Volume 15 (2024) - Issue 6, June
Review Articles
EVOLUTION OF ANTICONVULSANT DRUGS: BIRD’S EYE VIEW
This review covers the research on the anticonvulsant properties of marketed drugs with their side effects and adverse drug reactions and the importance of medicinal plants and homeopathic medications in the treatment of epilepsy with the mechanism of actions with fewer side effects in comparison to allopathic medications that cause side effects which may be dangerous in some situations so to over...
43
43
INITIATIVES AND CHALLENGES IN SCHEDULE Y REGULATION IN INDIA: STILL LONG WAY TO GO
Schedule Y has been established under Drugs and Cosmetic Act 1940 and rule 1945 for the conduction of clinical trials. It is referred to fundamentals and guidelines for import and manufacture of original drugs for trade or for clinical trials. Schedule Y provides guidance for conducting various clinical trials in different fields of clinical research, controlling and regulating any new drug prior ...
42
26
MYRICA ESCULENTA: A COMPREHENSIVE REVIEW ON PLANT PROFILE, PHYTOCHEMISTRY, ETHNOBOTANICAL AND PHARMACOLOGICAL USES
Medicinal plants usage has been continued since olden times for treatment of illness and various diseases internationally. They contain substances which have therapeutics activities and further study of these substances has led to discovery of new drugs. In present days, the medicinal plants play a significant role in the development of plant-based medicines. Myrica esculenta is a plant which belo...
48
29
ANTI-TUBERCULAR DRUGS: A REVIEW ON CURRENT TRENDS AND NOVEL DRUGS
Tuberculosis remains a challenge globally affecting the health of several individuals globally. The emergence of drug resistant tuberculosis has further increased the threat. Despite having several drugs available the peril of the mycobacterium continues to loom. Across the globe several scientists are putting in efforts to come up with newer drugs with novel mechanism of action and belonging to s...
47
28
β- SITOSTEROL: ANALYTICAL PROFILE AND COMPREHENSIVE REVIEW
Phytosterols, a subclass of steroids, have gained considerable attention in scientific research and nutrition due to their potential health benefits. This article presents an overview of phytosterols, encompassing their sources, chemistry, extraction methods, analytical techniques, and biological activities. Phytosterols, structurally resembling cholesterol, are found abundantly in plants, animals...
47
31
SYNTHESIS, ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF SULFUR QUANTUM DOTS: A REVIEW
Day by day it is challenging to prepare a chemical reagent against antimicrobial resistant pathogenic for pharmaceutical and food sector. There are several types of quantum dots are invented among them Sulfur Quantum Dots (SQDs) a new type of luminescent quantum dots which is prepared from unused sublimed sulfur can be replaced for these purposes. SQDs are highly water soluble, low toxicity and ha...
24
17
AN OVERVIEW ON TREATMENT OF RHEUMATOID ARTHRITIS
Rheumatoid arthritis (RA) is an autoimmune disease associated with chronic inflammation of the joints. If it is untreated then it leads to destruction of joints, erosion of cartilage and bone and eventually leads to loss of physical function. Since, RA is not complete curable disease, the treatment goals are to reduce the pain and stop/slow further damage. With advancement in the field of molecula...
26
12
HERBAL PLANTS USED IN VARICOSE VEINS
Varicose vein is a clinical class of Chronic Venous Disease also called the varicosites. Varicose veins are enlarged, swollen and twisting veins often appearing blue or dark purple. It is more common in women than men, superficial veins of the leg are under high pressure, hence this disorder is mostly seen in the leg. The pathophysiology includes genetic components, dysfunctional valves, and weak ...
28
13
AN UPDATE ON THE THERAPEUTIC POTENTIAL OF HEMIDESMUS INDICUS (INDIAN SARSAPARILLA)
Hemidesmus indicus (H. indicus), also known as Indian Sarsaparilla or Anantmul, is a plant with diuretic, demulcent, and diphoretic properties. It treats various illnesses, detoxifies the blood, and reduces Vata, Pitta, and Kaphadoshas. It has been shown in pre-clinical trials to reduce illnesses in everyday clinical practice. In order to effectively promote this herbal medicine, clinical trials a...
