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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.14
Five-Year Projected Impact Factor: 1.83

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Volume 10 (2019) - Issue 5, May

Review Articles

 
Title
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1.

A REVIEW ON SOME SELECTED TRADITIONAL INDIAN MEDICINAL PLANTS OF IMMUNOMODULATORY POTENTIAL AND THEIR THERAPEUTIC USE IN RHEUMATOID ARTHRITIS

Rheumatoid arthritis is a very common auto-immune inflammatory disorder, causing disability in developed and developing countries. Conventional drugs are not only costly but are also associated with very serious adverse effects. Several Indian medicinal plants have been traditionally used for their anti-arthritic effect since time immemorial. Present review focused on the immunomodulatory potentia...

S. Bagde and D. Biswas *

Department of Microbiology, Medical College, All India Institute of Medical Sciences (AIIMS), Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2087-00

2087-2100

1013

617

2.

IMPACT OF CELL SENESCENCE ON AGE – RELATED NEURODEGENERATIVE DISORDERS: THE MECHANISM TO THERAPY- A REVIEW

Aging is a natural phenomenon; it is a well-known fact that everyone is aging as time passes. A major contributor to this process is cell senescence. Cell senescence can be a result of the exposure to stress such as oxidative stress, epigenomic damage or DNA damage, or it can be due to telomere shortening is also known as end replication problem. It was first observed by Hayflick. Senescent cells ...

N. Jadon, N. Sabharwal and S. Bhattacharya *

Jaypee Institute of Information Technology, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2101-07

2101-2107

628

277

3.

BIOGENIC SYNTHESIS OF MYCONANOPARTICLES FROM MUSHROOM EXTRACTS AND ITS MEDICAL APPLICATIONS: A REVIEW

Mushroom extracts such as proteins, amino acids, polysaccharides and vitamins implicated as the reducing, stabilizing and capping agents in synthesis of myconanoparticles. Therefore, it is just a little attempt to study the journalism of this important of myconanoparticle. For this literature survey, basically library data was collected and digital resources were also included. From these sources ...

N. Prabhu *, S. Karunakaran, S. K. Devi, R. Ravya, P. Subashree and M. S. Vadivu

Department of Biotechnology, Vivekanandha College of Engineering for Women, Elayampalayam, Tiruchengode, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2108-18

2108-2118

723

249

4.

RECENT ADVANCES IN THE SYNTHESIS OF PHARMACOLOGICALLY BENIGN COUMARIN AND INDOLE HETERO-STRUCTURED DERIVATIVES: A REVIEW

Indole and coumarin are the most versatile and cogent heterocyclic scaffolds which are not only decisively used in the synthesis of various organic compounds but also play a consequence role in natural product synthesis, modulation of biofilm formation, virulence and stress responses. In last few decades, an individual has witnessed considerable activity towards the synthesis of indole derivatives...

A. K. Bahe and R. Das *

Department of Chemistry, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2119-32

2119-2132

606

220

5.

CANCER NANOTHERAPEUTICS – A REVIEW

Present study explains the cancer nano-therapeutics which is rapidly progressing and are being implemented to solve several limitations of conventional drug delivery systems such as nonspecific biodistribution and targeting, lack of water solubility, poor oral bioavailability. To improve the bio-distribution of cancer drugs, nanoparticles have been designed with optimal size and surface characteri...

A. Rama, M. Anjaneyulu and P. Munija *

Department of Pharmaceutics, Vision College of Pharmaceutical Sciences and Research, Boduppal, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2133-42

2133-2142

667

217

6.

PERMEATION ENHANCERS COMPATIBLE WITH TRANSDERMAL DRUG DELIVERY SYSTEMS OVERCOMING THE SKIN BARRIER FUNCTIONS: CURRENT AND FUTURE PROSPECTS

Transdermal drug delivery system (TDDS) provides a leading edge over injectables and oral routes by increasing patient compliance and avoiding the first-pass metabolism respectively. Transdermal delivery not only provides controlled, constant administration of the drug, but also allows continuous input of drugs with short biological half-lives and eliminates pulsed entry into the systemic circulat...

A. D. Paul, C. Prasanthi *, N. Sumiya, P. V. Prasad and J. V. Kumar

SVU College of Pharmaceutical Sciences, SV University, Tirupathi, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2143-55

2143-2155

183

63

7.

“AGATHIYAR KUZHAMBU”- NOT ONLY A PURGATIVE- AN OVERVIEW

The Siddha System of Medicine is one of the most ancient traditional medical systems was popular in the ancient Southern part of India. In this system, the herbals, metals, minerals and animal products have been used to prepare the medicines for treating diverse illness. Siddha medicines are divided into inner drug treatments and external drug treatments. Agathiyar Kuzhambu is one among the 32 int...

S. D. Muralidass * and M. S. Shree-Devi

Siddha Central Research Institute, CCRS, Arumbakkam, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2156-63

2156-2163

214

60

Research Articles

 
Title
Views
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Cited
8.

INFLUENCE OF THE SUPERDISINTEGRANTS IN NIFEDIPINE RELEASE FROM OSMOTIC PUSH-PULL TABLETS

Push-pull osmotic pumps are controlled drug delivery systems for drugs with a broad range of solubilities; especially drugs that are poorly water-soluble. The aim of the present study was to evaluate the performance of the superdisintegrants (SD), crospovidone (CPVP), croscarmellose sodium (CS), and sodium starch glycolate (SSG), in push-pull tablets containing Nifedipine (NP) as a model drug. We ...

J. E. Hernández Torres, E. Hernández Baltazar, M. J. B. Bernad and L. M. M. Contreras *

Universidad Autónoma Metropolitana, Unidad Xochimilco, Departamento de Sistemas Biológicos, Calzada del Hueso 1100 Col, Villa Quietud Delegación Coyoacán C.P, México D.F., México.

DOI: 10.13040/IJPSR.0975-8232.10(5).2164-71

2164-2171

689

245

9.

EFFECT OF CO-PROCESS EXCIPIENTS IN FORMULATION OF ODTs USING A MODEL DRUG

Different types of excipients were compared, in terms of their effect in (oral disintegrated tablets-ODTs) to optimize drug delivery and manufacturability. Therefore, the influence of excipients on the quality of ODTs was investigated by formulating and evaluate ODTs using an equal dose of water-soluble Baclofen (B) and poorly water-soluble Meloxicam (M) as model drugs. ODTs of both drugs were pre...

M. A. El-Nabarawi, R. A. Abd El-Monem and I. E. I. Al-Samadi *

Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Misr University for Science and Technology, Giza, Egypt.

DOI: 10.13040/IJPSR.0975-8232.10(5).2172-81

2172-2181

517

141

10.

