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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2018): 0.83 , CiteScore (2017): 0.27
Five-Year Projected Impact Factor: 1.81

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Volume 10 (2019) - Issue 8, August

Review Articles

 
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1.

NANOCARRIERS AS DELIVERY SYSTEMS FOR THERAPEUTICS AGENTS

Nanotechnology is emerging as a field in pharmacy and medicine that is expected to elicit significant therapeutic benefits especially in the field of drug targeting. The development of effective nanocarriers capable of carrying therapeutic agents specifically and safely to a desired site of action is one of the most challenging tasks facing drug formulation researchers. Serious research attemp...

F. H. Farah

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates.

DOI: 10.13040/IJPSR.0975-8232.10(8).3487-07

3487-3507

592

536

2.

THERAPEUTIC APPLICATIONS OF MUSHROOMS AND ITS COMPOSITIONAL ANALYSIS BY HIGH THROUGHPUT SCREENING TECHNIQUES

Mushrooms can be considered as a prolific resource for drugs as per previous literature surveys. Their constituent bioactive components are broadly classified such as phenols, flavonoids, triterpenoids, saponins. Whole mushrooms or mainly fruiting bodies extracts and compounds isolated from their mycelium are of immense pharmacological importance. Extraction employing suitable solvents leads to th...

D. Chatterjee *, S. Das and D. Halder

Department of Food Technology and Biochemical Engineering, Jadavpur University, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3508-18

3508-3518

498

279

3.

BISPHENOL- A INDUCED OXIDATIVE STRESS AND ITS FERTILITY ASPECTS

Bisphenol-A (BPA), 2,2-bis(4-hydroxyphenyl) propane is an emerging environmental toxicant with endocrine disrupting properties and toxic effects on living organisms. BPA is ubiquitously present in consumer products current in our daily lives. As it is released from consumer products and deposited in the environment, thus creating the potential for human exposure through oral, inhaled, and dermal r...

M. Sharma, R. Sharma, P. Gupta and S. Srivastava *

Department of Zoology, Reproductive Physiology Lab, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3519-31

3519-3531

380

187

4.

AN OVERVIEW OF THERAPEUTIC POTENTIAL OF THYMOQUINONE

Herbal medication has attracted much attention in recent years and is being used as an alternative to chemical medicines. Some evidence supports the positive effects of medicinal plants in the prevention and treatment of different types of diseases. Thymoquinone (TQ) is the most abundant component of Nigella sativa seeds, and most of the properties of Nigella sativa are attributed primarily to TQ....

S. Agarwal, R. Srivastava and N. Mishra *

Food and Nutrition, Department of Home Science, University of Allahabad, Allahabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3532-39

3532-3539

350

176

5.

A REVIEW OF PHARMACOLOGICAL ACTIVITY OF MARINE ALGAE IN INDIAN COAST

Indian coastline stretches about 5700 km covering 9 states on the mainland and about 7500 km including islands and union territories. Seaweeds, a renewable natural resource, found growing in large quantities along the Indian coast. Seaweeds are currently worldwide interest in finding new and safe promising organisms for health. It is one of the important essential producers of biomass in the marin...

A. Sharma *, R. Koneri and D. K. Jha

Department of Pharmacology, Karnataka College of Pharmacy, Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3540-49

3540-3549

391

164

6.

GREEN SYNTHESIS: A NOVEL APPROACH FOR NANOPARTICLES SYNTHESIS

There are different types of conventional approaches are used for the synthesis of nanoparticles like physical and chemical techniques. But above approaches used for nanoparticles synthesis is not eco-friendly due to the production of toxic compounds during nanoparticles formation. Therefore, interest in the green synthesis of nanoparticles has been increased. The green synthesis of nanoparticles ...

R. S. Sandhu, R. P. Aharwal and S. Kumar *

Faculty of Bio-Design Innovation Centre, Rani Durgavati University, Saraswati Vihar, Pachpedi, Jabalpur, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3550-62

3550-3562

210

74

7.

POLYELECTROLYTE COMPLEXATION AND IONOTROPIC GELLATION: THE POTENTIAL NOVEL APPROACH TO DESIGN HYDROGEL PARTICULATE FOR SUSTAINED, MODULATED DRUG DELIVERY SYSTEM: A REVIEW

The interest in using natural and chemically modified polysaccharides as a part of drug development has increased in the past two decades. For potential carriers in controlled, modulated drug delivery, great interest has also been focused on biopolymer-based hydrogels. Due to their advantages like biocompatibility, biodegradability, and low cost, biopolymers have been widely used in the developmen...

W. Akram *, R. Joshi and N. Garud

School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3563-74

3563-3574

163

51

8.

NEBULIZED DRUG DELIVERY: AN OVERVIEW

Inhaled Pharmacological therapy is key to treatments for patients with asthma and COPD. People who suffered from COPD died every year in low- and middle-income countries. The primary reason for COPD is tobacco smoking or second-hand smoke. Another risk factor is air pollution, dust, and fumes. Current guidelines endorsed inhaled pharmacology therapy as the favorable route of administration for tre...

S. Prajapati, S. Saha, C. D. Kumar and B. Sahoo*

Orbicular Pharmaceutical Technologies Pvt. Ltd., Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3575-82

3575-3582

170

52

9.

