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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2015): 1.11 , ICV (2015): 90.24
Five-Year Projected Impact Factor: 2.60

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Volume 8 (2017) - Issue 1, January

Review Articles

 
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1.

REACTIVE OXYGEN SPECIES (ROS) ARE BOON OR BANE

Reactive oxygen species (ROS) are inevitable by-products of cellular respiration. These are highly reactive chemical species derived from molecular oxygen (O2). These include the superoxide (O2−) and hydroxyl (HO−) free radicals as well as non-radical molecules such as hydrogen peroxide (H2O2). These act as both toxic and beneficial compounds, since they can be either harmful or helpful to the...

Seema Tripathy * and Prafulla Kumar Mohanty

Department of Zoology, Utkal University, Vani Vihar, Bhubaneswar, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.8(1).1-16

1-16

694

433

2.

MOLSARI (MIMUSOPS ELENGI LINN.): A BOON DRUG OF TRADITIONAL MEDICINE

Mimusops elengi L. is an Indian origin herb used in the Unani and other traditional systems of medicine since long time. It is commonly called by the names Spanish cherry, West Indian Medlar or Bullet wood tree. This plant is frequently cultivated throughout India especially in north India for its ornamental appearance and fragrant flowers. All parts of plant such as leaf, root, fruit, seed, bark,...

Seema Rani * and Khaleequr Rahman

Department of Ilmul Saidla, Jamia Tibbia Deoband, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(1).17-28

17-28

691

241

3.

AZOLES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS (NNRTIs): MINI REVIEW

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) in addition with Nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs) used in the treatment of HIV-1 infection. Non-nucleoside reverse transcriptase inhibitors (NNRTIs) gained exact place in the treatment of HIV-1 infections. Starting from the HEPT and TIBO derivatives, different classes of compounds have been id...

Rohit Singh *, Shweta Gupta , Jyoti Singh and Tarranum Arsi

Department of Pharmacy, Birla Institute of Technology, Ranchi, Jharkhand, India

DOI: 10.13040/IJPSR.0975-8232.8(1).29-34

29-34

533

178

4.

IN-SITU BUFFERED FORMULATION: AN EFFECTIVE APPROACH FOR ACID LABILE DRUG

“Acid labile drug” means a drug that is easily destroyed in acidic environment, Stomach is the main site for drug absorption mainly by oral rout. The pH of the stomach is acidic so the absorption of acid labile drugs through stomach is difficult. For this resign the drugs should be formulated as enteric coated or may be administered through parenteral rout. These approaches are effective but t...

Preeti Khulbe *, Birendra Shrivastava, Pankaj Sharma and Ajay Kumar Tiwari

Jaipur National University, Jagatpura Jaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.8(1).35-44

35-44

546

150

Research Articles

 
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5.

FORMULATION AND CHARACTERIZATION OF ACTIVATED CHARCOAL AND METRONIDAZOLE LAYERED TABLETS AND EVALUATION OF THE IN VIVO PERFORMANCE OF METRONIDAZOLE – ACTIVATED CHARCOAL FORMULATION IN SPRAGUE DAWLEY® RAT MODEL INFECTED WITH ESCHERICHIA COLI O157:H7

Background: Due to Escherichia coli O157:H7 bacteria’s peculiar biochemical characteristics it is considered an emerging pathogen. The aim of this study is to  design, develop and evaluate the  efficacy of a  single  formulation  combining  adsorptive  and   anti infective  properties  in  the   treatment of  diarrhoea  caused  by  Escherichia coli O157:H7  in an animal model....

Margaret Ilomuanya * Nashiru Billa, Cornelius Uboh, Ndu Ifudu, John Ciallella and Cecilia Igwilo

University of Pennsylvania, School of Veterinary Medicine Department of Clinical studies, New Bolton Center West Street Road, Kenneth Square PA 19348, USA

DOI: 10.13040/IJPSR.0975-8232.8(1).45-59

45-59

605

202

6.

RELEASE OF CEFUROXIME AXETIL FROM MATRIX TABLETS – EFFECT OF DIFFERENT HIGH VISCOSITY HYDROXYPROPYL METHYLCELLULOSE POLYMERS ON IN VITRO EXTENDED RELEASE

Extended release hydrophilic matrix tablet formulations of cefuroxime axetil were developed and evaluated to observe the effect of different high viscosity hydroxypropyl methylcellulose (Methocel® K100M, K100M CR and K100LV CR) polymers on in vitro drug release. Fifteen different formulations (F1-F15) were prepared by direct compression. The results of the physical parameters and assay were found...

Fozia Israr *, Zafar Alam Mahmood and Fouzia Hassan

Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

DOI: 10.13040/IJPSR.0975-8232.8(1).60-69

60-69

509

149

7.

ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITIES OF PEELS, PULPS AND SEED KERNELS OF THREE COMMON MANGO (MANGIFERA INDICAL L.) VARIETIES IN SRI LANKA

Mango products are well demanded by consumers due to their unique flavor and mango pulps are developed as various products while mango peels and seeds are the major agro-industrial wastes in canned fruit manufacture and fruit juice processing. Hence the aim of the present study was to investigate on their bioactive phenolic compounds in mango byproducts. Extracts of pulps, seed kernels and peels w...

A. Kuganesan, G. Thiripuranathar, A. N. Navaratne and P. A. Paranagama *

College of Chemical Sciences, Institute of Chemistry Ceylon, Rajagiriya, Sri Lanka

DOI: 10.13040/IJPSR.0975-8232.8(1).70-78

70-78

296

188

8.

SIMULTANEOUS DETERMINATION TRACE LEVELS OF VITAMIN B1 AND VITAMIN B9 IN HUMAN SAMPLES BY ULTRASOUND-ASSISTED DISPERSIVE LIQUID-LIQUID MICROEXTRACTION COUPLED WITH HPLC-UV

Ultrasound-assisted dispersive liquid-liquid micro extraction (UA-DLLME) was proposed for simultaneous determination of trace levels of Vitamin B1 (thiamine) and Vitamin B9 (folic acid) in the human urine and serum samples. High performance liquid chromatography (HPLC) coupled with chemometrics method was employed to analysis the extraxtants. Objective: The optimal conditions of the extraction rec...

Marzieh Ghassemi, Narges Chamkouri * and Mohammad Mahboubi

Abadan School of Medical Sciences, Abadan, Iran

DOI: 10.13040/IJPSR.0975-8232.8(1).79-87

79-87

513

117

9.

PHARMACOGNOSTIC EVALUATION AND ANTIMICROBIAL STUDIES ON MORINGA OLEIFERA LAM. (MORINGACEAE)

The pharmacognostic evaluation, anatomy and antimicrobial potentials of the leaf, stem and root of Moringa oleifera Lam were evaluated. Powdered extracts obtained from the various plant organs were used for the analytical standardization. The methanolic plant extracts were assayed for antimicrobial activities using the Agar well diffusion method. This was compared with standard antibiotics, Gentam...

CEC Ugwoke *, KA Eze, KM Tchimene and SPG Anze

Department of Pharmacognosy and Environmental Medicine, University of Nigeria, Nsukka, Nigeria

DOI: 10.13040/IJPSR.0975-8232.8(1).88-94

88-94

504

170

10.

PHYTOCHEMICAL SCREENING, ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF AQUEOUS AND ORGANICS STEM EXTRACTS OF STROPHANTHUS HISPIDUS DC.

Antibacterial and antioxidant activities of Strophanthus hispidus stem aqueous and organic (cyclohexane, chloroform, ethyl acetate and ethanol) extracts were investigated in order to assess its use in traditional medicine. In vitro antibacterial activity assessed by Disc diffusion and Microdilution methods, was tested against Gram positive bacteria (sensible Staphylococcus aureus) and gram negativ...

A. Mulula, K. Ntumba, M. M. Mifundu and K. M. Taba *

Department of Chemistry, University of Kinshasa, B.P 190 Kinshasa XI, D.R. Congo

DOI: 10.13040/IJPSR.0975-8232.8(1).95-100

95-100

105

62

11.

THE EVALUATION OF THE PRIMARY BONE TUMORS BY BONE MARKERS

Serum markers reflect a bone cell activity that regulate bone remodeling, bone alkaline phosphatase (PAO), Total Intact Procollagen Type I N-terminal propeptide (TP1NP) for training and tartrate-resistant acid phosphatase (TRAPB5), carboxy-terminal collagen crosslinks (Cross Laps) for bone resorption. These markers are sensitive and early tools, Elevated serum levels of these markers is a very goo...

K. Samy, M. Cohen Solal, C. Collet, A. Ostertag, M. Rabeh, L. Rouabah and A. Rouabah

Department of Biochemistry and Cellular and Molecular Biology, Faculty of Sscience, University of Constantine, Algeria

DOI: 10.13040/IJPSR.0975-8232.8(1).101-06

101-106

82

74

12.

IDENTIFICATION, METHOD DEVELOPMENT AND METHOD VALIDATION FOR THE PROCESS AND DEGRADATION IMPURITIES OF VARDENAFIL HCl BY RP-UPLC AND UPLC-TOF

This present work is on method development of assay and related substances of Vardenafil HCl and degradation of drug substance under acid, base hydrolysis and oxidation conditions. Identification of the impurities were done by the UPLC-TOF. Waters LCT Premier time of flight HRMS instrument with 5 ppm accuracy employed for degradation impurity identification. The validation of the method for its im...

Kaviraj Yarbagi *, Nagaraju Rajana , J. Moses Babu, B. Venkateswara Rao and Paul Douglas

Dr. Reddy’s Laboratories Ltd., Bollaram road, Miyapur, Hyderabad, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(1).107-19

107-119

105

85

13.