SYNERGISTIC EFFECT OF (S)-CIS-VERBENOL WITH THE ANTIBIOTICS AMOXICILLIN AND GENTAMICIN AGAINST SENSITIVE AND RESISTANT STAPHYLOCOCCUS AUREUS STRAINS

The synergistic activity among the monoterpene (S)-cis-Verbenol and the antibiotics Amoxicillin and Gentamicin were evaluated against a sensitive and a resistant strain of Staphylococcus aureus, is the last one also resistant to methicillin (MRSA). The combinations were evaluated by the checkerboard method. The combinations of both antibiotics with the terpene showed synergic effects for the MRSA ...

D. Bobadilla, M. E. Flores-Giubi and N. Alvarenga *

Department of Phytochemistry, Faculty of Chemical Sciences, National University of Asunción, San Lorenzo, Paraguay.

DOI: 10.13040/IJPSR.0975-8232.10(5).2182-88

2182-2188

470

148

11.

DETECTION OF RHINOVIRUS AND SOME DNA/RNA VIRUSES BY REVERSE TRANSCRIPTASE REAL-TIME PCR AND THEIR IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH ACUTE RESPIRATORY TRACT INFECTION IN IRAQ: MOLECULAR AND IMMUNOLOGICAL STUDY

Background and Objectives: Acute upper respiratory tract infections are the most frequent acute illnesses worldwide. This study has been undertaken for determining the diagnostic importance of Human Rhinovirus and other associated DNA/RNA viruses including human Respiratory Syncytial virus; Human Metapneumovirus; Human parainfluenza virus 1-4; human coronavirus; Human B, C, and E Adenovirus; and H...

M. T. S. Al-Ouqaili *, N. N. Al-Hayani and I. H. Saadoon

College of Medicine, University of Anbar, Ramadi, Iraq.

DOI: 10.13040/IJPSR.0975-8232.10(5).2189-99

2189-2199

448

106

12.

DOSE DEPENDENT ANTIDIABETIC ACTIVITY OF HYDRO-METHANOLIC EXTRACT (3:2) OF FLOWER OF M. BALBISIANA IN STREPTOZOTOCIN INDUCED DIABETIC MALE RAT

Background: Musa balbisiana Colla (Musaceae family) is used as folkloric medicine throughout India. Objective: To search out the potent dose of a hydro-methanolic extract of Musa balbisiana flower for antidiabetic and antioxidative activities in streptozotocin-induced diabetic rat. Material and Methods: The extract of the said plant part was administered orally at the dose of 5, 10 or 20 mg /100 g...

F. Ara, A. Tripathy and D. Ghosh *

Molecular Medicine and Nutrigenomics Research Laboratory, Department of Bio-Medical Laboratory Science and Management, Vidyasagar University, Midnapore, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2200-09

2200-2209

495

152

13.

EFFECTS OF GREEN TEA INFUSION AND EPICATECHIN ON DOXORUBICIN-INDUCED RENOCARDIOTOXICITY IN MALE ALBINO RATS

This study aims to assess the preventive effects of green tea infusion and epicatechin on doxorubicin (Dox)-induced kidney and heart injuries and oxidative stress in male Wistar rats. The male Wistar rats administered Dox at an intraperitoneal dose of 4 mg/kg body weight (b.w.)/ week were orally treated with green tea infusion (200 mg/kg b.w.) and epicatechin (25 mg/kg b.w.) every other day for 6 ...

O. M. Ahmed *, M. M. Abdul-Hamid, A. M. El-Bakry, H. M. Mohammed and F. E. S. A. Rahman

Physiology Division, Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.

DOI: 10.13040/IJPSR.0975-8232.10(5).2210-23

2210-2223

163

60

14.

PHYTOCHEMICAL AND GC-MS ANALYSIS OF OLEORESIN OF DIPTEROCARPUS GRACILIS BLUME: AS A BASIC CONSIDERATION FOR HUMAN REMEDY

Dipterocarpus gracilis Blume is one tropical species of Dipterocarps which is included in the red list IUCN as a rare and endangered tree species. In consideration of Dipterocarpus gracilis Blume conservation and sustainability of its oleoresin, this present study aimed to determine specific characteristics of oleoresin origin of Dipterocarpus gracilis Blume as an establishing basis for appropriat...

A. Fernandes * and R. Maharani

Department of Wood Science and Forest Product Technology, Research and Development Center of Dipterocarp Forest Ecosystem, Forest and Environment Research, Development and Innovation Agency (FOERDIA), Ministry of Environment and Forestry of Indonesia, Samarinda, East Kalimantan, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.10(5).2224-29

2224-2229

167

63

15.

COMPARISON OF 3%, 5% AND 8% CONCENTRATIONS OF SEVOFLURANE FOR INDUCTION AND INTUBATION IN ADULTS WITHOUT USING NEUROMUSCULAR BLOCKING AGENTS

Introduction: Tracheal intubation is commonly facilitated by the use of muscle relaxants. Sevoflurane fulfills the criteria for successful rapid & smooth inhalational induction when muscle relaxants are contra-indicated. Aim: To compare the success rate of intubation characteristics, hemodynamic changes, the effectiveness of the trapezius squeezing test for an adequate condition for intubation...

S. K. Khangwal, K. Shah * and B. M. Patel

Department of Anesthesia, Gujarat Cancer Research Institute, B. J, Medical College, Civil Hospital, Asarva, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2230-35

2230-2235

124

48

16.

A STUDY OF POSSIBLE PROTECTION BY NEFIRACETAM ON ESLICARBAZEPINE INDUCED MEMORY IMPAIRMENT IN TEMPORAL LOBE EPILEPSY

Memory impairment (MI) is commonly seen in epilepsy and is at times aggravated by antiepileptic therapy. Recent studies reported that co-administration of nootropic agent with an antiepileptic drug (AED) might decrease the MI. This study was designed to evaluate MI activity of Eslicarbazepine (ESL) in temporal lobe epilepsy (TLE) and to assess the protective effect of Nefiracetam (NEF) which is a ...

B. Ray, K. L. Krishna *, T. Madesh, V. Francis and J. M. Asher

Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagar, Mysuru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2236-39

2236-2239

118

58

17.

ANTIPYRETIC AND ANALGESIC ACTIVITY OF PICRORHIZA KURROOA RHIZOMES

Picrorhiza kurroa Royle ex Benth, belongs to the family Scrophulariaceae has gained immense medicinal value in Ayurvedic as well as in modern medicines including antioxidant, anti-inflammatory, anti-pyretic, immunomodulatory, anticancer, hepato-protective, etc. The present study aimed to ascertain analgesic and antipyretic activities of rhizome extracts of Picrorhiza kurrooa in Wister rats. Methan...

N. Kaila, S. Dhir and N. Vashist *

SGT College of Pharmacy, SGT University, Gurugram, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2240-43

2240-2243

151

67

18.