COSTUS IGNEUS – A THERAPEUTIC ANTI-DIABETIC HERB WITH ACTIVE PHYTOCONSTITUTENTS

Objective: Diabetes mellitus is an interminable metabolic disorder that has highly affected human health and quality of life. Conventional agents are being applied to control this disorder along with lifestyle management. But they are not totally effective and nobody has ever been diagnosed with full recovery of diabetes. Medicinal plants have been used for greater extent for control of diabetes m...

S. Laha and S. Paul *

Laboratory of Cell & Molecular Biology, Department of Botany, University of Calcutta, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3583-91

3583-3591

155

47

10.

PHARMACOLOGICAL SIGNIFICANCE OF MEDICINAL HERB ECLIPTA ALBA L. – A REVIEW

Though conventional medicines are slow in action, they represent safety in contrast to the synthetics that are regarded as somewhat unsafe to human and environment. The uses of many traditional herbs in the treatment of many diseases, which are usually free from side effects, are economical and also easily accessible to humans. Plants have formed the basis of sophisticated traditional medicine sys...

A. C. Udayashankar *, M. Nandhini, S. B. Rajini and H. S. Prakash

Department of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3592-06

3592-3606

151

41

11.

IMMEDIATE RELEASE TABLETS: A REVIEW

The scenario of pharmaceutical drug delivery are expeditiously challenging, but conventional pharmaceutical dosage forms are still dominating. Immediate release dosage forms are those wherein ≥85% of labeled amount dissolves within 30 min. Superdisintegrants are used to improve the efficacy of solid dosage forms. The basic approach used in the formulation of the tablet is the use of superdisinte...

N. Sharma *, S. Pahuja and N. Sharma

Swami Vivekanand College of Pharmacy, Banur, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3607-18

3607-3618

149

53

12.

POTENTIAL HERBS AGAINST DIABETES MELLITUS – AN UPDATE

Diabetes or Madhumeha as per Ayurveda is a disease in which there is improper functioning of insulin and as a result, the sugar level in the blood increases. Diabetes may cause heart problem, kidney failure, blurred vision if not treated timely with proper medication. Medicinal plants have been used since ancient times for the treatment and management of diabetic mellitus (DM) in traditional medi...

S. Singh *, A. Mazumder and G. S. Chakaraborthy

Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3619-26

3619-3626

145

61

13.

FLAVONOIDS AS COMPLEMENTARY AND ALTERNATIVE TREATMENT OPTIONS FOR DIABETES MELLITUS

Diabetes is a metabolic disorder, which is characterized by insulin deficiency, insulin resistance, and aberrant metabolism in glucose, protein, and lipid. The primary causes of diabetes are Genetic and environmental factors. Diabetes is a chronic progressive disease that leads to both microvascular and macrovascular complications. This disease affects around 5% of the world population now. But, r...

S. Jain * and G. Joshi

Ambe Durga Education Society’s Dadasaheb Balpande College of Pharmacy (DBCOP), Near Swami Samarth Mandir, Besa, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3627-34

3627-3634

108

44

14.

A SURVEY ON ANTICANCER PROPERTIES OF INDIAN MEDICINAL PLANTS – A BROAD SPECTRUM ANALYSIS

Several plants across the world possess specific therapeutic and diagnostic properties. The identification of the properties among them is the most difficult task. Several researchers have used several methodologies to express the therapeutic properties in the plants. The interest of scientists among the anticancer studies has been increasing widely as cancer has become one of the deadliest diseas...

K. Saranya, V. Manivasagan, R. Kanakadurga, V. P. M. Babu * and N. G. R. Babu

Department of Biotechnology, Adhiyamaan College of Engineering (Autonomous), Hosur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3635-40

3635-3640

149

45

15.

RELEVANCE OF GREEN CHEMISTRY 12 PRINCIPLES IN ORGANIC SYNTHESIS

Green chemistry or sustainable chemistry focuses on designing products and processes that minimize the generation or use of hazardous substances. Green chemistry, though not a new area, has recently gained much importance because of increasing environmental concerns. Industries now focus on adopting processes which are mainly non- hazardous, easier to undertake, lesser energy and time consuming, ...

A. Kulshrestha and J. Pandey *

Department of Chemistry, Amity University Uttar Pradesh, Lucknow Campus, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3641-47

3641-3647

118

49

16.

EXPERIMENTAL MODELS TO STUDY TUMOUR ANGIOGENESIS – IN-VITRO, EX-VIVO AND IN-VIVO APPROACH

Angiogenesis is the formation of new blood vessels from preexisting vasculature. It is a key process in some physiological conditions such as wound healing, growth and reproduction. Any disturbance in mechanisms of angiogenesis plays a key role in the pathogenesis of some diseases through the over-proliferation of blood vessels such as cancers, psoriasis, arthritis, retinopathies, obesity, asthma,...

K. A. Janani, T. K. Praveen and A. Wadhwani *

Department of Pharmaceutical Biotechnology, JSS Academy of Higher Education & Research - JSS College of Pharmacy, Ooty, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3648-59

3648-3659

154

65

Research Articles

 
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17.

CHEMICAL COMPOSITION AND ANTIBACTERIAL ACTIVITY OF MEDICINALLY USEFUL ESSENTIAL OIL FROM THE INFLORESCENCE OF EUPHORBIA HELIOSCOPIA L. GROWN IN EGYPT

The genus Euphorbia has about 2000 members making it one of the largest ones among the flowering plants. Euphorbia helioscopia L. As the chemical composition of the essential oil from Euphorbia helioscopia developed in Egypt has not yet been explored, along these lines the present to extricate the essential oil and investigate the oil chemical composition and antimicrobial activity. Essential oil ...

