Volume 16 (2025) - Issue 7, July
Review Articles
TIME-OPTIMIZED DRUG DELIVERY: THE ROLE OF CHRONOTHERAPY IN MODERN THERAPEUTICS
Circadian clock is an impressive timing system responsible for the control of several metabolic, physiological and behavioral processes. Chronotherapeutic is an approach that aligns the timing of drug delivery with the rhythms of diseases or disorders to optimize therapeutic responses and minimize side effects. This method ensures the purposeful and controlled release of medications in varying amo...
14
9
PSYCHOLOGICAL TRAUMA AND HEART HEALTH IN PTSD AND CVD
Post-traumatic stress disorder (PTSD) affects a significant portion of the global population and can lead to chronic psychiatric complications and other secondary health issues. Among these, cardiovascular disease (CVD) stands out prominently. The relationship between PTSD and CVD is complex and bidirectional, with PTSD increasing the risk of developing CVD and worsening its prognosis. This review...
16
8
AN UPDATED REVIEW ON ANALYTICAL METHODS FOR ESTIMATION OF AZELNIDIPINE
Hypertension is a ubiquitous and serious worldwide health concern, having a dramatic influence on individual health outcomes. In light of this rising worry, Azelnidipine, a third generation long-acting dihydropyridine calcium channel blocker, has emerged as a prospective therapeutic treatment. A vast body of research has indicated that Azelnidipine produces a strong antihypertensive impact, especi...
17
10
A SYSTEMATIC REVIEW ON CURRENT TREATMENT OPTIONS FOR INSULIN RESISTANCE IN POLYCYSTIC OVARY SYNDROME
Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder affecting women of reproductive age. It is characterized by symptoms such as elevated androgen levels, the presence of multiple cysts on the ovaries, irregular or absent ovulation and various metabolic disturbances. Women with PCOS commonly experience metabolic dysfunction, obesity and infertility. They also face a higher risk of p...
18
7
EMERGING BIOMARKERS FOR CARDIOMETABOLIC DISORDERS
Cardiometabolic disorders, encompassing cardiovascular diseases, diabetes mellitus, metabolic syndrome, and obesity, represent a significant global health burden. This comprehensive review explores emerging biomarkers that offer promising avenues for improving diagnosis, risk stratification, and management of these complex conditions. We focus on twelve novel biomarkers: growth hormone-15 (GH-15),...
12
8
INTRAVASCULAR LITHOTRIPSY: THERAPEUTIC AND DIAGNOSTIC APPLICATIONS IN HYPERTENSIVE PATIENTS WITH CORONARY CALCIFIED LESIONS
Background: Intravascular lithotripsy (IVL) is an innovative method for treating heavily calcified coronary and peripheral lesions. It employs acoustic shock waves to create microfractures in calcified plaques, facilitating stent placement and improving vessel compliance. Objective: To assess the efficacy, safety, and potential applications of IVL in hypertensive patients with calcified coronary l...
9
4
EXPLORING THE TOPICAL FORMULATION FOR MANAGEMENT OF DIABETES WOUND HEALING – A REVIEW
Diabetes is a multifaceted metabolic disorder that impacts individuals worldwide, and delayed wound recovery is a prevalent symptom of diabetes. There is a plethora of methods available now to heal these wounds. Since, chronic inflammation and untreated stages may lead to amputation and death. So, their consequences may cause a patient's financial strain. However, this review focuses on the mos...
9
4
CARDIAC SARCOIDOSIS: ADVANCEMENTS IN DIAGNOSTIC TECHNIQUES AND MANAGEMENT
Cardiac sarcoidosis, a systemic inflammatory disease characterized by the formation of non-caseating granulomas, poses significant diagnostic and therapeutic challenges due to its variable clinical presentation and potential for severe complications. This article reviews recent advancements in the diagnosis and treatment of cardiac sarcoidosis, emphasizing the importance of early recognition and i...
