Volume 16 (2025) - Issue 3, March
Review Articles
A BRIEF REVIEW OF WILD HIMALAYAN PEAR PYRUS PASHIA
Within the Magnoliopsida class, Pyrus pashia is widely found throughout the Himalayan areas. P. pashia is a member of the Rosaceae family of medicinal plants. It's commonly called a wild pear. The plant has a range of nutritional and medicinal uses. In ethnomedicine, it is widely utilized as a hepatoprotective, inflammatory, antibacterial, antifungal, disinfectant, antioxidant, antimicrobial, and ...
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BOMBAX CEIBA: A PLANT OF THERAPEUTIC POTENTIAL
Medicinal plants have been utilized to treat a wide range of illnesses throughout human history. Plants are able to produce a wide variety of secondary metabolites, which are chemical substances that assist them defend against predators. The plants are significant for their therapeutic significance because of these organic ingredients, which also have various biological actions. Red silk cotton tr...
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A SYSTEMATIC REVIEW ON MUCOADHESION A NOVEL DRUG DELIVERY SYSTEM
The phenomenon known as mucoadhesion is characterized by interfacial molecular attractive forces between a natural or synthetic polymer and the surface of a biological membrane. This allows the polymer to stick to the membrane's surface for a prolonged period of time. The idea of mucoadhesion has garnered significant attention in many pharmaceutics sectors during the past forty years. The mucoadhe...
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A COMPREHENSIVE INSIGHT INTO ANETHUM GRAVEOLENS COMPOSITION AND ITS MEDICINAL POTENCY
Anethum graveolens (Dill) leaves and seeds of the plant are mainly used for traditional health treatments like diuretics and stomach disorders. Various observations of Anethum graveolens plant oil and other extracts showed antidepressant, analgesic, antiproliferative, antimicrobial, anti-inflammatory, analgesic, antioxidant activity, effects on gastrointestinal system, hyperlipidaemic effects, con...
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THE NEUROBIOLOGY OF OVEREATING: DOPAMINE’S ROLE IN OBESITY
Today, obesity has become a global pandemic affecting billions of people worldwide. It is associated with increased risks of various diseases, including cardiovascular and musculoskeletal diseases, psychiatric disorders, cancer, and diabetes, making it a significant public health issue. Obesity has also been linked to an elevated risk of metabolic diseases and changes in brain structure and functi...
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PI3KΓ: A KEY PLAYER IN CANCER SIGNALLING PATHWAYS AND THERAPEUTIC TARGET FOR CANCER TREATMENT
Phosphoinositide 3-kinase gamma (PI3Kγ) plays a vital role in cell signaling pathways essential for various physiological processes, including cell growth, differentiation, and survival. Dysregulation of PI3K signaling is implicated in the development and progression of several cancers. Activation of PI3K leads to the phosphorylation of critical proteins such as protein kinase B (PKB), ribosomal ...
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CURRENT AND FUTURE ADVANCEMENT OF FAST DISSOLVING ORAL THIN FILM
The development of fast-dissolving oral thin films has recently followed the progression of dosage forms from straightforward ordinary tablets and capsules to modified release tablets and capsules, oral disintegrating tablets, and wafers. A hydrophilic polymer used in fast- dissolving oral thin films quickly hydrates or adheres when applied on the tongue or in buccal cavity. These films melt or di...
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FROM CONCEPT TO REALITY: THE RISE OF MESSENGER RIBONUCLEIC ACID IN MEDICAL MARVELS
Recent years have witnessed remarkable advancements in biomedical sciences, particularly in the realm of mRNA (messenger ribonucleic acid) technology. This manuscript offers a detailed overview of the burgeoning field of mRNA and its profound implications in science and medicine. Beginning with an introduction that elucidates the fundamental concepts and historical evolution of mRNA technology, th...
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NADIFLOXACIN AND ADAPALENE: A REVIEW ON REPORTED METHODS FOR PURPOSE OF VALIDATION AND QUALITY MONITORING
Acne vulgaris is a common chronic inflammatory skin disease found predominantly in adolescents in both sexes. The best acne treatment inhibits bacterial growth, encourages the shedding to the skin cells to unclog pores. Treatment for acne includes topical agents and systemic agents. Its quality monitoring becomes essential for assuring quality products for human care. So, for that purpose a detail...
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A REVIEW ARTICLE ON AN EXISTING SCHEDULE M VS REVISED SCHEDULE M
Schedule M is considered as an important part in the Drugs and Cosmetics Act 1940, Rules 1945. For making a product with proper quality and effective for the human beings it is necessary to maintain or follow the guidelines of schedule M. Schedule M is considered as the guidelines which talks mostly about Good Manufacturing Practices. Schedule M was first established in the year 2001 and it was di...
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AYURVEDIC INTERVENTIONS FOR MALNUTRITION: ENHANCING INDIA’S NUTRITION PROGRAMS FOR CHILDREN
Malnutrition continues to be a significant public health concern, affecting the survival, growth, and well-being of both current and future generations, especially in developing nations such as India. This study examines the intricate characteristics of malnutrition, including insufficient and excessive nutrition, with a major emphasis on protein-energy malnutrition (PEM) in children, the high occ...