A. M. Beltagy

Department of Pharmacognosy, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.

DOI: 10.13040/IJPSR.0975-8232.10(8).3660-67

3660-3667

405

209

18.

LESS TOXIC NANOPARTICLES OF PLATINUM BASED ANTI-CANCER DRUG

Objectives: The objective of this research was dose reduction and toxicity reduction. Dose reduction: various anti-cancer drugs are very costly, and their high dose increases cost. If bioavailability is enhanced, the dose shall be reduced thereby; the cost will also decrease. Dose reduction will also reduce toxicity, and the preparation will become more tolerable. Method: In this study, the nanopa...

V. Deva *, S. Singh and M. M. Abdullaha

Dr. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3668-83

3668-3683

368

145

19.

THE INFLUENCE OF ETHANOL EXTRACTS OF RAMBUTAN LEAVES (NEPHELIUM LAPPACEUM L.) AGAINST OBESITY AND INSULIN RESISTANCE IN RATS

Ethanol extracts of rambutan leaves have been investigated for their anti-diabetes properties using the glucose tolerance method as well as insulin deficiency through alloxan induction. This study aimed to further evaluate these properties in obese and insulin resistant animals. The rat models were feeding with foods high in carbohydrates, fats, and propylthiouracil. The animal models were divided...

E. Susilawati *, I. K. Sukmawati, Noranisa, N. S. Hayati and W. Aligita

Department of Pharmacology, Bandung School of Pharmacy, Bandung, West Java, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.10(8).3684-90

3684-3690

352

176

20.

PHYTOCHEMICAL SCREENING AND ANTINOCICEPTIVE ACTIVITY OF MIMOSA DIPLOTRICHA LEAVES

Though possessing a lot of ethnopharmacological use, Mimosa diplotricha did not explore thoroughly for its bioactivity & the phytoconstituents responsible for its bioactivity. The purpose of the current work was to conduct phytochemical screening and antinociceptive activity of methanolic extract and its different fractions of Mimosa diplotricha leaves. Phytochemical screening of methanolic ex...

J. Naima, M. R. Islam, N. M. Proma, S. R. Afrin, M. R. Hossain and M. K. Hossain *

Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.10(8).3691-96

3691-3696

419

181

21.

FORMULATION AND EVALUATION OF ORODISPERSIBLE DOSAGE FORMS INCORPORATING DRUG NANOPARTICLES CONTAINING CLOPIDOGREL BISULPHATE

Clopidogrel bisulphate (CB) is the rate of dissolution often controls a sparingly soluble orally administered drug and the rate of absorption. Reports suggest that the drug has poor water solubility which may be challenging for developing liquid dosage forms of Clopidogrel bisulphate. Hence in the present study, we sought to develop orodispersible nanoparticles to enhance the solubility by an anti...

A. D. Paul *, K. Kavitha, P. Sharma and B. Srivastava

School of Pharmaceutical Sciences, Jaipur National University, Rajasthan, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3697-14

3697-3714

418

169

22.

MICROSCOPIC CHARACTERISATION OF ROOT, STEM AND LEAVES OF AN UNRESOLVED SPECIES: RUBUS INDICUS (ROSACEAE)

The genus, Rubus is considered as highly potent plant crop and possesses economical, medicinal and ecological importance. Rubus plant species have been utilized inbreeding programme and has identified various pharmaceutical compounds. However, the taxonomy of the genus Rubus has been in a state of flux, because of the absence of comprehensive work and associated taxonomic disputes. Among the genus...

B. Narayanan *, H. C. Mana and U. B. Thara

Research and Development Centre, Bharathiar University, Coimbatore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3715-20

3715-3720

136

37

23.

IMMUNOMODULATING, ANTI-BACTERIAL AND ANTI-CANCER POTENTIAL OF ZA’ATAR (THYMUS VULGARIS) AND ITS COMBINATION WITH ESSENTIAL OIL (OLIVE AND BALSAM OIL)

Introduction: Thymus vulgaris (za’atar) is one of the most famous and traditional spices of Arab countries. Extracts of Thymus vulgaris (zatar) found to be useful as traditional medicine. The current studies are aiming to further explore the phytoconstituents of Thymus vulgaris and its biological activity. Methodology: The present study investigated the phytochemical constituent of za’atar and...

S. Soomro *, V. R. Chidrawar, M. Imran and H. O. Alshammari

Department of Basic Health Sciences, Faculty of Pharmacy, Northern Border University Rafha, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.10(8).3721-26

3721-3726

119

40

24.

IN-VITRO TRANSPORT EVALUATION OF GARCINIA MANGOSTANA L. PERICARP EXTRACT LOADED CREAM AND GEL

Garcinia mangostana L. pericarp (GMP) has been known as a traditional medicine in Asian countries. The bioactive from GMP has been recognized to be related to complex phenolic compounds linked with free radical scavenging activity. This research aimed to study the effects of topical formulation types (gel, oil in water cream and water in oil cream) of GMP extract on the in-vitro release and in-vit...

R. Kuswahyuning *, N. Yuniarti, I. Lesmana and N. Fadhilah

Faculty of Pharmacy, University of Gadjah Mada, Yogyakarta, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.10(8).3727-34

3727-3734

107

47

25.

