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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2015): 1.11 , ICV (2015): 90.24
Five-Year Projected Impact Factor: 2.60

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Volume 8 (2017) - Issue 2, February

Review Articles

 
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1.

PHYSICAL METHODS FOR ENHANCEMENT OF TRANSDERMAL DRUG DELIVERY IN PAIN MANAGEMENT

Pain is the major symptom associated with many diseases and disorders. Whether acute or chronic, pain causes much distress to the patient and can be debilitating in many cases. The quest for safe and effective pain management has driven the research efforts of the scientists for several decades. These ongoing efforts to come up with optimum therapeutic systems to deliver pain relief medication hav...

S. Mahant, V. Kumar, R. Rao and S. Nanda *

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India

DOI: 10.13040/IJPSR.0975-8232.8(2).353-67

353-367

674

624

2.

NATURAL HERBAL TREATMENT FOR RHEUMATOID ARTHRITIS -A REVIEW

Rheumatoid arthritis is an immune mediated inflammatory disease (IMID). Rheumatoid arthritis occurs when our immune system attacks the tissues near joints, this is due to release of certain chemicals and enzymes that begin to eat away the cartilage and bones. Rheumatoid arthritis affects all the joints in the body, some forms of arthritis can also affect the body’s internal organs. The symptoms...

R. Chandrasekar * and Sivagami Chandrasekar

Department of Pharmacognosy, MNR College of pharmacy, Fasalwadi, Sangareddy, Medak District, Hyderabad, Telangana, India

DOI: 10.13040/IJPSR.0975-8232.8(2).368-84

368-384

678

519

3.

TRANSDERMAL DRUG DELIVERY SYSTEM, ADVANCE DEVELOPMENT AND EVALUATION-A REVIEW

It is the most important part of pharmaceutical dosage forms; transdermal drug delivery system (TDDS) established itself as an integral part of novel drug delivery systems. On the application of Transdermal patches, the delivery of the drug across dermis gives the systemic effect. TDDS is costly alternative to conventional formulation. It is also important due to its unique advantage. Controlled a...

Garima Verma

Shambhunath Institute of Pharmacy, Jhalwa, Allahabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).385-00

385-400

622

358

4.

THE NEWER DIMENSION OF INHALATION AEROSOLS IN THE PROSPECTIVE OF VALIDATION

Aerosol drug delivery systems are much more importance in present days and have much advantage over other route of administration. Meter dose inhaler was used to deliver asthma medication in easy way and reliable multi dose preparation. The importance of the MDIs device play important role in determining drug delivery to the lungs. The word validation means,” Impose of validation or action of pr...

Sunil Kumar G. and M. P. Gowrav

Department of Pharmaceutics (Unit of Quality Assurance), J.S.S College of Pharmacy, J.S.S University, Sri Shivarathreeshwara Nagar, Mysore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).401-10

401-410

556

327

5.

ROLE OF DIFFERENT NEUROTRANSMITTERS IN ANXIETY: A SYSTEMIC REVIEW

Anxiety is a persistent feeling of dread, apprehension and impending disaster, or tension and uneasiness. The reported prevalence rates of psychiatric morbidity in the Indian industrial population range from 14-37%. Anxiety disorders may develop from a complex set of risk factors including genetics, brain chemistry, personality and life events. It is a specific class of psychopathology characteriz...

Sandeep Kaur and Rajmeet Singh *

Department of Pharmacology, G.H.G. Khalsa College of Pharmacy, Gurusar Sadhar, Ludhiana, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).411-21

411-421

524

302

6.

A REVIEW ON MICROWAVE ASSISTED GRAFTING OF POLYMERS

The use of microwave irradiation in grafting of synthetic polymers onto natural polysaccharides is a popular method. It reduces all the limitations of conventional method of grafting like use of toxic solvents as well reduces reaction time for grafting methods. Microwave irradiation also increases the yield of grafting. Also the microwave grafted polymer has better properties as compared to polyme...

Loveleenpreet Kaur * and G. D. Gupta

Department of Pharmaceutics, ASBASJSM College of Pharmacy, Bela, Ropar, IKGPTU, Jalandhar, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).422-26

422-426

184

75

7.

MULTI DIMENSION PROTEIN IMPACT MATRIX BASED PROTEIN SEQUENCE PREDICTION USING DATA MINING

Proteins are the most essential and versatile macromolecules of life, and the knowledge of their functions is a crucial link in the development of new drugs, better crops, and even the development of synthetic biochemicals such as biofuels. Experimental procedures for protein function prediction are inherently low throughput and are thus unable to annotate a non-trivial fraction of proteins that a...

A. Surendar

School of Electronics, Vignan’s University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).427-34

427-434

158

68

8.

A PROMISING ANTINEOPLASTIC DRUG – METFORMIN (AN AMPK ACTIVATOR) FOR THE FUTURE

Metformin, an AMPK activator, acts as an oral hypoglycaemic agent. It reduces the risk of cancer during the treatment of diabetes and diabetes associated cancers. The effect of metformin on different type of cancers is explained on the pathway of AMPK activation involving hepatic fatty acid oxidation, inhibition of triglyceride and cholesterol synthesis and also modulation of insulin secretion. Th...

Oinamjoychandra Singh, Indira Raleng, L. Surbala and N. Debashree *

Department of Pharmacology, JN Institute of Medical Sciences, Imphal, Manipur, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).435-39

435-439

184

75

9.