IN-VIVO APPRAISAL OF PHARMACOLOGICAL ACTIVITY OF BACOPA MONNIERI AND ITS HPLC ANALYSIS FOR BACOSIDE A

Bacopa monnieri is a herb, known to possesses various pharmacological and medicinal properties. Aim: The objective of the study was to analyse the activity of Bacopa monnieri as an antipyretic, analgesic and anti-ulcerogenic agent. Methods: Indomethacin was used as the standard of comparison for this study. Animals were arbitrarily separated into three groups of six animals in each group. The firs...

S. E. Prince *, A. P. Das and G. Arumugam

Department of Biomedical Sciences, School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2244-49

2244-2249

132

53

19.

BIOSYNTHESIS OF SILVER NANOPARTICLES USING EXTRACTS OF TWO SPECIES OF PORTULACA AND THEIR ANTIBACTERIAL ACTIVITY

Portulaca oleraceae commonly known as Purslane and Portulaca quadrifida commonly known as chicken weed are consumed in salads, pickles, and soup in Asia, Africa, and Mediterranean region. In the traditional systems of medicine in Asia and Africa, they have been attributed to several pharmacological properties. Phytochemical investigations point to the presence of various beneficial constituents in...

T. P. Durgawale *, C. C. Khanwelkar and P. P. Durgawale

Department of Pharmacology, Krishna Institute of Medical Sciences Deemed to be University, Karad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2250-56

2250-2256

135

59

20.

RECONSTITUTION OF ORAL ANTIMALARIAL SUSPENSIONS: AN UNRECOGNIZED FACTOR IN ANTIMALARIAL DRUG RESISTANCE

Malaria is a foremost universal public health problem, especially in the African region and development of resistance to the older and new generation malaria therapy, has become a persistent health threat requiring urgent solutions. This study intended to assess the ability of human subjects to accurately reconstitute antimalarial dry suspensions according to the manufacturer’s instructions. Two...

C. Y. Isimi, O. J. Olayemi *, K. Ekere, I. Ajeh, J. E. Okoh, D. Ugwu and M. O. Emeje

National Institute for Pharmaceutical Research and Development (NIPRD), Idu Industrial Area, Garki, Abuja, Nigeria.

DOI: 10.13040/IJPSR.0975-8232.10(5).2257-64

2257-2264

169

52

21.

IN-VIVO STUDIES OF OPTIMIZED L-GLUTAMINE HYDROGEL FOR ORAL MUCOSITIS

Mucositis is a foremost acute complication in the clinical setting, occurring in a large percentage of patients undergoing cytotoxic therapy. One of the major problems with mucositis is that the underlying mechanisms behind its development are not wholly understood, which makes it extremely difficult to develop effective interventions. Animal models provide a critical source of knowledge when samp...

P. K. Jain, R. Gilhotra and M. L. Kori *

Vedica College of Pharmacy, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2265-71

2265-2271

153

50

22.

IN-VITRO ANTI-CANCER ACTIVITY OF TWO BRITTLE STAR SPECIES: OPHIOCOMA ERINACEUS AND OPHIOMASTRIX ANNULOSA

Marine organisms are excellent sources of structurally diverse molecules that are potentially valuable as drugs. The brittle starfish was shown to contain the bioactive components which exhibit various biological activities including cytotoxicity effects. Hence, the present study was carried out to determine the cytotoxicity of the extracts of two different starfish species like Ophiocoma erinaceu...

S. Senthilkumari and K. Revathi *

Department of Zoology, Ethiraj College for Women, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2272-79

2272-2279

121

48

23.

ANTIDIABETIC AND LIPID LOWERING EXTENUATING IMPACT OF GLYCINE MAX LEAVES (SOYABEAN) IN TYPE II DIABETES MELLITUS SUBJECTS

Diabetes mellitus is possibly the world’s largest growing metabolic disease. Currently, a challenge is to identify such healthy foods that remain in the realms of obscurity and to establish them as functional foods to prevent the progression of metabolic complications. Glycine max is indigenous to India and is used extensively in the traditional system of medicine to treat diabetes, reduces coro...

K. Sharma, Akansha, Amandeep and E. S. Chauhan *

Department of Food Science and Nutrition, Banasthali Vidyapith, Vanasthali, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2280-84

2280-2284

131

54

24.

A STUDY OF PRESCRIBING PATTERN OF ANTIBIOTICS IN A TERTIARY CARE HOSPITAL – AN OBSERVATIONAL STUDY

The main objective was to study the prescribing pattern of antibiotic in a tertiary care hospital to assess the frequency and prescribing the practice of antibiotics. The study includes an observational study of antibiotic prescribing patterns conducted over 6 months. In this study, enrolled 300 patients who were prescribed with antibiotics from both outpatient and inpatient department. Data were ...

S. S. Jokandan * and D. K. Jha

Department of Pharm D, Karnataka College of Pharmacy, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2285-89

2285-2289

131

42

25.

ACTIVITY OF ETHYL ACETATE FRACTIONS OF TONGKAT ALI ROOTS (EURYCOMA LONGIFOLIA, JACK) ON BLOOD GLUCOSE LEVELS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

This study is to evaluate two ethyl acetate fractions of “Tongkat Ali Roots” (TAR) namely fractions-1 and fraction-2 (F-1; F-2) on blood glucose levels in streptozotocin (STZ) induced diabetic rats. Each fraction used sixty rats which grouped into six groups (n=10). Group 1 is normal rats which received aqua dest; group 2 is diabetic rats which received STZ 60 mg/kg b.w., group 3 is diabetic r...

H. Yusuf *, K. Hasballah and K. F. Jamil

Department of Pharmacology, Faculty of Medicine, University of Syiah Kuala, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.10(5).2290-93

2290-2293

170

51

26.

COMPARISON OF CONVENTIONAL AND REAL-TIME PCR FOR MONITORING OF RESPIRATORY SYNCYTIAL VIRUS AMONG PEDIATRIC PATIENTS IN NORTHERN INDIA 2011-2014

Background: In India, the respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections (17 to 32%) in the pediatric age group. Viral detection during the acute phase of infection is a critical step for care and prevention. Objectives: We sought to investigate the detection of RSV by rt-RT-PCR, conventional PCR and cell culture among pediatric patients. Methods: Throat/n...

S. Saxena, R. Tripathi, R. A. S. Kushwaha, R. Kumari, P. Bhattacharya and T. N. Dhole *

Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2294-00

2294-2300

134

39

27.

IN-VITRO NEUROPROTECTIVE ACTIVITY OF SILIBININ AGAINST MPTP (1-METHYL-4-PHENYL-1, 2, 3, 6-TETRAHYDROPYRIDINE) INDUCED NEUROTOXICITY MODEL

In the present study, we examined the effect of Silibinin on the accumulation of oxidative stress induced by MPTP by in-vitro. After decapitation, healthy rat brain was removed rapidly from the skull and rinsed with cold artificial cerebrospinal fluid (ACSF) which has been equilibrated with 95% O2 / 5% CO2 gas mixture. Group I brain was incubated in CSF serve as normal, Group II lenses brain was i...