EVALUATION OF ANTIDIABETIC POTENTIAL OF WITHANIA SOMNIFERA BY GLUCOSE UPTAKE ASSAY ON 3T3 F442A FIBROBLAST (ADIPOCYTE) CELLS

Antidiabetic potential of leaf and root extracts of Withania somnifera from Nimuch, Lucknow, Mumbai and Karnataka regions of India were evaluated against 3T3F442A fibroblast (3T3 adipocyte) cell line using glucose uptake assay. Leaf extracts from all the four regions were active on the cell line tested. Samples from Mumbai region found to be more active when compared with other regions. Root extra...

R. A. Shah *, S. Khan, M. Vakil and M. T. Qureshi

Department of Botany, The Institute of Science, Mumbai, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(1).120-25

120-125

109

54

14.

ASSESSMENT OF HEPATOPROTECTIVE ACTIVITY OF MUSA PARADISICA LINN. WHOLE PLANT EXTRACT AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN WISTAR RATS

Ethonolic whole plant extract of Musa paradisica has a multiple pharmacological activities including antimicrobial, antiviral, anti-inflammatory, anticancer effects. The present study aims to determine the effect of Musa paradisica on serum and tissue superoxide dismutase (SOD) levels and the histology in carbon tetrachloride (CCl4)-induced liver injury. Wister rats aged were injected Intraperiton...

P. Verma *, S. K. Paswan, S. Verma, S. P. Singh, Ch.V. Rao, S. Shrivastva and R. K. Gupta

Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute, Lucknow, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(1).126-31

126-131

80

54

15.

WOUND HEALING ACTIVITY OF SAMBUCUS EBULUS

This study aimed to evaluation of healing potential of Sambucus ebulus in full-thickness wound model in rats. A dorsal skin wound was created in rats. The 5% ointment applied to the wound area once a day for 12 days. Healing process was compared histologically between the groups. Parameters of wound healing were evaluated in the wound area. Extract improved wound contraction and closure. Histopath...

D. N. Zarrin Ghabaee, Md. Ali Ebrahimzadeh, J. Akbari and F. Talebpour Amiri *

Anatomy Department, Mazandaran University of Medical Sciences, Sari, Iran

DOI: 10.13040/IJPSR.0975-8232.8(1).132-35

132-135

121

99

16.

MODULATION OF 10 GHZ MICROWAVES INDUCED BIOCHEMICAL CHANGES IN DIFFERENT ORGANS OF SWISS ALBINO MICE BY PRUNUS DOMESTICA FRUIT EXTRACT

For the present study thirty male Swiss albino mice were selected from an inbred colony. They were divided into three groups consisting of ten mice in each group. Group I: Sham exposed, Group II: 10 GHz MW (microwave) exposed, Group III: PDE (Prunus domestica extract) +MW exposed. After 30 days of treatment the animals were sacrificed to study alterations in body weights and biochemical parameters...

Faiza Rifat and Rashmi Sisodia*

Neurobiology Laboratory, Department of Zoology, University of Rajasthan, Jaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.8(1).136-44

136-144

78

56

17.

PHARMACOLOGICAL AND ANTIBACTERIAL ASPECT OF PSIDIUM GUAJAVA L. AGAINST ACNE VULGARIS

Acne is a cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production and is characterized by both inflammatory (papules, pustules and nodules) and noninflammatory (comedones, open and closed) lesions. A lot of factor viz; hormone, increased sebum production  and diet causes Acne vulgaris but bacteria are the chief causal organism in which  Propionibacter...

M. Pandey, A. Qidwai, R. Kumar, A. Pandey, S. K. Shukla, A. Pathak and A. Dikshit *

Biological Product Laboratory, Department of Botany, University of Allahabad, Allahabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(1).145-50

145-150

88

50

18.

SYNTHESIS AND CHARACTERIZATION OF SITE SPECIFIC SUPERPOROUS HYDROGEL HYBRIDS OF LORATADINE

The aim of present study is to formulate and optimize the site specific controlled release formulation for release of loratadine in upper gastrointestinal tract. Superposrous hydrogel hybrids (SPHH) were prepared by using ferric chloride as crosslinking agent and sodium carboxymethyl cellulose as composite agent. The Superporous Hydrogels were evaluated for swelling ratio, mechanical strength, den...

Gitika Arora Dhingra *, Surinder Goyal and Shailesh Sharma

Department of Pharmaceutical Sciences, NIMS University, Jaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.8(1).151-64

151-164

88

47

19.