OPTOGENETICS- A BRIEF REVIEW

Optogenetics (a branch of biotechnology) is a biological tool used in the field of neuroscience that encompasses a combination of techniques from optics and genetics to study the functioning of individual neurons in a living tissue. Spatio-temporal precision in neuronal control can be achieved using optogenetic actuators or reporters and sensors or indicators. The present review highlights the bri...

Mahalaxmi Mohan

MGV’s Pharmacy College, Mumbai Agra Road, Panchavati, Nashik, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(2).440-45

440-445

192

93

10.

BENZOTRIAZOLE: A HETEROCYCLIC MOLECULE WITH DIVERSIFIED PHARMACOLOGICAL ACTIVITIES

1,2,3-Benzotriazole (BTA) is a heterocyclic compound with three nitrogen atoms. The enormous investigations on derivatives of benzotriazole reveals wide applicability of this molecules for tagging and delivering huge number of heterocyclic nuclei. This molecule has been used for the analytical determination of silver as well as a restrainer in photographic emulsions. The effectiveness of 1,2,3-Ben...

V. K. Singh, P. Rishishwar *, P. Bhardwaj and S. Alok

Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(2).446-56

446-456

186

97

Research Articles

 
Title
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11.

FRONTIER MOLECULAR, NATURAL BOND ORBITAL, UV-VIS SPECTRAL STUDY, SOLVENT INFLUENCE ON GEOMETRIC PARAMETERS, VIBRATIONAL FREQUENCIES AND SOLVATION ENERGIES OF 8-HYDROXYQUINOLINE

N-heterocyclic compounds have extensive biological and pharmaceutical applications. 8-Hydroxyquinoline (8-HQ) also plays a significant role in many fields of life. The excellent biological significance of the 8-HQ prompted us to extend the DFT based studies. The frontier molecular orbitals (FMOs), UV-VIS and solvation model based studies remained unknown. Therefore, we intended to study the natura...

Md. Khalid *, Md. Ali, Md. Aslam, S. H. Sumrra, Md. U. Khan, N. Raza, N. Kumar and Md. Imran

Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes, São Paulo, Brazil.

DOI: 10.13040/IJPSR.0975-8232.8(2).457-69

457-569

460

279

12.

SYNTHESIS AND ANTICANCER SCREENING OF HETEROCYCLIC COMPOUNDS BEARING PYRIMIDO [4, 5-B] QUINOLINE MOIETY

Due to your efforts diligent on quinoline nucleus new series containing pyrimido [4, 5-b] quinoline were synthesized via starting with the strategic 2-aminoquinoline-3-carbonitrile (2) intermediates to afford various pyrimido [4, 5-b] quinoline via cyclization with different reagents to get compounds 3-24. Compounds 3, 6, 9a, 9b, 12, 15, 16a, 16b, 17, 21 and 24 were tested for in vitro antitumor a...

Kamal M. El-Gamal

Organic Chemistry Department, Al-Azher University (Boy’s) , Nasser City, Cairo, Egypt

DOI: 10.13040/IJPSR.0975-8232.8(2).570-81

570-581

425

311

13.

ADAPTOGENIC POTENTIAL OF ARTEMISIA VULGARIS LINN. (1753) LEAF EXTRACT ON MALE ALBINO RATS

Artemisia vulgaris leaves are known to have anectodatal evidence of antioxidant activity which can be of use as an anti – stress remedy. However, this claim is yet to be proven and no available data on its adaptogenic potential hence, this study aimed to determine the adaptogenic potential of Artemisia vulgaris leaf extract on male albino rats using acute restraint stress. Six male albino rats w...

F. Jr. Villester Arce *, C. G. Mistula Hermogenes, R. M. Caňete Prendol and G. Lee Lo See

Department of Pharmacy, School of Health Care Professions, University of San Carlos, Robert Hoeppener Building, Nasipit Talamban, Cebu City, Philippines.

DOI: 10.13040/IJPSR.0975-8232.8(2).582-90

582-590

439

266

14.

FORMULATION AND CHARACTERIZATION OF NIMODIPINE NANOEMULSION AS AMPOULE FOR ORAL ROUTE

The aim of this study was to develop oil in water nanoemulsion of nimodipine intended for oral use. Nimodipine is a calcium channel blocker that has poor oral bioavailability (3-30%) due to its low solubility and first- pass metabolism. So, nanoemulsion of nimodipine increase its solubility and enhance its oral bioavailability. Pseudo -ternary phase diagrams were made by using aqueous titration me...

Mowafaq M. Ghareeb * and Abulfadhel J. Neamah

Department of Pharmaceutics, College of Pharmacy, Baghdad University, Baghdad, Iraq

DOI: 10.13040/IJPSR.0975-8232.8(2).591-02

591-602

466

295

15.

PROTECTIVE EFFECTS OF WHITE TEA EXTRACT AGAINST MERCURIC CHLORIDE INDUCED HEPATOTOXICITY IN MICE

The present work was aimed to evaluate the potential protective effect of white tea's extract against the liver injury in an experimental model of hepatotoxicity induced by HgCl2 in mice. Histopathological investigations, liver functions and flow. Cytometrical analyses were estimated. The experimental mice were divided into four groups, each of eight mice (each mouse weighed 25 - 30gm): Group 1 wa...

Eman Mohammed Mohammed Abdella

Zoology Dept., Faculty of Science, Fayoum University, Egypt

DOI: 10.13040/IJPSR.0975-8232.8(2).603-10

603-610

442

293

16.

