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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , SJR (2017): 0.137
Five-Year Projected Impact Factor: 1.83

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Posted by on Aug 5, 2008 in Blog | 0 comments

CHEMICAL SYNTHESIS OF BILE ACIDS AND THEIR PHYSICO-CHEMICAL PROPERTIES

CHEMICAL SYNTHESIS OF BILE ACIDS AND THEIR PHYSICO-CHEMICAL PROPERTIES

The main roles of bile acids as amphiphilic molecules are the micellar solubilization of the lipids, in the course of the welding process and the regulation of cholesterol homeostasis, which is essential as a precursor for the synthesis of bile acids. From the hydrophobic and hydrophilic surfaces of bile acids directly depends the level of their attachment to the receptors, ion channels and their effectiveness in the solubilization of lipid (hydrophobic drugs). The toxicity of membrane of bile acids is mainly determined by their hydrophobicity. We have synthesized the methyl ester of 7α-hydroxy-3-oxo-5β-cholanoic acid. We have reviewed and discussed the effects of the structure of bile acids to their hydrophobicity, which is expressed by the retention parameters by reverse phase chromatography, and hydrophobic properties, which is represented by partition coefficient 1-octanol / water. It also discusses the role of the lipophilicity of bile acids in their interactions with biological...

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Posted by on Aug 5, 2008 in Blog | 0 comments

ZIKA VIRUS: A CHALLENGE FOR HUMANS

ZIKA VIRUS: A CHALLENGE FOR HUMANS

Zika virus infection is caused by the bite of an infected Aedes mosquito, usually causing rash, mild fever, conjunctivitis, and muscle pain. First time the virus was isolated in 1947 in the Zika forest in Uganda. It is transmitted to people through the bite of an infected Aedes mosquito. Symptoms are similar to those of dengue and chikungunya, which are transmitted by the same type of mosquito. Autoimmune and Neurological complications are infrequent. Treatment consists of relieving pain, fever, and any other symptom that inconveniences the patient. To prevent dehydration, it is recommended to drink plenty of water, rest, and control the fever. Thus far, there is no vaccine for the virus. But since it is a self-remitting disease, a person can be hopeful of being cured within a week or two, and the treatment is usually symptomatic. This review covers about the Zika virus; epidemiology and guidelines issued by the health ministry for control and prevention of Zika...

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Posted by on Jan 27, 2008 in Blog | 0 comments

Vestibulum eu dui eget diam

Vestibulum eu dui eget diam

Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Sed pede felis, tempor eu, aliquet ut, pulvinar eu, nunc. Quisque sed magna non risus porta sollicitudin. Morbi congue sapien nec diam. Cras nibh lacus, ullamcorper sit amet, pretium congue, consectetuer convallis, metus. Aliquam erat volutpat. Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Class aptent taciti sociosqu ad litora torquent per conubia nostra, per inceptos himenaeos. Maecenas tincidunt justo sed dolor.Nullam ac erat. Donec a ipsum. Nullam tristique leo id lacus. Sed sed pede non arcu ornare interdum. Maecenas justo elit, rutrum in, adipiscing id, laoreet in, libero. Fusce quam. Donec a urna a enim gravida dictum. Nunc elementum, mauris sit amet imperdiet iaculis, dolor metus consectetuer mi, et tempor elit enim at massa. Duis ac nisl. Nullam pulvinar. Curabitur quam sapien, lobortis eu, luctus vitae, volutpat ac, metus. Nam elementum. Fusce fringilla. Praesent pulvinar turpis vitae justo cursus pulvinar. In hac habitasse platea dictumst. Nunc fermentum tellus interdum libero. Phasellus eros. Vestibulum euismod nunc at...

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Posted by on Jan 18, 2008 in Blog | 0 comments

At vero eos et accusamus et iusto

At vero eos et accusamus et iusto

At vero eos et accusamus et iusto odio dignissimos ducimus qui blanditiis praesentium voluptatum deleniti atque corrupti quos dolores et quas molestias excepturi sint occaecati cupiditate non provident, similique sunt in culpa qui officia deserunt mollitia animi, id est laborum et dolorum fuga. Et harum quidem rerum facilis est et expedita distinctio. Nam libero tempore, cum soluta nobis est eligendi optio cumque nihil impedit quo minus id quod maxime placeat facere possimus, omnis voluptas assumenda est, omnis dolor repellendus. Temporibus autem quibusdam et aut officiis debitis aut rerum necessitatibus saepe eveniet ut et voluptates repudiandae sint et molestiae non recusandae. Itaque earum rerum hic tenetur a sapiente delectus, ut aut reiciendis voluptatibus maiores alias consequatur aut perferendis doloribus asperiores repellat Nullam ac erat. Donec a ipsum. Nullam tristique leo id lacus. Sed sed pede non arcu ornare interdum. Maecenas justo elit, rutrum in, adipiscing id, laoreet in, libero. Fusce quam. Donec a urna a enim gravida dictum. Nunc elementum, mauris sit amet imperdiet iaculis, dolor metus consectetuer mi, et...

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Posted by on Sep 28, 2006 in Blog | 0 comments

Aenean bibendum elementum pede

Aenean bibendum elementum pede

Nulla ornare, nulla et egestas hendrerit, ipsum dui vulputate dolor, et ornare orci erat eleifend pede. Fusce eros libero, vestibulum non, elementum eu, suscipit eget, leo. Donec consectetuer tincidunt diam. Sed et mauris in ligula feugiat hendrerit. Cras neque purus, mollis non, adipiscing ac, pretium eget, turpis. Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Vestibulum vulputate metus in ligula. Ut at tellus. Suspendisse potenti. Mauris in orci eget risus condimentum tristique. Vivamus egestas, neque ac posuere egestas, ante justo malesuada nunc, elementum pretium mi lacus sit amet turpis. Curabitur scelerisque sodales justo. Pellentesque non sapien quis ligula iaculis vestibulum. Aenean dignissim arcu gravida nisi. Nulla facilisi. Fusce a augue. Nullam ac erat. Donec a ipsum. Nullam tristique leo id lacus. Sed sed pede non arcu ornare interdum. Maecenas justo elit, rutrum in, adipiscing id, laoreet in, libero. Fusce quam. Donec a urna a enim gravida dictum. Nunc elementum, mauris sit amet imperdiet iaculis, dolor metus consectetuer mi, et tempor elit enim at massa. Duis...

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