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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , ICV (2015): 90.24
Five-Year Projected Impact Factor: 1.83

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Volume 9 (2018) - Issue 4, April

Review Articles

 
Title
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1.

CHEMICAL SYNTHESIS OF BILE ACIDS AND THEIR PHYSICO-CHEMICAL PROPERTIES

The main roles of bile acids as amphiphilic molecules are the micellar solubilization of the lipids, in the course of the welding process and the regulation of cholesterol homeostasis, which is essential as a precursor for the synthesis of bile acids. From the hydrophobic and hydrophilic surfaces of bile acids directly depends the level of their attachment to the receptors, ion channels and their ...

T. Šarenac* and M. Mikov

University of Novi Sad, Faculty of Medicine, Department of Pharmacology, Toxicology and Clinical Pharmacology, Hajduk Veljkova , Republic of Serbia.

DOI: 10.13040/IJPSR.0975-8232.9(4).1317-32

1317-1332

370

435

2.

A BRIEF OVERVIEW ON MOLECULAR DYNAMICS SIMULATION OF BIOMOLECULAR SYSTEM: PROCEDURE, ALGORITHMS AND APPLICATIONS

Molecular Dynamics (MD) Simulation provides the details explanation of the atomic and molecular interactions that directed by macroscopic and microscopic behaviors of the various systems. This review provides a brief do-how about the theory, procedure, algorithm, and uses of molecular dynamic simulations in different bimolecular systems. An in-depth analysis of different prospects of MD simulation...

S. Gupta and P. K. Varadwaj*

Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1333-50

1333-1350

841

201

3.

PROBIOTIC GENOMES: SEQUENCING AND ANNOTATION IN THE PAST DECADE

Probiotics are live microorganisms that confer many health benefits to the host when administered in adequate quantities. These health benefits have garnered much attention towards probiotics and have given an impetus to their use as dietary supplements for the improvement of general health and as adjuvant therapies for certain diseases. The increased demand for probiotic products in the recent ti...

J. P. Joseph

Department of Genetic Engineering, SRM University, Kattankulathur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1351-62

1351-1362

835

148

4.

CARDIAC ARRYTHMIASIS AND ITS DETAILED PATHOPHYSIOLOGY – A REVIEW

Amid the previous couple of years, the improvement of powerful, experimental innovations for treatment of cardiovascular arrhythmias has surpassed the pace at which itemized information of the basic science has aggregated. Cardiac arrhythmia is a group of conditions in which the heartbeat is irregular, either too fast, or too slow and is characterized by abnormal electrical conduction in the heart...

A. D. Paul* and K. Manogna

SVU College of Pharmaceutical Sciences, SV University, Tirupati, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1363-76

1363-1376

647

150

5.

A REVIEW ON PHYTOCHEMICAL AND PHARMACOLOGICAL PROPERTIES OF PHYLLANTHUS AMARUS SCHUM. AND THONN.

Phyllanthus amarus Schum and Thonn herb is in traditional medicine for more than 3000 years. It belongs to a family of Euphorbiaceae and commonly known by the name of carry me seed, stone breaker, gala of wind, etc. It is a branching annual herb of 30 - 60 cm height widely spread throughout tropics and sub-tropics as a weed. Phyllanthus amarus is gaining momentum for its hepatoprotective, anti-car...

J. Meena*, R. A. Sharma and R. Rolania

Department of Botany, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1377-86

1377-1386

283

165

6.

PHYTOCHEMICAL AND PHARMACOLOGICAL IMPORTANCE OF GENUS URTICA – A REVIEW

Genus Urtica belongs to family Urticaceae and commonly known by name of nettles. The plant Urtica has been used as a folk medicine and as a food source from a long time. It has been used frequently for its medicinal properties since the Bronze age (3000 - 2000 B.C.) as a traditional herbal remedy in treatment of variety of diseases as rheumatism gouts, nephritis, haematuria, jaundice, menorrhagia,...

P. Rajput*, M. Chaudhary and R. A. Sharma

Department of Botany, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1387-96

1387-1396

189

64

7.