DEVELOPMENT OF PRINTING NATURAL FABRICS WITH CURCUMA NATURAL DYE VIA NANOTECHNOLOGY

The present work is undertaken with a view to harness nanotechnology as one of the most important frontier sciences for development of printing natural fabrics using the most eco-friendly dyes, i.e. natural colors. Curcuma natural dye was studied to clarify the impact of nature of nano-size color particles on size, shape, and particle distribution of the natural dye with comparative studies of the...

A. A. Ragheb, S. Tawfik, J. I. Abd –El Thalouth and M. M. Mosaad *

Faculty of Applied arts, Helwan University, Cairo, Egypt

DOI: 10.13040/IJPSR.0975-8232.8(2).611-20

611-620

151

113

17.

HIGH BODY MASS INDEX AND REDUCTION OF RESPONSE TO RITUXIMAB IN PATIENTS WITH RHEUMATOID ARTHRITIS

Adipose tissue has immunomodulating effects in rheumatoid arthritis (RA). Previous studies suggested that obesity could negatively affect the response to anti-TNF-α agents. We aimed to determine whether body mass index (BMI) is involved in the response to the anti-CD20 "Rituximab" in RA. In 100 patients with active RA, the BMI was categorized into two groups (<25 kg/m2 and ≥ 25 kg/m2) and ca...

Bahir Abdul Razzaq Mshimesh

Department of Pharmacology and Toxicology/ College of Pharmacy, Al-Mustansiriyah University/Iraq-Baghdad.

DOI: 10.13040/IJPSR.0975-8232.8(2).621-30

621-630

145

51

18.

VIRTUAL SCREENING, SYNTHESIS OF NEWER HETEROCYCLES AS PPAR γ AGONISTS WITH ANTIDIABETIC ACTIVITY

Recent decades have experienced a sharp increase in the incidence and prevalence of diabetes mellitus. The major therapeutic approach is to diabetes is to reduce gastrointestinal glucose production and absorption through the inhibition of carbohydrate digesting enzymes such as α-amylase and α-glucosidase. The agonists of PPAR γ is of great interest to the pharmaceutical industry since they regu...

R. Priyadarsini *, V. Durga and Shahana Ahmed

Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai, Tamilnadu India.

DOI: 10.13040/IJPSR.0975-8232.8(2).631-45

631-645

167

63

19.

EXPERIMENTAL DESIGN BASED OPTIMIZATION OF HPLC METHOD FOR DETERMINATION OF BLONANSERIN IN IN-VITRO HUMAN SERUM SAMPLE, FORCED DEGRADED SAMPLE AND PHARMACEUTICAL FORMULATIONS

Paper presents a novel high performance liquid chromatography method development, optimization, validation and application of determining blonanserin in bulk drug, its formulation, human serum and in the presence of its degradation products. Selection of important factors which may influence separation were concluded: percentage of acetonitrile in the mobile phase, the percentage of orthophosphori...

Rahul P. Chilbule and Rajendra B. Kakde *

Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).646-57

646-657

183

56

20.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR TENOFOVIR SOLID LIPID NANOPARTICLES

Tenofovirdisoproxilfumarate (TDF) is an essential component of highly active antiretroviral therapy (HAART) for HIV infection used in the treatment of human immunodeficiency virus (HIV) Type-1 patients. A stability-indicating HPLC method for the determination of TDF in solid-lipid nanoparticles was developed and validated. Chromatographic analysis was performed in a Agilent 1260 Infinity series, e...

Vasanti M. Suvarna and Preeti C. Sangave *

Department of Pharmaceutical Chemistry, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Vile Parle (West) Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).658-66

658-666

156

57

21.

SYNTHESIS AND CHARACTERIZATION OF NOVEL BENZALDEHYDE THIOSEMICARBAZONES AND EVALUATION OF THEIR ANTIBACTERIAL, ANTIFUNGAL AND ANTIOXIDANT ACTIVITY

In the present study 17 novel benzaldehyde thiosemicarbazone derivatives were synthesised using 2-methyl-3-thiosemicarbazide as the main reactant and different aromatic aldehydes. Reactions were monitored using thin layer chromatography technique and the newly synthesised derivatives were characterized by Elemental analysis, ATR and 1HNMR techniques. For antibacterial activity four bacterial strai...

Neetu Sharma * and Dharam Pal Pathak

Department of pharmaceutical chemistry, Delhi Institute of Pharmaceutical Sciences and Research, Pushp Vihar, New Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).667-78

667-678

143

73

22.

SPECTROSCOPIC CHARACTERISATION AND SYNTHESIS OF Cu(II) AND Ni(II) COMPLEXES WITH NITROGEN AND SULPHUR DONOR BIDENTATE SCHIFF’S BASE LIGAND

The complexes of Cu(II) and Ni(II) having the general composition ML2X2 (where L= 2-benzoylpyridine thiosemicarbazone, M=Ni(II),Cu(II), and X=Cl-, NO3-,SO42-, OAc-)  have been synthesised and were characterised by IR, elemental analysis, magnetic susceptibility, UV-Vis, conductivity, mass spectrometry and EPR spectral studies. The IR spectral data indicates that the ligand behave as a bidentate l...

Sulekh Chandra * and Meenakshi Gupta

Department of Chemistry, Zakir Husain Delhi Collage (University of Delhi), New Delhi, India

DOI: 10.13040/IJPSR.0975-8232.8(2).679-85

679-685

138

61

23.