DESIGN, SYNTHESIS AND COMPARATIVE PHARMACOLOGICAL ASSESSMENT OF NOVEL FLUOROQUINOLONE DERIVATIVES

One of the proposed groupings of the fluoroquinolones describes the excellent broad-spectrum activity forms an invaluable part of the present anti-infective armory of the clinicians. The fluoroquinolones are most significant weapons can be credited for saving more human lives than any other area of medicinal therapy. In this current research segment, the novel C-3 substituted fluoroquinolone scaff...

P. P. Majalekar *, P. K. Shirote, V. Nalawade and P. Shelake

Department of Pharmaceutical Chemistry, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3735-40

3735-3740

104

47

26.

SYNTHESIS AND ANTIBACTERIAL SCREENING OF SCHIFF BASES DERIVED FROM 3-(5-BROMOTHIOPHEN-2-YL)-1-(4-CHLOROPHENYL)-1H-PYRAZOLE-4-CARBALDEHYDE

A series of new Schiff bases were synthesized by condensation of 3-(5-bromothiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde with different aromatic aldehydes. The 3-(5-bromothiophen-2-yl)-1-(4-chlorophenyl)-1H-pyrazole-4-carbaldehyde was prepared from 1-(1-(5-bromothiophen-2-yl)ethylidene)-2-(4-chlorophenyl)hydrazine by the Vilsmeier Haack reaction. The 1-(1-(5-bromothiophen-2-yl)ethyl...

S. V. Manohare * and S. S. Thakare

Department of Chemistry, Adarsha Science, J. B. Arts, and Birla Commerce Mahavidyalaya, Dhamangaon Rly, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3741-45

3741-3745

127

43

27.

FORMULATION AND IN-VITRO CHARACTERIZATION OF 5-FLUOROURACIL AND FLAVONOID DUAL LIPID DRUG CONJUGATES LOADED SELF NANOMULSIFYING DRUG DELIVERY SYSTEM FOR CANCER TARGETING

Objective: The Failure in chemotherapy is mainly because of the resistance of the chemotherapeutic drugs towards the neoplastic cells. The main reason behind this study was to develop a novel combination of 5-Fluorouracil (5-FU) lipid curcumin conjugates for the treatment of cancer. Methods: In this study, the lipid group stearic acid and oleic acid was conjugated with the parent drug moiety 5-Flu...

C. Karthika and R. Sureshkumar *

Department of Pharmaceutics, JSS College of Pharmacy, Ootacamund, (Affiliated to JSS Academy of Higher Education and Research, Mysuru, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3746-54

3746-3754

120

36

28.

EVALUATION OF EFFECT OF AYURVEDIC PREPARATIONS ON NEPHROPATHY IN DIABETIC WISTAR RATS

Introduction: Type 2 diabetes, which is the most common type, is often a result of excess body weight and physical inactivity in genetically predisposed individuals. Over due course of time diabetes can cause blindness, kidney damage, neurological problems, and coronary artery disease. Improvement in glycemic control is important factors in delaying the onset and progression of diabetes-related co...

M. S. Bhosale, J. S. Dawane, V. A. Pandit * and P. S. Khatavkar

Department of Pharmacology, Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3755-62

3755-3762

106

38

29.

ISOLATION AND STRUCTURAL ELUCIDATION OF DEGRADATION PRODUCTS OF RANOLAZINE

Degradation studies are important to know the potentials degradation products and to develop a stability indicating method. Ranolazine active pharmaceutical ingredients subjected to in detailed forced degradation study using several stressing agents (HCl, NaOH, H2O2). Degradation products of Ranolazine under hydrolytic and oxidative stress conditions were identified, and their stabilities were ass...

S. Guduru, V. V. S. R. N. A. K. Mutha, B. Vijayabhaskar, J. Narkedimilli, M. Kaliyaperumal, R. B. Korupolu, K. B. Bonige and C. S. Rumalla *

Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd., IDA Mallapur, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3763-69

3763-3769

120

59

30.

PHYTOCHEMICAL SCREENING, POLYPHENOLS CONTENT AND A NOVEL SOURCE OF ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF ESSENTIAL OIL OF LAURUS NOBILIS FROM MOROCCO

Bacterial resistance and oxidative stress are an important etiology of chronic diseases. This is the reason why new alternatives were established to overcome the incidence of some pathologies. Thus, the present study was aimed to evaluate the antibacterial activity of the extracted oil against bacteria that causes nosocomial infections in neonatal intensive care by using disc diffusion method. The...

A. Taroq *, F. E. Kamari, I. Aouam, Y. E. Atki, B. Lyoussi and A. Abdellaoui

Laboratory of Physiology Pharmacology and Environmental Health, Department of Biology, Faculty of Sciences Dhar Mehraz, University Sidi Mohamed Ben Abdellah, Atlas, Fez, Morocco.

DOI: 10.13040/IJPSR.0975-8232.10(8).3770-76

3770-3776

110

43

31.

QUANTITATIVE SIMULTANEOUS ESTIMATION OF ASPIRIN AND OMEPRAZOLE BY RP-HPLC METHOD IMPLEMENTING AQbD APPROACH IN PHARMACEUTICAL DOSAGE FORM

A simple, accurate, rapid and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Aspirin (ASP) and Omeprazole (OMP). By using box benchen design method have been developed and optimized. Effective chromatographic separation achieved using C18 column (250 × 4.6 mm, 5 µm) as a stationary phase and mobile phase consisted of ...

C. Chandarana * and P. Kapupara

Department of Quality Assurance, School of Pharmacy, RK University, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3777-84

3777-3784

138

44

32.

