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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 14 (2023) - Issue 2, February

Review Articles

 
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1.

CERIUM OXIDE NANOPARTICLES APPLICATIONS IN THE FIELD OF CARDIOVASCULAR DISEASES

Cardiovascular disease (CVD) is the sixth most common human disease that causes about 17.3 million deaths yearly. Advancement in nanomedicine enables the usage of nanomaterials for treating cardiac disorders. Among these, Cerium Oxide (CeO2) nanoparticle is gaining attention due to their irreversible oxidative states (Ce3+ and Ce4+), which provide them with many unique, physiologically important t...

M. K. Shurfa, Agnishwar Girigoswami and Koyeli Girigoswami *

Medical Bionanotechnology, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Chettinad Health City, Rajiv Gandhi Salai, Kelambakkam, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).530-37

530-537

34

31

2.

SEMECARPUS ANACARDIUM LINN: AN ETHNOMEDICAL, PHYTOCHEMICAL AND PHARMACOLOGICAL REVIEW

Semecarpus anacardium Linn. (Family Anacardiaceae), generally known 'Ballataka' or' Bhilwa', is a factory well-known for its medicinal value in ayurvedic and siddha system of the drug; it's also used for non-medicinal purpose like marking of cloth, hair color, etc. since ancient time. Phytochemical analyses of Semecarpus anacardium nut shows that, its nut contains a variety of biologically active ...

Abhinav G. Bais *, Sachin M. Hiradeve and Vaibhav P. Uplanchiwar

Nagpur College of Pharmacy, Wanadongri, Hingna Road, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).538-46

538-546

24

17

3.

NANOSTRUCTURED LIPID CARRIERS: THE ADVANCED LIPID CARRIERS AND THEIR APPLICATIONS

Nanostructured Lipid Carriers (NLCs) is a novel type of drug-delivery system. They are binary system which is stable in a different environment. Nanostructured Lipid Carrier (NLC) comprises a blend of solid and liquid lipids as a core matrix. NLCs have aggravated the incessant impulsion for developing safe and valuable drug delivery systems due to their exceptional physicochemical and biocompatibl...

Shailendra S. Salvankar *, Akshada A. Aghav, Devang S. Mahale, Shital S. Kshirsagar and Mukesh P. Ratnaparkhi

Department of Pharmaceutics, Marathwada Mitra Mandal’s College of Pharmacy, Thergoan, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).547-61

547-561

24

19

4.

AN OVERVIEW OF HERBAL FORMULATIONS: FROM PROCESSING TO PHARMACOVIGILANCE

Herbs have been a surviving unit since we were born on this planet. Currently, they are the most probed topic in the food industry or pharmacotherapy due to their multidimensional approach where one herb targets various diseases and proffers a wide range of health benefits. Moreover, some herbal supplements are merchandised globally, and people are devouring these products blithely to extract addi...

Neha Singh, Meenakshi Garg * and Rajni Chopra

Department of Food Technology, Bhaskaracharya College of Applied Science, Dwarka, New Delhi, Delhi, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).562-78

562-578

30

18

5.

SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM: SPECIAL EMPHASIS ON VARIOUS OILS USED IN SMEDDS

In pharmaceuticals formulation, poorly aqueous soluble medications are becoming more difficult to administer into dosage form as 40-50% of new chemical entities discovered are reported to be poorly aqueous soluble, preventing appropriate absorption from the GI tract. Oral administration is preferred over other forms of administration due to its ease of administration & painless approach. The m...

Mukesh Ratnaparkhi *, Rajnandini Ahire, Hrushikesh Shinde and Shailendra Salvankar

Department of Pharmaceutics, Marathwada Mitra Mandal's College of Pharmacy, Thergaon, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).579-89

579-589

22

13

6.

REVIEW ON PATHOPHYSIOLOGY OF MIGRAINE: TYPES AND VARIOUS ANTIOXIDANTS

The review briefs the information mainly about migraine disease. It tells about genes that are responsible for migraine. Alternating Hemiplegia in Childhood, Cortical spreading depression, Monogenic Migraine, Hemicrania Ophthalmoplegia, Hemicrania Alia Definite, Hemicrania, Complicated Migraine, Status Migrinous these are types of migraine, sign and symptoms also included. The history gives all th...

Pravin J. Patil * and Sapna G. Suryawanshi

Department of Pharmacology, Marathwada Mitra Mandal’s College of Pharmacy, Thergoan, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).590-06

590-606

25

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7.

AN INSIGHT INTO NEUROPATHIC PAIN: A SYSTEMIC AND UP-TO-DATE REVIEW

Neuropathic pain is a chronic illness that originates when abnormal functioning in the nervous system is observed or if the nervous system, including peripheral nerves, spinal cords, and brain, is damaged or not working properly, and originating pain. Therefore, it can be said that neuropathic pain is a chronic illness that directly impacts a large number of patients, society, and healthcare syste...

Himanshu Sharma *, Tanzeeb Rani and Shahbaz Khan

School of Pharmaceutical Sciences, IFTM University, Lodhipur-Rajpoot, Moradabad, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).607-21

607-621

22

9

8.