DEVELOPMENT AND CHARACTERIZATION OF FLOATING MICROSPHERES OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE BY SOLVENT EVAPORATION METHOD

The objective of this research was to develop and characterize floating microspheres of esomeprazole magnesium trihydrate by solvent evaporation method using various polymers.  The esomeprazole magnesium trihydrate floating microspheres was successfully developed by solvent evaporation method using HPMC, CA, Carbopol 940, Eudragit L 100 in various proportions. Further, the prepared floating micro...

Maina Chouhan *, A.V. S. Chundawat and C. S. Chauhan

B. N. Institute of Pharmaceutical Sciences, Udaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).686-97

686-697

137

88

24.

ANTIBACTERIAL ACTIVITIES OF THE METHANOL EXTRACT AND FRACTIONS OF THE LEAF OF ERIOSEMA PSORALEOIDES (LAM.) G. DON (LEGUMINOSAE)

Eriosema psoraleoides leaves have been reported to be used in traditional African medicine to treat cuts and wounds, hence the present investigation of its antibacterial activity using the agar pour plate method.  The leaves contain tannins and flavonoids. A methanol extract was obtained from the leaves by maceration, and then the n-hexane and ethyl acetate fractions were obtained from this. Stat...

N. A. Elechi * and O. T. Igboh

Department of Pharmacognosy and Phytotherapy, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.8(2).698-05

698-705

162

64

25.

A SIMPLE AND SENSITIVE RP-HPLC METHOD FOR TRACE-LEVEL QUANTIFICATION OF METHYL VINYL KETONE, A POTENTIAL GENOTOXIC IMPURITY, IN DRUG SUBSTANCES

An HPLC method was developed with the aim of quantifying the levels of Methyl Vinyl Ketone (MVK), a Potential Genotoxic Impurity (PGI), in Ivabradine HCl. A limit level concentration of 0.5 ppm for MVK was calculated by applying the concept of Threshold of Toxicological Concern (TTC). The developed HPLC method employs a Phenyl analytical column (150 mm х 4.6 mm, 3.5 μ), 5-μL injection volume, m...

Deepali Gangrade * and Jessica D’Souza

Department of Quality Assurance, Vivekanand Education Society’s College of Pharmacy, Chembur(East), Mumbai-400074, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).706-12

706-712

156

66

26.

COMPARATIVE IN VITRO ANTIBACTERIAL EVALUATION OF SOME COMMERCIALLY AVAILABLE BRANDS OF MOUTH WASHES AGAINST HUMAN PATHOGENIC BACTERIA

Colonization of bacteria causes various diseases of oral cavity such as plaque and gingivitis. Staphylococcus and Streptococcus species are the most important pathogens causing dental caries.  The present study was designed to screen the anti bacterial action of four different marketed mouth washes namely Listerine zero, Colgate plax, Signal expert protection and Aloe dent against selected human ...

Mohammed M. Safhi

Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, Kingdom of Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.8(2).713-15

713-715

142

97

27.

EVALUATION OF ANTIASTHMATIC ACTIVITY OF CITRULLUS COLOCYNTHIS FRUIT

The present investigation was under taken to evaluate the anti-asthmatic activity of ethanolic extract of Citrullus colocynthis Fruits in experimental animals. Citrullus colocynthis Fruits was evaluated for anti-histaminic activity using isolated goat tracheal chain preparation and histamine induced Bronchoconstriction in Guinea pig. Citrullus colocynthis Fruits significantly inhibited dose depend...

Chandan Genwa *, Umesh K. Gilhotra, Anil K. Varma and Bhawna Rajpurohit

G. D. Memorial College of Pharmacy, Jodhpur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).716-21

716-721

194

68

28.

PHARMACOLOGICAL EFFICACY OF METHANOLIC EXTRACT OF THE PLANT GINKGO BILOBA, AGAINST ISOPROTERENOL INDUCED CARDIAC TOXICITY IN RATS

Ginkgo Biloba is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was designed to evaluate the cardio protective role of chronic oral administration of Ginkgo biloba leaf extract against Isoproterenol induced myocardial injury. Male Wistar albino rates were ran...

Narendra S Badore *, Prabhat Kumar Das and Sujit Pillai

GRY Institute of Pharmacy, Borawan, Khargone, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).722-28

722-728

152

72

29.

STUDY OF ANTHELMINTIC AND INSECTICIDAL ACTIVITIES OF DIFFERENT EXTRACTS OF KAEMPFERIA GALANGA

Kaempferia galanga has profound implications in the treatment of nematocide, larvicide, abdominal discomfort, cholera, various inflammatory diseases and many more. It is a potential candidate in terms of evaluating its medicinal activities. Therefore, the present study was conducted to evaluate anthelmintic and insecticidal activities of different extracts of the rhizome of Kaempferia galanga. For...

P. R. Dash *, K. M. Mou, I. N. Erina, F. A. Ripa, K. N. Al Masud and Md. Shawkat Ali

Department of Pharmacy 1, BRAC University, Mohakhali, Dhaka, Bangladesh

DOI: 10.13040/IJPSR.0975-8232.8(2).729-33

729-733

427

103

30.

EFFECT OF THE PREGNANCY PERIOD PREPARATION CLASSES ON THE NUTRITIONAL BEHAVIOR OF THE POSTPARTUM PERIOD

Postpartum period is an important step because the mother's body needs to heal and recover, after pregnancy period and childbirth. So taking good care and a balanced diet in the postpartum period, plays an important role in the women's health. Thus, training of nutrition is so necessary at this period. The aim of this study was an evaluation the effect of the pregnancy period preparation classes o...