A REVIEW ON IMPACT OF NANOMICELLE FOR OCULAR DRUG DELIVERY SYSTEM

In this article, we have reviewed several features of nanomicelles relating to their general properties, preparation and characterization techniques, and their applications in the areas of ocular drug delivery system. Nanomicelles can be rummage-sale as 'smart drug carriers' for targeting certain areas of the eye by making them stimuli-sensitive or by attachment of a specific ligand molecule onto ...

P. Singh* and N. Verma

Department of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1397-04

1397-1404

782

79

8.

ROLE OF COMPUTER AIDED DRUG DESIGN IN DRUG DEVELOPMENT AND DRUG DISCOVERY

The process of drug development and drug discovery is very challenging, expensive and time consuming. It has been accelerated due to development of computational tools and methods. Over the last few years, computer aided drug design (CADD) also known as in silico screening has become a powerful technique because of its utility in various phases of drug discovery and development through various adv...

N. Bisht and B. K. Singh*

Department of Pharmaceutical Sciences, Kumaun University, Bhimtal Campus, Bhimtal, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1405-15

1405-1415

676

111

9.

PHYTOCHEMICAL CONSTITUENTS OF ALOE VERA AND THEIR MULTIFUNCTIONAL PROPERTIES: A COMPREHENSIVE REVIEW

Aloe vera belongs to the family Liliaceae commonly known as Ghrit Kumari, is the ever known oldest and the most applied medicinal plant worldwide. Aloe Vera is used for vigor, wellness and medicinal purposes since rigvedic times. Health benefits of Aloe vera include its application in wound healing, treating burns, minimizing frost bite damage, protection against skin damage from x-rays, lung can...

S. K. Kar and T. K. Bera*

Department of Physiology, Universal College of Medical Sciences, Bhairahawa, Lumbini Zone, Nepal.

DOI: 10.13040/IJPSR.0975-8232.9(4).1416-23

1416-1423

641

82

10.

VARIOUS MEDICINAL PLANTS USED IN THE TREATMENT OF ANTICANCER ACTIVITY

Cancer is a major public health burden in both developed and developing countries. It is actually a group of many related diseases that all have to do with cells. It is one of the major causes of death worldwide where the number of cancer patients is in continuous rise. It is a major public problem whose estimated worldwide new incidence is about 6 million cases per year. It is the second major ca...

D. K. Chanchal *, S. Alok, M. Kumar, R. K. Bijauliya, R. D. Yadav and M. Sabharwal

Department of Pharmacognosy, Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1424-29

1424-1429

1403

151

Research Articles

 
Title
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11.

PREPARATION AND PHYSIOCHEMICAL CHARACTERIZATION OF CHITOSAN NANOPARTICLES FOR CONTROLLED DELIVERY OF OXYTOCIN

This study aimed to characterize and evaluate chitosan nanoparticles (CSNPs) as a carrier system for the hormone, oxytocin. Ionotropic gelation was the technique used to synthesize the CSNPs. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) showed narrow particle size distribution of 30-50 nm and spherical particle shape. Differential scanning calorimetry (DSC), X-ray ...

K. A. Milligan, C. Winstead* and J. Smith

Department of Chemistry, Delaware State University, 1200 N. DuPont Highway, Dover, Delaware, USA.

DOI: 10.13040/IJPSR.0975-8232.9(4).1430-1440

1430-1440

251

157

12.

MOLECULAR EVENTS IN PROSTATE CANCER: LENTIVIRUS INDUCED KNOCKDOWN OF HUMAN MKP-2 ENHANCES ERK SIGNALLING IN LNCaP (AI) CELLS

The MAP kinase phosphatases regulate the magnitude and kinetics of MAP kinase signalling within the cell and as a consequence cell cycle progression and division. Therefore, these enzymes have been implicated in the regulation of number of disease conditions. One member of this family, MKP-2, has been linked to cancers of the breast and prostate. However, in human cells correlating changes in MKP-...

M. Shweash

University of Anbar, College of Pharmacy, Department of Clinical Laboratories Sciences, Anbar - Ramadi, Iraq.

DOI: 10.13040/IJPSR.0975-8232.9(4).1441-50

1441-1450

221

105

13.

COMPARATIVE PHARMACOGNOSTIC STUDIES OF TWO GHANAIAN MEDICINAL PLANTS: SABA SENEGALENSIS AND SABA THOMPSONII

The study sought to describe the pharmacognostic features for identification and quality control of closely related species Saba senegalensis (A. DC.) Pichon and Saba thompsonii (A. Chev.) Pichon (Apocynaceae), useful medicinal plants against inflammation and its related diseases in Ghana and West Africa. Macro-morphological, qualitative and quantitative microscopic features as well as physicochem...

