Volume 16 (2025) - Issue 6, June
Review Articles
HARNESSING THE POTENTIAL OF PAT TOOLS IN PHARMACEUTICAL CRYSTALLIZATION
Controlling the crystal growth in a crystallization set up is a complex and time taking process. In the domain of pharmaceutical set up, crystal differences will largely affect the drug performance and stability. Therefore, it is essential to control the crystallization process and optimize the experimental set up to get desired particle characteristics. Process Analytical Technology (PAT) tools a...
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A REVIEW ON COMPUTER AIDED DRUG DESIGN IN DRUG DISCOVERY
Computer-aided drug design programs use mathematical formulas to predict the property value and structure of stable, unknown, and molecular species. Quantum mechanics, hybrid QM/MM, molecular bonding, molecular modelling, molecular mechanics, and QSAR are some of the techniques used in molecular bonding studies. An average drug discovery cycle, from lead identification to clinical trials, is expec...
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MODERN SOLUTIONS FOR HERNIA REPAIR: A REVIEW OF MESH INNOVATIONS AND EMERGING SURGICAL TRENDS
Hernia repair is one of the most common surgeries, with recent advancements in mesh technology and surgical techniques significantly improving outcomes. Mesh implants are the standard for reinforcing abdominal walls, reducing recurrence rates compared to traditional sutures. However, complications like chronic pain, infection, and adhesions have driven innovations in mesh development. Modern synth...
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IN DEPTH STUDY ABOUT CHROMOSOMAL NON-DISJUNCTION IN A BRIEF REVIEW
Chromosomal non-disjunction is a pivotal error in cell division where chromosomes fall to separate properly during meiosis or mitosis, resulting in an abnormal number of chromosomes, the condition is known as aneuploidy. This phenomenon has significant consequences for human health, as it underpins several kinds of genetic disease, such as Downsyndrome, Turner syndrome and Klinefelter syndrome. No...
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HERBAL INTERVENTIONS FOR HYPERTENSION: A REVIEW OF TRADITIONAL PLANTS, BIOACTIVE COMPOUNDS, AND NANOTECHNOLOGICAL ADVANCES
Hypertension (HTN), a major global health concern and the primary cause of cardiovascular disease (CVD) death is expected to impact 29% of all adults by 2025. Hypertension (HTN) is a multifactorial condition, arising from the complex interaction of hereditary, environmental, and physiological variables that contribute to elevated systolic and diastolic blood pressure. It is frequently caused by dy...
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LUMPY SKIN DISEASE: A REVIEW
Lumpy skin disease (LSD) causes enormous economic losses in the livestock business. Lumpy skin disease virus (LSDV) a member of the Poxviridae family causes the condition. The Neethling strain is the pro to type. LSDV is part of the Capri poxvirus genus which also includes sheep and goat poxviruses. LSD is an enzootic illness that causes skin nodules and is seldom lethal in cattle. Cattle and wate...
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UNVEILING THE SIDDHA HERBO-MINERAL FORMULATION FOR STERILITY- A LITERATURE REVIEW
In recent days some groups are seeking infertility treatment, on the other hand there are groups seeking contraception methods. Nowadays there are several ways are available for contraception such are Oral contraceptive pills, implants, injectable, patches, rings, intra uterine devices, Male and Female sterilization and so on. WHO stated that the number of women desiring to use family planning has...
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A BRIEF INSIGHT INTO THE PHARMACOTHERAPY OF OBESITY, DRUGS WITHDRAWN, DRUGS IN MARKET AND IN PIPELINE: A REVIEW
A Multifactorial disorder primarily of energy balance, which occurs due to imbalance between energy expenditure and excess of calorie intake. Obesity is becoming a serious health related problem worldwide. Appropriate Treatment plans as well as Goals have been established for this disorder, when a patient presents with certain complications, for example, type-2 diabetes mellitus, cardiovascular di...