H. Morteza *, M. Rezaeyan, S. Tahereh Mirmolaei and A. Kazemnejad

Semnan University of Medical Sciences and Health Services, Semnan, Iran

DOI: 10.13040/IJPSR.0975-8232.8(2).734-39

734-739

139

57

31.

ANTI-DIABETIC ACTIVITY OF ETHANOL EXTRACT OF PRAECITRULLUS FISTULOSUS LEAVES ON STREPTOZOTOCIN INDUCED DIABETIC RATS

Objective: The present study was designed to evaluate the anti-diabetic activity of ethanol extract of Praecitrullus fistulosus leaves on streptozotocin induced diabetic rats. Materials and Methods: The anti-diabetic activity of plant leaves was investigated in streptozotocin induced diabetes model. Effect of ethanol extract of Praecitrullus fistulosus (EPF) leaves on normal blood glucose levels a...

Sandeep Jain *, Pawan Gupta and Atul Kaushik

Institute of Professional Studies, College of Pharmacy, Gwalior, Madhya Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(2).740-45

740-745

139

72

32.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDIES OF 3-SUBSTITUTED SCHIFF BASES OF QUINAZOLINE2,4-DIONES

Objective: 3-Substituted Schiff bases of Quinazolne-2,4-diones belongs to the N-containing heterocyclic compounds. The aim of the present study is to synthesis and characterization of ten novel derivatives of 3-Substituted Schiff bases of Quinazoline2,4-diones and their pharmacological study. In the current course of work the novel Schiff bases of Quinazolne-2,4-diones  which are synthesized  ar...

Deepali Gangrade *, Sayali Lad and Viren Bhatia

Department of Pharmaceutical Chemistry, Vivekanand Education Society College of Pharmacy, Chembur (E), Mumbai, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(2).746-55

746-755

127

66

33.

ASSESSMENT OF HEAVY METALS IN COASTAL WATER AND FISH SAMPLES FROM KALAPET AREA, PONDICHERRY

Now days the potential toxic effect of heavy metals in the aquatic organisms has been intensively studied. The present study was aimed to determine the  proximate composition and the heavy metal concentrations (Cd, Pb & Cr) of three different marine fish species Grey mullet (Mugil cephalus), Red snapper (Lutjanus sanguineus), and Indian sardine (Sardinella longiceps) along with the water  sa...

S. Celine Hilda Mary, S. Sundaravadivel , R. Ramabai and A. Lawrence

PG and Research Department of Biochemistry, St. Joseph’s college of Arts & Science, Cuddalore, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.8(2).756-62

756-762

169

63

34.

EVALUATION OF IN VITRO ANTIOXIDANT PROPERTIES OF GARCINIA BRASILIENSIS LEAF EXTRACT

The in vitro antioxidant activity of n-hexane, chloroform, ethyl acetate and alcoholic fraction of the total ethanolic extract of the leaves of Garcinia brasiliensis have been tested using various antioxidant model systems viz., ferric reducing power assay and hydrogen peroxide scavenging assay. Ethyl acetate fraction is found to possess higher ferric reducing power and superoxide radical scavengi...

Shereen Sunny * and K. Krishnakumar

Department of Pharmaceutical Chemistry, St. James College of Pharmaceutical Sciences. Chalakudy, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.8(2).763-67

763-767

159

71

35.

CROCUS SATIVUS AND NYCTANTHES ARBORTRISTIS EXTRACT MODULATES ANTI-INFLAMMATORY CYTOKINE IN EXPERIMENTAL ARTHRITIS

Rheumatoid arthritis (RA) is a chronic inflammatory disease, affecting 1-2% population worldwide. RA is common among the women in comparison to men. The disease mostly affects the age group 45 onwards, while juvenile cases are also reported. Exact pathogenesis of the disease is still a question. Studies indicate RA as an overabundance of pro-inflammatory cytokines, and inadequate anti-inflammatory...

Brijesh Rathore *, Farzana Mahdi, Abbas Ali Mahdi and Siddharth K. Das

Department of Biochemistry, Era’s Lucknow Medical College, Lucknow, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(2).768-74

768-774

139

62

36.

PRELIMINARY DEVELOPMENT STUDIES OF HALOBETASOL PROPIONATE ORGANOGEL FOR MANAGEMENT OF ATOPIC DERMATITIS

Halobetasol propionate (HP) is an ultra-potent corticosteroid used in management of severe and recurrent cases of Atopic Dermatitis (AD).  The marketed cream formulations are based on synthetic surfactants which often aggravate AD. The present studies investigate biocompatible pluronic lecithin organogel (PLO) of Halobetasol propionate in management of AD. Organogels were prepared by aqueous titr...

M. S. Lalan *, S. S. Khode, K. S. Shah and P. C. Patel

Babaria Institute of Pharmacy, BITS edu campus, Varnama, Vadodara, Gujarat, India

DOI: 10.13040/IJPSR.0975-8232.8(2).775-83

775-783

129

77

37.

FORMULATION AND CHARACTERIZATION OF CALCIUM SILICATE BASED FLOATING MICROSPHERES OF FAMOTIDINE FOR THE TREATMENT OF PEPTIC ULCER

The aim of the present study was to prepare and evaluate floating microspheres consisting of (i) calcium silicate (CS) as porous carrier; (ii) famotidine and (iii) hydroxypropyl methylcellulose (HPMC) and ethylcellulose (EC) as polymers. The floating microspheres were evaluated for particle size, micromeritic properties, percent drug content, in vitro floating behavior, and in vitro drug release. ...