N. A. Mireku-Gyimah*, K. Sarpong, I. K. Amponsah, A. Y. Mensah and R. A. Dickson

Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

DOI: 10.13040/IJPSR.0975-8232.9(4).1451-61

1451-1461

241

118

14.

DEVELOPMENT AND EVALUATION OF CHRONOMODULATED PULSINCAP DRUG DELIVERY SYSTEM OF KETOPROFEN

Chronotherapeutic drug delivery systems have been recognized as potentially beneficial to the chrono-therapy (time optimized) of chronic diseases that display time-dependent symptoms. In pulsincap system, therapy can be optimized by tailoring the dosing schedule based on chrono-biological pattern. The safety and efficacy of the drug is achieved by coordinating the peak plasma concentration with ci...

P. Mathew* and B. M. Jacob

Nazareth College of Pharmacy, Othera, Thiruvalla, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1462-77

1462-1477

975

139

15.

DESIGN AND EVALUATION OF AMOXICILIN TRIHYDRATE FLOATING GRANULES PREPARED BY MELT GRANULATION TECHNIQUE

The purpose of this study was to design and evaluate Amoxicillin trihydrate floating granules by melt granulation technique using Gelucire 43/01 and Campritol 888 ATO as lipid carriers. Polymers HPMC K4M and Ethyl Cellulose as release rate modifiers. The granules were evaluated by FTIR studies, differential scanning calorimetry, Scanning Electron microscopy, drug content, in vitro floating ability...

U. K. Gondrala, Shayeda* and V. Bejjenki

Department of Pharmacy, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1478-85

1478-1485

239

116

16.

HEPATOPROTECTIVE ACTIVITY OF APONOGETON NATANS (LINN.) ENGL. AND KRAUSE – AN IMPORTANT FOLKLORE MEDICINE

The liver plays a significant role in metabolism and detoxification. Aponogeton natans(Linn.) Engl. and Krause is a important ingredient in preparation of an important Ayurvedic preparation Useerasava. The screening for hepatoprotective activity against carbon tetrachloride induced hepatotoxicity was followed as per standard procedure. Animals received CCl4 (2 ml/kg, 1:1 in olive oil, i.p.) to ind...

S. Dash*, A. C. Sahoo and B. Mishra

Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1486-92

1486-1492

134

65

17.

STABILITY INDICATING UPLC METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF CRIZOTINIB IN PHARMACEUTICAL DOSAGE FORMS

A stability indicating method was developed for the estimation of Crizotinib in pharmaceutical dosage form by using Ultra Performance Liquid Chromatography (UPLC). The separation was done on isocratic mode with Hibra C18 (100 mm × 2.1 mm, 2 µ) column and 0.1% Ortho-phosphoric acid and acetonitrile (45:55% v/v) as mobile phase at a flow rate of 0.3 mL/min and at room temperature. The detection wa...

J. Bandla* and S. Ganapaty

Department of Pharmaceutical Analysis and Quality Assurance, Faculty of Pharmacy, Vishnu Institute of Pharmaceutical Education and Research, Narsapur, Medak, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1493-98

1493-1498

124

58

18.

FINGERPRINT ANALYSIS FOR VALIDATION AND SIMULTANEOUS QUANTIFICATION OF QUERCETIN AND KAEMPFEROL IN MORINGA OLEIFERA BY RP-HPLC AND HPTLC

To establish authenticity and integrity for usage of herbal drugs quantitative analysis by sensitive analytical instrument is highly desirable. Quercetin and Kaempferol from whole plant of Moringa oleifera was chosen for simultaneous quantification by RP-HPLC and HPTLC method due to their pharmacological activities. HPTLC method of quercetin and kaempferol was developed on HPTLC plates using Tolue...

N. Meghani, B. Jethra, R. Shah and S. Nagendran *

SVKM’s NMIMS, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management (SPPSPTM), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1499-10

1499-1510

157

67

19.