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Research Articles
IDENTIFICATION OF POTENTIAL BIOACTIVE DSBA-INHIBITORS AS AN ANTIMICROBIAL RESTORATION STRATEGY: AN IN-SILICO SCREENING AND ADMET STUDY
Antimicrobial resistance continues to cause antibiotics treatment failure and millions of deaths globally. Inhibition of a double-stranded binding protein-A enzyme (DsbA), machinery in bacteria resistance and pathogenesis mechanisms make the bacteria vulnerable to existing antibiotics, allowing restoration of antimicrobial efficacy. However, there is a gap in identifying bioactive and safe DsbA-in...
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ACCELERATING NITRENDIPINE DELIVERY: NANOSUSPENSION FAST-DISSOLVING FILM FOR ORAL TRANSDERMAL USE
The present research work is aimed to formulate and evaluate Nitrendipine nanosuspension (NTD-NS) and nanosuspension loaded oral fast dissolving film (NS-OFDF) to improve its low solubility and bioavailability. Wet media milling technique was employed to prepare NTD-NS, which was optimized and evaluated for different parameters. Poloxamer 188, Poloxamer 407, HPC, HPMC E5, HPMC E15, HPMC E50, HPMC ...
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OPTIMAL BIODEGRADATION OF METHYL VIOLET ACHIEVED BY ENTEROBACTER STRAIN
The most widely used cationic dye, methyl violet (MV), has significant carcinogenic potential. The textile, cosmetic, printing, pharmaceutical, and food processing sectors all make extensive use of artificial dyes. They are typically referred to as xenobiotics because of their strong resistance to biodegradation. Microbes are beneficial because of their rapid growth and ability to break down and m...
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GC-MS PROFILING OF AQUEOUS AND METHANOLIC EXTRACTS OF MEYNA LAXIFLORA ROBYNS FRUIT PULP
Medicinal plants are of great importance to researchers in the field of pharmacology as most pharmaceutical industries depend on medicinal plant for their raw materials. Meyna laxiflora belongs to the family Rubaceae and is well known for its medicinal properties. The present study was carried out in continuation of our previous findings to determine the possible bioactive components present in th...
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PHYTOCHEMICALS, IN-VITRO CYTOTOXICITY, ANTIOXIDANT, AND ANTIMICROBIAL EVALUATION OF BARLERIA CRISTATA L: PHILIPPINE VIOLET
The current study aims to find out how effective different extractions of Barleria cristata leaves are at fighting cancer, free radicals, and bacteria. Physical and chemical qualities and preliminary phytochemical analysis will also be assessed. It also quantifies several active ingredients by total phenolic and flavonoid. Five leaf extracts of Barleria cristata were made with ethyl acetate, chlor...
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EVALUATION OF KERATINASE DEPOSITION AND PERMEABILITY IN THE SKIN
The skin acts as a protective barrier shielding our body from external aggression. This fact hinders the entry of substances into the various layers of the skin. One of the skin components involved in this defense function is keratin. Keratin is a fibrous structural protein very resistant to proteolysis but susceptible to be hydrolyzed by keratinases; however, the mechanisms of keratinolysis is st...
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COMPARATIVE STUDY OF EFFICACY AND SAFETY OF ORAL TRANEXAMIC ACID WITH TOPICAL TRIPLE COMBINATION VERSUS TRIPLE COMBINATION ALONE IN MELASMA
Objective: Melasma is a chronic acquired hyper melanosis of skin, involving sun exposure areas of the face and neck. Even with various treatment modalities, melasma recurs and long-term treatment is associated with many side effects. Tranexamic acid, the antifibrinolytic agent is a drug of research for melasma, as it inhibits melanogenesis. Hence, the present study compares the efficacy and safety...
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FROM PHYLOGENY TO PHARMACOLOGY: THERAPEUTIC INSIGHTS INTO THE ANTI-DIABETIC POTENTIAL OF MOMORDICA CYMBALARIA
Momordica cymbalaria, an underexplored vegetable crop native to India, holds significant therapeutic potential due to its traditional antidiabetic use. This study explores its phylogenetic characterization, protein structure modelling, and phytochemical profiling, emphasizing its role in diabetes management. The 5.8S rRNA internal transcribed spacer sequence was retrieved from NCBI and analysed us...