9
4
TECHNOLOGICAL ADVANCEMENTS AND INNOVATIONS IN CARDIOMEMS DEVICES
CardioMEMS devices represent a significant advancement in heart failure management, offering continuous, real-time pulmonary artery pressure monitoring. This review explores the technological foundations, recent innovations, clinical applications, challenges, and future directions of CardioMEMS technology. Based on micro-electromechanical systems, these devices have undergone substantial improveme...
9
4
SMART HYDROGELS FOR ADVANCED DRUG DELIVERY
Hydrogels are three-dimensional polymeric network structures having high water content. Stimuli-responsive or smart polymers are macromolecules that show a significant physiochemical change in response to small changes in their environment. These smart hydrogels with chemical and structurally responsive moieties show excellent characteristics of reacting under different environmental conditions su...
9
4
RECENT ADVANCES IN CARDIAC SURGERY: MINIMALLY INVASIVE TECHNIQUES AND ROBOTIC ASSISTANCE
Minimally invasive cardiac surgery (MICS) has emerged as a transformative approach in cardiovascular medicine, aiming to reduce surgical trauma and improve patient outcomes compared to traditional open-heart procedures. Originating nearly a century ago, MICS has undergone significant advancements, evolving from rudimentary instruments to sophisticated robotic-assisted and AI-driven techniques. Thi...
9
4
FILM-FORMING GELS: A PROMISING ALTERNATIVE FOR ENHANCED DERMAL AND TRANSDERMAL DRUG DELIVERY
A new method in this field called film-forming gels may offer an alternative to the common skin dosage forms such ointments, creams, gels, or patches. When applied as a liquid, the polymeric solution evaporates to create a nearly undetectable layer on the skin. Dermal medication delivery and transdermal drug delivery systems compared to traditional pharmaceutical dosage formulations, the approach ...
10
5
A REVIEW ON THE APPLICATION OF DRUG LOADED NANOCARRIERS, LIMITATIONS, FUTURE PERSPECTIVES AND IMPLEMENTATION OF ARTIFICIAL INTELLIGENCE
The central nervous system disorders represent a worldwide public health problem. Neurodegeneration is associated with many transitions in brain including synaptic disorder and neuro cognition decline. It is shielded by a barrier which controls the entry of compounds into the brain known as blood brain barrier (BBB), thereby regulating brain homeostasis. In achieving a therapeutic amount of drug t...
9
5
INNOVATIVE APPROACHES TO MIGRAINE MANAGEMENT: EXPLORING HERBAL THERAPIES
Migraines are a debilitating neurological condition affecting millions worldwide, characterized by intense headaches often accompanied by nausea, photophobia, and sensitivity to sound. Conventional treatments, such as analgesics and triptans, provide relief but are often associated with side effects and limited efficacy for chronic sufferers. This has led to a growing interest in alternative thera...
11
5
PHARMACOGENOMICS AND PERSONALIZED MEDICINE: ADVANCING TAILORED THERAPIES FOR IMPROVED HEALTHCARE
Background: Pharmacogenomics, a cornerstone of precision medicine, studies genetic variations that influence individual drug responses. By leveraging genomic technologies, it enables personalized medicine, optimizing drug efficacy and reducing adverse effects. Objective: This review provides a comprehensive overview of pharmacogenomics, examining its scientific principles, technological advancemen...
12
4
THE ROLE OF HERBAL TEA IN FUNCTIONAL FOODS: A COMPREHENSIVE REVIEW OF HEALTH BENEFITS AND APPLICATIONS
Herbal tea has emerged as a key component in the development of functional foods, offering a wide range of health benefits and applications. This comprehensive review explores the role of herbal teas in promoting health and wellness, focusing on their rich content of bioactive compounds such as polyphenols, flavonoids, and antioxidants. These compounds contribute to various health-promoting proper...
10
4
DRUG DEVELOPMENT: ROLE OF GENERATIVE ARTIFICIAL INTELLIGENCE
This article explores the transformation of pharmaceutical research and development by the combination of digital twins and generative artificial intelligence (AI), especially in drug discovery. It highlights various cases that illustrate the increasing use of digital twins of biological systems alongside generative AI algorithms to speed up the identification of new drugs. This approach involves ...