PHARMACOLOGICAL EVALUATION OF SOME NOVEL THIENO 1, 2, 3-TRIAZINES-4-ONES FOR ITS ANALGESIC ACTIVITY

The analgesic activity was assessed using hot plate method, formalin induced paw licking test, acetic acid induced writhing test. Preliminary investigations were carried out with water, DMSO and chloroform for solubility. For analgesic activity 1, 2, 3- triazine-4-ones series of compounds CP1, CP2, CP3 showed significant increase in jumping time of mice in hot plate method at only higher dose leve...

P. Raghav, R. Srinath and P. Deep*

Amity Institute of Pharmacy, Amity University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1511-18

1511-1518

146

56

20.

PROTECTIVE EFFECT OF OKRA, ABELMOSCHUS MOSCHATUS SEED EXTRACT ON DEVELOPING BRAIN OF RATS DURING PRE- AND POST-NATAL FLUORIDE EXPOSURE

This study reports protective effect of Abelmoschus moschatus seed extract against sodium fluoride (NaF) induced alterations in behavior correlated with neurochemical changes in developing brain of rats. Excessive intake of fluoride during pregnancy cross the blood brain barrier (BBB) and cause adverse effects on neonatal development. As the BBB in fetuses, neonates and infants is immature, it can...

K. Sudhakar, M. Nageshwar and K. P. Reddy*

Department of Zoology, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1519-28

1519-1528

124

53

21.

EVALUATION OF ANTI-DIABETIC AND ANTI-HYPERLIPIDEMIC ACTIVITIES OF ETHANOLIC LEAF EXTRACT OF ORIGANUM MAJORANA IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Diabetes mellitus or sugar diabetes is a condition that occurs when the body can't use glucose (a type of sugar) normally. It is a chronic disease associated with abnormally high levels of the glucose in the blood because of disturbances in carbohydrates, fat and proteins metabolism and it is due to one of two mechanisms that inadequate production of insulin (which is made by the pancreas and lowe...

B. Tripathy*, S. Satyanarayana, K. A. Khan and K. Raja

St. Mary’s Pharmacy College, Deshmukhi (V), Greater Hyderabad, Telengana, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1529-36

1529-1536

857

99

22.

IMMUNOMODULATORY ACTIVITY OF LEAVES OF RUMEX VESICARIUS LINN. AND SYMPLOCOS RACEMOSA ROXB.

Objective: To determine the immunomodulatory activity of leaves of Rumex vesicarius Linn. and Symplocos racemosa Roxb. Methods: The ethyl acetate and ethanolic extract of Rumex Vesicarius Linn. and ethanolic and N-hexane extract of Symplocos racemosa Roxb. were administered orally at the dosage level of 200 mg/kg/day and 400 mg/kg/day each according to the body weight of Rat. The assessments of im...

J. Y. Manure* and N. S. Naikwade

Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1537-44

1537-1544

144

65

23.

TYPICAL PHYSICAL ATTRIBUTES OF MICROCRYSTALLINE CELLULOSE DRIED BY SPRAY, SPIN FLASH AND BULK DRIER AND THEIR RESULTANT EFFECTS ON TABLET PROPERTIES

The solid dosage form is the easiest method of administering drugs for systemic effect. All dosages forms are made by two main components one is API and second is excipient. Excipient is present in bulk quantity and is required for binding the API. There are mainly two techniques uses for manufacturing the tablets (i) wet granulation (ii) direct compression. Wet granulation is a time consuming pro...

M. Tomar, A. R. Sinha* and A. K. Singh

Sigachi® Industries Private Limited, Dahej Sez, Bharuch, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1545-54

1545-1554

115

49

24.

ANTI-MICROBIAL, OVICIDAL, LARVICIDAL, ANTI-DIABETIC AND CYTOXICITY ACTIVITY OF SILVER NANOPARTICLES FROM BROWN SEAWEED (STOECHOSPERMUM MARGINATUM)

The present study aimed to green synthesis the nanoparticles using bioactive compounds from unique seaweeds and testing its application for anti-microbial, anti-diabetic, ovicidal, larvicidal and cytotoxic activity. Seaweeds are marine non- flowering plants have much of the secondary metabolites and had not been explored widely. There are very limited amount of literature are there for seaweeds. S...

P. Sabatini and C. A. Devi*

Department of Biotechnology, Women’s Christian College, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1555-64

1555-1564

122

53

25.