MOMORDICA CHARANTIA (BITTER MELON) CHEWABLE LOZENGES- A HYPOTHESIS-BASED APPROACH TO THE TREATMENT OF DIABETES MELLITUS

Diabetes Mellitus is a prevalent global health problem commonly known as diabetes, a metabolic disease resulting in high blood sugar levels. India considered as "Capital of Diabetes” and more than 61 million Indians suffer from diabetes. Plants are incredible natural reservoirs of phytochemicals and vital medicines. Momordica charantia (MC), commonly known as bitter melon, has high phytochemical...

Chanchal Tiwari *, Mavia Khatoon, Amit Kumar, Mahima, Nand Kishor, Pankaj Kumar Jaiswal and Princy Malik

Department of Pharmacy, IEC College of Engineering and Technology, Plot No. 04, Knowledge Park-1, Surajpur, Kasna Road, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).622-38

622-638

14

9

9.

A REVIEW: “SKIN-RELATED RARE DISEASES: PACHYONYCHIA CONGENITAL”

Keratin is a structural protein from the intermediate filament network, i.e., responsible for maintaining the keratinocyte's structural integrity. Pachyonychia congenita is not a lifetime disease. It is a rare dermatosis disease occurred in the sole’s feet and palm’s hand.  In this review, we have discussed the keratinization that occurs in the stratum corneum that follows mutation in the ker...

Payal Saxena *, Himani Devi and Abhishek Panchwal

School of Pharmacy and Research, Devbhoomi Uttarakhand University, Manduwala, Dehradun, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).639-44

639-644

20

7

10.

A BURDEN OF GASTROENTERITIS ASSOCIATED WITH COMORBIDITIES AN EFFECTIVE MANAGEMENT STRATEGY

Acute gastroenteritis prevalent amongst children and newborns is considered a serious infection globally. The Acute diarrhea as a result of gastroenteritis as per logistics suggest that there were more than 1.5 million outpatient visits along with 200,000 hospitalizations and 300 fatalities per year in children in U.S. Diarrhea is the leading cause of deaths amongst children with 30% relapse rate....

Sneha Thakur *, Ayesha Unissa, Saleha Begum and Mahvish Fatima

Department of Pharmacognosy, St. Pauls College of Pharmacy, Sy. No. 603 & amp; 605, Hyderabad, Nagarjuna Sagar Rd, Turkayamjal, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).645-53

645-653

21

8

11.

EFFECT OF SWARNAPRASHANA ON CHILD HEALTH: A REVIEW

Introduction: Gold preparations are highly prized and often utilized for their tonic and revitalizing effects in Indian systems of medicine. Gold has both preventive and curative medicinal properties. The Kashyap Samhita, under the name Swarnaprashana, describes the usage of gold internally in children via the oral route. After birth, it is indicated in Lehan karma (supplementary feeding to improv...

Sahadat Khan * and Nisha Kumari Ojha

Department of Kaumarbhritya, National Institute of Ayurveda, Deemed To Be University (De Novo), Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).654-60

654-660

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12.

A BRIEF REVIEW ON SLEEP PARALYSIS: MANAGEMENT AND TREATMENT

The brain alternates between wakefulness, nonrapid eye movement (NREM) sleep and rapid eye movement (REM) sleep during sleep. Sleepwalking, sleep terrors, sleepwalking and sleep paralysis are common examples of the behavioral manifestations linked with parasomnias or partial arousals from sleep. Sleep Paralysis is a condition in which someone lying supine position, about drop off to sleep or just ...

Debgopal Ganguly, Soumyadip Ghosh *, Madhumita Banerjee, Abid Alam and Rajesh Ghosh

School of Pharmacy, Calcutta Institute of Pharmaceutical Technology and AHS, Uluberia, Howrah, Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).661-73

661-673

20

9

13.

HETEROCYCLE-FUSED BENZIMIDAZOLE: A PRIVILEGED SCAFFOLD IN ANTIMICROBIAL DRUG DISCOVERY

Compounds with heterocyclic moiety are important for life and are abundant in nature. Heterocyclic compounds have a crucial part in the metabolism of all biological cells. Humanity relies heavily on nitrogen-based heterocyclic compounds. Benzimidazole, in particular, is a vital component of the entire nitrogen-based heterocyclic chemical family, not just physiologically but also industrially. Beca...

Sugat Shukla, Arun Kumar *, Shikhar Verma and Kuldeep Singh

Faculty of Pharmacy, Integral University Kurshi Road, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).674-87

674-687

18

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14.

SCHIFF BASE: A REVIEW OF PHARMACOLOGICAL ACTIVITIES

Schiff bases are generally aldehyde or ketone-like compounds in which an imine or azomethine group replaces the carbonyl group. They are versatile and exhibit a broad range of pharmacological activities as antimicrobial, antibacterial, antifungal, antiviral, and anticonvulsant. Anti-cancer activity has been used widely for industrial purposes or therapeutic use. Thus, Schiff bases are highly desir...

Neelam Singh *, Mojahid Ul Islam and Himanchal Sharma

Department of Pharmacy, IIMT College of Medical Science, Meerut, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).688-95

688-695

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15.