10
4
SMART DRUG DELIVERY SYSTEMS
Smart drug delivery systems are a key innovation in pharmaceutical technology that aims to enhance the efficacy and safety of therapeutic interventions. These systems integrate advanced materials, microelectronics, and responsive mechanisms to deliver drugs in a controlled, targeted, and adaptive manner. The development of smart drug delivery systems is driven by the need to improve patient compli...
8
4
COMPREHENSIVE REVIEW ON ACNE VULGARIS AND ITS TREATMENT
Acne vulgaris is a multifactorial skin disorder of pilosebaceous unit which majorly affects teenagers, but it can continue into adulthood and cause aesthetical as well as psychological problems. This review article enlightens the knowledge related to cause and treatment of acne vulgaris. Several factors which are involved in the development of acne vulgaris are hormonal activity, sebum production,...
9
4
Research Articles
PREPARATION AND CHARACTERIZATION OF FACIAL POWDER CLEANSERS PREPARED FROM COLORED CLAYS
The objectives of the present study were to formulate facial powder cleansers using colored clays, green clay or red clay, as main ingredients and to investigate the foaming and cleansing properties of the powder cleansers. For foaming and cleansing purposes, natural foaming tea and synthetic sodium cocoyl isethionate (SCI), were employed. Eight formulations were prepared by varying types and amou...
11
6
IN-VIVO EXPERIMENTATION OF TUPICHINOL E, OSIMERTINIB, AND THEIR COMBINATION USING A XENOGRAFT MODEL
This comprehensive study investigates the in vivo effects of Tupichinol E, osimertinib, and their combination in a xenograft model of triple-negative breast cancer (TNBC), an aggressive and therapeutically challenging breast cancer subtype. By employing a multi-faceted approach, the study evaluates tumor growth inhibition, apoptosis, and proliferation through histopathological and immunohistochemi...
13
8
ANTIOXIDANT AND ANTI-INFLAMMATORY INSIGHTS OF PSEUDOPTEROGORGIA AUSTRALIENSIS COLLECTED FROM WEST COAST OF MUMBAI
The study investigates to find the antioxidant and anti-inflammatory properties of the crude extract of coral Pseudopterogorgia australiensis. Various assays were used to assess the biological activities of the crude extract. The antioxidant capacity was evaluated using DPPH, ABTS, and FRAP tests. The DPPH assay indicated a dose-dependent radical scavenging effect whereas the ABTS assay showed a s...
13
6
A COMPARATIVE STUDY TO EVALUATE THE EFFICACY AND SAFETY OF ROSUVASTATIN 5MG VERSUS ATORVASTATIN 20MG IN PATIENTS WITH DYSLIPIDAEMIA
Dyslipidemia is a known risk factor for Atherosclerotic Cardiovascular Diseases (ASCVD). Statins are first choice drug for the treatment of dyslipidemia. The FDA advises a low starting dose of rosuvastatin at 5 mg/day in Asians. The present study is a randomized, open labelled study done at Victoria Hospital, Bangalore to compare the efficacy and safety of rosuvastatin 5mg versus atorvastatin 20mg...
11
8
A STUDY OF ANOMALOUS ORIGIN OF OVARIAN ARTERIES AND ITS CLINICAL SIGNIFICANCE IN HUMAN CADAVERS
Background: The Gonadal Arteries most commonly arise from the abdominal aorta at the level of the second lumbar (L2) vertebra, supplying the testes and ovaries. The gonadal arteries variations are commonly seen in males on right side however there are few instances where there is variation in ovarian arteries seen in females which could be of importance. Aim of the Study: To re-evaluate the origin...