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DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR THE DETERMINATION OF ALVIMOPAN IN BULK AND PHARMACEUTICAL FORMULATION
Objective: The present investigation demonstrates a simple, sensitive and accurate high-pressure liquid chromatographic (HPLC) method for the determination of Alvimopan (AMP) in bulk and dosage form. The chromatographic separation was achieved within 10 minutes by using acetonitrile: potassium dihydrogen phosphate buffer pH 3.0 adjusted with orthophosphoric acid (50:50) as mobile phase on Altima G...
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HERBAL IMMUNOMODULATORS: FORMULATION AND EVALUATION OF A TABLET CONTAINING INDIAN HERBS
The quest for natural immunomodulators has led to the exploration of traditional Indian herbs, renowned for their immune-boosting properties. In this study the goal was to create and assess a polyherbal formulation that contained extracts of all herbs. A polyherbal tablet was formulated using a combination of Giloy (Tinospora cordifolia), Amla (Emblica officinalis Gaertn), and Tulsi (Ocimum sanctu...
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PERIOPERATIVE AIRWAY MANAGEMENT FOR TRACHEAL RECONSTRUCTION IN A PATIENT WITH SUBGLOTTIC STENOSIS – A CASE REPORT
Benign subglottic stenosis is a life-threatening condition. It commonly corresponds to postintubation injuries associated with prolonged endotracheal intubation. The surgical correction of a subglottic stenosis presents anaesthetic challenges which are unique to airway anatomy, physiology and shared surgical airway. Management of these patients involves an integrated multidisciplinary approach a...
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AN ISOLATED FACIAL NERVE PALSY IN NASOPHARYNGEAL CARCINOMA: A RARE CASE REPORT
The fossa of Rosenmuller is the most common site of NPC. It arises from the lining mucosa of the nasopharynx. Around one-fifth of NPC patients presented with cranial nerve palsy. The tumor can penetrate the skull and surrounding cranial nerves because fossa of Rosenmuller is situated next to the foramen lacerum. A 57-year-old male patient arrived at the medical college and Hospital, Kolkata ENT op...
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IMPACT OF COVID-19 TREATMENT AND PANDEMIC ON EPILEPTIC PATIENTS – A CROSS-SECTIONAL STUDY
Background: The SARS-CoV-2 pandemic has severely impacted individuals with epilepsy, increasing their risk of seizure exacerbation and medication dependence. Methods: This cross-sectional study evaluated antiepileptic drug (AED) prescribing management and adverse drug reactions in patients at a tertiary care hospital from September 2020 to September 2022 influenced by COVID-19 Pandemic. Results: T...
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PRESCRIBING PRACTICES AND OUTCOMES OF ANTI-PARKINSONIAN MEDICATIONS IN INDIA: CURRENT STATUS AND FUTURE PROSPECTS
Background: Managing Parkinson's disease (PD) requires a multimodal strategy, with pharmaceutical therapies being an essential component. This study's goal was to look into how antiparkinsonian drug prescriptions are given to PD patients at a tertiary care facility. Methods: Five hundred Parkinson's disease (PD) patients who visited the Department of Neurology at Mallige Hospital in Bengaluru, Ind...
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EFFECT OF METHANOLIC EXTRACT OF PLUMERIA PUDICA JACQ. LEAVES AGAINST DMBA-INDUCED MAMMARY CARCINOMA IN RATS
Background: Breast cancer is the most occurring cancer in women and the second most reason for tumour related deaths in women. Chemoprevention, which involves employing dietary, natural, or synthetic items, has emerged as an intriguing strategy to deal with increase in Breast cancer cases. Plumeria pudica Jacq. is fast growing, having medium size and belongs to the family Apocynaceae. The high con...