EVALUATION OF EFFECT OF ROFLUMILAST ON BLOOD GLUCOSE LEVELS IN STREPTOZOTOCIN INDUCED DIABETIC ALBINO WISTAR RATS

Objective: To Evaluate hypoglycemic effect of Roflumilast in streptozotocin induced diabetic albino wistar rats. Materials and Methods: 18 albino rats were divided into 3 groups each group containing 6 animals, Group-1 (Diabetic Control): Distilled water 10ml, Group-2 (Standard): Glibenclamide 1.35mg, Group-3 (Test): Roflumilast 0.045mg/kg. A freshly prepared solution of Streptozotocin (45mg/kg bo...

R. Poornima *, VH Pushpa, Divya Reddy, Sabreen Bashir and Nagma Firdose

Department of Pharmacology, JSS Medical College, S. S. Nagar, Mysore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.8(1).165-69

165-169

94

45

20.

PHYTO-MEDIATED SYNTHESIS OF SILVER NANOPARTICLES FROM ANNONA MURICATA FRUIT EXTRACT, ASSESSMENT OF THEIR BIOMEDICAL AND PHOTOCATALYTIC POTENTIAL

Plant extract-mediated biosynthesis of nanoparticles has proven to be a novel, rapid, cost-effective, non-toxic and eco-friendly method.  For the first time, biological material in the form of aqueous extract of Annona muricata fruit (AMF) was successfully utilized for the synthesis of silver nanoparticles (AgNPs).  The various parameters such as metal ion concentration, volume of the extract, t...

V. S. Shaniba, Ahlam Abdul Aziz and P. R. Manish Kumar *

Department of Biotechnology, University of Calicut, Malappuram, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.8(1).170-81

170-181

93

56

21.

SCREENING OF MARINE SOILS FROM BAY OF BENGAL NEAR CHIRALA COAST OF ANDHRA PRADESH FOR ISOLATION OF LIPOLYTIC ACTINOBACTERIA AND CHARACTERIZATION OF THE MOST POTENT ISOLATES

Three marine soil samples collected at various seashores of the Bay of Bengal near Chirala Coast of Andhra Pradesh were screened for the isolation of lipolytic Actinobacteria by tributyrin agar clearing method. The isolates were cultured under submerged fermentation conditions and assayed for their extra cellular lipase producing capabilities using olive oil as substrate. Enzyme profiling of the s...

A. Rajanikanth and T. Damodharam *

Department of Biotechnology, Department of Environmental Sciences, Sri Venkateswara University, Tirupati, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(1).182-90

182-190

73

40

22.

SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM FOR COMBINATION OF HYDROPHILIC AND LIPOPHILIC DRUGS

Improvement in the bioavailability of poorly soluble drugs is one of the challenges faced in the formulation development of the drugs. One of the most admirable and viable formulation approaches for this is self micro emulsifying drug delivery system (SMEDDS). A combination of clarithromycin and amoxicillin has been proved effective for treatment of H. pylori which are available only in tablet dos...

Siya D. Sinai Kunde * and Shilpa P. Bhilegaonkar

Department of Pharmaceutics, PES’ Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda, Goa, India.

DOI: 10.13040/IJPSR.0975-8232.8(1).191-96

191-196

84

63

23.

FORMULATION AND IN-VITRO EVALUATION OF SUN PROTECTION FACTOR IN A POLYHERBAL CREAM

Sunscreens aid the body's natural defense mechanisms to protect against harmful UV radiation from the sun. The present study involves the formulation of sunscreen cream with herbal active ingredients and evaluation for its effectiveness. Naturally occurring traditional substances are gradually replacing synthetic counterparts due to their effectiveness and absence of adverse effects. The herbal dr...

Sreelesh Brinda *, Dhingra Gitika and Vaze Varsha

NCRD’s Sterling Institute of Pharmacy, Nerul (East), Navi Mumbai, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(1).197-00

197-200

94

52

24.

ECCENTRICITY ATOM-BOND CONNECTIVITY INDEX OF POLYCYCLIC AROMATIC HYDROCARBON PAHk

Let G=(V,E) be molecular graph with vertex set V (G) and edge set E(G) in which the set of vertices and the set of edges of the graph correspond to the atoms of the molecule and chemical bonds, respectively. We denote d(u,v) the distance between u and v i.e the length of the shortest path connecting u and v. The eccentricity of a vertex in V(G) is defined to be Recently, we proposed the fifth atom...

M. R. Rajesh Kanna, R. P. Kumar, Md. Kamran Jamil and Md. Reza Farahani *

Department of Applied Mathematics, Iran University of Science and Technology (IUST), Narmak, Tehran, Iran

DOI: 10.13040/IJPSR.0975-8232.8(1).201-06

201-206

94

43

25.

TREATMENT OUTCOME OF TUBERCULOSIS PATIENTS ON DOTS THERAPY FOR CATEGORY 1 AND 2 AT DISTRICT TUBERCULOSIS CENTRE

Background: India is highest tuberculosis (TB) burden country accounting for approximately 20% of global TB burden. To tackle this problem, Revised National Tuberculosis Control Programme (RNTCP) based on the DOTS (Directly Observed Treatment Short course) strategy has been made available in the entire country by March 2006.  Present study describes the achievements under RNTCP in terms of treatm...

