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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

Inclusion in Web of Science (Thomson Reuters) - ESCI
Projected Impact Factor (2017): 0.59 , ICV (2015): 90.24
Five-Year Projected Impact Factor: 1.83

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Posted by on Sep 4, 2008 in Blog | 0 comments

MEDICINAL PLANTS – FROM TRADITIONAL USE TO TOXICITY ASSESSMENT: A REVIEW

MEDICINAL PLANTS – FROM TRADITIONAL USE TO TOXICITY ASSESSMENT: A REVIEW

Herbal medicine is gaining popularity once again and there is an increased interest in green medicine simply because it is considered as safe.  Traditionally also plants and plant extracts were used to cure many diseases and disorders. However, before usage it is of utmost important to ensure its safety. The extract may be therapeutically very efficient but if it’s toxicity assessment is not worked out, it will not be accepted.  Hence, toxicity assessment of plants with proven therapeutic use is of utmost important. Toxicity data are required to predict the safety associated before the use of medical products.  In the present review, parameters required to be analyzed in acute, sub acute and chronic toxicity are discussed with their relevant importance.  In the end ninty eight plants whose toxicity is worked out are listed along with their botanical name, family, ethnomedicinal uses, part used, solvent used, safety levels, dose levels used, route of administration, LD50 values and references.  Researchers who wish to work on some pharmacological activity can directly choose...

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Posted by on Aug 5, 2008 in Blog | 0 comments

CURCUMIN: TRANSFORMING THE SPICE TO A WONDER DRUG

CURCUMIN: TRANSFORMING THE SPICE TO A WONDER DRUG

Turmeric is a spice obtained from the dried rhizomes of Curcuma longa, family Zingiberaceae. It has been extensively used in traditional Indian (Ayurveda) and Chinese medicine for various ailments such as anti-inflammatory, blood purifier and even as a cosmetic. Curcumin, the chief constituent in turmeric has been isolated centuries ago, has been found to have a wide range of pharmacological actions such as antioxidant, anti-inflammatory, anticancer, antimicrobial and much more. Thus curcumin and its analogues have immense therapeutic potential for use in rheumatoid arthritis, Crohn’s disease, cancer, diabetes, cardiovascular disease, HIV-I and Alzheimer’s disease. Phase I clinical studies have shown that high doses of curcumin is well tolerated in man. Despite its safety, curcumin still evades clinical use due to poor bioavailability. Novel formulations of curcumin with piperine, soluble fibres of fenugreek, liposomes, micelles, nanoparticles, cyclodextrin and turmerone have shown enhanced bioavailability to some extent, each one having its own limitations. Recent formulation of curcuminoid with 45% turmerone seems to be promising. Further research in this direction is imperative...

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Posted by on Aug 5, 2008 in Blog | 0 comments

COLON TARGETED DRUG DELIVERY SYSTEM: A REVEIW ON PRIMARY AND NOVEL APPROACHES

COLON TARGETED DRUG DELIVERY SYSTEM: A REVEIW ON PRIMARY AND NOVEL APPROACHES

In the recent years there is new development in field of colon specific drug delivery system. The colon is the terminal part of the GIT which has gained as a potential site for delivery of various novel therapeutic drugs. The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease, Crohn’s disease, ulcerative colitis, etc. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. It also plays vital role in systemic delivery of proteins, therapeutic peptides, anti-asthmatic drugs, antihypertensive drugs and anti-diabetic agents. This review article discusses introduction of colon, need and Primary approaches for CDDS (Colon Specific Drug Delivery), which includes prodrugs, pH and time dependent systems and microbially triggered drug delivery system. Newly developed CDDS, which includes pressure controlled colonic delivery capsules (PCDCS), CODE and osmotic controlled drug delivery and also focuses on evaluations of Colon targeted drug delivery in...