AN UPDATED STATUS OF ALANINE RACEMASE INHIBITORS: A REVIEW

Enzyme Alanine racemase is well known for performing a predominating role in mycobacterium cell wall synthesis. D-alanine provided by Alanine racemase serves as a peptidoglycan precursor, utterly vital for maintaining the growth and integrity of the cell wall. The lipid-rich mycobacterium cell wall is prevalent amidst prokaryotes with immense potential of becoming a therapeutic target for new drug...

P. Rathee, S. Saini and A. Khatkar *

Faculty of Pharmaceutical Sciences, B. M. University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).696-03

696-703

19

12

Research Articles

 
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16.

MOLECULAR DOCKING STUDY OF HEMAGGLUTININ PROTEIN OF INFLUENZA A VIRUS TO DEVELOP A NOVEL ANTI-INFLUENZA DRUG

The Hemagglutinin (HA) protein of the Influenza virus plays a vital role in viral replication. In this study, numerous small molecules were screened systematically against the HA protein to find a compound that can bind to it selectively. The HA protein’s three-dimensional crystal structure was obtained from RCSB PDB and inputted into the FTMap Web Tool to identify the best possible drug gable h...

Anika Chebrolu

Texas Academy of Mathematics & Science, University of North Texas, Denton, TX, USA.

DOI: 10.13040/IJPSR.0975-8232.14(2).704-10

704-710

24

21

17.

HERBAL BASED ANTI-MICROBIAL BOOSTER FOR THE TREATMENT OF RESISTANT MYCOBACTERIUM TUBERCULOSIS

Persistent Mycobacterium tuberculosis (Mtb) attributable to resistant strains has increased the burden leading to poor quality of life to the patients. Drugs of herbal origin have been identified as potential sources of new anti-tubercular agents for the treatment of this disease and emerging resistant strains of the bacterium. In this research, therefore, five herbs/plants that have been indicate...

O. D. Ezechukwu, C. D. Nwakile *, C. E. Umeyor, O. C. Dozie-Nwakile, E. M. Uronnachi, U. M. Okezie, C. J. Ike, J. C. Obasi, I. J. Okeke and A. N. Oli

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University Awka, Anambra State Nigeria.

DOI: 10.13040/IJPSR.0975-8232.14(2).711-18

711-718

24

17

18.

DIURETIC ACTIVITY OF ETHANOLIC EXTRACT OF IMPERATA CYLINDRICAL (L.) P. BEAUV. (POACEAE) LEAVES ON RAT

This work aimed to evaluate the diuretic activity of Imperata cylindrica (Poaceae) leaves on rat. The extract was administered orally at doses 100, 200 and 400 mg/kg. The 24h urine volume and its pH were measured, natriuresis and kaliuresis were dosed. The results show that I. cylindrica increases diuresis, natriuresis and kaliuresis, but doesn’t affect urine pH. Diuresis of 24 h urine increases...

S. G. Andriamalala *, T. T. Andriamampianina, R. Razanadrabenafindra, F. Randimbivololona, N. Quansah and P. Randrianavony

Department of Pharmacology, Faculty of Sciences, University of Antananarivo, Madagascar.

DOI: 10.13040/IJPSR.0975-8232.14(2).719-24

719-724

20

16

19.

ANTI-ULCER ACTIVITY OF POLYHERBAL FORMULATION ACIDEZ IN EXPERIMENTALLY INDUCED GASTRIC ULCERS IN RATS

Aim and Objective: Acid-related health problems mostly affect the quality of life and are a major factor in morbidity and mortality in patients. This study is designed to evaluate the anti-ulcer activity of Polyherbal formulation ACIDEZ against experimentally induced gastric ulcers in rats. Methodology: To determine anti-ulcer activity, ulcers were induced by aspirin plus pylorus ligation and acet...

Atul Desai *, Hemshree Desai, Rutvij Desai, Ankit Merai, Chirag Desai, Kaynat Mulla and Arindam Paul

Dhanvantari Clinic, Ayurveda Health Care and Research Centre, Vyara, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).725-30

725-730

21

14

20.

SCREENING OF PGPR TRAITS AND MONOCROTOPHOS PESTICIDE DEGRADATION PROPERTIES OF ACTINOBACTERIAL ISOLATES

Bioremediation of organic compounds and heavy metals has been recognized to be a successful and effective technique in rhizoremediation of soil toxicity using the beneficial microbes which produce different metabolites and enzymes to degrade the toxic compounds/ pesticides available in the soil. In the present study, actinobacterial isolates were explored and identified for bioremediation of soil ...

Ankita Rani *, Abhishek Mathur and Sanjay Gupta

Department of Biotechnology, School of Biosciences, Swami Rama Himalayan University, Dehradun, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).731-39

731-739

20

15

21.

NATURAL ALKALOIDS AS POTENTIAL ANTIMALARIAL DRUGS FROM BAUHINIA PURPUREA LEAVES -AN IN-SILICO APPROACH

Malaria is the most important parasitic disease in humans, with transmission occurring in over 100 countries with a population of three billion people. Protozoan parasites of the genus Plasmodium cause it. These parasites are transmitted from one person to another by the female anopheles mosquito. Medicinal plants possess many phytochemicals of great therapeutic value, and many effectively kill ma...