LAYER BY LAYER ASSEMBLY ON THE SURFACE OF NANOPARTICLE FOR CHEMOTHERAPEUTIC DRUG LOADING

In the present investigation, fluorescently labelled sulfated polystyrene beads were coated with oppositely charged polyelectrolytes {i.e. Poly diallyl dimethyl ammonium chloride, Poly (sodium 4-styrene sulfonate)} through an electrostatic interaction by using layer by layer assembly method. Doxorubicin is a model anticancer drug with protonatable amine group that acquires net positive charge in a...

N. Shruthi, S. J. Fathima, F. Khanum and D. Nagesha*

Department of Pharmaceutics, JSS College of Pharmacy, Jagadguru Sri Shivarathreeswara University, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1565-75

1565-1575

547

82

26.

SYNTHESIS OF NANOSTRUCTURED MAGNESIUM OXIDE BY SOL GEL METHOD AND ITS CHARACTERIZATION

Metals are able to form a large number of oxides. These metal oxides play an important role in many areas of chemistry, physics and material science. An important metal oxide known as magnesium oxide (MgO) having good reactivity is widely used in producing electronics, catalyst, ceramics, oil, paint etc. Magnesium oxide nanoparticle is non-toxic and need a small amount, so it is suitable for the d...

M. Sharma, D. Gandhi and M. Sharma*

Department of Zoology, Maharshi Dayanand University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1576-81

1576-1581

142

63

27.

FORMULATION AND EVALUATION OF DILTIAZEM HCl FAST DISSOLVING TABLETS USING DIFFERENT CO-PROCESSED EXCIPIENTS BY DIRECT COMPRESSION METHOD

The aim of present work was to prepare Diltiazem HCl Fast Dissolving tablets by Direct compression  method because of their convenience in administration and suitability for patients having dysphagia using co-processed excipients-Disintequik MCC25, Disintequik MCC, Lubritose MCC, Lubritose SD, Lubritose AN, NF Fast flo Lactose Monohydrate modified spray dried. The Prepared powdered blend and tabl...

M. S. Reddy *, N. Kore and S. M. F. Ul-Haq

Centre for Pharmaceutical Sciences, Institute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1582-88

1582-1588

115

69

28.

SYNTHESIS AND CHARACTERISATION OF CHALCONE BASED COPOLYESTERS AND THEIR ANTICANCER ACTIVITY

Breast cancer is one of the most common causes of death in women. Chalcone exhibit chemopreventive and antitumor effects.  As  a part of proactive  approach  in the fight against  breast cancer, two  copolyesters using varying  chalcone  diols  as monomer and varying  aliphatic  and  aromatic  acid  chlorides were synthesised by solution  polycondensation  method. The two copolyest...

D. Lakshmi Devi, R. Aswini and S. Kothai *

Department of Chemistry, Ethiraj College for Women, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1589-93

1589-1593

129

44

29.

GRANULES OF UNISTRAIN LACTOBACILLUS AS NUTRACEUTICAL ANTIOXIDANT AGENT

The present study was conducted with the aim to prepare probiotics Lactobacillus acidophilus (L. acidophilus) granules which are stable at room temperature. Lactobacillus acidophilus 2285 probiotics was obtained from the N.C.I.M (National Collection of Industrial Microorganism), Pune. The formation of the semi-solid mass occurred after the further incubation at 34 °C from range (33 °C to 37 °C)...

A. Patil *, S. Pawar and J. Disouza

D. Y. Patil University, Centre for Interdisciplinary Research, Kolhapur, Maharashtra India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1594-99

1594-1599

109

50

30.

GC-MS ANALYSIS AND IN VITRO ANTILEISHMANIAL ACTIVITY OF ETHYLACETATE FRACTION OF ALLIUM CEPA (EAFAC)

In this study, GC-MS analysis shown that ethyl acetate fraction of Allium cepa (EAFAC) (band one) consists of 55 compounds which shown antileishmanial activity. (IC50 73.1 ± 2.1 ug/ml) is the inhibitory concentration which is observed for ethyl acetate fraction of Allium cepa (EAFAC) (band one). Leishmania major is the specie used for this leishmanicidal assay. In this bioassay, Amphotericin B (I...