G. D. Rao, S. P. Begum * and H. Penchalaiah

University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2301-05

2301-2305

147

42

28.

RADIOPROTECTIVE EFFECT OF OPUNTIA ELATIOR ON BLOOD OF SWISS ALBINO MICE

The modulatory effect of Opuntia elatior stem extract was studied in Swiss albino mice at dose 6 Gy of gamma radiation. Four groups were divided in the presence (experimental) or absence (control) of Opuntia extract 10 mg/kg body wt.) to observe hematological alterations. Four groups are Group I without any treatment as control, Group II treated with 10 mg/kg body weight dose of plant Opuntia elat...

K. Poonia and J. Sharma *

Department of Zoology, Radiation Biology Laboratory, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2306-14

2306-2314

110

51

29.

ACUTE ORAL TOXICITY AND NEUROBEHAVIOURAL TOXICOLOGICAL EFFECTS OF METHANOLIC EXTRACT OF CHRYSOPHYLLUM PERPULCHRUM IN RATS

This study aimed to investigate the acute toxicity of methanolic extract of Chrysophyllum perpulchrum on biochemical, behavioral and histopathological variation in male Wistar rats. Acute toxicity of the methanol extract of Chrysophyllum perpulchrum was carried out on 36 male rats using different doses of the extract ranging from 500 to 2000 mg/kg body weight. Behavioral tests were used to determi...

F. Z. Kacimi, F. Z. Azzaoui, AOT Ahami, N’go Pacome and S. Boulbaroud *

Polydisciplinary faculty, Polyvalent research and development Laboratory, Sultan Moulay Slimane University, Beni Mellal-Morocco.

DOI: 10.13040/IJPSR.0975-8232.10(5).2315-25

2315-2325

130

45

30.

DEVELOPMENT AND INVESTIGATION OF EUDRAGIT S-100 ENCAPSULATED CHITOSAN COATED LIPOSOMES OF PREDNISOLONE FOR COLON TARGETING

The objective of the study was to formulate coated liposomes containing Prednisolone for colon targeting and localization of the therapy to the inflamed colon mucosa. Liposomes were prepared using thin film hydration method. Liposomal formulations were optimized using 32 factorial design using varying concentrations of SPC and cholesterol as independent variables and % EE as the dependent variable...

S. B. Mascarenhas *, M. Koland and H. Kumar

Department of Pharmaceutics, N. G. S. M. Institute of Pharmaceutical Sciences, NITTE Deemed to be University, Paneer, Deralakatte, Mangalore, Dakshina Kannada, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2326-34

2326-2334

141

51

31.

PREVALENCE OF PATHOGENIC ORGANISMS IN MEAT SAMPLES OF ONGKHARAK NAKHONNAYOK THAILAND

Globally, foodborne pathogens are the origin of diseases and deaths. To prevent the foodborne pathogens billions of dollars spending. Coliforms level, psychrotrophs mesophiles, E. coli, and Staphylococcus aureus, are routinely assessed to determine microbial safety, sanitation conditions, improper hygiene in poultry carcasses. Thai-population consumes more broiler meat due to its availability and ...

M. V. B. Reddy * and J. Pusapukdepob

Faculty of Public Health, St. Theresa International College, Bungsan, Ongkharak, Nakhonnayok, Thailand.

DOI: 10.13040/IJPSR.0975-8232.10(5).2335-42

2335-2342

118

48

32.

RP-HPLC METHOD FOR QUANTIFICATION OF OROTIC ACID IN CAPSULE FORMULATION

A simple, sensitive and specific RP-HPLC method was developed and validated for the determination of Orotic acid in bulk and capsule dosage form. Chromatography was carried out on an Enable C18G (250 × 4.6 mm i.d.,5µ) column using filtered and degassed mixture of acetonitrile and methanol in the ratio of 60:40% v/v as mobile phase at a flow rate of 1 ml/min and effluent was monitored at 280 nm. ...

T. H. Kumar *, D. Jhanavi, K. V. P. Rao and Y. S. Rao

Department of Pharmaceutical Analysis and Quality Assurance, Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2343-47

2343-2347

158

56

33.

BIOPROSPECTING FOR LIPASE PRODUCING MICROORGANISMS

Extracellular lipases are ubiquitous in occurrence and are essential for various applications such as organic synthesis, hydrolysis of fats and oils, modification of fats, flavor enhancement in food processing, resolution of racemic mixtures and chemical analysis. In the present study, an attempt was made to screen and characterize potent extracellular lipase producing bacteria from the pond water...

E. Venkatanagaraju *, P. S. S. Prasad, J. A. George, M. F. J. Jill, A. B. George and J. Xavier

Department of Life Sciences, Christ (Deemed to be University), Bengaluru, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2348-52

2348-2352

160

48

34.

EFFECTS OF DAUCUS CAROTA SEED EXTRACT ON REPRODUCTIVE HORMONES AND ESTROUS CYCLE IN ALBINO MICE

The use of plants for contraception and abortion is recorded throughout history, with contemporary reports from India and many other countries. Daucus carota is one of the several plants traditionally used for birth control. The present work was undertaken to evaluate the antifertility effect of the seeds of the plant by carrying out pharmacological studies with the methanolic extract of the see...

G. Mausumi, M. Rita, H. Jnyandeep *, B. K. Priya and K. S. R. Pai

Department of Chemistry, Cotton University, Guwahati, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2353-57

2353-2357

121

45

35.

IODOMETRIC METHOD FOR THE DETERMINATION OF MEZLOCILLIN

Kinetics and stoichiometry S-oxidation reaction of sodium monohydrate Mezlocillin (Mezl) using potassium hydrogen peroxomonosulfate in aqueous solutions using iodometric titration were studied. Baypen®-powder Mezl sodium monohydrate in flacons for preparation of solution for injections (Mezl 1.0 g). A new iodometric method for the quantitative determination of sodium monohydrate Mezl in Baypen® ...

S. P. Karpova *, T. V. Krutskikh, O. O. Mozgova, and A. A. Krutskikh

Department of Physical and Colloid Chemistry, National University of Pharmacy, Kharkiv, Ukraine.

DOI: 10.13040/IJPSR.0975-8232.10(5).2358-61

2358-2361

166

47

36.

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING ASSAY METHOD FOR DETERMINATION OF LOXAPINE SUCCINATE IN CAPSULE DOSAGE FORM

To develop and validate simple, selective, specific, sensitive and accurate stability indicating assay method by RP-HPLC for determination of Loxapine succinate in the capsule dosage form. Several trials are taken by changing mobile phase composition, and ratio and finally the drug was eluted on a C18 Purospher star (250 mm × 4.6 mm, 5 µm) column using mobile phase consisting of water: Methanol:...

K. A. Thakor * and T. Y. Pasha

Department of Chemistry, Parul Institute of Pharmacy and Research, Parul University, Limda, Waghodia, Vadodara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2362-68

2362-2368

136

56

37.