POTENTIAL ANTIBACTERIAL AND ANTIOXIDANT PROPERTIES OF AQUEOUS, ETHANOL AND METHANOL EXTRACTS OF TECTARIA MACRODONTA C. CHR

Tectaria macrodonta C. Chr. locally known as Kaali negro in Sikkim is a rhizome and spore-bearing terrestrial fern, traditionally used in folk medicine. In the present study, the aqueous, ethanol and methanol extracts of the rhizomes of Tectaria macrodonta C. Chr were evaluated for its potential antibacterial and antioxidant properties. The phytochemical analyses of different solvent extracts were...

B. Poudyali * and B. Singh

Department of Microbiology, School of Life Sciences, Sikkim University, Gangtok, Sikkim, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3785-94

3785-3794

105

36

33.

THE POTENTIAL ROLE OF FLAVONOIDS IN THE CONTROL OF OXIDATIVE STRESS FOR TYPE II DIABETES

Introduction: Antioxidant properties of flavonoids may guard against oxidative damage to cells, DNA, or lipids. The ample literature about flavonoids can affirm the structural and pharmacological cherishing of this class of phytochemicals. The presence of aromatic rings in the flavonoid molecule consent the receiving and donation of electrons from free radical species, which abets to curb the free...

S. R. Nelli *, N. K. Sharma, P. M. Kumar and S. S. Singh

Cancer and Translational Research Lab, Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3795-99

3795-3799

98

34

34.

SELECTIVE ISOLATION AND CHARACTERIZATION OF NOCARDIOPSIS FLAVESCENS VJMS-18 FROM COASTAL REGIONS OF ANDHRA PRADESH, INDIA

Objective: To evaluate the antimicrobial potential of Nocardiopsis flavescens isolated from the marine environment. Methods: Attempts were made to isolate actinomycete strains from marine coastal regions of Andhra Pradesh, India. The soil samples collected were pre-treated with calcium carbonate, diluted and plated on three different media to isolate actinomycetes. All the isolates were screened f...

M. S. Mogili and V. Muvva *

Department of Botany and Microbiology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3800-07

3800-3807

108

33

35.

COMPATIBILITY STUDIES BETWEEN PACLITAXEL AND EXCIPIENTS IN THE PREFORMULATION PHASE OF NANOCRYSTAL FORMULATION

Paclitaxel is one of the best anti-cancer drugs and recently known as the best anti-cancer products of natural origin. The purpose of the present work was to study the physicochemical properties and compatibility of paclitaxel with the selected surfactants employed in nanocrystal formulations. The melting point and loss on drying of paclitaxel were found 216 °C and 0.11% respectively. A log P val...

A. Gannimitta, P. Srinivas, A. V. Reddy and S. Pedireddi *

Vijaya College of Pharmacy, Munaganoor, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3808-15

3808-3815

115

34

36.

SURFACE MODIFICATION AND NON-COVALENT FUNCTIONALIZATION OF SINGLE-WALLED CARBON NANOTUBES AND THEIR CHARACTERIZATION

Single-walled carbon nanotubes (SWNTs) though emerged as a promising material for delivery of biomolecules into various cells, due to their high cytotoxicity, they are limited in use in many biological systems and also in humans. The present research explores the preparation of functionalized SWNTs of low cytotoxicity and biocompatibility by altering the size and surface functionalization. Noncova...

K. N. Lalitha, G. K. Mohan and A. Uma *

Centre for Biotechnology, Institute of Science and Technology (Autonomous), Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3816-24

3816-3824

120

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37.

ANTIBACTERIAL ACTIVITY OF NIGELLA SATIVA EXTRACTS AGAINST EXTENDED SPECTRUM Β-LACTAMASE PRODUCING ESCHERICHIA COLI ISOLATES

The most striking feature of natural products in connection to their long-lasting importance in drug discovery is their structural diversity that is still largely untapped. Most natural products are not only sterically more complex than synthetic compounds but also differ in regards to the statistical distribution of functionalities. The chemical diversity and unique biological activities of a wid...

W. Parveen * and A. Subhashini

Department of Plant Biology and Plant Biotechnology, Quaid-E-Millath Government College for Women, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3825-30

3825-3830

123

33

38.

DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF VINBLASTINE SULFATE AND MOXIFLOXACIN HYDROCHLORIDE

Objective: To develop a simple, accurate and precise method for the simultaneous estimation of Moxifloxacin hydrochloride (MOX) and Vinblastine sulfate (VIN). Methods: The normal spectrum of VIN and MOX were converted to its second derivative spectrum and the amplitude minima of VIN and MOX were measured at 214 nm and 297 nm, respectively. MOX and VIN solution were simultaneously determined in 0.1...

N. Pradhan *, H. Giri, H. Rajkhowa and B. Shrestha

Department of Pharmaceutical Analysis and Quality Assurance, Himalayan Pharmacy Institute, Majhitar, Sikkim, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3831-36

3831-3836

105

33

39.

ANTIOXIDANT POTENTIAL, TOTAL PHENOLIC AND FLAVONOID CONTENT OF ROOTS OF SEVEN ASPARAGUS SPECIES FROM NORTH-WEST INDIA

The aim of current study was to compare the total phenolic content (TPC), total flavonoid content (TFC) and antioxidant activity of roots of seven Asparagus species from North-West India. Total phenolic content measured by Folin-Ciocalteu method ranged from 3.85 ± 0.25 (A. racemosus) to 7.74 ± 0.03 (A. falcatus), 3.42 ± 0.14 (A. racemosus) to 7.22 ± 0.12 (A. falcatus) and 1.12 ± 0.13 (A. offi...