26
10
RECENT ADVANCEMENTS IN THE TREATMENT OF ONYCHOMYCOSIS: A COMPREHENSIVE REVIEW
The most prevalent condition affecting the nails is onychomycosis. It is a typical nail fungal infection that causes millions of individuals globally. Yeasts, non-dermatophyte moulds, and dermatophytes can all be the cause. It's not only results in physical discomfort but also has a major negative effect on the affected person's quality of life. This infection affects the nails of the toes and fin...
26
13
A PERSPECTIVE OF TRADITIONAL MEDICINE (TM) IN REDUCING TRANSPLACENTAL GENOTOXICITY CAUSED BY MODERN MEDICINES
The contemporary generation utilizes specific pharmaceuticals to treat ailments, irrespective of their detrimental effects on genetic material. More specifically, the lifestyles of expectant mothers and the medications they come across during pregnancy, such as antiemetic, antacid, antihistamine, analgesic, antibacterial, diuretic, sedative, and other medications, exert a significant influence on ...
33
14
A REVIEW ARTICLES ON MUCOADHESIVE BUCCAL FILMS: A PROMISING APPROACH FOR ENHANCED DRUG DELIVERY
Mucoadhesive buccal films have gained significant attention as a promising drug delivery system for various therapeutic applications. This review article provides a comprehensive overview of the recent advancements in mucoadhesive buccal films, focusing on their formulation strategies, mucoadhesive mechanisms and potential applications. The article discusses the various polymers used in the formul...
26
20
Research Articles
EFFECT OF CALCIUM PHOSPHATE COMPOSITE WITH DOXYCYCLINE AS A GRAFT FOR BONE DEFECT
The objective was to determine the effect of calcium phosphate composite with doxycycline molecularly included as a graft on bone defect after tooth extraction for slow delivery of drug. Methods: animal were distributed in to four groups: Group 1 (Blood Clot), Group 2 (TCP), Group 3 (TCP/PCL/PLGA), and Group 4 (TCP/PCL/ PLGA/ DOX/CD). An alveolar bone defect was created, and the analysis was condu...
43
24
IDENTIFICATION OF NOVEL NCP7 INHIBITORS FOR HIV DRUG DISCOVERY USING LIGAND-BASED COMPUTATIONAL APPROACHES
Background: NCp7 is a nucleocapsid protein of HIV-1, a retrovirus causing AIDS in human beings. It is a small protein of 72 amino acids that plays an important role in being a chaperone protein involved in viral development. HIV has shown resistance to drugs engineered to treat its infections. Objectives: In this study, a Structure-Activity Relationship analysis of two distinct derivatives based o...
39
19
ORAL GLUCOSE TOLERANCE, HEPATOPROTECTIVE AND NEPHROPROTECTIVE EFFECT OF COMBINATION THERAPY OF LINAGLIPTIN AND EMBLICA OFFICINALIS AND ITS AMELIORATING EFFECT ON STREPTOZOTOCIN INDUCED DIABETIC RATS
Background & Objectives: Emblica officinalis Gaertn is a widely used medicinal plant with antidiabetic activity. This study was aimed to improve oral glucose tolerance, hepatoprotective and nephroprotective effect of linagliptin by given combination of aqueous fruit extract of Emblica officinalis on streptozotocin induced diabetic rats. Materials & Methods: Diabetes was produced on Wister ...
43
19
ALOE VERA EXTRACT STABILISED NANO SILVER- REDUCED GRAPHENE OXIDE NANO COMPOSITES AS VISIBLE LIGHT PHOTOCATALYST FOR OXIDATIVE DEGRADATIONS OF RANITIDINE HYDROCHLORIDE AND SODIUM DICLOFENAC IN AQUEOUS MEDIUM: A KINETIC STUDY
Nano composites of reduced graphene oxide (rGO) and silver nanoparticles (AgNps) were prepared in this work, adopting green reaction conditions. Aloe vera plant extract was used as the stabilizing agent in the AgNps system and graphite precursor has been chosen for rGO preparation adopting mild hydrothermal and sonication methods. AgNps and AgNp–rGO Nano composites are characterized using UV-VIS...