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Research Articles
FORMULATION AND IN-VITRO CHARACTERIZATION OF METFORMIN MICROSPHERE FOR ENHANCED DRUG DELIVERY VIA SPRAY DRYING IN TYPE 2 DIABETES MANAGEMENT
This study focuses on developing and characterizing metformin microspheres using spray drying with hydroxypropyl methylcellulose (HPMC) as a polymer, aiming to enhance gastrointestinal drug delivery, reduce gastric irritation, and lower dosage requirements for type 2 diabetes management. Metformin hydrochloride and HPMC concentrations are varied to generate microspheres with1 to1000µm diameter. T...
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DEVELOPMENT OF A MASS PROPAGATION PROTOCOL FOR URARIA PICTA AIMED AT ITS CONSERVATION AND SUSTAINABLE UTILIZATION
Uraria picta (family Fabaceae) is an important woody medicinal herb. This plant has been used in traditional systems of medicine for the treatment of various diseases. It is also used in an Ayurvedic formulation of “Dashmula”. The utilization of roots by uprooting the entire plant and the problems associated with seed germination threaten this plant in its natural habitat and cause a shortage ...
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FORMULATION AND EVALUATION OF CLINDAMYCIN PHOSPHATE LOADED CALCIUM CARBONATE NANOPARTICLES FOR TREATING OSTEOMYELITIS
This study focuses on developing clindamycin phosphate-loaded calcium carbonate nanoparticles to treat osteomyelitis, utilizing the chemical precipitation method. These nanoparticles were optimized for particle size, zeta potential, drug content, and encapsulation efficiency, resulting in seven different formulations (F1-F7), with formulation F5 was identified as the most effective. Particle size ...
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TO INVESTIGATE THE ANTIBACTERIAL AND ANTIBIOFILM EFFICACY OF URARIA PICTA AND ITS ADULTERANT SPECIES AND THEIR EFFECTIVENESS AGAINST MULTIDRUG-RESISTANT BACTERIA
An ayurvedic nutritional tonic, i.e., Dashmularishta, is made up of ten different plants that support gut health and restore appetite by relieving indigestion, bloating, etc. U. picta is one of the important medicinal plant used in this formulation. Due to ever increasing demand U. picta is now in the status of endangered. As a result, many of its similar species are being used as its adulterant i...
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TRANSITION CHALLENGES IN TYPE 1 DIABETES MELLITUS FROM PAEDIATRIC TO ADULT CLINIC
Objectives: Transitioning from a family-centred clinic to a patient-centred clinic is an inevitable and fragile process through which patients and caregivers have to go through. This study aimed to identify transition issues and assess the role of pharmacists during this phase. Method: A mixed-method approach combining qualitative and quantitative analysis was used to identify factors that may con...
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SYNTHESIS OF NOVEL SPIROTHIAZOLIDINONE DERIVATIVES AND EVALUATION OF ANTI-INFLAMMATORY ACTION
The objective of this investigation was to synthesize spirothiazolidinone-chalcone derivatives and evaluate them for anti-inflammatory action. Five 4-substituted benzaldehydes were utilized for the aldol condensation leading to chalcones of spirothiazolidinone. The compounds were obtained in yield of 64-72% and displayed varying solubility with all compounds soluble in chloroform and DMSO. The NMR...
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SYNERGISTIC EFFECT OF ETHANOL EXTRACT OF ANACARDIUM OCCIDENTALE LEAVES AND MUSA SAPEINTUM PEELS ON FINE MOTOR FUNCTION AGAINST CADMIUM-INDUCED NEUROTOXICITY IN RATS
Cadmium (Cd) is the seventh most toxic heavy metal; a potentially hazardous metal found that has a substantial impact on the peripheral (PNS) and central nervous systems (CNS). This study is aimed at investigating the concommitant administration of ethanol leaf extract of Anacardium occidentale (AO) and ripe Musa sapientum (MS) peels on fine motor functions in Cd-induced neurotoxicity in female wi...
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HR LC-MS FOR THE MANAGEMENT OF SYSTEMIC HYPERTENSION (RATHTHA KOTHIPPU NOI)
The delineation, characterization, and fingerprint profiling of metabolites derived from Siddha formulations are pivotal in advancing drug development and substantiating time-honored evidence-based medicinal practices. This study employs an untargeted metabolomics approach utilizing High Resolution Liquid Chromatography Mass Spectrometry (HR-LCMS) to investigate the Siddha herbal formulation 'Vaas...
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PHARMACOGNOSTICAL CHARACTERIZATION OF STEVIA REBAUDIANA BERT. LEAVES: VALUABLE ANTIDIABETIC PLANT
Globally, traditional herbal medicine has played a crucial role in primary healthcare. The recent surge in research on herbal medicine systems has led to a higher demand for medicinal plants in the global phytomedicine market. However, this increased demand also raises the risk of adulteration of raw drugs, posing potential threats to consumer health and safety. Thus, there is a pressing need for ...