Manoj Goyal *, Paras Sharma and S. C. Mehta

I. P. S. College of Pharmacy, Gwalior, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).784-93

784-793

161

59

38.

GC-MS ANALYSIS OF THE CHLOROFORM EXTRACT OF BARK OF TERMINALIA TRAVANCORENSIS WIGHT & ARN. (COMBRETACEAE)

Gas Chromatography-Mass Spectrometry (GC-MS) studies play an important role in isolation and identification of phytocompounds. Since, the chemical composition of the plants usually determines its biological activity, phytochemicals of possible pharmaceutical importance can be subjected to a detailed analysis. The present study is concerned with the GC-MS analysis of chloroform extract of the bark ...

M. Lakshmi * and Bindu R. Nair

Department of Botany, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala, India

DOI: 10.13040/IJPSR.0975-8232.8(2).794-98

794-798

145

54

39.

Micro-coulometric Estimation of Nitrofurantoin

The objective of the present work was to set up micro-coulometric technique in the laboratory and estimate microgram level quantity of nitrofurantoin in the pharmaceutical tablets. A simple, sensitive, and reproducible manually operated microcoulometric technique has been successfully used for the estimation of nitrofurantoin in pharmaceutical tablets. A potentostat and coulometric cell was used i...

Sushil B. Kapoor *, Parmanand M. Shende and Dilip B. Patil

Arts, Commerce and Science College, Tukum, Chandrapur, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(2).799-03

799-803

180

67

40.

FORMULATION AND EVALUTION OF LANSOPRAZOLE ORODISPERSABLE TABLETS

Lansoprazole a proton pump inhibitor used in the short term treatment of gastric and duodenal ulcer, reflux esophagitis, structuring and erosive esophagitis. In the present investigation an attempt has been made to enhance the solubility and dissolution rate of lansprozole by formulating it as solid dispersions with KollidonVA64, Soluplus and poly ethylene glycol 6000 by solvent evaporation method...

T. Balakrishna, S. Vidyadhara, RLC. Sasidhar *, P. Satya Prasanna and T.E.G.K. Murthy

Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(2).804-12

804-812

142

64

41.

INVESTIGATIONS ON HYPOLIPIDEMIC ACTIVITY OF ASPARAGUS FILICINUS BUCH-HAM EX D. DON

Saponins are the foam producing secondary metabolites of plant. They have been evaluated for a number biological activities like anticancer, anti-inflammatory, hepatoprotective, antimicrobial, antitumor, blood cholesterol lowering properties etc. In the present study we have attempted to check the role of isolated saponins from Asparagus filicinus for its hypolipidemic activity. Saponin rich fract...

Shilpi Mishra *, Ashish Mishra , Mayank Thakur, Ajay Sharma and Shashi Alok

Advance Institute of Biotech and Paramedical Sciences, Naramau, Kanpur, Uttar Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(2).813-18

813-818

167

60

42.

STATUS OF DIABETIC HYPERTENSION IN KANPUR CITY AND ROLE OF PHARMACIST AS A HEALTHCARE PROFESSIONAL IN TREATMENT AND CONTROL OF DIABETIC HYPERTENSION

Pharmacists in all practice settings are in a key position to start providing care to people, who have diabetes or are at risk of developing it, or to expand and improve their care. Pharmacy programs for patients with diabetes involve activities ranging from identifying and referring at-risk patients, to supporting American Diabetes Association recognized multi-disciplinary diabetes care programs....

A. Gautam, A. Katiyar, A. Sameen, A. K. Gupta and P. Verma

University Institute of Pharmacy, C.S.J.M. University, Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).819-24

819-824

130

58

43.

FERTILITY EFFECT OF CYCAS CIRCINALIS AND IONIDIUM SUFFRUTICOSUM IN ALCOHOL INDUCED STERILITY OF MALE WISTAR RATS – AN HISTOMORPHOMETRIC STUDY

Alcohol abuse is well known to impair reproductive performances due to impaired testosterone production and testicular atrophy. Many natural nontoxic herbs were found to enhance the fertility in male. The study is done to evaluate the effect of Cycas circinalis (Cc) and Ionidium suffruticosum (Is) in improving the fertility of alcohol induced sterile male albino rats. A total of 30 healthy young m...

B. Senthil Kumar

Department of Anatomy, Vinayaka Mission’s Kirupananda Variyar Medical College and Hospital, Salem, Tamilnadu, India

DOI: 10.13040/IJPSR.0975-8232.8(2).825-30

825-830

125

53

44.

KNOWLEDGE, ATTITUDE AND PERCEPTION OF HEALTH CARE PROVIDERS (HCPS) AT INTERNAL MEDICINE WARD OF A TERTIARY CARE HOSPITAL TOWARDS PHARMACEUTICAL CARE

Introduction: Pharmaceutical care entails the work of addressing patient's medication related needs and problems. The involvement of the pharmacist in India in this regard has been somewhat restricted, contrary to trends in developed countries. Materials and methods: Questionnaire-based explorative, semi-quantitative study involving Doctors, Pharmacists and Nurses of the study department in the fo...

