIFICA KYLIN ON IN VIVO ANTI DIABETIC AND ALTERATIONS IN ENZYMATIC ACTIVITIES OF STZ INDUCED RATS

In recent years there is more research work taken in Marine sources for its pharmaceutically valuable compounds and active medicines for anticancer, anti diabetic, anti oxidant, antimicrobial, and anti-inflammatory.  The present study investigated for the medicinal value of red algae Griffithsia pacifica Kylin (GPK) and its alterations in enzymatic activity of STZ induced diabetic rats. The resul...

R. Lalitha * and S. Palani

Department of Biochemistry, Kamban College of Arts and Science for Women, Tiruvannamalai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2641-47

2641-2647

89

43

41.

PREVALENCE OF MUSCULOSKELETAL DISORDERS AND AWARENESS OF PHYSIOTHERAPY MANAGEMENT FOR THE ABOVE AMONG PRIMARY SCHOOL TEACHERS

Background: According to World Health Organization the global prevalence of musculoskeletal disorder ranges from 14% to as high as 42%.Teachers are generally prone to neck, shoulder and low back pain . The work tasks of school teachers often involve significant use of a head down posture, such as frequent reading and marking of assignments. According to World Health Organization working with a hea...

P. Ponmathi *, M. Keeerthiga and V. P. R. Sivakumar

SRM College of Physiotherapy, SRM University, Kattankulathur, Kancheepuram, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2648-53

2648-2653

115

48

42.

ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICE OF PHARMACOVIGILANCE AMONG THE UNDERGRADUATE MEDICAL STUDENTS IN A NORTHERN INDIAN TERTIARY CARE TEACHING HOSPITAL – AN OBSERVATIONAL STUDY

Objective: Underreporting of adverse drug reactions (ADRs) is the major drawback encountered in the pharmacovigilance programs. Inadequate knowledge and skill about pharmacovigilance among the health care professionals are the major reasons for underreporting of ADRs. This study was done to assess knowledge, attitude and practice (KAP) of undergraduate medical students about pharmacovigilance as t...

Rohini Gupta ⃰ , Diwanshu Sharma and Pavan Malhotra

Department of Pharmacology and Therapeutics, ASCOMS & H, Sidhra, Jammu (J&K), India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2654-59

2654-2659

102

48

43.

SYNTHESIS AND SPECTROSCOPIC CHARACTERISATION OF Cr(III) COMPLEXES DERIVED FROM 2-BENZOYLPYRIDINE AND 2-BENZOYLTHIOPHENE WITH THIOSEMICARBAZONE AND SEMICARBAZONE

The complexes of chromium(III) are synthesised with thiosemicarbazone (L1&L3) and semicarbazone (L2) derived from 2-benzoylpyridine and 2-benzoylthiophene having general composition [CrL2X2]X (Where L=L1&L3(L1&L3= thiosemicarbazone ligand and L2= semicarbazone ligand) and X= NO3- and OAc-) have been synthesised. The complexes and ligand under study are characterised by elemental analys...

S. Chandra * and Meenakshi Gupta

Department of Chemistry, Zakir Husain Delhi College University of Delhi, New Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.8(6).2660-66

2660-2666

104

46

44.

A STUDY TO ASSESS THE VACCINATION COVERAGE OF UNIVERSITY STUDENTS IN MUMBAI, INDIA

Background: Immunization is the most cost-effective intervention for infectious diseases which are the major cause of morbidity and mortality worldwide. There is a scarcity of information on the vaccination status of young adults and the role of socioeconomic conditions in India. Objectives: Present study explored the adult vaccination status and influence of income and education of parents on adu...

D. Limaye *, V. Limaye and G. Fortwengel

Faculty III, Hochschule Hannover, University of Applied Sciences and Arts, Hannover, Germany.

DOI: 10.13040/IJPSR.0975-8232.8(6).2667-76

2667-2676

99

57

45.

PREVALENCE AND CORRELATION OF VIRAL INFECTION (HEPATITIS B OR/AND HEPATITIS C) AMONG HYPERTENSIVE AND DIABETIC PATIENTS IN MALAYSIA AND INDONESIA WHO UNDERWENT HEMODIALYSIS

Background: Increase prevalence of viral infection such as hepatitis B or/and hepatitis C are followed by high incidence of mortality among hemodialysis patients. Objective: To determine prevalence and correlation of viral infection (Hepatitis B or/and Hepatitis C) among Hemodialysis Patients that died for the last five years in Indonesia and Malaysia in relation to gender, age, causes, and countr...

D. L. Ramatillah *, S. A. Syed Sulaiman, A. Hayat Khan, D. DR Ong Loke Meng and Markum

Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia.

DOI: 10.13040/IJPSR.0975-8232.8(6).2677-81

2677-2681

93

44

46.

TRAUMATIC FACTORS AFFECTING THE SELF-REALIZATION OF STUDENTS

The article is dedicated to studying the impact of the cases causing trauma on the self – realization of students. The levels of the self – realization of students who often subject to traumas with different professions and who rarely subject to trauma are distinguished, and the impact of trauma on the level of their emotional tolerance and academic achievements is determined. It is establishe...

Rashid Jabbarov

Department of Social and Pedagogical Psychology of Baku State University, Baku, Z. Khalilov, Azerbaijan.

DOI: 10.13040/IJPSR.0975-8232.8(6).2682-90

2682-2690

119

42

47.

