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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

A Web of Science - ESCI Indexed Journal
Projected Impact Factor (2019): 1.230 , CiteScore (2017): 0.27

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Posted by on Sep 4, 2008 in Blog | 0 comments

BENZOTHIAZOLE – A MAGIC MOLECULE

BENZOTHIAZOLE – A MAGIC MOLECULE

Antimicrobial resistance has been called one of the world’s most pressing public health problems. Addressing the issue of antimicrobial resistance is one of the most urgent priorities in the fields of public health today. Alarmingly, the development of resistance such as multi-drug resistance towards a number of antibiotics poses a challenge to the scientific community in the discovery of new therapies. Thus, there is a need to develop newer and effective molecules with high safety profile. Benzothiazoles are fused membered rings, which contain heterocycles bearing thiazole. Sulphur and nitrogen atoms constitute the core structure of thiazole and many pharmacologically and biologically active compounds. Benzothiazole is an interesting pharmacophore exhibiting diverse pharmacological activities like antimicrobial, anticancer, anthelminthic, antidiabetic, antitubercular, anticonvulsant, antioxidant, anti-inflammatory, antifungal, antipsychotic etc. The present article extensively covers various procedures of synthesis of 2-substituted benzothiazole core and its analogs – by utilizing distinctive catalysts, solvent conditions, reactants immobilized on solid support and microwave irradiation. Variations in synthetic procedures are studied to explore chemo-selectivity of the reactions, in-expensive, eco-friendly,...

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Posted by on Aug 5, 2008 in Blog | 0 comments

CHEMICAL SYNTHESIS OF BILE ACIDS AND THEIR PHYSICO-CHEMICAL PROPERTIES

CHEMICAL SYNTHESIS OF BILE ACIDS AND THEIR PHYSICO-CHEMICAL PROPERTIES

The main roles of bile acids as amphiphilic molecules are the micellar solubilization of the lipids, in the course of the welding process and the regulation of cholesterol homeostasis, which is essential as a precursor for the synthesis of bile acids. From the hydrophobic and hydrophilic surfaces of bile acids directly depends the level of their attachment to the receptors, ion channels and their effectiveness in the solubilization of lipid (hydrophobic drugs). The toxicity of membrane of bile acids is mainly determined by their hydrophobicity. We have synthesized the methyl ester of 7α-hydroxy-3-oxo-5β-cholanoic acid. We have reviewed and discussed the effects of the structure of bile acids to their hydrophobicity, which is expressed by the retention parameters by reverse phase chromatography, and hydrophobic properties, which is represented by partition coefficient 1-octanol / water. It also discusses the role of the lipophilicity of bile acids in their interactions with biological...

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Posted by on Aug 5, 2008 in Blog | 0 comments

AN OVERVIEW ON COVID-19 OUTBREAK: EPIDEMIC TO PANDEMIC

AN OVERVIEW ON COVID-19 OUTBREAK: EPIDEMIC TO PANDEMIC

COVID-19 is a disease caused by the novel coronavirus, which was initially called 2019-nCoV, consequently termed as SARS-CoV-2 by the experts of the International Committee on Taxonomy of Viruses (ICTV) as it is exceptionally alike to the virus that caused the SARS outbreak in 2002 to 2003. World Health Organization already had declared COVID-19 as an international emergency as the disease is spreading at alarming levels. COVID-19 has affected more than 1,016,372 people around the world and killed more than 53,238 people. And even where the virus hasn’t yet spread, hospitals and clinics around the world have been preparing for a rush forward of coronavirus patients as a priority over everyday illnesses they treat. The label ‘international emergency’ has triggered governments of various countries to activate vigilance plans and probably take emergency measures to protect the public, such as more strong travel and trade restrictions. It is being observed that this is the first time this kind of virus, a coronavirus, has been labeled a pandemic, “but at the...