Mir Javid Iqbal and Geer Mohammad Ishaq*

Department of Pharmaceutical Sciences University of Kashmir Srinagar, India

DOI: 10.13040/IJPSR.0975-8232.8(2).831-37

831-837

125

87

45.

A COMPARATIVE PHARMACOGNOSY STUDY OF BLACK AND WHITE SEEDS OF KAPIKACCHU (MUCUNA PRURIENS (L.) DC.)

Background:  Kapikacchu (Mucuna pruriens (L.) DC.) belonging to the family Fabaceae is commonly known as Velvet bean, Cowitch, Cowhage in English and Kawaanch, Kavach in Hindi. It is mainly distributed in Asia, Africa, Pacific Islands and the United State. Kapikacchu is very famous plant for its aphrodisiac effect. Traditionally it is being used as a potent antiparkinsonian, anti-inflammatory, ap...

Tarun Sharma *, A. Ramamurthy, Sumit Nathani and Gaurav Sharma

Dept. of P.G. Studies in Dravyaguna, National Institute of Ayurveda, Jaipur, Rajasthan, India

DOI: 10.13040/IJPSR.0975-8232.8(2).838-44

838-844

159

65

46.

EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF MORUS INDICA LINN. AGAINST TOXICITY INDUCED BY CARBON TETRACHLORIDE IN RATS

Morus indica- MI-S36 is a potential source of phytochemicals and is well explored for its medicinal properties such as antidiabetic and antioxidant activity. In the present study, Mous indica aqueous (MAq) and dechlorophyllised (MDc) extracts efficacy to protect against the carbon tetrachloride (CCl4) induced hepatotoxicity was studied in rats in comparison with standard drug Liv52. The experiment...

Vanitha Reddy P. * and Asna Urooj

DOS in Food Science and Nutrition, University of Mysore, Mysore, India

DOI: 10.13040/IJPSR.0975-8232.8(2).845-51

845-851

131

60

47.

PHYTOCHEMICAL ANALYSIS OF SELECTED WOUND HEALING MEDICINAL PLANTS

In the present study, pharmacognostical, qualitative and quantitative phytochemical analysis of Azardirachta indica, Cassia auriculata, Moringa oleifera and Curcuma longa was done. The results showed the presence of various vital secondary metabolites. Primary metabolites was found to be more in Cassia auriculata whereas the secondary metabolites content was higher in Azardirachta indica. In the s...

K. Devi, M Santhi * and U. Umadevi

Department of Botany Specialized with Plant Biotechnology, The Standard Firework Rajaratnam College for Women, Sivakasi, Tamilnadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).852-55

852-855

168

64

48.

DOSE RESPONSE RELATIONSHIP OF HYDROXYCHLOROQUINE SULPHATE IN THE TREATMENT OF RHEUMATOID ARTHRITIS: A RANDOMISED CONTROL STUDY

Background: RA is an autoimmune disease triggered by faulty immune system and affects various joints of body including wrist and finger. Nowadays slow acting or DMARDs (Disease modifying anti-rheumatoid drugs) are mainstay of treatment in RA. HCQs belong to this group. They are slow acting so they take weeks to months to become effective. HCQ is less effective when compared to gold or penicillamin...

J. V. Modi, K. R. Patel *, Z. M. Patel, H. R. Patel, S. S. Dhanani, B. H. Shah

B. J. Medical College, Civil Hospital, Asarwa, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).856-58

856-858

156

55

49.

SCREENING OF PHYTOCHEMICALS AND EVALUATION OF ANTI-MICROBIAL, ANTI-OXIDANT AND IN-VITRO ANTIDIABETIC ACTIVITY OF CRASSULA OVATA LEAVES

The study involved both aqueous extraction and methanolic extraction of the powered leaves, which ensure all plant components are extracted for better results. Phytochemical analysis from the extracts was performed using the standard protocols. The antimicrobial susceptibility of the extracts was tested against E-coli, Pseudomonas and Klebsilla sp using  agar disc diffusion method. Antioxidant pr...

K. Chokhone, Nayan Talukdar, Manash Pratim Sarma, Karabi Das and Partha Pratim Kalita *

Department of Biotechnology, Assam down town University, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).859-64

859-864

131

56

50.

SYNTHESIS AND BIOLOGICAL ACTIVITIES OF SOME NEW HETEROCYCLES CONTAINING NITROGEN AND SULPHUR

The literature survey on 1,2,4-Triazoles and chalcone derivatives revealed that they  are  endowed  with  wide  variety  of  biological  activities. During the present investigation newer series of chalcone derivatives S-4-(isonicotinamido)-5-(phenoxymethyl) - 4H-1,2,4 triazole-3-yl-3(-4-chlorophenyl) propanethioate (7a-7f) were synthesized by coupling  suitably  modified 1,2,4-Triazole ...

Md Akram *, Abdul Sayeed and Syed Yousuf Hussain

MESCO College of Pharmacy Hyderabad (T.S), Andhra Pradesh, India

DOI: 10.13040/IJPSR.0975-8232.8(2).865-77

865-877

149

61

51.

PHYTOCHEMICAL SCREENING AND IMMUNOMODULATORY ACTIVITY OF DIFFERENT EXTRACT OF SPINACIA OLERACIA LEAVES

The extracts of Spinacia oleracia leaves studied for Phytochemical screening and different extract of Spinacia oleracea leaves was studied for immunomodulatory activity. The immunomodulatory effect was evaluated by delayed type hypersensitivity response using SRBCs. The n-hexane, dichloromethane, methanolic and aqueous extract of Spinacia oleracea leaves was studies for DTH response. The dichlorom...