A COMPARISON BETWEEN WELLS’ SCORE AND MODIFIED DOPPLER ULTRASOUND IN THE DIAGNOSIS OF DEEP VENOUS THROMBOSIS OF THE LOWER LIMB

The assessment of the probability of occurrence of deep vein thrombosis played a very important part in making a correct diagnosis and modified Wells’ score is a widely used prediction rule for pre-test probability assessment. We aimed to evaluate the diagnostic accuracy of the modified Wells’ score in the diagnosis of lower extremity deep vein thrombosis compared to Doppler ultrasound study. ...

M. K. A. Razak *, J. I. Rasheed and A. A. Hamad

Department of Medicine, The University of Baghdad, Baghdad College of Medicine, Baghdad, Iraq.

DOI: 10.13040/IJPSR.0975-8232.10(5).2369-74

2369-2374

141

41

38.

FORMULATION AND EVALUATION OF TRANSDERMAL PATCH FOR TREATMENT OF INFLAMMATION

Background: Quercetin is one of the important bioflavonoids present in more than twenty plants material and which is known for its anti-inflammatory, antihypertensive, vasodilator effects, antiobesity, antihyper-cholesterolemic and antiatherosclerotic activities. Free-radical is one of the key factors for the development of diseases such as hypertension, vascular disorders, and metabolic syndrome....

A. Kharia *, R. Gilhotra and A. K. Singhai

Suresh Gyan Vihar University, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2375-84

2375-2384

158

72

39.

COMPARISON OF SURGICAL SITE INFECTION RATE BETWEEN ANTIBACTERIAL COATED SURGICAL SUTURE AND CONVENTIONAL SUTURE: A RANDOMIZED CONTROLLED SINGLE CENTRE STUDY FOR PREVENTIVE MEASURE OF POSTOPERATIVE INFECTION

The main objective of this study is to compare the reduction rate of surgical site infection (SSI) between Triclosan coated (TC) and conventional surgical (CS) suture postoperatively. Surgical site infection (SSI) can be presented as a major challenge for people in the sense of mortality and morbidity mostly in developing countries. The result of SSI with antibacterial suture in developed countrie...

P. K. Roy *, P. Kalita, H. Lalhlenmawia, R. S. Dutta, K. Thanzami, C. Zothanmawia, Lalrosangi, L. Pachuau and S. Chenkual

Department of Pharmacy, Regional Institute of Paramedical & Nursing Sciences, Zemabawk, Aizawl, Mizoram, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2385-91

2385-2391

135

55

40.

CHEMICAL COMPOSITION OF FAGOPYRUM ESCEULENTUM MOENCH SEED THROUGH GC-MS

Medicinal herbs are a precious heritage for us and since long is a part of traditional as well modern system of medicine. These herbs provide less toxic and more effective drug molecules which are helpful in various ailments. In the present work, we have focused on an edible herb which bears a large number of medicinal properties. Fagopyrum esceulentum Moench (Buckwheat) has a long tradition of be...

Neeraj *, N. Vasudeva and S. Sharma

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2392-96

2392-2396

113

51

41.

UTILIZATION OF MAIZE EXTRACT FOR THE SYNTHESIS AND CHARACTERIZATION OF GOLD NANOPARTICLES AT ROOM TEMPERATURE

In present work, the gold nanoparticles have been prepared through green synthesis using maize extract at room temperature, the maize extract was used as reducing and stabilizing agents for AuNPs (gold nanoparticles), synthesized gold nanoparticles were confirmed by the color change of the aqueous solution, and the PH of the solution was 7.8, after the confirmation, green gold nanoparticles were c...

R. Jon *, P. R. Dasari, V. Singh and D. P. Jayapandian

Department of Physics, Faculty of Science, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2397-02

2397-2402

121

50

42.

STABILITY INDICATING UPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ALBUTEROL SULPHATE, THEOPHYLLINE AND BROMHEXINE IN BULK AND COMBINED DOSAGE FORM

A new simple, precise, accurate and selective UPLC method has been developed and validated for stability indicating UPLC method for simultaneous estimation of Albuterol sulfate, Theophylline and Bromhexine HCl in the tablet dosage form. The method was carried out on a Hibra C18, 250mm x 4.6mm, 5µm. a column with a mobile phase consisting of buffer and acetonitrile and buffer in the ratio of (55: ...

V. Padmaja * and M. Prasanthi

Department of Pharmaceutical Analysis, Nirmala College of Pharmacy, Atmakuru, Mangalagiri, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2403-11

2403-2411

128

58

43.

EFFECT OF ANGIOTENSIN-CONVERTING ENZYME INHIBITORS ON SERUM AMYLASE AND LIPASE IN PATIENTS WITH HYPERTENSION

Introduction: Angiotensin-converting enzyme (ACE) inhibitors are a class of potential drugs used as first-line agents for the treatment of hypertension and heart failure in physiologically young patients despite its side effects. Apart from the other common side effects, they are known to induce bradykinin release which alters vascular permeability leading to pancreatic edema resulting in intrapan...

N. Ojha, J. A. Ebens and P. Shanmugasundaram *

Department of Pharmacy Practice, School of Pharmaceutical Sciences, VISTAS, Pallavaram, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2412-16

2412-2416

135

76

44.

BIOCHEMICAL STUDY OF AN ENDANGERED ETHNOMEDICINAL PLANT CURCULIGO ORCHIOIDES GAERTN. OCCURRING IN PURULIA DISTRICT OF WEST BENGAL, INDIA

Ethnic peoples from Purulia district of West Bengal in India use a lot of plants for their primary health care without studying phytochemical analysis and biological activities in detail. Main objectives of the present study are to evaluate the antibacterial and antioxidant activities of the whole plant extract of Curculigo orchioides using polar and nonpolar solvents. Total phenol content (TPC) w...

G. Mahato and N. Banerjee *

Department of Botany, Vidyasagar University, Paschim Medinipur, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2417-22

2417-2422

139

59

45.

SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL QUINOLINE / CHALCONE HYBRID AS POTENTIAL ANTIBACTERIAL AGENTS

A series of new quinoline/chalcone hybrids 3a-e and 4a-e were designed and synthesized. The structures of all new target molecules 3a-e and 4a-e have been confirmed by various spectral techniques and elemental analyses. The newly synthesized compounds were screened for their antibacterial activity using agar disc diffusion method. Results showed that most of the newly synthesized compounds showed ...

B. G. M. Youssif

Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf, Sakaka, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.10(5).2423-29

2423-2429

158

58

46.

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF BCS CLASS II DRUG RITONAVIR USING LIQUISOLID TECHNIQUE

BCS class II drugs usually suffer inadequate bioavailability as a dissolution step is the absorption rate-limiting step. In this work, the effect of solubility increase at the main absorption site for these drugs was investigated using ritonavir as a drug model. The liquidsolid technique was applied to prepare ritonavir per-oral tablets of high dissolution rate using versatile non-ionic surfactant...