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Posted by on Jan 27, 2008 in Blog | 0 comments

Vestibulum eu dui eget diam

Vestibulum eu dui eget diam

Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Sed pede felis, tempor eu, aliquet ut, pulvinar eu, nunc. Quisque sed magna non risus porta sollicitudin. Morbi congue sapien nec diam. Cras nibh lacus, ullamcorper sit amet, pretium congue, consectetuer convallis, metus. Aliquam erat volutpat. Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Class aptent taciti sociosqu ad litora torquent per conubia nostra, per inceptos himenaeos. Maecenas tincidunt justo sed dolor.Nullam ac erat. Donec a ipsum. Nullam tristique leo id lacus. Sed sed pede non arcu ornare interdum. Maecenas justo elit, rutrum in, adipiscing id, laoreet in, libero. Fusce quam. Donec a urna a enim gravida dictum. Nunc elementum, mauris sit amet imperdiet iaculis, dolor metus consectetuer mi, et tempor elit enim at massa. Duis ac nisl. Nullam pulvinar. Curabitur quam sapien, lobortis eu, luctus vitae, volutpat ac, metus. Nam elementum. Fusce fringilla. Praesent pulvinar turpis vitae justo cursus pulvinar. In hac habitasse platea dictumst. Nunc fermentum tellus interdum libero. Phasellus eros. Vestibulum euismod nunc at...

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Posted by on Jan 18, 2008 in Blog | 0 comments

At vero eos et accusamus et iusto

At vero eos et accusamus et iusto

At vero eos et accusamus et iusto odio dignissimos ducimus qui blanditiis praesentium voluptatum deleniti atque corrupti quos dolores et quas molestias excepturi sint occaecati cupiditate non provident, similique sunt in culpa qui officia deserunt mollitia animi, id est laborum et dolorum fuga. Et harum quidem rerum facilis est et expedita distinctio. Nam libero tempore, cum soluta nobis est eligendi optio cumque nihil impedit quo minus id quod maxime placeat facere possimus, omnis voluptas assumenda est, omnis dolor repellendus. Temporibus autem quibusdam et aut officiis debitis aut rerum necessitatibus saepe eveniet ut et voluptates repudiandae sint et molestiae non recusandae. Itaque earum rerum hic tenetur a sapiente delectus, ut aut reiciendis voluptatibus maiores alias consequatur aut perferendis doloribus asperiores repellat Nullam ac erat. Donec a ipsum. Nullam tristique leo id lacus. Sed sed pede non arcu ornare interdum. Maecenas justo elit, rutrum in, adipiscing id, laoreet in, libero. Fusce quam. Donec a urna a enim gravida dictum. Nunc elementum, mauris sit amet imperdiet iaculis, dolor metus consectetuer mi, et...

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Posted by on Sep 28, 2006 in Blog | 0 comments

Aenean bibendum elementum pede

Aenean bibendum elementum pede

Nulla ornare, nulla et egestas hendrerit, ipsum dui vulputate dolor, et ornare orci erat eleifend pede. Fusce eros libero, vestibulum non, elementum eu, suscipit eget, leo. Donec consectetuer tincidunt diam. Sed et mauris in ligula feugiat hendrerit. Cras neque purus, mollis non, adipiscing ac, pretium eget, turpis. Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Vestibulum vulputate metus in ligula. Ut at tellus. Suspendisse potenti. Mauris in orci eget risus condimentum tristique. Vivamus egestas, neque ac posuere egestas, ante justo malesuada nunc, elementum pretium mi lacus sit amet turpis. Curabitur scelerisque sodales justo. Pellentesque non sapien quis ligula iaculis vestibulum. Aenean dignissim arcu gravida nisi. Nulla facilisi. Fusce a augue. Nullam ac erat. Donec a ipsum. Nullam tristique leo id lacus. Sed sed pede non arcu ornare interdum. Maecenas justo elit, rutrum in, adipiscing id, laoreet in, libero. Fusce quam. Donec a urna a enim gravida dictum. Nunc elementum, mauris sit amet imperdiet iaculis, dolor metus consectetuer mi, et tempor elit enim at massa. Duis...

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