M. A. Panezai, J. K. Achakzai*, A. M. Kakar, A. K. Tareen, N. Y. Khan, J. Khan, A. Kakar and Samiullah

Institute of Biochemistry, University of Balochistan, Quetta, Pakistan.

DOI: 10.13040/IJPSR.0975-8232.9(4).1600-08

1600-1608

115

58

31.

PREFERRED SAMPLE FOR THYROID PROFILE IN DIABETIC PATIENTS

Hypothyroidism and Hyperthyroidism are the two primary pathological conditions that involve the thyroid gland. Diabetic patients have a higher prevalence of thyroid disorders compared with the normal population. Accurate measurement of thyroid hormone concentrations is the key for proper diagnosis of thyroid gland dysfunction. This article is mainly focused on the effect of food on serum levels of...

D. Abhijith*, K. Pratibha, S. Baliarsingh and V. Vijayakumari

ESIC Medical College and Post Graduate Institute of Medical Science and Research (ESICMC & PGIMSR), Rajajinagara, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1609-12

1609-1612

111

41

32.

KINETIC AND MECHANISTIC STUDIES ON OXIDATION OF DONEPEZIL HYDRO CHLORIDE BY CHLORAMINE – T IN BASIC MEDIUM

Donepezil hydrochloride is United States Food and Drug Administration (USFDA) approved drug marketed under the trade name “Aricept” used for the treatment of mild to moderate alzheimer disease. The aim of the current investigation was Kinetic and mechanistic study of donepezil hydrochloride by sodium-N-chloro-p-tolunesulfonamide or chloramine-T (CAT) in NaOH medium was studied at 308 K. the re...

N. Kallesha*and N. Prasad

Department of Chemistry and Research Center, Vidya Vikas Institute of Engineering & Technology (Affiliated to Visvesvaraya Technological University, Belagavi), Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1613-19

1613-1619

124

62

33.

IN-VITRO ANTI-PROLIFERATIVE ASSAY AND CELL VIABILITY ACTIVITY OF BAICALEIN USING BREAST CANCER CELL LINE

Objective: The flavonoid baicalein, is historically used as an herbal medicine by the Chinese, which produces a wide range of pharmaceutical effects, among which is the potent anticancer activity which has raised a great conflict of interest in the recent years. This study aims to verify the anti-proliferative and the cell viability effects of baicalein on metastasis of MCF-7 human breast cancer c...

V. Jayashree* and N. Thenmozhi

School of Pharmaceutical Sciences, Vels University, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1620-24

1620-1624

797

51

34.

EVALUATION OF HYDROXYL RADICAL SCAVENGING ACTIVITY OF ETHANOLIC EXTRACT OF THYMUS SERPYLLUM

Ethanolic extract of the aerial parts of Thymus serpyllum was evaluated for antioxidant activity. As many diseases in today’s world are due to free radicals, finding antioxidants of herbal origin can lead to development of safe herbal medicines for these diseases. Hydroxyl radical scavenging method was used to evaluate the antioxidant activity of Thymus serpyllum in the present study. The result...

T. Joshi* and V. Juyal

Department of Pharmaceutical Sciences, Kumaun University, Bhimtal, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1625-27

1625-1627

110

58

35.

ANTIMICROBIAL ACTIVITY OF COCONUT SHELL OIL

Coconut shell oil was extracted from raw coconut shells, collected from Thiruvallur District. These were extracted using various solvents based on the polarity which includes ethanol, chloroform, acetone, petroleum ether and aqueous. The antibacterial activity against the growth of Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Salm...

S. D. S. J. Pritha* and S. Karpagam

Department of Botany, Queen Mary’s College, (Autonomous) Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1628-31

1628-1631

555

81

36.

STUDY OF BUCKWHEAT (FAGOPYRUM ESCULENTUM) SEED POWDER AS A TABLET BINDER

Buckwheat has been a major food source in Asian countries such as China, Japan, and Bhutan etc. for its nutritional values. It has been a major functional food supplement for nutraceutical industry. It is the first time exploration of buckwheat seed powder as tablet binder. The aim the study was to expand the area off tablet binders from gums and extracted polysaccharides to whole seed powders so ...

P. Singh*, J. Tayade, V. Shinde, A. F. Ansari, A. Lamkhede and V. Sonawane

Department of Pharmaceutics, Alard College of Pharmacy, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1632-37

1632-1637

359

51

37.