B. Bonthagarala, V. Dasari * and V. Kotra

Department of Pharmaceutics, Sri Indu Institute of Pharmacy, Sheriguda (V), Ibrahimpatnam (M), Ranga Reddy, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2430-38

2430-2438

144

48

47.

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL IMIDAZO THIAZOLE CHALCONES AS ANTIOXIDANT AGENT

A series of condensed Imidazo [2, 1-b] [1,3] thiazole Chalcones have been synthesized by Claisen–Schmidt condensation reaction. Imidazo thiazole Chalcones are associated with immense biological activities. Novel Imidazo thiazole-based chalcones were synthesized using Imidazo thiazole-3-carboxaldehydes and various acetyl ketones in PEG-400. The structures of the compounds were characterized by I...

V. Sonawane *, D. Hiwarale, B. Sonawane, S. Kamble, K. Sonawane and R. Bhosale

Smt. Kusumtai Rajarambapu Patil Kanya Mahavidyalaya Islampur, Walva, Sangli, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2439-46

2439-2446

158

64

48.

XANTHOGRANULOMATOUS PYELONEPHRITIS- A RARE CASE REPORT

An unusual type of the long-lasting pyelonephritis demonstrating a long-lasting granulomatous disease resulting in a non-functional kidney in the patient is generally linked with xanthogranulomatous pyelonephritis. The name itself suggests this involves a granulomatous progression that is chronic, due to a chronic or sub-acute infection in the patient inciting a chronic but incomplete immune react...

K. S. Vasudev *, T. Avinash and R. H. Babu

Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2447-50

2447-2450

113

48

49.

NEW SPECTROPHOTOMETRIC TECHNIQUES FOR THE ESTIMATION OF BREXPIPRAZOLE IN TABLET DOSAGE FORM

Brexpiprazole is an atypical antipsychotic drug indicated for the treatment of schizophrenia. Four novels, simple, precise and accurate spectrophotometric methods were developed for the determination of Brexpiprazole (Rexulti) in pharmaceutical dosage forms. The absorption maxima was found to be at 214 nm in method A (0.1N HCl) and shows linearity over the concentration range of 0.002-0.02 µg/mL ...

S. Mondal *, V. G. Kumar and P. Mondal

Department of Pharmaceutical Analysis & Quality Assurance, GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2451-55

2451-2455

117

55

50.

STABILITY INDICATING HPTLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND LOSARTAN POTASSIUM AND CHARACTERISATION OF ACID DEGRADANT PRODUCT OF LOSARTAN

An accurate, precise, sensitive and selective stability indicating High-Performance Thin Layer Chromatographic method has been developed and validated for simultaneous estimation of Amlodipine besylate (AML) and Losartan potassium (LOS) in bulk and pharmaceutical dosage formulation. Chromatographic separation of both the drugs was achieved by using TLC aluminum plates pre-coated with silica gel 60...

K. Shelar, J. R. Rao * and C. Dhale

Department of Pharmaceutical Chemistry, Bharati Vidyapeeth Deemed University’s, Poona College of Pharmacy, Erandwane, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2456-64

2456-2464

128

41

51.

ATTITUDE TOWARDS VACCINATION: A CROSS-SECTIONAL STUDY AMONG THE PARENTS IN SUNGAI PETANI, KEDAH, MALAYSIA

Purpose: To evaluate parent’s attitude towards childhood vaccination and to determine the factors associated with non-adherence of parents to the mandatory vaccination schedule in Sungai Petani, Kedah, Malaysia. Methods: a Validated questionnaire was used as an instrument for evaluating parent’s attitude regarding childhood vaccination. Data obtained was classified based on Bloom’s cut-off p...

S. Aziz *, M. Z. Iqbal, M. S. Iqbal, S. G. Mohiuddin, S. Sivadasan, R. Veerasamy, A. N. Ali, S. K. Prajapati and J. M. Chandran

Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Pulau Pinang Malaysia.

DOI: 10.13040/IJPSR.0975-8232.10(5).2465-72

2465-2472

116

41

52.

SELF RATED SYMPTOM MEASURE OF VARIOUS MENTAL HEALTH DOMAINS OF UNDERGRADUATE MEDICAL STUDENTS OF TERTIARY CARE TEACHING HOSPITAL

Introduction: Mental disorders account for nearly 12% of the global burden of disease. They are expected to become the second most important cause of disability in the near future. Medical students remain under great academic pressure to pass internal and external exams which continuously keep them under pressure. It is also very important to know how students feel rather than to treat only those ...

L. Kumar, S. G. Mundhava * and P. A. Singh

Department of Pharmacology, P.D.U. Government Medical College, Rajkot, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2473-77

2473-2477

332

98

53.

STANDARDIZATION WITH HPTLC ANALYSIS OF POLYHERBAL POWDER FORMULATION: SAFOOF-E-MUSAKKIN

Background & Objectives: Standardization of polyherbal Unani formulations is essential to assess the quality of drugs, based on their active principles, physical and chemical standards. This work reports on standardization of a polyherbal Unani powder formulation Safoofe- Musakkin (SM) consist of Rauwolfia serpentina Benth. Ex kurz root, Coriandrum sativum Linn. seed and Piper nigrum Linn. fru...

G. J. Rather, Hamidudin *, M. Ikram, M. Zaigham, G. Sofi and T. Nayak

Department of Ilmul Saidla (Unani Pharmacy), National Institute of Unani Medicine (NIUM), Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2478-86

2478-2486

124

51

54.

AFFINITY CHROMATOGRAPHY PURIFICATION AND PARTIAL CHARACTERISATION OF D-GALACTOSE BINDING LECTIN FROM SEEDS OF JATROPHA CURCAS L.

A lectin curcin was isolated from mature seeds of Jatropha curcas L. Seeds were collected locally and purified by affinity chromatography on guar gum column. The lectin content was found to be 1.3 mg/ml. Curcin agglutinated B+ve human RBC type showing galactose and N-galactosylamine specificity. Galactose sugar was found to be the most potent inhibitor of curcin hemagglutinating activity (minimum ...

R. M. Phadke and K. Pai *

Department of Zoology, Savtribai Phule Pune University, Ganeshkhind, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2487-91

2487-2491

113

44

55.

PHYTOCHEMICAL SCREENING AND GC-MS STUDIES OF THE METHANOLIC EXTRACT OF TRIDAX PROCUMBENS

Use of plants as a source of medicine has been inherited and is an important component of the health care system in India. Tridax procumbens Linn. (Asteraceae) one of the medicinally important plants commonly found in subtropical countries growing primarily at waste places, roadsides throughout India during the raining season was chromatographically evaluated in the present work for various phytoc...

P. Kushwaha, S. S. Yadav, V. Singh and L. K. Dwivedi *

Institute of Biomedical Sciences, Bundelkhand University, Jhansi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2492-96

2492-2496

166

66

56.