17
7
CLINICAL ANALYSIS OF ROLE OF BLOOD EOSINOPHIL AND BASOPHIL LEVELS AS PROGNOSTIC MARKER IN ALLERGIC FUNGAL RHINOSINUSITIS (AFRS)
Background: Allergic Fungal Rhinosinusitis (AFRS) is a common disease and denoted as Chronic Rhinosinusitis with polyps (CRSwNP). Presents as Eosinophilic nasal polyps, and allergic mucin in the nose and sinuses demonstrable with Functional Endoscopic sinus surgery (FESS) surgery. The biological markers predicting this disease entity are uncertain. Physicians experience difficult to predict the ou...
9
4
CONCOMITANT RECURRENT GENITAL HERPES AND GENITAL WARTS IN A YOUNG MALE WITH INSULIN-DEPENDENT DIABETES MELLITUS: A CASE ANALYSIS & TREATMENT APPROACH
We present the case of a 25-year-old unmarried male driver diagnosed with recurrent genital herpes (RGH) and genital warts, associated with insulin-dependent diabetes mellitus (IDDM). The patient reported a history of unprotected sexual intercourse with a commercial sex worker (CSW) four months prior. He developed multiple painful genital erosions and verrucous growths on the penile shaft. Laborat...
9
5
COMPARATIVE ANALYSIS OF CONVENTIONAL METHODS WITH CATRIDGE BASED PCR METHOD IN THE DIAGNOSIS OF PAEDIATRIC TUBERCULOSIS
Background: Tuberculosis is a great menace to mankind since ancient times. The genus mycobacterium was known to originate 150 million years ago. Despite the discovery of many newer methods in the diagnosis of tuberculosis, a robust point of care test is required for effective management of Paediatric tuberculosis. Methodology: We conducted this study in paediatrics department of N.M.C.H for 1 year...
9
4
ANTIANEMIC ACTIVITY OF MAHUA FLOWER CONCENTRATE AND MAHUA LADDOO AGAINST 2,4-DINITROPHENYLHYDRAZINE INDUCED ANEMIA IN A RAT MODEL
Anaemia is a widespread problem that can be characterized by a decreased number of red blood cells and decreased haemoglobin levels. The aim of this study was to explore the antianaemic efficacy of mahua flower concentrate and mahua laddoo in comparison to the clinically prescribed iron tablet, Livogen XT, in an anaemic rat model. The anaemic rat model was developed by the administration of 2,4-di...
9
4
RANDOMIZED CONTROLLED TRIAL BETWEEN LEVETIRACETAM AND PHENOBARBITONE IN THE TREATMENT OF NEONATAL SEIZURE DUE TO PERINATAL ASPHYXIA
Background: Seizure occurs more frequently in neonatal period than in any other time of life. Estimated incidence of neonatal seizure varies according to case definition, method of ascertainment and definition of the neonatal period and ranges from 1 to 5 per 1000 live births. Methodology: Neonates admitted in Nicu, department of Paediatrics, Nalanda Medical College and Hospital, Patna in time per...
9
4
CARBOPROST: A PROMISING PREVENTIVE APPROACH FOR THE POSTPARTUM HAEMORRHAGE
Background: Childbirth is a multi-stage process, and the postpartum period holds significant implications for maternal health. The third stage of labour, when the placenta detaches, is the most dangerous for women because of excessive bleeding (postpartum hemorrhage or PPH). This is often caused by the uterus not contracting properly (uterine atony). Thus, there's a well-established practice calle...
9
4
EVALUATION OF ANTI-IMPLANTATION ACTIVITY OF LUFFA ACUTANGULA FRUIT EXTRACT ON FEMALE ALBINO RATS
The study investigates the anti-implantation and early abortifacient effects of Luffa acutangula fruit, traditionally claimed by tribals in the Pandharkawada region of Maharashtra, on female albino rats. To evaluate its efficacy, fertile male and female albino rats were paired, and the females were divided into 13 groups, including a control group receiving distilled water and 12 experimental grou...
10
4
SINUS BRADYCARDIA IN SUPER VASMOL POISONING: A RARE BUT SIGNIFICANT CLINICAL MANIFESTATION – REPORT OF TWO CASES
Introduction: Super Vasmol, an emulsion-based hair dye containing paraphenylenediamine (PPD), is an emerging cause of suicidal poisoning in developing countries, commonly presenting with cervicofacial oedema, rhabdomyolysis, and acute kidney injury (AKI). Cardiac involvement, though rare, typically manifests as tachycardia or myocarditis. This report highlights sinus bradycardia as an unusual pres...
