Volume 15 (2024) - Issue 5, May
Review Articles
AN AMALGAMATION OF SGLT-2 AND DPP-4 INHIBITORS: A PLAUSIBLE NOVEL TREATMENT FOR DIABETES MELLITUS
Diabetes Mellitus is characterized as metabolic chronic disease spreading all over the world ata high pace. Due to its speedily wide population spreading it is termed as 3rd most populated country in the world since the number of individuals diagnosed with diabetes is just behind population of China and India. To date treatment therapy concerning diabetes majorly responds to insulin-dependent mech...
826
967
REVIEW ON SRC KINASES AS A PROMISING PHARMACOLOGICAL TARGET FOR VARIOUS DISEASES
This review explores the multifaceted roles of Src kinases, a subfamily of non-receptor tyrosine kinases, shedding light on their involvement in diverse diseases. Src-family protein tyrosine kinases (SFKs) exhibit widespread expression across various cell types, influencing their behavior and functionality. Src's presence in distinct subcellular locations, such as plasma membranes, perinuclear mem...
617
420
ELECTROCEUTICAL APPROACHES IN PARKINSON’S DISEASE MANAGEMENT: A REVIEW OF EFFICACY, SAFETY, AND LIMITATIONS
The utilisation of electroceuticals in the treatment of Parkinson's disease is the predominant topic of discussion in this review. Electroceuticals, which are frequently referred to as "bioelectronics medicine," are the result of the utilisation of electrical impulses for the goal of therapeutic treatment. It has been investigated if electroceuticals could serve as an alternative or adjuvant to th...
557
398
EVIDENCE-BASED HEALTH BENEFITS OF MULTIFACETED PLANT GREEN TEA: A REVIEW
In response to the increasing popularity and greater demand for medicinal plants, several conservation groups recommend cultivating wild medicinal plants. Green Tea is among the most ancient and popular therapeutic beverages worldwide. This product is made from the plant leaf called “Camellia sinensis.” It can be prepared as a drink, which can have many systemic health effects or an “extract...
519
376
TOPICAL APPLICATION OF BACTERIOPHAGES FOR THE TREATMENT OF WOUND INFECTIONS:
Wound infections persist as a significant and persistent challenge within the realm of healthcare, posing numerous detrimental consequences that extend far beyond the affected individuals. These infections, characterized by the infiltration of harmful microorganisms into wounds, encompass a multifaceted predicament that engenders slower healing periods, heightened morbidity rates, and an onerous f...
527
370
A REVIEW: MOUTH DISSOLVING TABLET
The demand for Mouth Dissolving Tablet has been increasing for the last decade particularly in geriatric, peadiatric and patient with some sort of disabilities in swallowing. Mouth dissolving tablets are those tablets which when placed in mouth get dissolved rapidly in saliva without the need of liquid and can be swallowed. European pharmacopeia adopted the term Oro-dispersible tablet for MDTs. Mo...
212
142
OVERVIEW OF ORAL DISPERSIBLE TABLETS
The need to deliver pharmaceuticals to patients quickly and with minimal side effects has driven pharmaceutical companies to invest in the development of novel drug delivery systems. Solid dose forms, such as pills, are difficult for pediatric and geriatric patients to swallow. The best treatment for this issue is a mouth dissolving pill that dissolves or disintegrates quickly in the oral cavity. ...
232
122
CHRONOTHERAPY THROUGH REGULATION OF CIRCADIAN RHYTHMS- AN OVERVIEW
The objective of chronotherapy is to optimize medical treatments taking into account the body's circadian rhythms. Drug delivery systems that precisely control the release rates or target drugs to a specific site have an enormous impact on the health care system. Over the past few years, pharmaceutical industry has focused its research in the development of various Chrono therapeutic delivery s...
190
114
Research Articles
AMELIORATIVE POTENTIAL OF MORINGA OLEIFERA AQUEOUS LEAF EXTRACT ON PARACETAMOL-INDUCED TESTICULAR TOXICITY IN ADULT MALE SPRAGUE-DAWLEY RATS
Testicular toxicity has been associated with long-term paracetamol usage. Moringa oleifera is known to eliminate toxins from organs and restore functionality. This study seeks to ascertain the potency of moringa in ameliorating paracetamol-induced testicular toxicity. Forty nine (49) Sprague-Dawley rats were randomly assigned into seven (7) groups composed of 7 rats each treated for 5 weeks. One g...