S. Suganya, M. Murugalakshmi *, J. Mari Selvi and P. R. Kavitha Rani

PG & Research, Department of Chemistry, The Standard Fireworks Rajaratnam College for Women (Autonomous), Institution Affiliated to Madurai Kamaraj University, Sivakasi, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).740-47

740-747

19

7

22.

PHARMACOGNOSTICAL, PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES ON TUBER OF PUERARIA TUBEROSA

Medicinal herbs have an important role in illness prevention, and their promotion and usage are compatible with all current disease preventive techniques. Pueraria tuberosa, widely known as kudzu, is a climber with tuberculated woody stems. It has exhibited Cardio-tonic, Aphrodisiac, Abthyperglycemic Galactogogic, and anti-lipidemic characteristics Daidzin, Puerarin, Puerarone, Genistein, Puetuber...

Manjari Verma *, Priyanka Singh and Sheetal

Department of Pharmacy Meerut Institute of Technology, Baral, Partapur, Meerut, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).748-55

748-755

17

10

23.

AMELIORATIVE EFFECT OF KALYANAKGHRITA (KG) ON WITHDRAWAL SYMPTOMS IN ALCOHOL-DEPENDENT MICE

Introduction: Alcohol de-addiction is challenging due to the severe alcohol withdrawal symptoms. This article reports ameliorative effect of KalyanakGhrita (KG) on ethanol withdrawal symptoms in animal model. Material and Methods: After approval from Animal Ethics committee, alcohol dependence was developed in pre Rota road trained Swiss mice by intermitted access of 20% ethanol in 14 days. After ...

T. M. Chotai, S. M. Kapgate * and V. H. Mate

Department of Agadtantra, BV (DU) College of Ayurved, Pune- Satara Road, Dhankawadi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).756-65

756-765

14

7

24.

DRUG UTILISATION STUDY OF ANTI-EPILEPTIC DRUGS IN PEDIATRIC PATIENTS IN A TERTIARY CARE HOSPITAL

Few studies are available to study the drug utilization pattern and adverse drug reactions of anti-epileptic drugs (AEDs) in paediatric population. Hence, this study was planned with the primary objective of studying the drug utilization pattern of anti-epileptic drugs in a tertiary care centre pediatric population. The secondary objective was to assess adverse drug reactions in the same populatio...

P. R. Shankpal, R. H. Savant and P. C. Mainkar *

Department of Pharmacology, Topiwala National Medical College and B. Y. L. Nair Charitable Hospital, Dr. A. L. Nair Road, Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).766-73

766-773

16

10

25.

IDENTIFICATION AND QUANTIFICATION OF POTENTIAL BIOACTIVE COMPOUNDS FROM SEAWEED OF CHAMPIA COMPRESSA

The present investigation was carried out to analyze the bioactive metabolites of red seaweed Champia compressa collected from Mandapam, Ramanathapuram district, Tamil Nadu, India. The collected sample was evaluated for qualitative and quantitative phytochemical screening analysis using five different solvents methods. The preliminary qualitative analysis of Champia compressa solvent extracts reve...

M. Shantha and A. Arockia Jenecius Alphonse *

Department of Botany, St. Mary’s College (Autonomous), Thoothukudi, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).774-81

774-781

16

11

26.

NOVEL, RAPID, ISOCRATIC RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF BETAMETHASONE DIPROPIONATE, MICONAZOLE NITRATE AND CHLOROCRESOL IN PHARMACEUTICAL DOSAGE FORM

A novel, rapid, isocratic, reversed-phase HPLC method was developed to simultaneously determine betamethasone dipropionate, miconazole nitrate and chlorocresol in a topical dosage form. The separation was performed on the C18 prontosil (250 x 4.6mm x 5µ) column. The mobile phase used for this study consists of acetonitrile and phosphate buffer of pH 2 in the ratio of 70:30 v/v, respectively. The ...

Vandana Jain * and Pallavi Gadhave

Department of Quality Assurance, Oriental college of Pharmacy, Sanpada, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).782-87

782-787

15

8

27.

DEVELOPMENT AND VALIDATION OF QBD-ASSISTED RP-HPLC METHOD FOR DAPAGLIFLOZIN AND METFORMIN HCL IN BULK AND ITS COMBINED DOSAGE FORM

Dapagliflozin and Metformin HCl Combination is the novel SGLT2 inhibitor used to control Hyperglycemia in type 2 diabetes mellitus. A literature survey reveals that various Analytical methods have been developed for Dapagliflozin in single and combined with other drugs. No QbD-assisted RP-HPLC method is available to estimate Dapagliflozin and Metformin HCl in combination. So, present work describe...

Vidhi Dave * and Paresh U. Patel

Department of Quality Assurance, S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).788-94

788-794

20

10

28.