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EFFECT OF ADD ON THERAPY WITH OMEGA 3 FATTY ACIDS AMONG DIABETIC AND NON-DIABETIC DYSLIPIDEMIC PATIENTS ON RANDOM BLOOD GLUCOSE- A COMPARATIVE, RANDOMISED, OPEN LABEL, PROSPECTIVE STUDY
Background: Diabetes is one of the leading non communicable disease-causing various health complications like Cerebrovascular accidents, micro and macrovascular complications. In Indian population, very few comparison studies have been conducted to evaluate the glucose lowering effect of omega 3 fatty acid between diabetic and non- diabetic dyslipidemic patients. Hence the present study was planne...
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PHARMACOLOGICAL APPROACHES TO HYPERTENSION IN A TERTIARY CARE CENTRE IN NORTH INDIA: A STUDY OF PRESCRIPTION TRENDS AND RATIONALITY
Background: Hypertension is a prevalent health concern, often managed using Fixed Dose Combinations (FDCs) of antihypertensive drugs. Presently many FDCs are present in market without being assessed for safety efficacy and rationality, therefore evaluating the rationality of FDC usage is crucial for ensuring effective treatment and patient safety. Objective: This study aims to assess the rational ...
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A CROSS-SECTIONAL STUDY TO EVALUATE THERAPEUTIC EFFICACY AND SAFETY PROFILE OF ESCITALOPRAM VERSUS VENLAFAXINE/DESVENLAFAXINE IN PATIENTS OF DEPRESSION IN A TERTIARY CARE HOSPITAL
Background: Depression is a major public health disorder, with antidepressants like Selective Serotonin Reuptake Inhibitors (SSRI) and Serotonin and Norepinephrine Reuptake Inhibitors (SNRI) improving outcomes for Major Depressive Disorder (MDD) patients. However, determining which category is superior remains unclear. This study aimed to compare the efficacy and safety profile of Escitalopram (SS...
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IN-SILICO MOLECULAR DOCKING INSIGHTS OF BIO ACTIVE COMPOUNDS OF GENUS MOMORDICA AND NOVEL SYNTHETIC ANTI –PARKINSON’S DRUG: A PROMISING LEAD IN THE QUEST FOR MAO-B INHIBITORS
Discovering Novel MAO-B inhibitors is promising therapeutic strategy for Parkinson’s disease. The pharmacological effects of MAO-B inhibitor showed significant neuro-protection and improved motor function and reduced oxidative stress marker. In-silico molecular docking simulation to investigate the interaction between target protein (MAO-B Inhibitors) and revealing promising hits with high bindi...
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MODULATION OF ANTIOXIDANT ENZYME ACTIVITY IN VIGNA RADIATA BY POLYETHYLENE GLYCOL (PEG): INSIGHTS INTO CELLULAR DEFENSE MECHANISM
The physiological and biochemical changes in plants are affected by water deficiency caused by polyethylene glycol (PEG). It is a synthetic, water-soluble polymer and induces water deficit conditions. Its application is useful to induce drought stress in different plant varieties. The purpose of this study is to understand the effects of different concentrations of polyethylene glycol on the antio...
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GC-MS PROFILING OF BIOACTIVE COMPOUNDS IN ASPARAGUS RACEMOSUS: IMPLICATIONS FOR PHARMACOLOGICAL PROPERTIES
Background: Plants for remedial applications are well known, realizing the pharmacological potentials of plants through analytical techniques. Asparagus racemosus is a well-known medicinal plant analyzed using biological approach. The present study was carried out to evaluate the antioxidant, ani-inflammatory, antibacterial effects and the possible bioactive compounds present in the chloroform, me...
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ETHNOBOTANICAL INVESTIGATION OF MEDICINAL PLANTS FOR LACTATION ENHANCEMENT AND POSTPARTUM RECUPERATION IN TRIBAL COMMUNITIES OF SOUTHERN RAJASTHAN
Giving birth is the most physically exhausting experience for a woman's body. Tribal societies use medicinal plants and nutrient-dense foods as natural remedies to boost vitality, facilitate healing, and increase milk supply after delivery of women. The present study was carried outinthetribal-dominated areas of southern Rajasthan, including Banswara, Chittorgarh, Dungarpur, Pratapgarh, Udaipur, a...
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BIOPHYSICAL CHARACTERIZATION OF EXUDATES OF ENDOPHYTIC FUNGI ISOLATED FROM CENTELLA ASIATICA AS A SOURCE OF BIOACTIVE COMPOUNDS
Fungal exudate is the phenomenon that involves the exudation of water and metabolites produced by fungal cells, Fungal exudates are rich sources of bioactive secondary metabolites with potential applications. Exudates are a prevalent phenomenon in the fungal domain, influenced by various factors, such as the composition of the growth medium and incubation temperature. Filamentous fungi, renowned f...
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