ASSESSMENT OF DRUG USE PATTERN, THEIR COST AND SAFETY IN EMERGENCY DEPARTMENT AT A TERTIARY CARE TEACHING HOSPITAL, RAJKOT

Introduction: The practice of emergency medicine has the primary mission of evaluating, managing and providing treatment to patients with unexpected injury or illness. The emergency department of a tertiary care unit of a developing country is faced with the problem of heavy patient load and a paucity of human and economic resources. So, this study was conducted with the objective of Studying patt...

H. V. Kacha*, S. G. Mundhava and A. R. Kubavat

Department of Pharmacology, P. D. U. Government Medical College, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1638-43

1638-1643

112

49

38.

EFFICACY AND COST OF GRANISETRON VERSUS ONDANSETRON IN THE PREVENTION OF CHEMOTHERAPY INDUCED NAUSEA AND VOMITING AMONG CANCER PATIENTS AT KENYATTA NATIONAL HOSPITAL

Differences in cost and similarities in the efficacy between ondansetron and granisetron have been reported in many clinical studies and prompted this study to determine whether such differences are important as Kenyatta National Hospital. Thirty-four adult cancer patients scheduled to start their consecutive three weekly cycles of cisplatin-based chemotherapy regimens, were recruited into a doubl...

M. Innocent * , P. N. Karimi, D. G. Nyamu and I. S. O. Maranga

Rwanda Military Hospital, Rwanda.

DOI: 10.13040/IJPSR.0975-8232.9(4).1644-49

1644-1649

146

52

39.

ANTIBACTERIAL ACTIVITY OF HEXANIC EXTRACT OF RUTA GRAVEOLENS ON KLEBSIELLA PNEUMONIAE- A COMMON POST- ORTHOPEDIC SURGERY INFECTION

Introduction: Klebsiella pneumoniae is one of the most frequent infection organism following orthopedic surgeries and specifically total hip arthroplasty. Recently, attitude toward herbal medicine is being popular both in people and health care systems. Ruta graveolens is a traditional herbal remedy Iranian medicine and some other countries with a wide spectrum of therapeutic utilities. Our purpos...

A. Taheriazam, A. Saeidinia and F. Keihanian*

Cardiology Department, Imam Reza and Ghaem Hospitals, Mashhad, Iran.

DOI: 10.13040/IJPSR.0975-8232.9(4).1650-53

1650-1653

112

55

40.

THE EFFECT OF QUINCE PASTE ON MENORRHAGIA: A CLINICAL STUDY

Introduction: Menorrhagia that means excessive uterine bleeding is one the most common reasons that women refer to gynecological centers. Despite the use of "Quince paste" in Iranian Traditional Medicine (ITM) clinics, no studies have been done in this regard. Objectives: This study was carried out to investigate the effect of "Quince paste" on uterine bleeding in patients with menorrhagia. Materi...

M. Bahman, A. Mirahi, H. Hajimehdipoor and M. Tansaz*

Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

DOI: 10.13040/IJPSR.0975-8232.9(4).1654-59

1654-1659

1045

66

41.

CHARACTERIZATION AND QUANTIFICATION OF ETHYLHEXYLGLYCERIN

Ethylhexylglycerin is an alkyl glyceryl ether. This means that the ethyl hexyl group is bound to glycerin at one end by an ether linkage. it has been used as a common ingredient in bath products, body and hand products, cleansing products, deodorants, eye makeup, foundations, hair care products and suntan products. The compound is synthesized by esterfication of 2-Ethylhexanol and epichlorohydrin,...

R. Arla *, J. S. Rao and K. Koumaravelou

Department of Pharmacy, Prist University, Thanjavur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1660-65

1660-1665

120

48

42.

METAL COMPLEXES OF RIBAVIRIN; SYNTHESIS, CHARACTERIZATION AND IN-VITRO BIOLOGICAL SCREENING

Medicinal applications of metals and its compound were reported centuries ago but it gained huge appreciation after the discovery of anticancer activity of metal based drug cisplatin. After cisplatin discovery many medicinal synthetic chemist moved into the field of organometallics for combating diseases and investigating the excellent pharmaceutical potential of metal complexes, giving birth to m...