A SIMPLE STABILITY INDICATING HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF LEVOCETIRIZINE DIHYDROCHLORIDE, PHENYLEPHRINE HYDROCHLORIDE AND PARACETAMOL IN PHARMACEUTICALS

An accurate and precise HPLC method was developed and validated for simultaneous determination of Levocetirizine dihydrochloride, Phenylephrine hydrochloride and Paracetamol in syrup formulations. The separation between Levocetirizine dihydrochloride, Phenylephrine hydrochloride, and Paracetamol was achieved within 20 min using an L1 column of 100 × 4.6 mm, 3 µ dimension using gradient programme...

A. P. G. Nikalje *, R. Gadikar and S. Turwale

Department of Pharmaceutical Chemistry, Y. B. Chavan College of Pharmacy, Aurangabad, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2497-03

2497-2503

137

47

57.

SPECTROPHOTOMETRIC DETERMINATION OF MEBENDAZOLE THROUGH CHARGE TRANSFER INTERACTIONS

This article presents the development of a direct, simple and sensitive spectrophotometric method for the quantitative analysis of mebendazole (MBz), an anthelmintic medication in its pure and pharmaceutical forms. The method is based on the charge transfer (CT) interactions between MBz, an electron donor, and chloranilic acid (CA), 3,5-dinitrosalicylic acid (DNSA), and picric acid (PA), (all of w...

R. M. Alghanmi * and L. Y. Alhazmi

Department of Chemistry, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia.

DOI: 10.13040/IJPSR.0975-8232.10(5).2504-15

2504-2515

112

48

58.

ANTIMALARIAL ACTIVITY AND TOXICITY EVALUATION OF THE ALKALOID-RICH FRACTION OF MOMORDICA CHARANTIA FRUITS

Introduction: We investigated to an in-vitro and in-vivo evaluation of antimalarial and toxicity of the alkaloid-rich fraction of Momordica charantia fruits. Materials and Methods: In-vitro and in-vivo antimalarial activity tests of Plasmodium falciparum strain 3D7 culture were performed on Plasmodium berghei-infected mice using suppressive and prophylactic methods, and evaluation of fraction toxi...

S. Abdillah *, Y. Farida, Kartiningsih, N. M. D. Sandhiutami and K. Mohamad

Department of Pharmacology, Faculty of Pharmacy, Pancasila University, Jl. Srengseng Sawah, Jagakarsa, South Jakarta, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.10(5).2516-22

2516-2522

114

42

59.

ANTIMICROBIAL ACTIVITY OF ENDOPHYTIC BACTERIA ISOLATED FROM FEW PLANTS OF MUTHATHI WILDLIFE SANCTUARY MANDYA, KARNATAKA

The worldwide usage of medicinal plants have been rapidly improved due to their medicinal property. Endophytic microorganisms are recognized as a potential source of novel chemical molecules that might be useful in the treatment of various diseases. In the present study, the plant samples were collected from Muthathi Wild Life Sanctuary, Mandya. The purpose of this study was to isolate the endophy...

S. Suresha * and M. Jayashankar

Department of Studies and Research in Microbiology, Jnana Kaveri Mangalore University, Post Graduate Centre, Jnana Kaveri Campus, Kodagu, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2523-27

2523-2527

115

47

60.

NOVEL BIOMARKERS OF ATHEROGENIC DIET INDUCED DYSLIPIDEMIA AND METABOLIC SYNDROME SUPPRESSED BY TERMINALIA ARJUNA

Atherosclerosis results from the slow deposition of fatty materials in media and large arteries leading to mortality worldwide. Terminalia arjuna is an herb of Combretaceae family which contains flavonoids, terpenoids, cardiac glycosides with high antioxidant properties. This study was conducted to determine the effect of hydroalcoholic extract fraction of T. arjuna on blood lipids and atheroscler...

S. Uthirapathy

Department of Pharmacology, Faculty of Pharmacy, Tishk International University, Erbil, Kurdistan Region, Iraq.

DOI: 10.13040/IJPSR.0975-8232.10(5).2528-36

2528-2536

133

59

61.

ACTIVE COMPOUND FROM n-HEXANE FRACTION OF RAMPAI (LYCOPERSICON ESCULENTUM) LEAVES ETHANOL EXTRACT

Lycopersicon esculentum leaves had traditionally been used to stimulate hair growth in Lampung Pesisir tribes, Tanggamus Regency, Lampung, Indonesia. This study aimed to examine the active compounds from the n-hexane L. esculentum leaves. The study based on our previous research showing that the n-hexane had hair growth stimulating effects. The study started with sample collection, extracted by ma...

Z. Oktoba, M. Moektiwardoyo and R. Mustarichie *

Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia.

DOI: 10.13040/IJPSR.0975-8232.10(5).2537-44

2537-2544

168

52

62.

EXTRACELLULAR LIPASE FROM BACILLUS SUBTILIS KUBT4: ISOLATION, IDENTIFICATION AND CHARACTERIZATION

Lipases occupy a prominent place amongst biocatalysts as they can hydrolyze fats into fatty acids and glycerol at the water-lipid interface. Lipase production is a prime area of interest for microbiologists, process engineers, and biochemists. Recent advances in green energy have led to renewed interest in the ability of microbial lipases to catalyze trans-esterification reaction for biodiesel pro...

R. D. Nadaf and C. T. Shivasharana *

PG Department of Biotechnology and Microbiology, Karnataka University, Dharwad, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2545-49

2545-2549

131

52

63.

FORMULATION DEVELOPMENT AND IN-VIVO RADIOGRAPHIC STUDIES OF DILTIAZEM HYDROCHLORIDE LOADED FLOATING CAPSULES PREPARED BY MODIFIED PULSINCAP TECHNOLOGY

Oral extended release formulation with site-specific drug delivery formulations has been of greater importance in the field of drug delivery system to achieve adequate therapeutic results. The concept of novel gastro-retentive drug delivery system aroused due to site specificity behavior of the drug concerning drug absorption and solubility. The objective of the research work is to develop and eva...

P. Srikanth *, S. Hemalatha and V. S. Suggala

Jawaharlal Nehru Technological University Anantapur (JNTUA), Ananthapuramu, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2550-64

2550-2564

107

52

64.

DESIGN, SYNTHESIS AND IN-SILICO STUDY OF NOVEL SERIES OF 2-PHENYL- 3-(5-SULFANYL-1,3,4-THIADIAZOL-2-YL)-1,3-THIAZOLIDIN-4-ONE DERIVATIVES WITH POTENTIAL ANTI-TUBERCULAR ACTIVITY

In an attempt to identify potential new agents active against tuberculosis with Shikimate kinase as the target, a novel series of 2-phenyl- 3-(5-sulfanyl-1,3,4-thiadiazol-2-yl)-1,3-thiazolidin-4-one derivatives were synthesized by convenient one-pot three-component reaction of amine, aldehyde and mercaptoacetic acid on montmorillonite KSF clay as a solid acidic catalyst in good yields. The structu...