IMPROVEMENT IN SOLUBILITY OF CEFIXIME TRIHYDRATE BY HYDROTROPIC METHOD

Background: Solubility is an important boundary to obtaining the needed drug concentrations in systemic circulation for pharmacological response to be shown. In today’s time, poor water solubility is the crucial issue faced with developing new chemical entities. Objective: Cefixime trihydrate (CT) is an oral third-generation cephalosporin antibiotic used to treat bacterial diseases. It has an or...

Rita Saini *, Poornima Gupta and Shivanand Patil

Department of Pharmacy, Shree Dev Bhoomi Institute of Education, Science and Technology, Poundha, Dehradun, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).795-02

795-802

21

7

29.

ROLE OF AQUEOUS EXTRACT OF JUSSIAEA REPENS ON CELLULAR OXIDATIVE STRESS AND METABOLIC STATUS IN DIABETIC RATS INDUCED BY STZ.

This work aimed to explore how crude aqueous extract of Jussiaea repens affected oxidative stress and metabolic status in streptozotocin (STZ) induced diabetic male rats. The diabetic rats were gavaged with aqueous extract of Jussiaea repens (50 mg/100 g body weight/day for 32 daysconsicutively) after an induction of STZ (8 mg/100g body weight, i.p.). Fasting blood glucose, insulin, serum LDH, tot...

Tasneem Khandekar and Nirmal Pradhan *

Department of Physiology, Hooghly Mohsin College, The University of Burdwan, Chinsurah, Hooghly, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).803-08

803-808

15

9

30.

ATTENUATION OF INFLAMMATION BY ETHANOLIC EXTRACT OF CAESALPINIA BONDUCELLA USING IN-VITRO INFLAMMATORY MODELS

Background: Caesalpinia bonducella F. (Leguminosae) has long been used in traditional medicinal treating methods. It has high therapeutic values in India Ayurveda. They contain tannin, saponins, flavonoids, and alkaloids. The seeds of Caesalpinia bonducella are claimed to be styptic, purgative, anthelmintic and cures inflammations. Today the interest in traditional medicine and demand for more pla...

Manisha Mohanty and Amala Reddy *

Department of Biotechnology, SRMIST, Kattankulathur, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).809-15

809-815

19

8

31.

ANTI-ARTHRITIC POTENTIAL OF BIOPOLYMERIC FRACTION OF SEEDS OF TRIGONELLA FOENUM GRACEUM ALONE AND ITS COMBINATION WITH GLYCYRRHIZIN AS A BIO-ENHANCERS IN ARTHRITIC RATS

Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune disorder. It is characterized by inflammation of the synovial joints and concomitant destruction of cartilage and bone. However, rheumatoid arthritis is typically a progressive illness that has potential to cause joint destruction and functional disability. In the present research, GSH content were significantly decreased in art...

Santosh Ghule *, Praveen Sharma, Kiran B. Kotade and Tanvirsing Rajput

Samarth College of Pharmacy, Belhe, Junnar, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).816-26

816-826

15

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32.

PRELIMINARY PHYTOCHEMICAL INVESTIGATION, IN-VITRO ANTIOXIDANT, IN-VITRO α-AMYLASE INHIBITION, IN-VITRO AND IN-VIVO ANTICATARACT ACTIVITY OF ETHYLACETATE ROOT EXTRACT OF ABUTILON INDICUM

The present study aims to evaluate the in-vitro antioxidant, in-vitro α-amylase inhibition, in-vitro and in-vivo anti-cataract potential of ethyl acetate root extract of Abutilon indicum. Antidiabetic activity was evaluated against alpha-amylase by spectrophotometric assays. DPPH determined antioxidant activity, Reducing power assay, Phosphomolybdenum antioxidant assay, Nitric oxide-scavenging ac...

G. V. N. Kiranmayi *, P. Sirisha and R. Sanjana

Faculty of Pharmacy, Dr. M. G. R. Educational and Research Institute, Deemed to be University, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).827-37

827-837

15

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33.

ASSESSMENT OF CURRENT PRESCRIBING PRACTICES USING WORLD HEALTH ORGANIZATION PRESCRIBING INDICATORS AT A PRIVATE GENERAL HOSPITAL IN WESTERN INDIA– A CROSS-SECTIONAL STUDY

Purpose: Drug use studies are essential in health, as the research provides insight into drug use in communities. The current study aimed to evaluate the prescription pattern of drugs prescribed in a private general hospital's out-patient department (OPD),using prescribing indicators developed by the World Health Organization (WHO). Methods: The study was a prospective, observational, cross-sectio...

Amol Gujar *, Vishal Gulecha and Amar Zalte

School of Pharmaceutical Sciences, Sandip University, Nashik, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).838-44

838-844

14

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HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF ACALYPHA COMMUNIS MULL. ARG. AGAINST INTOXICATION OF THIOACETAMIDE AND RIFAMPICIN-INDUCED RATS

Background: The present study aimed to evaluate the hepatoprotective activity of aqueous extract of Acalypha communis in Wistar rats. Methods: The hepatoprotective activity was studied by Thioacetamide (TAA) (100 mg/kg b.wt.i.p) and Rifampicin (RMP) (100 mg/kg, po) induced models. Acute toxicity studies and preliminary phytochemical screening were also studied to evaluate the toxicity. Results: No...