502
498
PROSTANOIDS CONTRIBUTE TO ACETAMINOPHEN INDUCED VASCULAR DYSFUNCTION IN RATS
Acetaminophen (APAP) is the most consumed potentially toxic drug in the world, and its cardiovascular injury has been emphasized. We evaluated the role of inflammatory mediators in the impaired vascular relaxation after APAP treatment. Rats were treated with APAP for 2 weeks (400 mg/Kg/day/p.o.) and after euthanasia, blood was collected for biochemical analysis (hepatic transaminases, lipid peroxi...
472
348
THE QUANTITATIVE ANALYSIS OF METABOLITES FROM SELECTED CHENOPODIUM SPECIES
Chenopodium album L., Chenopodium murale L., and Chenopodium giganteum L. are annual herbs with ethno-medicinal value. The present study investigates the primary and secondary metabolites quantification of Chenopodium species. The quantitative estimation of bioactive molecules from the root, stem, and leaves showed the presence of proteins, carbohydrates, starch, phenols, and flavonoids. However, ...
544
417
IN-SILICO STUDY: MYRICETIN FROM THE STEM BARK OF SYZYGIUM CUMINI INHIBITS THE GROWTH OF NON-SMALL CELL LUNG CANCER CELLS THROUGH THE EGFR PATHWAY
Around the world, cancer frequently leads to death. Lung cancer is the primary cause of cancer-related deaths globally. Through in-silico analysis, this study sought to assess the anticancer effectiveness of myricetin on human lung cancer cells. The study's goal is to assess how well myricetin adheres to the Lipinski rule of 5. To evaluate the ADMET properties (Absorption, Distribution, Metaboli...
490
315
BIOEQUIVALENCE STUDY OF LUMEFANTRINE RECTAL ENEMA AND THE COMMERCIALLY AVAILABLE GENERIC ORAL SUSPENSION. A PILOT STUDY
Children under five years of age, with severe or cerebral malaria, cannot consume oral medication especially if they are vomiting or are unconscious. In such situations they are given an injectable drug until they can tolerate oral medication. The situation is bad in Sub-Saharan Africa, especially in rural areas as children are sometimes referred to the closest referral health care facility for pr...
493
343
GREEN SYNTHESIS OF SILVER NANOPARTICLES USING THE LEAF EXTRACT OF ARGYRIA NERVOSA AND ANTIMICROBIAL STUDIES
The green synthesis of silver nanoparticles (AgNPs) gained interest and attracted to many researchers due to physical, optical, chemical and biological properties, enhancing a range of activities such as antibacterial, antifungal, anti-inflammatory and anticancer us activity. The purpose of this study is to synthesize and characterize silver nanoparticles from fully expanded leaves of Argyria nerv...
323
187
FORMULATION AND EVALUATION OF TASTE MASKED ORAL DISINTEGRATING TABLET OF LACOSAMIDE
Lacosamide is an antiepileptic bitter drug used to treat partial onset seizure. The aim of the work was to mask the taste of lacosamide and then formulation and evaluation of tablet. Taste was masked using spray dryer. Oral disintegrating tablet was prepared using 3 superdisintegrants Sodium starch glycolate, Crosscarmellose sodium and Polyplasdone XL10. Out of these polyplasdone showed quick disi...
179
126
IN-VITRO ANTIMICROBIAL ACTIVITY OF CURCUMA AMADA ON THE CLINICAL ISOLATES OBTAINED FROM BURN’S WOUND
The increasing resistance of microorganisms to conventional antibiotics has prompted scientists to explore alternative sources for antimicrobial compounds. This study focuses on Curcuma amada, a perennial herb, and its rhizome extracts for antibacterial activity against major bacterial strains identified in burn wounds: Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomona...