41
18
DEVELOPMENT OF VALIDATED RP-HPLC METHOD FOR ESTIMATION OF CAPECITABINE BY QBD APPROACH
It belongs to the group of medications called as anti-metabolites and is a fluoropyrimidine carbonate with anti-cancer properties. The chemotherapy drug capecitabine is taken orally and is used to treat metastatic colorectal and breast cancers. A review of the literature reveals several analytical techniques have been developed for Capecitabinein single and combined with other drugs. No QbD-assist...
41
21
ANTIDIABETIC AND ANTIOXIDANT PROPERTIES OF IMPORTANT TRADITIONAL MEDICINAL PLANTS FROM NORTHEASTERN INDIA
The antidiabetic and antioxidant efficacy of traditional medicinal plants from North-Eastern India remains largely unexplored. This study seeks to address this gap by examining the properties of 11 such plants. The plant samples were subjected to extraction using four different solvents. Their antidiabetic potential was evaluated through in-vitro α-glucosidase and α-amylase inhibition bioassays,...
30
12
PHARMACEUTICAL POTENTIAL OF FLEXIRUBIN PIGMENT FROM CHRYSEOBACTERIUM
The study was carried out to isolate and characterize pigment producing bacteria from rhizosphere soil. In our study, isolation and characterization of bacteria that produced pigments were performed using serial dilution, spread plating method followed by gram staining and various other biochemical tests (Oxidase, Catalase and IMViC tests). Our study concluded that bacteria isolated from rhizosphe...
25
13
A NOVEL METHOD AND VALIDATION FOR THE QUANTIFICATION OF SACCHARINE AND ASPARTAME IN THE LOCAL MARKETED PRODUCTS
Artificial sweeteners are non-nutritive sugar substitutes designed to provide sweetness without the calorie content of sugar. Examples like Saccharin, Aspartame, Neotame Acesulfame K and they are used in producing a low- or no-calorie diet to lose weight. In the last few years, they have be used in most of the products. Now a days artificial sweeteners are used because they have no calories and po...
25
13
METHOD DEVELOPMENT AND VALIDATION OF AMOXICILLIN TRIHYDRATE BY HPTLC IN BULK AND PHARMACEUTICAL DOSAGE FORM
Amoxicillin Trihydrate is an extensively used antibiotic, and the accurate determination of its content in bulk and pharmaceutical dosage forms is of greatest importance. This thesis focuses on the development and validation of a High-Performance Thin-Layer Chromatography (HPTLC) method for the analysis of Amoxicillin Trihydrate. The study begins with an inclusive review of the existing analytical...
27
15
FORMULATION DEVELOPMENT AND CHARACTERIZATION OF ION AND PH DUAL ACTIVATED NASAL IN-SITU GEL CONTAINING LEVODOPA AND CARBIDOPA FOR THE TREATMENT OF PARKINSON’S DISEASE
Levodopa suffers from low oral bioavailability and less than 1% of the drug reaches the brain because of its peripheral degradation. This study aimed to prepare a nasal in-situ gel of levodopa and carbidopa to provide prolonged drug release, improve bioavailability, and increase drug uptake by the brain. Preliminary studies were carried out using different polymers. The concentration of polymer to...
27
14
AN EVALUATION OF BELIEFS/NOTIONS OFPHARMACY PROFESSIONALS TOWARD PSYCHOPATHS
Psychopathy is associate rising health issue in current times. In recent years, there has been increasing acknowledgement of mental state that plays a very important role in achieving international development goals. Several health conditions will be effectively treated at comparatively low price, however the gap between individuals needing care and people with access to worry stay substantial. Th...
25
13
SAFETY AND EFFICACY OF FORMOTEROL/TIOTROPIUM BROMIDE AND FORMOTEROL/GLYCOPYRRONIUM COMBINATION IN COPD WITH GOLD GRADE 3 PATIENTS
An increasing airflow limitation that is not entirely reversible is a hallmark of chronic obstructive pulmonary disease (COPD). In patients with COPD, the present study investigated the effectiveness and safety of formoterol/tiotropium bromide vs formoterol/glycopyrronium in fixed combinations. In conjunction with formoterol, the long-acting anti-muscarinic drug glycopyrrolate has recently receive...
29
14
ANTIMICROBIAL RESISTANCE PATTERN IN A TERTIARY CARE HOSPITAL: RETROSPECTIVE STUDY
Introduction: Antibiotics’ efficacy is declining over a period of time because of haphazard use in humans and animals. Empirical use of antibiotics and reduction in the new drug development strategies by pharmaceutical industry can lead to antibiotic resistance crisis in near future. Hence, identifying the common causative organism and their resistance pattern in the geographical region would be...