T. Muthuramu *, Gopinath, Thressiamma Sebastin, Neethu Murali and K. U. Athira

Department of Pharmacology and Toxicology, KTN College of Pharmacy, Palakkad, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).845-51

845-851

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35.

BACTERIOPHAGE MEDIATED MODULATION OF GUT MICROBIOME RESPONSIBLE FOR COLORECTAL CANCER

The gut microbiome composition directly correlates with the disease's development and thus with an individual's health. According to the published scientific literature, gut microbiota is directly linked with developing diseases such as colorectal cancer. On the other hand, Bacteriophages are the group of viruses that infects the bacterial cells typically and can be utilized to manage the dysbiosi...

Sutripto Ghosh and Tamalika Chakraborty *

Department of Biotechnology, Guru Nanak Institute of Pharmaceutical Science and Technology, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).852-59

852-859

22

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36.

EVALUATION OF PHARMACOGNOSTICAL AND PHYSICOCHEMICAL PARAMETERS OF STEM OF ACACIA ARABICA WILLD.

Acacia Arabica Willd.(syn: Acacia nilotica) is a thorny tree belonging to the family Fabaceae and subfamily Mimosoideae. Gum acacia, an exudation obtained from this plant, is included in the GRAS category and used widely as pharmaceutical aid. The plant contains flavonoids, tannins, and phenolic compounds as its phytoconstituents. The plant possesses antioxidant, antipyretic, antimicrobial, antivi...

Jyoti Alambayan and Vandana Garg *

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).860-66

860-866

13

12

37.

ALLOPOLYHERBAL GEL FORMULATION AGAINST MICROORGANISM: IN-VITRO STUDIES

The cases of skin infections are increasing daily, and the conventional treatment loses its strength in treating those skin infections because of resistance of the microorganisms against the medications, including antibacterial as well as antifungal with the topical and oral administration, or both. The advancement of the treatment of treating skin infections by the combination with the synthetic ...

Laxmi Srivastava, J. N. Mishra, D. K. Vishwakarma * and Chitranshu Pandey

Kailash Institute of Pharmacy & Management, Gida, Gorakhpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).867-75

867-875

18

10

38.

SIMULTANEOUS DETERMINATION OF FLAVONOIDS IN POLYHERBAL FORMULATION BY A VALIDATED HPTLC METHOD

A rapid, sensitive, selective and robust quantitative densitometric high-performance thin-layer chromatographic method is developed and validated for separation and quantification of flavonoids namely rutin, quercetin, kaempferol and myricetin in herbal formulations. The separation is performed on silica gel 60F254 high-performance thin-layer chromatography plates using phase cyclohexane: ethyl ac...

Mittal Thakkar * and Sangita Sharma

Department of Chemical Engineering, Dharmsinh Desai University, Nadiad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).876-82

876-882

22

14

39.

THE FOOD AND MEDICINAL BENEFITS OF OYSTER MUSHROOM (PLEUROTUS OSTREATUS): A REVIEW

The oyster mushroom (Pleurotus ostreatus) is a culinary mushroom. Mushrooms are considered a potential source of many essential nutrients and therapeutic bioactive compounds. Pleurotus ostreatus is a macro fungus that belongs to the class Basidiomycetes and the family Pleurotaceae, known as the oyster mushroom. It is the most important commercially cultivated mushroom in the world. Mushroom contai...

Prasad Kadam, Kavita Yadav *, Abhijit Karanje, Damini Giram, Rutuja Mukadam and Manohar Patil

Department of Pharmacognosy, Marathwada Mitra Mandal’s College of Pharmacy, Thergaon, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).883-90

883-890

28

15

40.

MORPHOLOGICAL AND BIOCHEMICAL CHARACTERIZATION OF CYANOBACTERIAL ISOLATES FROM BIOLOGICAL SOIL CRUST OF RAJASTHAN, INDIA

The BSC sample was collected at four sites from the arid region of Rajasthan and these isolates were characterized based on morphological and biochemical parameters. We have to isolate both heterocysts and non-heterocysts cyanobacterial species. Oscillatoria tenuis species showed maximum chlorophyll accumulation and Phormium showed maximum carotenoids compared to heterocystous forms. The soluble p...

Lokesh Sharma, Shailendra Kumar Singh, Shruti Srivastava and Shanthy Sundaram *

Centers of Biotechnology, University of Allahabad, Prayagraj, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).891-97

891-897

17

11

41.

MIXED HYDROTROPY TECHNIQUE USED FOR SOLUBILITY ENHANCEMENT OF ALBENDAZOLE

Purpose: Albendazole (ABZ) is a drug that shows anthelmintic activities, also used for treating neurocysticercosis, also known as pork tapeworm infection caused by contact with infected human stool, infected food, and water. But the serious challenge is the hydrophobicity of albendazole, which slow down the dissolution rate and bioavailability, so it can be given in high concentration, which can c...

Akanksha Hatwal *, Rita Saini and Shivanand Patil

Department of Pharmacy, Shree Dev Bhoomi Institute of Education Science & Technology, Dehradun, Uttarakhand, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).898-03

898-903

24

9

42.