9
4
COST EFFECTIVE ANALYSIS OF INHALERS USED FOR ASTHMA MANAGEMENT: AN INTERVENTIONAL APPROACH
Background and Objectives: The aim of the study is to evaluate the comparison based on cost effectiveness of inhalers used for asthma managements. The study utilized prospective interventional sampling approach and included Patient above 18 years and below 60 years, outpatients and In-patients, Asthma patients with comorbid conditions and excluded Pregnant and lactating women, unwilling patients, ...
10
6
AN INTERVENTIONAL STUDY ON THE EFFICACY OF RIFAXIMIN-LACTULOSE COMBINATION WITH AND WITHOUT PROBIOTICS IN THE TREATMENT OF HEPATIC ENCEPHALOPATHY IN SOUTH KERALA
Background: Hepatic Encephalopathy (HE) is a condition that is generally seen in individuals suffering from liver cirrhosis. HE is described as a range of neuropsychiatric diseases in individuals with liver diseases. It is characterized by personality changes, intellectual impairment and a depressed consciousness. Toxic substances that are generally excluded from the body by the liver accumulate...
10
5
PRE FORMULATION STUDY OF DEXKETOPROFEN TROMETAMOL
The research aims to do a pre-formulation study on powdered drug of Dexketoprofen Trometamol to know its physical, chemical and pysico-chemical properties. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are widely used for pain relief and inflammation reduction. Dexketoprofen Trometamol, a highly soluble Non-Steroidal Anti-Inflammatory Drug (NSAID) is tromethamine salt of Dexketoprofen (Active ena...
10
4
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF TAMULOSIN AND DUTASTERIDE IN A BULK AND TABLET DOSAGE FORM
Chromatography is a separation process that is achieved by distributing the substances to be separated between a moving phase and a stationary phase. HPLC is high resolution, high pressure and high-speed liquid chromatography. It has several resolving powers than open column liquid chromatography hence it is used for speedy resolution of complex mixture, separation and determination of species in ...
9
4
IMPACT OF CNS DEPRESSANTS ON COGNITIVE FUNCTION IN PATIENTS WITH NEUROLOGICAL DISORDER AND COMORBIDITIES: A PROSPECTIVE CROSS-SECTIONAL STUDY
Background: Cognitive impairment is a serious problem, especially for the elderly. Cognitive impairment is often associated with neurological disorders and congenital diseases. The impact of central nervous system depressants (CNSDs) on cognition needs to be further investigated. Objective: This study aims to evaluate the relationship between CNSD use and cognitive impairment with neurological dis...
10
6
CARDIOVASCULAR DISEASE MANAGEMENT IN A TERTIARY CARE HOSPITAL
Background: The study assesses pharmacological management of CAD in a tertiary care center, focusing on medication adherence and quality of life (QOL) among hypertensive female patients. Materials and Methods: A prospective observational study conducted at LPS Institute of Cardiology, GSVM Medical College, Kanpur, included 140 diagnosed CAD patients between September 2021 to November 2022. Results...
9
4
PREVENTIVE EFFECTS OF HIBISCUS SABDARIFFA LINN. (WHITE VARIETY) AQUEOUS EXTRACTS ON GLUCOSE AND LIPID METABOLIC DISORDERS CHARACTERISTIC OF PREDIABETES IN HIGH-CALORIE DIET-INDUCED WISTAR RATS
Prediabetes, a transitional metabolic state preceding type 2 diabetes, is characterized by insulin resistance, moderate hyperglycaemia, dyslipidaemia, and oxidative stress. This study evaluates the preventive effects of aqueous extracts from the leaves, calyces, and seeds of Hibiscus sabdariffa L. (white variety) on glucose and lipid metabolism disorders induced by a high-calorie diet in Wistar ra...
9
5