Kiran G. Piparva

Pharmacology Department, P.D.U. Govt. Medical College, Rajkot, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.8(1).207-12

207-212

81

63

26.

A STUDY TO EVALUATE THE RENAL FUNCTION PARAMETERS IN PRECLAMPSIA

Preeclampsia usually develops systemic hypertension, proteinuria, coagulation abnormalities and eclampsia develops when convulsions superimpose on the syndrome of preeclampsia. Disturbed renal functions with elevated blood urea and serum creatinine levels were reported in various studies but, elevations of serum uric acid levels are controversial. The aim of the current study is to determine the r...

T. Ilanchezhian *, R. Shanmuga Priya, S. Suganya and Balaji Rajagopalan

Department of Biochemistry, Shri Sathya Sai Medical College and Research Institute, Ammapettai, Kancheepuram District, Tamil Nadu, India

DOI: 10.13040/IJPSR.0975-8232.8(1).213-16

213-216

77

59

27.

NOVEL SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 3-AMINO PHENYL-5-METHYL PYRAZOLES AND ITS DERIVATIVES

Pyrazoles and fused heterocyclic pyrazoles derivatives constitute an interesting class of heterocyclic compounds due to their synthetic versatility and effective biological activity in the field of pharmaceutical science, agriculture etc.  In the present study, new substituted pyrazoles were prepared by condensation of substituted primary amine and ethyl acetoacetate at 1400C to form analides as ...

Priti Warbhe and Reshal Deshmukh*

Department of Chemistry, Shri Shivaji Science College, Congress Nagar, Nagpur, M.S., India

DOI: 10.13040/IJPSR.0975-8232.8(1).217-21

217-221

131

52

28.

PHYTOCHEMICAL SCREENING AND EVALUATION OF ARTEMISIA NILAGIRICA (CLARKE) PAMP BY GC-MS

The phytochemicals of various parts of the plants mainly the secondary metabolites are well known for its high potential therapeutic values such as antifungal, antibacterial, anti-inflammatory, anticancer, antiplasmodial, antioxidant, insecticidal etc. In the present investigation an attempt was made to analyze the various phytochemicals present in Artemisia nilagirica (Clarke) Pamp which is wide ...

P. Parameswari * and R. Devika

Department of Biotechnology, Sathyabama University, Chennai, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.8(1).222-25

222-225

74

53

29.

ROLE OF LABETALOL AND METHYLDOPA IN NEWLY DIAGNOSED MILD HYPERTENSION IN PREGNANCY: A PROSPECTIVE DRUG COMPARATIVE STUDY IN A RURAL TERTIARY CARE HOSPITAL IN INDIA

Aim: Labetalol is useful in severe hypertension (HT) in pregnancy; however, there was a need to define its role in mild HT in pregnancy. The present study was done to evaluate efficacy of labetalol in mild HT in pregnancy, compare it with that of methyldopa, and compare the tolerability of methyldopa and labetalol in patients. Methods: A prospective drug comparative study was conducted for one yea...

N. Maheshwari *, R. Wagh, S. Sharma, M. Mutalik, M. Gupta and W. Siddiqui

Department of Pharmacology, Department of Obstetrics-Gynaecology, MIMER Medical College, Talegaon- Dabhade, Pune, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(1).226-30

226-230

116

49

30.

PROTECTIVE PROFILE OF HYDNOCARPUS LAURIFOLIA ON STREPTOZOTOCIN INDUCED OXIDATIVE STRESS IN RATS

The present study was aimed to evaluate the anti-oxidative defence system of Hydnocarpus laurifolia in diabetic rats and its potential effect against the β-cell damage induced by oxidative stress. Hydnocarpus laurifolia is a plant which belongs to the family Flacourtiaceae. According to the Indian system of traditional medicine it is used in the treatment of diabetes mellitus. Also literature rev...

P. Sailaja Rao * and G. Krishna Mohan

Department of Pharmacology, Sri Venkateshwara College of Pharmacy & Research centre, Madhapur, Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.8(1).231-35

231-235

96

51

31.

SIMULTANEOUS ESTIMATION OF NORFLOXACIN AND TINIDAZOLE IN COMBINED TABLET DOSAGE FORM BY USING RP- HPLC METHOD

Simultaneous estimation method for Norfloxacin and Tinidazole in tablet dosage form had been developed by RP- HPLC. Both the drugs come under the category of antimicrobials and prescribed frequently in combination. The developed method is a gradient method which gives retention time of Norfloxacin and Tinidazole as 3.8min and 4.8min respectively. The separation was carried out on Supelco C18 (25cm...