Namrata Singh *, Mukul Tailang and S. C. Mehta

School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).878-82

878-882

126

80

52.

WHEN HEALTH POLICIES AND PROFESSIONALS’ NEEDS COLLIDE: A QUESTIONNAIRE-BASED STUDY ON PHARMACY TECHNICIANS IN EGYPT

Introduction: Expanding technicians’ role allows pharmacists to focus on patient care. In Egypt, the health authorities refuse to admit technicians’ role. In the draft amendments to the law, the “technician” was removed from the pharmacy workforce. Despite the high pharmacist density; technicians manage shifts alone. Technicians’ role is unclear and they have no educational programs resu...

E. A. Bassiouny *, M. M. Abbassi and S. F. Farid

Clinical Pharmacy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

DOI: 10.13040/IJPSR.0975-8232.8(2).883-94

883-894

206

67

53.

STUDY OF CHEMICAL COMPOSITION AND MEDICINAL PROPERTIES OF VOLATILE OIL FROM CLOVE BUDS (EUGENIA CARYOPHYLLUS)

The aim of this study was to analyze the chemical composition of dried clove buds volatile oil in Bangladesh by Gas Chromatography-Mass Spectrometry (GC-MS) technique and also show their medicinal properties according to the characteristics of the constituents present in that essential oil. In this experiment the clove buds essential oil was extracted by hydro distillation method. The major consti...

Md. Azir Uddin, Md. Shahinuzzaman * , Md. Sohel Rana and Zahira Yaakob

Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.8(2).895-99

895-899

178

78

54.

BIO-SYNTHESIZED NANO-FORMULATION OF ZINC OXIDE – ALOE VERA AND TO STUDY THEIR CHARACTERIZATION AND ANTIBACTERIAL ACTIVITIES AGAINST MULTIPLE PATHOGENS

Nano-sized ZnO particles of specific morphology were synthesized using the plant leaf extracts of Aloe vera. In modern science Nanotechnology is an ablaze field for the researchers. Nanoparticles having a size of 1-100 nm in one dimension are used significantly concerning medical chemistry, atomic physics and all other known fields. Nanoparticles are used immensely due to its small size, orientati...

G. Parthasarathy *, M. Saroja and M. Venkatachalam

Department of Electronics, Erode Arts and Science College (Autonomous), Erode-638 009, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.8(2).900-07

900-907

219

89

55.

EVALUATION OF THALASSEMIA AWARENESS AMONG THE FUTURE HEALTHCARE PROVIDERS OF UNITED ARAB EMIRATES

Thalassemia is among the most common genetic disorders worldwide. It constitutes a major public health problem in the United Arab Emirates (UAE). The present study assessed the level of awareness regarding thalassemia among the students of RAK Medical and Health Sciences University, Ras Al Khaimah, UAE. A specially designed, pretested and validated questionnaire was distributed to the students and...

Syed Arman Rabbani * Aicha Ahmed, Besher Abdulkader and Sara Suliman

Department of Clinical Pharmacy and Pharmacology, RAK College of Pharmaceutical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates

DOI: 10.13040/IJPSR.0975-8232.8(2).908-14

908-914

158

60

56.

FORMULATION AND EVALUATION OF DORZOLAMIDE AND TIMOLOL OCUSERTS

Objective: This study aims to formulate novel dorzolamide hydrochloride and timolol maleate ocuserts to enhance patient compliance through providing controlled drugs release from polymeric matrix. Methods: Ocuserts were prepared by solvent-casting method using different polymers Ethyl Cellulose, Eudragit S100 and Hydroxy propyl methyl cellulose in different ratios. The prepared ocusters were physc...

Ebtsam M. Abdou * and Soha M. Kandil

Department of Pharmaceutics, National Organization of Drug Control and Research (NODCAR), Cairo, Egypt

DOI: 10.13040/IJPSR.0975-8232.8(2).915-24

915-924

150

57

57.

STUDY ON DETECTION METHODS FOR URIC ACID IN BIOLOGICAL SAMPLES

Uric acid is the end-product of purine metabolism and a major antioxidant in humans. Most of the uric acid produced from the catabolism is readsorbed into the blood circulation system after primary filtration and partial secretion by the kidney. Uric acid levels in physiological fluids such as plasma and urine serve as valuable indicators for certain clinical conditions. An elevated uric acid in u...

Xiaodong Dong

College of Medicine, Hebei University, Baoding, China

DOI: 10.13040/IJPSR.0975-8232.8(2).925-29

925-929

153

85

58.

DEVELOPMENT AND OPTIMIZATION OF CHITOSAN-CA-PECTINATE BEADS OF AMORPHOUS CELECOXIB BY RESPONSE SURFACE METHODOLOGY

The aim of the present work was to develop a new microbeads system for colon-targeted delivery of celecoxib. The ternary system were develop using PVP (polyvinylpyrrolidone) and hydroxypropyl-β-cyclodextrin (HPB) to increase solubility of celecoxib.  DSC and XRD results confirmed formation of amorphous celecoxib complex with HPB. Chitosan and pectin were used for the development of microbeads of...

Y. D. Pawar *, S. I. Devare and P. D. Chaudhrari

SCES’s Indira College of Pharmacy, Pune, Maharashtra, India

DOI: 10.13040/IJPSR.0975-8232.8(2).930-39

930-939

106

96