V. G. Dadlani *, R. R. Somani and P. K. Tripathi

Department of Pharmaceutical Chemistry, Dr. L. H. Hiranandani College of Pharmacy, Ulhasnagar, Thane, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2565-76

2565-2576

124

44

65.

STUDY OF EFFECT OF INSULIN ON COGNITIVE FUNCTION IN DIABETES MELLITUS IN A TERTIARY CARE HOSPITAL

Diabetes Mellitus is a major lifestyle metabolic disorder and doubtlessly a challenging public health problem of the 21st century. Diabetes is associated with reduced performance on various domains of cognitive function, this study was aimed to access the effect of insulin on cognitive function in patients of Diabetes Mellitus. It was a prospective, observational and non-interventional study. 60 c...

D. A. Patel *, N. D. Kantharia and D. J. Patel

Department of Pharmacology, Government Medical College, Surat, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2577-82

2577-2582

98

43

66.

EFFICACY OF 10% TOPICAL TRANEXAMIC ACID IN MELASMA – A RANDOMIZED PLACEBO-CONTROLLED SPLIT FACE STUDY

Introduction: Melasma is a common facial pigmentary dermatosis in Indians. In spite of various treatment modalities, treatment of melasma is often challenging and recalcitrant. In this context, the present study was carried out to elucidate efficacy and safety of topical 10% Tranexamic acid (TXA) in melasma treatment. Materials and Methods: 40 Melasma patients with malar type were enrolled in the ...

S. Saka, G. R. R. Rao, R. B. Komaram *, S. Kotha, R. Tatavarthi and L. P. Chitturi

Department of Pharmacology, GSL Medical College and General Hospital, Rajahmundry, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2583-86

2583-2586

111

66

67.

MEASUREMENT OF pH OF THE DIGESTIVE VACUOLE ISOLATED FROM THE PLASMODIUM FALCIPARUM-INFECTED ERYTHROCYTE BY DIGITONIN PERMEABILIZATION

The acidic pH of the digestive vacuole (DV) of P. falciparum is thought to play a major role in the mechanisms of digestion of host erythrocyte hemoglobin, detoxification of heme, and chloroquine (CQ) action and resistance. However, a definitive measurement of the DV pH has been technically difficult. A previous study by Abu Bakar (2015) measured the DV pH by using fluorescein isothiocyanate-dextr...

N. Ibrahim and N. Abu-Bakar *

School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

DOI: 10.13040/IJPSR.0975-8232.10(5).2587-93

2587-2593

111

45

68.

IMPACT OF PERIODIC SAFETY UPDATE REPORTING SYSTEM IN A TERTIARY CARE TEACHING HOSPITAL OF SOUTHERN INDIA: A DELPHI STUDY

The process and functioning of newly implemented periodic safety update report system (PSUR) in the hospital were assessed using validated PSUR function assessment questionnaire (PFAQ) vetted by Delphi panel. Classical Delphi survey method was used to assess and validate the PFAQ in two successive review rounds with Delphi panel. Final validated PFAQ was circulated among health care practitioners ...

A. K. Lokhande, M. M. Prabhu and M. K. Unnikrishnan *

National College of Pharmacy, KMCT Medical College Road, Manassery, Mukkam, Kozhikode, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2594-04

2594-2604

135

42

69.

EVALUATION OF THE ANTI – PROLIFERATIVE EFFECT, ANTIOXIDANT AND PHYTOCHEMICAL CONSTITUENTS OF FICUS PUMILA LINN.

This study sought to evaluate the heavy metal content of the raw powder and extract of the plant, the phytochemical constituents, antioxidant effect by the use of DPPH assay, the total phenolic content using Folin Ciocalteu assay and the cytotoxic effect using the MTT Assay of Ficus pumila ethanolic extract, methanolic and hydro fractions on liver cancer cells (HepG2), Leukemic cells (Jurkat) and ...

D. Torkornoo *, C. Larbie, S. Agbenyegah, J. N. N. Dowuona, R. Appiah-Oppong, E. Dotse, A. Aning, B. Adu and C. Sinclear

Center for Molecular Biomedicine, Institute for Molecular Cell Biology, Jena University Hospital, Jena, Germany.

DOI: 10.13040/IJPSR.0975-8232.10(5).2605-18

2605-2618

140

58

70.

INVESTIGATION OF IN-VITRO THROMBOLYTIC AND IN-VIVO ANTIPYRETIC, ANTIDEPRESSANT POTENTIALITY AND ANALGESIC ACTIVITY WITH PHYTO-CHEMICAL NATURE OF METHANOLIC EXTRACT OF NYMPHOIDES HYDROPHYLLA

Nymphoides hydrophylla (NH) is mainly an aquatic herb of Menynthaceae family and traditionally used to treat fever, insect bites, different ulcers, and also to wash skin, where parasitic affection occurs. In this study, methanolic extract of Nymphoides hydrophylla (NH) plant was examined for the determination of thrombolytic, antipyretic, Central Nervous System (CNS) and analgesic activities. The ...

S. Bhattacharjee, S. Roy, M. M. Hosen, A. Das, T. D. Aka, S. C. Paul * and S. R. Debi

Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Sonapur, Noakhali, Bangladesh.

DOI: 10.13040/IJPSR.0975-8232.10(5).2619-27

2619-2627

216

79

71.

A STUDY ON PRESCRIBING PATTERN OF ANTIPSYCHOTICS IN SCHIZOPHRENIA AT A TERTIARY CARE HOSPITAL

Introduction: Schizophrenia is a chronic and debilitating psychiatric illness affecting around 0.4% to 1.4% of people at some point in their life. Early onset and the chronic course make schizophrenia a worrying disease. Prescribing pattern in Schizophrenia has seen a significant shift in the last two decades, from the first generation to second-generation antipsychotics. This study was carried ou...

S. Nukala, R. B. Komaram * and S. Singisetti

Department of Pharmacology, GSL Medical College & General Hospital, Rajahmundry, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2628-32

2628-2632

103

49

72.

NEW VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND VALSARTAN IN PHARMACEUTICAL FORMULATION

A simple, specific, accurate and precise and stability indicating RP-HPLC method was developed and validated for the simultaneous estimation of Amlodipine Besylate and Valsartan in pharmaceutical formulation. The method was developed using Enable C 18G column (250 × 4.6 mm, 0.5 µm) with a mobile phase consisting of sodium acetate buffer (pH 5.0) and methanol (35:65% v/v) with a flow rate of 1 mL...

T. H. Kumar * and C. H. Asha

Department of Pharmaceutical Analysis and Quality Assurance, Vignan Institute of Pharmaceutical Technology, Duvvada, Vishakapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.10(5).2633-43

2633-2643

108

39