S. Akhtar *, M. A. Khan, K. Shahid and H. Akhtar

Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan.

DOI: 10.13040/IJPSR.0975-8232.9(4).1666-72

1666-1672

117

65

43.

ANTI-HYPERGLYCEMIC AND ANTIOXIDANT ACTION OF AZADIRACHTA INDICA LEAF IN ALLOXAN INDUCED TYPE-I DIABETES MELLITUS IN EXPERIMENTAL DIABETIC SWISS ALBINO MICE: A HISTOPATHOLOGICAL INVESTIGATION

Objective: To attenuates hyperglycemia-mediated oxidative stress and protects liver marker enzymes in Swiss albino mice. Material and methods: Hyperglycemia was induced in mice by single intraperitoneal injection of alloxan (150 mg/kg body weight). Three days after alloxan induction, the hyperglycemic mice were treated with Azadirachta indica orally at the dose of 200 and 400 mg/kg body weight dai...

V. Kumar, S. Ranjan, V. Akhouri, M. S. Siddiqui and B. Sharma*

School of Science, Suresh Gyan Vihar University, Jagatpura, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1673-82

1673-1682

133

55

44.

SIMULTANEOUS ESTIMATION OF TELMISARTAN, HYDROCHLORTHIAZIDE AND AMLODIPINE IN BULK AND SOLID DOSAGE FORM BY CHEMOMETRIC ASSISTED SPECTROPHOTOMETRIC METHODS

Chemometric designs were applied to develop a simple UV-visible spectroscopic method for the simultaneous estimation of Hydrochlorthiazide (HCT), Amlodipine (AMLO) and Telmisartan (TEL) in bulk and solid dosage form. The simultaneous spectroscopic method was developed for the three drugs and the data generated from the spectra were determined by using Chemometric methods such as trilinear regressi...

S. Yarramsetti *, A. E. Prabahar, P. S. Geervani and R. R. Nadendla

Department of Pharmaceutical Analysis, Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1683-91

1683-1691

100

63

45.

FORMULATION AND EVALUATION OF TRAMADOL HYDROCHLORIDE ORAL THIN FILMS

Oral films are a novel approach for the development of orally disintegrating dosage forms. They are thin, elegant in appearance and can be made into various sizes and shapes like rectangular or circular. The strips may be flexible or brittle, opaque or transparent. Oral films are made up of various hydrophilic and hydrophobic polymers to provide rapid disintegration on the tongue without the need ...

A. V. Murthy *, L. U. Ayalasomayajula, R. R. Earle and P. Jyotsna

Department of Pharmaceutical Technology, Maharajah’s College of Pharmacy, Vizianagaram , Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1692-98

1692-1698

99

47

46.

PHARMACOLOGICAL ACTIVITY OF ETHANOLIC EXTRACT LEPIDIUM SATIVUM LINN. SEEDS ON THYROID HORMONES IN MALE RATS

Pharmacological activities have been reported for the seed extracts of Lepidium sativum L.; however, the plant has not been widely studied for its effects on the thyroid gland. Objective: The present study was designed to investigate to possible potential pharmacological activity of ethanolic extract of Lepidium sativum L. seeds on regulation of thyroid hormone concentrations in male rats. Methodo...

R. Sciarrillo*, M. Guarino and C. Guarino

Department of Science and Technology, University of Sannio, Benevento, Italy.

DOI: 10.13040/IJPSR.0975-8232.9(4).1699-04

1699-1704

796

44

47.

A VALIDATED STABILITY INDICATING RP – HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF METFORMIN AND TENELIGLIPTIN IN BULK AND PHARMACEUTICAL DOSAGE FORM

This is a simple, economic, sensitive stability indicating RP-HPLC method for the simultaneous estimation of metformin and teneligliptin in bulk and pharmaceutical formulation. The method was carried out on octa-decyl C18 column (5 μm, 25 cm × 4.6 mm, i.d) using methanol: water in the ratio of 70:30 and pH of the mobile phase up to 3 was adjusted with OPA at a flow rate of 1.0 ml/min. The wavele...

A. R. Shaikh *, B. A. R. K. Ahmed and M. Ibrahim

M.C.E. Society’s Allana College of Pharmacy, Azam Campus, Camp, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.9(4).1705-12

1705-1712

6

2