IN-SILICO ANTI-ULCERATIVE ACTIVITY EVALUATION OF SOME BIOACTIVE COMPOUNDS FROM CASSIA TORA AND BUTEA MONOSPORA THROUGH MOLECULAR DOCKING APPROACH

Background and Aim: In-silico approach is commonly the method for predicting and confirming drug design. Hence the present study was undertaken to evaluate in-silico the anti-ulcerative activity of some bioactive compounds from Cassia tora and Butea monospora through a molecular docking approach. Method: Docking is performed using 22 runs of the Lamarckian Genetic Algorithm with the grid box sized...

Lalchand D. Devhare * and Niharika Gokhale

Oriental College of Pharmacy and Research, Oriental University Indore, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).904-11

904-911

13

10

43.

EFFECT OF SOLANUM TORVUM SW. METHANOLIC EXTRACT ON IN-VITRO AND IN-VIVO MODELS OF INFLAMMATION

The word inflammation comes from the latin word called “inflmmare” which means “To set on fire”. It is a complex biological process that is mediated by several chemicals and biological mediators like pollens, irritants, pathogens and damaged cells. The body's inflammatory reaction destroys such chemical and biological mediators and gets rid of injured tissues. But in chronic state this inf...

B. Mahanta

Department of Zoology, Morigaon College, Morigaon, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).912-19

912-919

16

11

44.

IN-SILICO ADMET PREDICTION ON PHYTOCHEMICAL COMPONENTS OF CITRUS SINENSIS

Citrus sinensis are treasuries to deliver novel drugs and a significant aromatic medicinal plant reported to possess a broad spectrum of medicinal uses. The compounds present in these plants can deliver the potential therapeutic drug. A free web tool, SWISS ADME predictor, was used to evaluate the pharmacokinetics, drug-likeness, and medicinal chemistry friendliness of phytoconstituents under inve...

Smita Singh and Nehal Nabya *

Department of Biotechnology, Faculty of Engineering & Technology, Rama University Kanpur, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).920-23

920-923

18

13

45.

DEVELOPMENT AND EVALUATION OF FAVIPIRAVIR AGGLOMERATES FOR DIRECT COMPRESSION BY CRYSTALLO-CO-AGGLOMERATION TECHNIQUE

During the severe worldwide pandemic caused due to SARS COV-2 Corona virus, Favipiravir has been used for the treatment. It is a water insoluble anti-viral drug with poor dissolution and poor flow properties, resulting in poor oral absorption and less bioavailability. For a long time, the phrase "direct compression" was used to describe the compression of a single crystalline component into a comp...

S. P. Mahaparale * and H. B. Kulkarni

Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).924-33

924-933

22

11

46.

CELLULOSE ETHER HYDROGELS AS POTENTIAL CARRIERS FOR PULSATILE DRUG DELIVERY SYSTEM

Hydrogels are cross-linked polymers with the capacity to bulge in an aqueous medium. Because of their extraordinary properties, these are utilized as brilliant drug delivery vehicles that particularly necessitate focusing on the drug to specific sites. On account of the eminent hydration and biocompatibility properties generally utilized in pharmaceutical field, especially cellulose derivatives. I...

M. Sreelatha *, P. V. Swamy and P. Shailaja

Department of Pharmaceutics, Vagdevi College of Pharmacy, Gurazala, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).934-45

934-945

18

9

47.

META-ANALYSIS OF HERBAL CURE FOR PITYRIASIS VERSICOLOR: A CASE REPORT

Background: Pityriasis Versicolor (PV) is a cutaneous fungal infection of the skin revealed by changes in skin pigmentation due to colonization by a dimorphic lipophilic fungus of the skin, known as Malassezia furfur. There is an impact on the psychological status of patients resulting in anxiety or depression. This disease is predominant in warm and hot climates. Currently, no ideal drug of choic...

Puranapanda Suvarna Siddeswari *, Kiranmai Mandava and Sneha Thakur

Department of Pharmacy Practice, St. Pauls College of Pharmacy, Turkayamjal, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).946-51

946-951

24

9

48.

DEVELOPMENT AND EVALUATION OF LAWSONE (HENNA) NANOEMULSION FOR ANTIFUNGAL AND ANTI-BACTERIAL ACTIVITY

Nanoemulsions, also mentioned as submicron emulsions, ultrafine emulsions and miniemulsions, are submicron-sized colloidal particulate systems considered as thermodynamically and kinetically stable isotropic dispersions; they contain two liquids like water and oil (immiscible), stabilized by an interfacial film consisting of a suitable surfactant and co-surfactant to form a single phase. In this r...

Nidhi Gupta, Krishna Kumar *, Neeraj Kumar and Amresh Gupta

Samarpan College of Pharmacy, Lucknow, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).952-63

952-963

18

11

49.

POTENTIATION OF ANTI-PROLIFERATIVE EFFECT OF DOXORUBICIN USING METFORMIN AND HESPERIDINON HUMAN BREAST CANCER CELL LINE MDA-MB-468

Among various subtypes of breast cancer, triple-negative breast cancer (TNBC) is aggressive breast cancer. Doxorubicin is the standard therapy used for treating TNBC, but poses a risk of severe adverse effects affecting patient compliance. Hence, there is a need for therapy that reduces the adverse effect and increase compliance for better overall pathological complete response (pCR). Metformin, w...