161
110
METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF NICOTINAMIDE AND METRONIDAZOLE IN GEL USING UV-SPECTROPHOTOMETER
An easy, precise and accurate spectroscopic technique for the simultaneous estimation of nicotinamide and metronidazole in semi-solid dosage form and in bulk form has been developed. The present method involves the addition of 0.1M hydrochloric acid solution, followed by dilution with water and subjecting the resulting solution to UV spectroscopic assessment. Absorption maximum was found to lie at...
190
225
CHARACTERIZING MICROSTRUCTURES AND CRYSTALLOGRAPHIC PHASES IN KIDNEY STONES FROM THE NAGPUR REGION, MAHARASHTRA
The increasing incidence of urolithiasis in the Asian population has been noted, and this condition can result in renal failure. The recurrent nature of stone formation presents a substantial apprehension, as it engenders iterative episodes of calculi development, culminating in gradual renal deterioration. Consequently, there exists a pressing imperative for comprehending the composition and etio...
153
111
DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF RIFAMPICIN AND ISONIAZID IN BULK AND TABLET DOSAGE FORM
A new HPLC method has been developed and validated for the simultaneous estimation of Rifampicin and Isoniazid, offering a reliable and efficient approach for their analysis. The method employs a mobile phase composed of pH 3.5 phosphate buffer, methanol, and water in a 45:30:25 ratio. It demonstrates a linear response for both drugs within specific concentration ranges, allowing for accurate quan...
151
111
PERIUMBILICAL PERFORATING PSEUDOXANTHOMA ELASTICUM: A RARE CASE REPORT WITH A DISTINCTIVE PRESENTATION
Periumbilical perforating pseudoxanthoma elasticum (PPPXE) presents as well-defined, yellowish, atrophic plaques encircling keratotic papules, often observed in obese, multiparous women. This dermatosis is considered either a localized acquired cutaneous disorder or a variant of hereditary pseudoxanthoma elasticum. We report a case clinically diagnosed with differentials but confirmed as PPPXE thr...
203
110
PUNICA GRANATUM L. WINE – HEALTH BENEFITS
Punica granatum L. is the reddish colour fruit, commonly known as Pomegranate. It is known to have many health and therapeutic benefits which can be used as agent. The pomegranate juice is also used to prepare wine. The present study was carried out to determine the optimum fermentation parameters of pomegranate wine preparation. The antimicrobial and antioxidant activity of various wine preparati...
178
110
AN INVESTIGATION OF THE N-BUTANE EXTRACT OF COCOS NUCIFERA L’S ANALGESIC AND ANTI-INFLAMMATORY EFFECTS IN EXPERIMENTAL ANIMALS
Background and Aim: Coconut sprouts, often referred to as coconut shoots or coconut hearts, have the potential to be analgesic and anti-inflammatory because of their abundance of phytochemicals, antioxidant capabilities, and traditional usage. In northeastern Brazil, herbal remedies made from coconut husk fiber are used to treat inflammatory diseases like arthritis. This study aimed to evaluate th...
192
115
MOLECULAR DOCKING ANALYSIS OF COMPARISON BETWEEN INDOLE ALKALOID COMPOUNDS FROM CATHARANTHUS ROSEUS WITH THE TARGETS FOR BREAST CANCER
Endocrine-disrupting chemicals are environmental pollutants that have been associated with a wide range of diseases, including breast cancer, the most prevalent cancer in women worldwide, according to the WHO. Among the different cancers affecting the female population, breast cancer has the highest incidence and mortality rate. The incidence of breast cancer is 100 times higher in women than in m...
170
120
DESIGN, FABRICATION, AND EVALUATION OF BUCCAL DRUG DELIVERY OF BENIDIPINE HYDROCHLORIDE
The present study involves the formulation development and in-vitro evaluation of benidipine hydrochloride buccal tablets. Designed to prolong the time of release of drug and also to enhance the better bio-availability of the drug. Benidipine hydrochloride is a long-acting calcium channel blocker. It exerts its antiangial, antihypertensive action through blocking the influx of ca ions through volt...