M. Kapoor, P. Mawal * and R. C. Gupta

Department of Botany, Punjabi University, Patiala, Punjab, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3837-42

3837-3842

103

43

40.

INFLUENCE OF PIOGLITAZONE ON IMMUNOMODULATORY ACTIVITY OF AZATHIOPRINE IN RODENT MODELS

The present study was designed to investigate the antioxidant and immunomodulatory activity of Azathioprine-Pioglitazone combination therapy to check whether it has added on benefit over monotherapy with Azathioprine or Pioglitazone in rodent models. The test drugs in combination showed better inhibition of free radicals in both H2O2 radical scavenging assay and nitric oxide scavenging assay than ...

P. V. Babu *, V. Soundarya and M. G. Raju

Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3843-49

3843-3849

112

31

41.

SYNTHESIS AND SCREENING N-(2, 4′-DIOXO-1, 2-DIHYDRO-3’H-SPIRO [INDOLE-3, 2′-[1,3]THIAZOLIDIN]-3′-YL)-2-HYDROXYBENZAMIDES FOR ANTI-BACTERIAL ACTIVITY

A novel synthesis of N-(2, 4'-dioxo-1, 2-dihydro-3'H-spiro [indole-3, 2'-[1, 3] thiazolidin]-3'-yl)-2 -hydroxybenzamide derivatives were synthesized by cyclization of isatin hydrazones with thioglycolic acid. The synthesized compounds were characterized by spectral data (IR, 1H-NMR, Mass) and evaluated for antibacterial activity against various strains of bacteria at the concentrations of 200 µg/...

N. S. Devi *, B. Srinivas and M. Sarangapani

Medicinal Chemistry Division, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3850-55

3850-3855

137

38

42.

IN-VITRO ANTIDIABETIC ACTIVITY OF 2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-4H-CHROMEN-4-ONE ISOLATED FROM THE METHANOLIC EXTRACT OF ANDROGRAPHIS ECHIOIDES LEAVES

In the present study the 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one  isolated from the methanolic extract of leaves of Andrographis echioides was studied for alpha-amylase and alpha-glucosidase inhibition using an in-vitro model. The isolation was done using column chromatography using gradient elution with different mobile phase. Structural elucidation was carried out on the basis...

S. Gurupriya *, L. Cathrine and P. Pratheema

P. G. and Research Department of Chemistry, Holy Cross College, Tiruchirappalli, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3856-64

3856-3864

104

60

43.

QUALITY CONTROL, CHEMICAL COMPOSITION AND ANTIOXIDANT ACTIVITY OF SOME MARKETED PEPPERMINT OIL SAMPLES

This work aimed to evaluate the quality of some commercial peppermint oil products available in the Egyptian market. Also, analysis of peppermint oil extracted from Mentha piperita L. leaves marketed in Egypt. Thus, quality control of both herb extracted and purchased oil products. Essential oils were analyzed using GC/MS, and the main ingredients of each peppermint oil sample were quantified. The...

A. M. Beltagy * and D. M. Beltagy

Department of Pharmacognosy, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.

DOI: 10.13040/IJPSR.0975-8232.10(8).3865-72

3865-3872

126

38

44.

FORMULATION AND IN-VITRO EVALUATION OF MUCOADHESION AND FLOATING MICROSPHERES OF ETODOLAC USING IONIC GELATION METHOD

The purpose of this study is to formulation and evaluation of floating and mucoadhesion microspheres of etodolac using ionic gelation method. The floating and mucoadhesion microspheres were studied for micromeritic properties were found to be within limits. The percentage yield of floating microsphere formulation F1 to F6 and mucoadhesive microspheres M1 to M3 were in the range of 77.14 ± 0.64 to...

R. S. Sura

Department of Pharmacy, University of Technology, Osmania University, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3873-82

3873-3882

151

38

45.

PHYSICOCHEMICAL CHARACTERIZATION OF 99mTECHNITIUM – LUTEOLIN AS RADIOPHARMACEUTICAL PREPARATION FOR ANTIOXIDANT COMPOUND

The objective of this study was to formulate luteolin with radioisotope Technetium-99m (99mTc) to be 99mTc-Luteolin as an antioxidant compound. After optimization, this radiopharmaceutical preparation should be examined for its physicochemical characteristics, such as radiochemical purity, stability, lipophilicity, protein plasma binding, electronic charge, and stability test. The formulation was ...

D. Ramdhani, M. E. Sriyani and R. Mustarichie *

Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.10(8).3883-90

3883-3890

94

37

46.

FORMULATION AND EVALUATION OF MOXIFLOXACIN MICROSPHERES IMPLANT FOR INTRA-PERIODONTAL POCKETS

Periodontal disease is one of the most prevalent oral diseases is caused by the gram-negative bacterial infection of periodontal pocket identified by inflammation of subgingival plaque and degeneration of alveolar bones, teeth, dental cementum, and periodontal ligaments. 80% of American adult and more than 50% of the Indian community suffers from this chronic inflammatory infection depicting the s...

R. Maurya *, M. P. Singh and K. M. Kymonil

Department of Pharmaceutics, School of Pharmacy, Babu Banarasi Das University, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3891-97

3891-3897

114

32

47.