Mrunal Bulbule and Deepali Gangrade *

Vivekanand Education Society’s College of Pharmacy, Mumbai University, Chembur (E), Mumbai, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(1).236-43

236-243

101

49

32.

CHEMICAL COMPOSITION OF ESSENTIAL OILS AND ANTIOXIDANT ACTIVITIES OF EXTRACTS OF TWO ENDEMIC PLANTS FROM ALGERIA

Essential oils extracted from two Algerian endemic plants Lavandula antineae and Thymus algeriensis were analyzed by the GC, the results showed the presence of a large amount of oxygenated sesquiterpenes in both species. Total phenolics and flavonoids content were determined according to the Folin-Ciocalteu method and the aluminum trichloride method, the antioxidant activities of two types of extr...

F. Z. Benabdallah *, A. Zellagui and I. Demirtas

Laboratory of Biomolecules and Plant Breeding, Life Science and Nature Department, Faculty of Exact Science and Life Science and Nature, University of Larbi Ben Mhidi Oum El Bouaghi, Algeria

DOI: 10.13040/IJPSR.0975-8232.8(1).244-50

244-250

76

46

33.

DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF DICLOFENAC SODIUM USING DIFFERENT GRADE HYDROPHILIC POLYMER & PEG 6000 AS RELEASE RETARDANT

Diclofenac Sodium, being NSAID, its oral administration restricted due to its inherent problems. Hence in the present study, attempt has been made to design oral sustained release once daily matrix tablets of Diclofenac Sodium using combination of hydroxyl propyl methyl cellulose (HPMC) & PEG 6000 and to study the effect of various process and formulation variables like polymer properties and ...

Gunjan Kalyani, Rahul Singh * and A. K. Singh Parihar

Shri Rawatpura Sarkar Institute of Pharmacy (SRIP), Kumhari, Durg Chhattisgarh, India

DOI: 10.13040/IJPSR.0975-8232.8(1).251-53

251-253

91

49

34.

SYNTHESIS, CHARACTERIZATION & BIOLOGICAL STUDIES OF NEWER CLASS OF QUNINOLONE DERIVATIVES

Background: Antimicrobials are used for bacterial infections & has a great benefits in health related problems of human life. The main objectives of medicinal chemistry is synthesising and producing newer molecules having a valuable significant therapeutic action. Quinolones has a considerable scientific and clinical interest since their discovery. Objective: Quinolones class of drugs are usef...

Deepali Gangrade * and Ashish Mehta

Department of Pharmaceutical Chemistry, Vivekanand Education Society College of Pharmacy, Chembur (E), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(1).254-61

254-61

87

50

35.

BIOLOGICAL ACTIVITY EVALUATION OF NOVEL N-HETEROCYCLIC CARBENE PRECURSORS

Five novel benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors (1a-e). They were characterized by different techniques. The antimicrobial activities of these compounds were tested. The compounds showed moderate activity against three Gram (+) and seven Gram (-) bacteria in comparison to tetracycline, which was used as the standard antibiotic, whereas all the compounds...

Senem Akkoç *, Yetkin Gök, Hülya Erdoğan and Sevil Albayrak

Department of Chemistry, Faculty of Sciences, Erciyes University, Kayseri, Turkey

DOI: 10.13040/IJPSR.0975-8232.8(1).262-67

262-267

81

50

36.

SIMULTANEOUS ESTIMATION OF HYDROCHLOROTHIAZIDE, AMLODIPINE BESYLATE AND TELMISARTAN IN COMBINED TABLET DOSAGE FORM BY USING RP- HPLC METHOD

A simple, selective, rapid, precise reverse phase high pressure liquid chromatographic method has been developed for the simultaneous estimation of Hydrochlorothiazide, Amlodipine besylate and Telmisartan in tablet dosage form as per ICH guidelines. The wavelength selected for the analysis was 239 nm for amlodipine besylate, telmisartan and hydrochlorothiazide. The solvents used were methanol and ...

Priyanka Kulkarni and Deepali Gangrade *

Vivekanand Education Society’s College of Pharmacy, Mumbai University, Chembur (E), Mumbai, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(1).268-76

268-276

68

75

37.

CHANGES IN THE GIRLS’ AWARENESS ABOUT REPRODUCTIVE HEALTH AFTER PREMARTIAL EDUCATION BY THE PREMARTIAL COUNSELING CENTER IN GARMSAR CITY, IRAN

Awareness of reproductive health is rights of humans and lack of accurate notification will lead to numerous complications.Pre-marriage is one of the best times to training of these issues. Therefore, this study was done in order to evaluation the effects of premarital education on the girls’ awareness about reproductive health. In this semi-experimental study, 152of womens that participated in ...

Maryam Rezaeyan and Habibeh Morteza *

Faculty of Nursing and Midwifery, Islamic Azad University Branch of Borujerd, Lorestan, Iran

DOI: 10.13040/IJPSR.0975-8232.8(1).277-81

277-281

100

44

38.