30
12
SELF-MEDICATION PRACTICES AMONG DENTAL STUDENTS IN A PRIVATE DENTAL COLLEGE IN NORTH INDIA
Background: Self-medication is of particular concern as the trend is increasing now-a-days, especially during the post COVID-19 pandemic. Without adequate knowledge, self-medication may lead to adverse drug reactions, or in extreme cases, may require hospitalization for further management. Methods: A questionnaire-based cross-sectional study was undertaken involving the dental undergraduate studen...
26
13
QUALITATIVE AND QUANTITATIVE DETERMINATION OF TRACE ELEMENTS IN GLINUS OPPOSITIFOLIUS (L) USING ATOMIC ABSORPTION SPECTROSCOPY
Glinus oppositifolius (L) is a medicinal plant as well as edible leafy vegetables that has long been utilized for its therapeutic effects. The goal of this work is to use Atomic Absorption Spectroscopy to determine trace elements in Glinus oppositifolius (L). Acid digestion was used as a flexible method and all elements were determined using Atomic Absorption Spectroscopy. Calibration curves were ...
31
15
ASSESSMENT OF CAESAREAN SECTION TRENDS BY USING ROBSON’S TEN GROUP CLASSIFICATION SYSTEM IN A TERTIARY CARE HOSPITAL IN WEST BENGAL, INDIA: A RETROSPECTIVE ANALYSIS
Introduction: The increasing trends for caesarean section (CS) not only in India but also globally have been a cause of concern. With the aim of comparing and analyzing CS rates worldwide, the WHO suggests Robson’s ten group classification system (RTGCS). Aims and Objectives: To find the groups of women with high CS rate which will help policymakers to target that specific groups of women for th...
25
14
PRODUCTION OF NUTRABEVERAGE THROUGH FERMENTATION OF POMEGRANATE, STRAWBERRY AND PINEAPPLE JUICES WITH KEFIR GRAINS
The term nutrabeverage was applied to the product of alcoholic fermentation made by using Kefir grains. In the present studies initially, the pH of the pomegranate juice sample was 3.7, 3.5 for strawberry and 3.8 pH for pineapple. The titrable acidity optimum was found in pineapple at 3.37 % while 16% TSS was found in pomegranate. The highest TSS content before fermentation was observed at 160brix...
26
13
ACUTE AND SUBACUTE TOXICITY STUDIES OF LIVAMURTHA, TRADITIONAL FORMULATION
Livamurtha, traditional polyherbal formulation possess hepato-protective, antibacterial, and antihepatotoxic properties used for treating liver disorders. This exploratory study was designed to evaluate the acute and sub acute toxicity effects of traditional formulation in albino mice based on the OECD Guidelines. 10g of formulation ”Livamurtha” was boiled in 500ml of water for 1 hour. The dec...
26
14
PHARMACOTHERAPY AND DRUG INTERACTIONS IN PATIENTS WITH CHRONIC KIDNEY DISEASE AT A TERTIARY CARE CENTRE– A CROSS-SECTIONAL STUDY
Background: Chronic kidney disease (CKD) is defined as either kidney damage or a decreased glomerular filtration rate (GFR) of less than 60 mL/min/1.73m2 for 3 or more months. The prevalence of CKD in India is 17.2% and it is substantially higher in hypertension, Diabetes, and vascular disease patients. Polypharmacy potentiates the risk of medication-related problems, such as drug-drug interaction...
27
14
PRODUCTION, CHARACTERIZATION, APPLICATION OF CHITOLOGIOSACCHARIDES HYDROLYSATE WITH PARTIALLY PURIFIED CHITOSANASE ENZYME FROM MARINE ISOLATE BREVIDOMONAS DIMINUTA
Microbial chitosanase has received greater attention for producing chitooligosaccharides. In this study, chitooligosaccharide hydrolysate was developed using the chitosanase enzyme, and its bioactivity was evaluated. Marine muddy samples proved to be a source of isolating novel chitosan-degrading bacteria when compared to the other samples collected. A chitosan-degrading marine bacterium was isola...
29
14