PROTECTIVE ROLE OF HONEY AND ROYAL JELLY ON CISPLATIN INDUCED OXIDATIVE STRESS IN LIVER OF RAT

Background: Cisplatin is active cytotoxic agents in the treatment of cancer and has many adverse side effects, including hepatotoxicity. Honey and royal jelly are natural products and having antioxidants properties. Aim of the study: To investigate the protective role of combined administration of honey and royal jelly against cisplatin-induced changes in biomarkers of oxidative stress in rat live...

B. B. Waykar * and Y. A. Alqadhi

Department of Zoology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3898-04

3898-3904

182

38

48.

FLAVONOIDS OF BOERHAVIA DIFFUSA – GC-MS ANALYSIS AND INHIBITORY ACTIVITY AGAINST PATHOGENIC MICROBES

Boerhavia diffusa is a species of flowering plant in the four o'clock family, Boerhavia belongs to family Nyctaginaceae the plant holds the tremendous potential of medicinal value and has been traditionally used in various ailments like syphilis, leukoderma, blood disorders to name a few. The present study focuses on the GC-MS analysis of extracts of all the plant parts of B. diffusa which reveal...

R. Bhardwaj * and R. A. Sharma

Department of Botany, The IIS University, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3905-14

3905-3914

169

45

49.

EFFECT OF CO-ADMINISTRATION OF QUERCETIN ON GOAT INTESTINAL PERMEABILITY OF BERBERINE CHLORIDE

The purpose of the present study was to explore the effect of co-administration of bioenhancer quercetin on membrane permeability of poorly permeable berberine chloride, on goat intestinal membrane model. The effect of co-administration of quercetin was investigated at 2, 6, and 10 mg concentrations. The study revealed a beneficial effect of low concentration of quercetin on % cumulative drug rele...

S. B. Narade * and Y. V. Pore

Department of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3915-19

3915-3919

101

32

50.

DESIGN AND IN-VITRO EVALUATION OF ANTI-AMOEBIC TABLETS ON COLON DRUG DELIVERY SYSTEM

The present study aims to formulate colon targeted drug delivery of Metronidazole compression coated tablets by using different ratios of chitosan and pectin. Carbopol 934P coating is given for compression coated tablets which makes them able to release the drug at the pH of the colonic fluid. Core tablets of Metronidazole (400 mg) were prepared by using swellable and pH dependent polymers like ch...

R. Malshetty, M. M. Iqbal *, N. Fatima, T. Tadmale and R. Saraswat

Mesco College of Pharmacy, Mustaidpura, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3920-27

3920-3927

106

37

51.

A VALIDATED ANALYTICAL METHOD FOR QUANTIFICATION OF CRISABOROLE IN MATRICES BY UPLC-ESI-MS/MS

The validated analytical method was applied for the estimation of Crisaborole in aqueous and human plasma with Crisaborole-D4 as an internal standard by using UPLC-ESI-MS/MS. The chromatographic separation was achieved with 10mM ammonium acetate buffer solution (pH- 4.5): Methanol, (10:90) (% v/v) using the Xterra C18, 100 × 4.6, 5µ. The total analysis time was 2 min, and the flow rate was set t...

T. M. Rao *, C. B. Reddy and P. S. Babu

Jawaharlal Nehru Technological University, Kakinada, Kakinada, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3928-36

3928-3936

128

34

52.

EXPLORING THE POTENTIAL EFFECTS OF AMARANTHUS TRICOLOR LEAVES IN DYSLIPIDEMIA AND DYSLIPIDEMIA INDUCED COMPLICATIONS IN RATS

The present research work was considered to achieve preliminary phytochemical screening, acute oral toxicity, antioxidant activity, and to evaluate the antihyperlipidemic property of the aqueous and ethanolic extracts of leaves of Amaranthus tricolor. Antioxidant activities of the aqueous and ethanolic extracts of leaves of Amaranthus tricolor were investigated by Free Radical Scavenging Activity ...

L. Singh *, S. Kumar and N. A. Khan

Department of Pharmacology, Sanskar College of Pharmacy and Research, Ghaziabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3937-45

3937-3945

113

30

53.

EVALUATION OF ANTI-ULCER ACTIVITY OF ETHANOLIC EXTRACT OF OECOPHYLLA SMARADINA IN ALBINO RATS

Objective: Oecophylla smaradina (Formicidae) is an ant evaluated for its variety of medicinal uses. The objective of this study to evaluate the anti-ulcer activity using albino rats. Methods: The albino rats of either sex were divided into four groups. Ethanolic extract of Oecophylla smaradina (EEOS) was tested in the dose of 200 and 400 mg/kg p.o. respectively against by pylorus ligation induced ...

P. Natarajan *, R. S. Singh and K. Balamurugan

Department of Pharmacy, Annamalai University, Chidambaram, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3946-50

3946-3950

153

38

54.

PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND ANTIDIABETIC EVALUATION OF LEAF EXTRACTS FROM DIOSPYROS BLANCOI A. DC.

The objective of the study was to determine the phytochemicals present in the leaf extracts of Diospyros blancoi A. DC and to evaluate its antioxidant and antidiabetic activities. Qualitative phytochemical tests were used to detect the presence of bioactive compounds present in leaf extracts of D. blancoi. Antioxidant activity was measured through diphenyl-1-picrylhydrazyl assay, and antidiabetic ...