P. Patel and J. Shah *

Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).964-73

964-973

19

13

50.

A STUDY ON KNOWLEDGE, PRACTICE AND EXPERIENCE ON THE USE OF GENERIC MEDICINES AMONG PATIENTS, HEALTHCARE PROFESSIONALS & COMMON PEOPLE

Generic medicines have the same efficacy, route of administration, strength, indication and side effects as branded medicines. In spite of the lower price, generic medicines are not popular among healthcare professionals. The study's objective was to explore knowledge, practice and experience in using generic medicines among patients, common people, & healthcare professionals (nurses, pharmaci...

Yashank K. Gupta * and Ajay K. Gupta

Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).974-80

974-980

21

10

51.

EVALUATION OF ANTIDIABETIC ACTIVITY OF WITHANIA COAGULANS L. DUNAL

The present study estimated the antidiabetic activity of methanolic extract of plant fruits of plant Withania coagulans L. Dunal. Withania coagulans (family Solanaceae) is commonly known as “Paneer ke phool” in Hindi and “Indian cheese maker” or “Vegetable rennet” in English, distributed in drier parts of India. The primary aim of this study was to confirm antidiabetic action of Withan...

M. D. Rageeb *, M. D. Usman and N. G. Bhat

Department of Pharmacognosy, Smt. Sharadchandrika Suresh Patil College of Pharmacy, Chopda, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).981-87

981-987

18

11

52.

EVALUATION OF IN-VITRO ANTIPLASMODIAL ACTIVITY OF SELECTED ETHNOBOTANICALLY IMPORTANT MEDICINAL PLANT EXTRACTS

Purpose: A serious cause of morbidity and mortality, malaria remains a major public health concern. Failure of available treatments due to the rapid emergence of drug-resistant parasite strains emphasizes the need for a continuous search for new, safe, accessible, and affordable drug treatments. Methods: In this context, an ethnobotanical survey was conducted, different parts of seventeen medicina...

Cheryl Sachdeva, Sunny Dhir, Amit Kaushik, Vineet Kaswan, Yashika Walia and Naveen Kumar Kaushik *

Amity Institute of Virology and Immunology, Amity University Uttar Pradesh, Sector-125, Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).988-96

988-996

19

13

53.

SYNTHESIS OF BIOACTIVE MONONUCLEAR COPPER (II), NICKEL (II), COBALT (II) AND MANGANESE (II) SCHIFF BASE COMPLEXES DERIVED FROM ISATIN: ANTIOXIDANT, ANTI-BACTERIAL AND DNA CLEAVAGE ACTIVITIES

Potentially bioactive tetradentate novel Schiff base ligand and its mononuclear metal (II) complexes have been synthesized by the condensation method of p - nitroaniline, isatin, and 2, 2′ bipyridyl molecules in the ratio of 1:1:1. The ligand and its reported complexes exactly categorized by diverse physicochemical techniques that include elemental analysis, conductance measurements, IR, electro...

T. Sujeshwari, E. Akila and P. Maheswaran *

Department of Chemistry, P. G. P College of Arts and Science, Namakkal, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).997-03

997-1003

16

13

54.

IN-SILICO ANALYSIS OF GALLIC ACID DERIVATIVES FOR IDENTIFICATION OF NOVEL ALANINE RACEMASE INHIBITORS

Background: In drug design development, Alanine racemase grabbed researchers' attention as it is a potential target for many antimicrobial agents due to its imperative role in bacterial cell wall synthesis. The irresponsible binge eating of antibiotics leads to drug resistance is a key issue of concern for the researchers. The development of multidrug resistance, responsible for causing immense hu...

P. Rathee, S. Saini and A. Khatkar *

Department of Pharmaceutical Sciences, M. D. University, Rohtak, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.14(2).1004-15

1004-1015

20

12

55.

HYDROETHANOLIC EXTRACT OF CEDRELA ODORATA IMPROVES HYPERLIPIDEMIA AND REDUCES THE ACTIVITY OF ENZYMES IN THE LIVER OF ETHANOL-INDUCED HYPERLIPIDEMIC RATS

Hydroethanolic extract of the Cedrela odorata (HeECo) showed hypolipidemic potential in diabetic rats. Thus, we evaluate the hypolipidemic effect and the mechanism of the action of the HeECo in a rat model of ethanol-induced hyperlipidemia. Male Wistar rats are divided: normolipidemic (C); hyperlipidemic non-treated (Hl); hyperlipidemic treated with HeECo 500 mg.kg-1 (HlCo); and hyperlipidemic tre...

E. W. Allebrandt Neto, S. F. Santos, F. H. S. Silva Gomes, C. V. Santos, M. I. Watanabe, M. A. Giordani, N. H. Kawashita and M. P. Pereira *

Universidade Federal de Mato Grosso, Departamento de Química, Cuiabá, Mato Grosso, Brazil.

DOI: 10.13040/IJPSR.0975-8232.14(2).1016-26

1016-1026

18

11