ASSESSMENT OF PYRAZINO-PYRIMIDINE COMPOUND AND SOME INFLAMMATORY BIOMARKERS IN PATIENTS WITH TYPE 2 DIABETES

Neopterin, pyrazino-pyrimidine compound, is a metabolite of guanosine triphosphate and is produced by the activated monocytes, macrophages and dendritic cells upon stimulation by interferon gamma produced by T-lymphocytes. Aim: This study purposed to analyze the serum level of neopterin and to evaluate its correlation with other markers of inflammation in patients with type 2 diabetes at various s...

Feryal Hashim Rada

Ph.D. Clinical Therapeutic and Biochemistry, Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Nahrain University, Iraq

DOI: 10.13040/IJPSR.0975-8232.8(6).2691-95

2691-2695

102

45

48.

PHARMACOGNOSTIC EVALUATION OF THE LEAF OF ANTIARIS TOXICARIA (FAMILY: MORACEAE)

Background:  Antiaris toxicaria is a tree in the mulberry and fig family of Moraceae. The leaf is used to remedy various ailments but the preparation depends on individuals. There is a need to set a standard for its preparation that would ensure optimum therapeutic benefits. Medicinal plants are generally reputed as cheaper and safer alternatives to synthetic drugs but these are often adulterated...

C. E. C. Ugwoke *, S. P. G. Anze, A. E. Nweze and C. V. Obisike

Department of Pharmacognosy and Environmental Medicines, University of Nigeria, Nsukka, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.8(6).2696-00

2696-2700

99

49

49.

DETERMINATION OF TOTAL PHENOLIC CONTENT AND ANTIOXIDANT ACTIVITY OF BORASSUS FLABELIFFER LINN. FRUIT PULP COLLECTED FROM SEVERAL PARTS OF SRI LANKA

Borassus flabeliffer Linn. (Palmyra Palm) is widely distributed in the Northern parts of Sri Lanka. Its leaves, fruits and pith have various uses. Palmyra based industries provide living for many families in that region. Palmyra pulp obtained from the ripe fruit is used in many traditional food items in the Jaffna Peninsula and surrounding areas. It is also being used in folk medicine to cure vari...

A. Kurian, G. Thiripuranathar and P.A. Paranagama *

Department of Chemistry, Faculty of Science, University of Kelaniya, Kelaniya, Sri Lanka.

DOI: 10.13040/IJPSR.0975-8232.8(6).2701-05

2701-2705

112

50

50.

METHOD DEVELOPMENT AND VALIDATION OF ATENOLOL USING TWO HPLC SYSTEMS

A reverse phase high performance liquid chromatography (RP-HPLC) method was developed and validated for the determination of Atenolol (ATN) in bulk and pharmaceutical formulation. The method was optimized selecting chromatographic conditions of 60: 40 acetonitrile: water, Inertsil_ column(ODS-3 250 mm × 4.6 mm 5 𝜇m), 20 𝜇L injection volume, flow rate of 1 mL/min at ambient temperature (30 ...

Nidhal Sher Mohammed

School of Chemistry, Faculty of Science, University of Zakho, Duhok, Kurdistan, Iraq.

DOI: 10.13040/IJPSR.0975-8232.8(6).2706-11

2706-2711

103

48

51.

DRUG THERAPY PROBLEMS AND THEIR PREDICTORS AMONG HYPERTENSIVE PATIENTS ON FOLLOW UP IN DIL-CHORA REFERRAL HOSPITAL, DIRE-DAWA, ETHIOPIA

Background: The objective of this study was to assess drug therapy problems (DTPs) and their predictors among hypertensive patients on follow up at Dil-Chora Referral Hospital, Ethiopia. Methods: Hospital based cross-sectional study involving medical record review was conducted from February-to-April 2015 using a structured questionnaire and this was complemented by a face-to-face interview. Adult...

Abadir Hussen and Fekede Bekele Daba *

School of Pharmacy, Institute of Health, Jimma University, Jimma, Ethiopia.

DOI: 10.13040/IJPSR.0975-8232.8(6).2712-19

2712-2719

116

69

52.

CHARACTERIZATION AND PHYSICAL STABILITY EVALUATION OF SNAKEHEAD FISH (OPHIOCEPHALUS STRIATUS) POWDER NANOEMULSION

Snakehead fish powder containing albumin has macromolecule size which is difficult to penetrate into membrane cell. So, It was formulated into nanoemulsion utilizing the best comparison of surfactant, co-surfactant and oil. Nanoemulsion of snakehead fish powder was characterized by particle size analyzer. The snakehead fish were extracted by atomizer (-40 °C, 1atm) to gain powder which was formul...

R. Tungadi *, D. R. Moo and W.R. Mozin

Department of Pharmacy, Faculty of Sport and Health, State University of Gorontalo, Gorontalo, Indonesia, Jenderal Soedirman Street No. 6, Gorontalo, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.8(6).2720-24

2720-2724

105

61

53.

SYNTHESIS OF NEW FLAVANOID AND CHALCONE DERIVATIVES AS ANTIMICROBIAL AGENT BY GREEN CHEMISTRY APPROACH

Flavanoids are plant secondary metabolites, synthesized by microwave assisted synthesis and green chemistry approach since, the conventional method of synthesis uses various organic solvents, hazardous by product, tedious work that requires more reaction time. Flavonoids have general structure of 15-carbon skeleton which consists of two phenyl ring (A and B) and heterocyclic pyran ring(C). Flavone...

Ashish Patel *, Ishan Panchal, Inaxi Parmar, Bharat Mishtry

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Parul University, Limda, Vadodara, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.8(6).2725-30

2725- 2730

100

52