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Posted by on Jan 27, 2008 in Blog | 0 comments

Vestibulum eu dui eget diam

Vestibulum eu dui eget diam

Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Sed pede felis, tempor eu, aliquet ut, pulvinar eu, nunc. Quisque sed magna non risus porta sollicitudin. Morbi congue sapien nec diam. Cras nibh lacus, ullamcorper sit amet, pretium congue, consectetuer convallis, metus. Aliquam erat volutpat. Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Class aptent taciti sociosqu ad litora torquent per conubia nostra, per inceptos himenaeos. Maecenas tincidunt justo sed dolor.Nullam ac erat. Donec a ipsum. Nullam tristique leo id lacus. Sed sed pede non arcu ornare interdum. Maecenas justo elit, rutrum in, adipiscing id, laoreet in, libero. Fusce quam. Donec a urna a enim gravida dictum. Nunc elementum, mauris sit amet imperdiet iaculis, dolor metus consectetuer mi, et tempor elit enim at massa. Duis ac nisl. Nullam pulvinar. Curabitur quam sapien, lobortis eu, luctus vitae, volutpat ac, metus. Nam elementum. Fusce fringilla. Praesent pulvinar turpis vitae justo cursus pulvinar. In hac habitasse platea dictumst. Nunc fermentum tellus interdum libero. Phasellus eros. Vestibulum euismod nunc at...

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Posted by on Jan 18, 2008 in Blog | 0 comments

At vero eos et accusamus et iusto

At vero eos et accusamus et iusto

At vero eos et accusamus et iusto odio dignissimos ducimus qui blanditiis praesentium voluptatum deleniti atque corrupti quos dolores et quas molestias excepturi sint occaecati cupiditate non provident, similique sunt in culpa qui officia deserunt mollitia animi, id est laborum et dolorum fuga. Et harum quidem rerum facilis est et expedita distinctio. Nam libero tempore, cum soluta nobis est eligendi optio cumque nihil impedit quo minus id quod maxime placeat facere possimus, omnis voluptas assumenda est, omnis dolor repellendus. Temporibus autem quibusdam et aut officiis debitis aut rerum necessitatibus saepe eveniet ut et voluptates repudiandae sint et molestiae non recusandae. Itaque earum rerum hic tenetur a sapiente delectus, ut aut reiciendis voluptatibus maiores alias consequatur aut perferendis doloribus asperiores repellat Nullam ac erat. Donec a ipsum. Nullam tristique leo id lacus. Sed sed pede non arcu ornare interdum. Maecenas justo elit, rutrum in, adipiscing id, laoreet in, libero. Fusce quam. Donec a urna a enim gravida dictum. Nunc elementum, mauris sit amet imperdiet iaculis, dolor metus consectetuer mi, et...

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Posted by on Sep 28, 2006 in Blog | 0 comments

Aenean bibendum elementum pede

Aenean bibendum elementum pede

Nulla ornare, nulla et egestas hendrerit, ipsum dui vulputate dolor, et ornare orci erat eleifend pede. Fusce eros libero, vestibulum non, elementum eu, suscipit eget, leo. Donec consectetuer tincidunt diam. Sed et mauris in ligula feugiat hendrerit. Cras neque purus, mollis non, adipiscing ac, pretium eget, turpis. Cum sociis natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Vestibulum vulputate metus in ligula. Ut at tellus. Suspendisse potenti. Mauris in orci eget risus condimentum tristique. Vivamus egestas, neque ac posuere egestas, ante justo malesuada nunc, elementum pretium mi lacus sit amet turpis. Curabitur scelerisque sodales justo. Pellentesque non sapien quis ligula iaculis vestibulum. Aenean dignissim arcu gravida nisi. Nulla facilisi. Fusce a augue. Nullam ac erat. Donec a ipsum. Nullam tristique leo id lacus. Sed sed pede non arcu ornare interdum. Maecenas justo elit, rutrum in, adipiscing id, laoreet in, libero. Fusce quam. Donec a urna a enim gravida dictum. Nunc elementum, mauris sit amet imperdiet iaculis, dolor metus consectetuer mi, et tempor elit enim at massa. Duis...

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