181
111
PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND IN-VITRO ANTICANCER ACTIVITIES OF TINOSPORA CORDIFOLIA LEAVES EXTRACTS
Globally, cancer is a disease that is affecting the human population in abundance. According to the traditionally ayurvedic literature, Tinospora cordifolia are commonly applied in the treatment of various diseases. The present study was designed to investigate the antioxidant and anticancer activities of Tinospora cordifolia on the basis of its on biochemical and histopathological parameters. The...
171
126
OPIOID SPARING & SUPPRESSION OF HEMODYNAMIC RESPONSE BY PREOPERATIVE MULTIMODAL NON-OPIOID ANALGESIC REGIME IN LAPAROSCOPIC SURGERIES UNDER GENERAL ANAESTHESIA: A PROSPECTIVE RANDOMIZED COMPARATIVE STUDY
Background & Aims: Laparoscopic surgeries produces significant hemodynamic changes leading to increased opioid consumption. This study aims to assess the efficacy of a unique opioid free multimodal analgesia in the prevention of adverse hemodynamic changes during intubation and pneumoperitoneum in a patient undergoing laparoscopic surgery in comparison with standard opioid based anaesthesia. M...
191
128
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF TEPOTINIB IN PRESENCE OF ITS IMPURITIES IN A TABLET DOSAGE FORM
A simple, rapid, precise, sensitive and reproducible Reverse phase high performance liquid chromatography (RP-HPLC) method has been developed for the quantitative analysis of Tepotinib in presence of its impurities (1&2) in pharmaceutical dosage form. Chromatographic separation of Tepotinib and its known impurities were achieved on Waters Allianace-e 2695 by using Inertsil ODS C18 250x4.6mm 5...
169
109
AN EXPERIMENTAL STUDY TO EVALUATE THE POTENTIATING EFFECT OF SELENIUM, ZINC, VITAMIN C AND VITAMIN E AS SUPPLEMENT TO SULFONYLUREAS ON STREPTOZOTOCIN INDUCED DIABETIC RATS
Objectives: To study potentiation of hypoglycaemic effect of Glimepiride with combination of Selenium, Zinc, Vitamin C and Vitamin E on Streptozotocin induced diabetic rats and to compare potentiating hypoglycaemic effect of above-mentioned drugs with that of standard diabetic control group. Methods: Study was carried out in Research Laboratory, Department of Pharmacology, BIMS, Belagavi. Albino r...
139
105
DESIGN, DEVELOPMENT, AND CHARACTERIZATION OF BUCCAL MUCOADHESIVE PATCH LOADED WITH CLINDAMYCIN HYDROCHLORIDE AND CURCUMIN USING DESIGN EXPERT SOFTWARE FOR THE TREATMENT OF PERIODONTITIS
Periodontitis is a widespread oral gum infection having multiple antibiotics for the treatment, but large oral doses and the emergence of antibiotic resistance constrain their usage. The goal of this study was to develop and characterize buccal mucoadhesive patches made of clindamycin and polymers for the treatment of Periodontitis. Patches were developed by solvent casting method using Clindamyci...
177
122
DESIGN, FABRICATION AND EVALUATION OF BIOADHESIVE BUCCAL TABLETS OF CILNIDIPINE
Buccal drug delivery is the most suited route for local as well as systemic delivery of drugs. The purpose of this study was to develop and optimize formulations of mucoadhesive tablets of Cilnidipine with an objective to enhance therapeutic efficacy, bioavailability and was developed to administer into the unconscious and less-co-operative patients. Cilnidipine buccal tablets were prepared by dir...
173
108
EVALUATION OF HYPOGLYCEMIC EFFECT AND PHYTOCHEMICAL CONSTITUENTS OF VERNONIA AMYGDALIN DEL. FAM. ASTERACEAE
Purpose: Leaf of Vernonia amygdalin Del Fam. Asteraceae has been shown to have hypoglycemic activity. This work was designed to identify the secondary metabolites present in the plant leaf, test their lethality, and then determine the best solvent system for their extraction. Methodology: One kilogram of crushed leaves of the plant Vernonia amygdalin was extracted with 5.0 L of methanol using Sohl...
132
112