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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Posted by on Sep 15, 2010 in Portfolio | 0 comments

Our Other Publication

Our Other Publication

International Journal of Pharmacognosy (IJP) is an official publication of Society of Pharmaceutical Sciences & Research. It is an open access online International Journal published monthly. For more details visit...

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Posted by on Sep 15, 2010 in Portfolio | 0 comments

ABSTRACTING AND INDEXING INFORMATION

ABSTRACTING AND INDEXING INFORMATION

EMBASE- Elsevier’s, Hinari- WHO, Directory of open access journals (DOAJ), Chemical Abstract, Scirus – Elsevier’s, Gale- Expanded Academic ASAP, EBSCO, Google, Google scholar, International consortium for the advancement of academic publication (ICAAP), Scientific common, Pharmaceutical Sciences Open Access Resources (PSOAR), Index Copernicus, Ulrich’s International Periodical Directory, ProQuest, New York University Health Sciences Libraries, Research Gate, Open-J-Gate, Geneva Foundation for Medical Education & Research, Ayush Research portal, Genamics Journal...

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Posted by on Sep 15, 2010 in Portfolio | 0 comments

The Masked Model

The Masked Model

Aenean eget dui eros, non lobortis lectus. Vestibulum eleifend laoreet orci ac elementum. Nulla lacinia, orci et sollicitudin ullamcorper, massa risus porta felis, id egestas dolor diam et risus. Pellentesque convallis leo eget lacus cursus dapibus. Sed in nisl at nisi semper malesuada sed fringilla augue. Quisque venenatis felis non velit placerat tincidunt. Suspendisse potenti. Praesent fermentum malesuada placerat. Phasellus pretium interdum neque, nec accumsan tortor lacinia ut. Fusce eget orci nunc, non sagittis augue. Donec sodales, erat fermentum aliquam interdum, magna metus condimentum ante, nec imperdiet purus sem ac dui. Maecenas enim sapien, ultricies id feugiat nec, blandit at...

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Posted by on Sep 4, 2008 in Blog | 0 comments

BENZOTHIAZOLE – A MAGIC MOLECULE

BENZOTHIAZOLE – A MAGIC MOLECULE

Antimicrobial resistance has been called one of the world’s most pressing public health problems. Addressing the issue of antimicrobial resistance is one of the most urgent priorities in the fields of public health today. Alarmingly, the development of resistance such as multi-drug resistance towards a number of antibiotics poses a challenge to the scientific community in the discovery of new therapies. Thus, there is a need to develop newer and effective molecules with high safety profile. Benzothiazoles are fused membered rings, which contain heterocycles bearing thiazole. Sulphur and nitrogen atoms constitute the core structure of thiazole and many pharmacologically and biologically active compounds. Benzothiazole is an interesting pharmacophore exhibiting diverse pharmacological activities like antimicrobial, anticancer, anthelminthic, antidiabetic, antitubercular, anticonvulsant, antioxidant, anti-inflammatory, antifungal, antipsychotic etc. The present article extensively covers various procedures of synthesis of 2-substituted benzothiazole core and its analogs – by utilizing distinctive catalysts, solvent conditions, reactants immobilized on solid support and microwave irradiation. Variations in synthetic procedures are studied to explore chemo-selectivity of the reactions, in-expensive, eco-friendly,...

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Posted by on Aug 5, 2008 in Blog | 0 comments

CHEMICAL SYNTHESIS OF BILE ACIDS AND THEIR PHYSICO-CHEMICAL PROPERTIES

CHEMICAL SYNTHESIS OF BILE ACIDS AND THEIR PHYSICO-CHEMICAL PROPERTIES

The main roles of bile acids as amphiphilic molecules are the micellar solubilization of the lipids, in the course of the welding process and the regulation of cholesterol homeostasis, which is essential as a precursor for the synthesis of bile acids. From the hydrophobic and hydrophilic surfaces of bile acids directly depends the level of their attachment to the receptors, ion channels and their effectiveness in the solubilization of lipid (hydrophobic drugs). The toxicity of membrane of bile acids is mainly determined by their hydrophobicity. We have synthesized the methyl ester of 7α-hydroxy-3-oxo-5β-cholanoic acid. We have reviewed and discussed the effects of the structure of bile acids to their hydrophobicity, which is expressed by the retention parameters by reverse phase chromatography, and hydrophobic properties, which is represented by partition coefficient 1-octanol / water. It also discusses the role of the lipophilicity of bile acids in their interactions with biological...

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