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RISK FACTORS LINKED TO IATROGENIC WITHDRAWAL AND ITS MANAGEMENT IN PEDIATRIC CRITICAL CARE PATIENTS
In paediatric critical care settings, the use of sedatives is common for managing pain, agitation and anxiety. However, prolonged administration of sedatives can lead to iatrogenic withdrawal syndrome, posing significant challenges in patient care. This study investigates the risk factors associated with iatrogenic withdrawal syndrome in paediatric critical care patients and explores effective man...
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COVID-19 ASSOCIATED FUNGAL INFECTIONS, A DEFINITE BOON FOR MYCOLOGY LABORATORIES – AN EXPERIENCE FROM A TERTIARY CARE HOSPITAL IN PUNJAB, INDIA.
Fungal infections constituted a major chunk of secondary infections in COVID-19 due to immunosuppresion and rampant use of steroids. Invasive Aspergillosis, Candidemia and COVID associated mucormycois (CAM) post second wave in India among COVID-19 patients was a challenging experience for the clinicians. Increased burden of fungal infections led to a tremendous increase in the sample load of the m...
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EFFECTIVENESS OF PLANNED TEACHING PROGRAM ON KNOWLEDGE REGARDING CHILDHOOD OBESITY AMONG THE PARENTS OF SCHOOL AGE CHILDREN IN URBAN COMMUNITY, LUCKNOW, U. P. – PRE-EXPERIMENTAL STUDY
Introduction: Obesity is condition wherein a person starts to gain unnecessary body fat.” Obesity in children has reached epidemic levels in developed & its prevalence is increasing in developing countries as well. The identification of parental health knowledge related to obesity and overweight status in children is an important area. Its importance relates to understanding gaps in knowledg...
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IMPACT OF PHARMACIST INTERVENTION IN ENHANCING MEDICATION ADHERENCE AMONG HEMODIALYSIS PATIENTS
Background: Chronic Kidney Disease (CKD) is a progressive condition associated with high rates of morbidity and mortality, often leading to end-stage renal disease (ESRD), cardiovascular events, and a reduced quality of life. Effective medication adherence is critical for preventing adverse outcomes and improving long-term survival. Objective: The primary objective of this study was to assess the ...
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A COMPARATIVE INTERVENTIONAL STUDY ON EFFECTS OF CALCIUM CITRATE AND ISOFLAVONES ON LOW BONE MINERAL DENSITY IN PERIMENOPAUSAL WOMEN
Perimenopause is a transitional stage in a woman's life, typically occurring in her 40s, leading up to menopause. During this time, hormonal changes, particularly a decline in estrogen levels, can have a significant impact on bone health. Calcium citrate is a commonly used calcium supplement that is known to promote bone health. Isoflavones are a type of phytoestrogen found in plants, particularly...
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EXPLORING THE INTRICATE MORPHO-ANATOMY OF TONNA DOLIUM (CAENOGASTROPODA: TONNIDAE) FROM THE GULF OF MANNAR, INDIA
The study provides a detailed morpho-anatomical description of Tonna dolium (Linnaeus, 1758), a commercially important tonnid gastropod, based on specimens collected from the Gulf of Mannar, India. The research examines the shell characteristics, head-foot morphology, mantle organs, visceral mass, reno-pericardial system, digestive system, reproductive system, and central nervous system of T. doli...
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LOW-DOSE VALPROIC ACID ENHANCES ENDOTHELIAL CELL PROLIFERATION AND ACCELERATES RE-ENDOTHLIALIZATION IN BALLOON-INJURED RAT CAROTID ARTERY
Re-endothelialization after stent implantation and vascular injury is a critical step in the process of vascular healing. Proliferation of human umbilical vein endothelial cells (HUVECs) is a major factor influencing the induction of re-endothelialization. Valproic acid (VPA) is a widely used anti-epileptic drug. VPA was recently shown to modulate expression of various genes involved in angiogenic...
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