M. T. Demetillo *, O. M. Nuñeza, M. M. Uy and W. T. P. S. K. Senarath

Department of Biology, Caraga State University, Butuan City, Philippines.

DOI: 10.13040/IJPSR.0975-8232.10(8).3951-56

3951-3956

133

33

55.

PRELIMINARY PHYTOCHEMICAL INVESTIGATIONS AND ANTIEPILEPTIC ACTIVITY OF TREMA ORIENTALIS (LINN.) EXTRACTS

Objective: The antiepileptic potential of the petroleum ether (PETO) and methanolic extracts (METO) of the whole plant (roots, leaves, stem, and bark) of Trema orientalis (family: Ulmaceae) was evaluated using different experimental models of epilepsy in rats and mice. Materials and Methods: The anti-epileptic activity of the PETO and METO was evaluated using Picrotoxin, Isoniazid, and NMDA induce...

K. M. Geetha *, K. Vishnnupriya, F. Jaferi and V. Murugan

Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3957-62

3957-3962

90

26

56.

A NOVEL RP- HPLC METHOD FOR THE QUANTIFICATION OF CABOZANTINIB IN ACTIVE PHARMACEUTICAL INGREDIENTS AND PHARMACEUTICAL DOSAGE FORMS

A simple, specific, accurate reversed-phase high performance liquid chromatographic method was developed for the quantification of Cabozantinib. Although extensive studies on Cabozantinib have been developed for determining Cabozantinib in human place and urine by LC-MS, studies on the pharmaceutically active ingredient and formulation are scarce. The effective separation was achieved through BDS ...

A. K. Kuna *, G. Seru and G. V. Radha

Department of Pharmaceutical Analysis, Gitam Institute of Pharmacy, Gitam University (Deemed to be University), Rushikonda, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3963-69

3963-3969

116

33

57.

IN-VIVO PLATELET ANTI-AGGREGATION ACTIVITY OF CRUDE FUCOIDAN OF SARGASSUM POLYCYSTUM

Platelet or thrombosis is one of the most important factors in blood clots formation. However, activation of platelet aggregation plays a significant role in homeostasis process, but in excess, it causes different cardiovascular diseases such as myocardial infarction, atherothrombosis disease, and coronary artery disease. To reduce the occurrence of these diseases, anti-platelet agents can be used...

R. A. Borang, Kusmardi, B. P. Priosoeryanto, D. R. Laksmitawati and S. Abdillah *

Department of Pharmacology, Faculty of Pharmacy, Universitas Pancasila, Jakarta, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.10(8).3970-73

3970-3973

129

65

58.

MOLECULAR DETECTION OF β-LACTAMASE GENE [SHV] IN KLEBSIELLA PNEUMONIAE

Klebsiella pneumoniae is a significant pathogen for nosocomial infections and quickly becomes the most prevalent beta-lactamases produced that are resistant to several antimicrobials. To comprehend deeper the condition of multidrug resistance [MDR]. Objectives: Our research was directed at identifying Klebsiella pneumoniae isolates containing shv β-lactamase gene and the relationship between them...

Z. O. Hamed * and A. A. Awni

Department of Clinical Pharmacology and Therapeutics, Baghdad College of Medical Sciences, Baghdad, Iraq.

DOI: 10.13040/IJPSR.0975-8232.10(8).3974-78

3974-3978

148

41

59.

EFFICIENT GENOMIC DNA EXTRACTION AND MOLECULAR ANALYSIS OF MEDICINALLY RICH VALERIANA JATAMANSI DRY ROOTS

One of the major problems faced by the pharmaceutical industry is to maintain the quality and efficacy of herbal drugs due to the lack of purity of herbal raw materials. Furthermore, using traditional identification methods to identify the correct plant part needed for the preparation of herbal medicine can be difficult. Creating a novel system to assess the quality of a medicinal herb and to disc...

N. H. Joglekar * and S. S. Barve

Department of Biotechnology, KET’s V. G. Vaze College of Science, Commerce and Arts, Mithagar Road, Mulund (E), Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3979-83

3979-3983

80

30

60.

EVALUATION OF ANTIOXIDANT PARAMETERS OF MUKIA MADERASPATANA

The present study was an attempt to investigate the effect of extracts and fractions of Mukia maderaspatana on glycemia, lipid profile, lipoprotein level and antioxidant profile in STZ induced diabetic rats for 21 days. Diabetes was induced using streptozotocin (50 mg/kg i.p) and after the induction of diabetes the animals were given with MMEE (100 mg/kg, 200 mg/kg), MMCF (100 mg/kg) and MMBF (100...

A. V. S. R. S. Nadh *, P. R. Rao and A. P. Rani

Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3984-88

3984-3988

82

24

61.

DIURETIC ACTIVITY OF HYDROALCOHOLIC EXTRACT OF FRAGARIA ANANASSA FRUIT IN WISTAR ALBINO RATS

Fragaria ananassa fruit are small shrubs belonging to family rosaceae. Fragaria ananassa mainly contains anti-oxidants such as tocopherols, ascorbic acid and b-carotene which are effective against cancer, heart disease and cataracts. The focus of the study was toanalyze the diuretic activity of hydro alcoholic extract of Fragaria ananassa fruit in albino rats. Diuretic activity of hydroalcoholic (...

P. Lodhi, A. Maru *, A. Joshi, S. Malviya and A. Kharia

Modern Institute of Pharmaceutical Sciences, Gram Alwasa, Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(8).3989-92

3989-3992

74

0