EFFECT OF MOISTURE CONTENT OF EXICIPIENT (MICROCRYSTALLINE CELLULOSE) ON DIRECT COMPRESSIBLE SOLID DOSAGE FORMS

Quality of pharmaceutical product is very important because pharmaceuticals drugs should be safe and therapeutically active formulation performance should be consistent and predictable. Final product quality depends on all ingredients which is used for making the final product tablet. Final product tablet is made by the addition of bulk drug and excipients. The continuous evolution of the bulk dru...

Monika Tomar *, Singh Ajay Kumar and Sinha Amit Raj

Sigachi® Industries Private Limited, Dahej SEZ Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.8(1).282-88

282-288

80

53

39.

ANTIMICROBIAL ACTIVITY OF FRUIT JUICES ON ORAL BACTERIA

To determine the Antimicrobial activity of fruit juices on the bacterial flora of mouth. The study is done to analyze whether the fruit juices helps in reducing the oral bacterial count which is constantly increasing. Fruits and vegetables are the main sources for essential nutrients. They also have a series of bio active components which have multiple effect on human general health. One such effe...

Sahana Kritivasan * and N.P. Muralidharan

Department of Microbiology, Saveetha Dental College and Hospitals, Chennai, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.8(1).289-93

289-293

98

45

40.

ESTIMATION OF QUERCETIN BY HIGH PERFORMANCE CHROMATOGRAPHY AND ANTIFUNGAL ACTIVITY OF MOSS PHILONOTIS REVOLUTA

Bryophytes- the small, slow growing group of plants is stockroom of naturally occurring materials. They contain a high number of biologically active compounds, however their use as a natural fungicides is negligible. In the recent years bryophytes has emerged as a potential biopharming tool for production of complex biopharmaceutiticals. In order to evaluate potential use of bryophytes as an antif...

G. S. Deora and D. Suhalka *

Department of Botany, B.N University, Udaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.8(1).294-00

294-300

70

41

41.

IMPACT OF TEACHING CLINICAL ASPECTS OF CARDIOVASCULAR PHARMACOLOGY AT BEDSIDE

Introduction: Medical students of present era have to prove their efficiency in every step of life. To do so one has to become a competent doctor. This is possible only with the proper knowledge and application of the rational therapeutics in clinical practice. This can happen when the students are motivated and taught medicine in such a way that can produce better learning. The clinical aspect of...

D. K. Singh, P. Shankar *, S. Tutu, P. Lakhani and R. K. Dixit

Department of Pharmacology and Therapeutics, King George’s Medical University, Lucknow, Uttar Pradesh India

DOI: 10.13040/IJPSR.0975-8232.8(1).301-04

301-304

90

48

42.

SONOPHORETIC TRANSDERMAL DELIVERY OF LOSARTAN POTASSIUM PRONIOSOMAL GEL

Proniosomes based drug delivery systems have potential as a significant drug carrier in a variety of therapeutic applications. The objective of the present study was to investigate in vitro sonophoretic transdermal delivery of Losartan Potassium (LP) across albino rat skin using proniosomal gel and its comparison with aquasonic gel. Proniosomes of LP were fabricated with L-a-lecithin (egg yolk), c...

R. Rao and S. Nanda *

Department of Pharmaceutical Sciences, Maharishi Dayanand University, Rohtak, Haryana, India

DOI: DOI: 10.13040/IJPSR.0975-8232.8(1).305-11

305-311

73

42

43.

STATUS OF SERUM FRUCTOSAMINE IN HYPERTHYROID SUBJECTS IN UDAIPUR, RAJASTHAN

Introduction: Measurement of glycated hemoglobin (HbA1c) and fructosamine has a growing role in the assessment of glycemic control but their use for screening purpose is questionable. Material and methods: The study was carried out on 50 controls and 50 patients suffering from hyperthyroidism from October 2014 to March 2015 at Geetanjali Medical College & Hospital, Udaipur (Rajasthan). Results...

Avdhesh Kumar Sharma, Umesh Kumar Pareek, Milind N. Dudhane and G. S. Gupta

Biochemistry department, Annanta Institute of Medical Sciences and Research Center, Rajsamand, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.8(1).312-15

312-315

104

42

44.

EVALUATION OF ANTIDIABETIC ACTIVITY OF HYDRO ALCOHOLIC EXTRACT OF CHRYSOPHYLLUM CAINITO FRUITS

Anti-diabetic activity of hydro-alcoholic extract of Chrysophyllum cainito frutis (CCE) was investigated against experimentally induced diabetics in rats using alloxan and streptozotocin (STZ). Acute toxicity study was performed and hydro-alcoholic extract of CCE was found to be safe at a dose of 2000 mg/kg bodyweight. Two doses 200 mg/kg and 400 mg/kg b.w p.o. of the CCE were subjected for the ev...

Karunakar Hegde *, A. P. Arathi and Anupama Mathew

Department of Pharmacology, Srinivas College of Pharmacy, Valachil, Mangalore, Karnataka, India

DOI: 10.13040/IJPSR.0975-8232.8(1).316-22

316-322

70

41

45.

ANTIMICROBIAL ACTIVITIES OF PHARMACOLOGICAL AND ANTIOXIDANT COMPOUNDS OF SOME EDIBLE MUSHROOMS AGAINST BRUCELLA SPP.

Although there are numerous studies on antimicrobial activities of mushrooms against many common pathogenic microorganisms, there is hardly any study against Brucella spp., responsible for brucellosis in animals and human beings throughout the globe. The present study was aimed to evaluate the in vitro antimicrobial activities of ethanol extracts of five edible mushrooms namely, Pleurotus ostreatu...

D. Chatterjee, D. Halder, U. Chakraborty, D. Dutta, P. Kuila and S. Das *

Peerless Hospital & B. K. Roy Research Centre, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.8(1).323-29

323-329

95

45

46.

FIRST AND SECOND ZAGREB INDICES AND POLYNOMIALS OF V-PHENYLENIC NANOTUBES AND NANOTORI

Let G be a simple molecular graph with vertex and edge sets V(G) and E(G), respectively. In 1972, Gutman and Trinajstić introduced the First and Second Zagreb topological indices of molecular graphs. These topological indices are useful in the study of anti-inflammatory activities of certain chemical instances, and in elsewhere. In this present study, compute the First Zagreb index Zg1(G)=  and ...

Mohammad Reza Farahani *, R. Pradeep Kumar and M. R. Rajesh Kanna

Department of Applied Mathematics, Iran University of Science and Technology (IUST) Narmak, Tehran, Iran.

DOI: 10.13040/IJPSR.0975-8232.8(1).330-33

330-333

66

50

47.

MMP DATABASE: ONLINE REPOSITORY PROVIDING INFORMATION REGARDING MMPS AND ITS INHIBITORS

Although technologies are emerging day to day and bioinformatics is also growing with number of databases developed, but being a very important factor in cancer invasion and metastasis, MMPs have no exclusive database. Matrix Metallo-Protienase (MMP) is a major class of proteolytic enzymes that plays a dominant role in ECM degradation. Every time researchers are searching and gathering information...

P. Shankar *, D. K. Singh, P. Lakhani, S. Tutu, S. Singh, A. K. Sachan and R. K. Dixit

Department of Pharmacology and Therapeutics, King George’s Medical University, Lucknow, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(1).334-38

334-338

70

36

48.

COMPUTATIONAL PREDICTION OF BLOOD-BRAIN PARTITIONING OF DRUGS

Increasing use of bioinformatics made very easy to researchers in biological and drug discovery field. Bioinformatics is involved at each and every step of drug discovery to drug development. The first step of the drug discovery is a question about disease and the treatment by drugs and whenever term drug comes, means something has to be given and the second question arises the given compound is d...

P. Shankar *, P. Lakhani, D. K. Singh, S. Tutu, S.N. Sankhawar, A. K. Sachan and R. K. Dixit

Department of Pharmacology and Therapeutics, King George’s Medical University, Lucknow, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(1).339-41

339-341

74

42

49.

A COMPARATIVE ANTIMICROBIAL EVALUATION OF EMBELIARIBES BURM. F. AND EMBELIAROBUSTA AUCT. NONROXB. FRUITS

Background: Vidang (Embeliaribes Burm. f.) is a very famous plant for its anthelmintic activity. In Ayurveda, it is a first choice of drug for its krimighna action or to kill foreign pathogens. Embeliarobusta auct. Nonroxb., the other species of vidang is adulterated in Embeliaribes Burm. f. Therefore shastrokta or original vidang and its adulterant species were selected for the comparative study....

Malvika Saini*, Gaurav Sharma and Mita Kotecha

Department of Dravyagunavigyan, National Institute of Ayurveda, Jaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.8(1).342-49

342-349

69

41

50.

HEMORRHAGIC COMPLICATIONS AND CRITICAL CARE CHALLENGES DURING HEPARIN PRESCRIPTION: A CASE REPORT

Periorbital ecchymosis occurs due to head and face trauma, base skull fracture, craniotomy or ophthalmic operations. There are some less common causes including: hematologic disorders (coagulation disorders, thrombocytopenia), vascular disorders (hemangioendothelioma, varicose veins around the eyes), inflammatory diseases (myositis, amyloidosis), skin disorders (herpes simplex), migraine and incre...

G. Sabetian, F. Zand, M. Masjedi, B. Maghsoudi, Z. Salami, M. R. Sasani and M. Savaie *

Subspecialty resident of critical care medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

DOI: 10.13040/IJPSR.0975-8232.8(1).350-52

350-352

117

46