Volume 15 (2024) - Issue 4, April
Review Articles
THEPESIA POPULNEA FOR THE MANAGEMENT OF DIVERSE DISEASES: AN OVERVIEW
Thespesia populnea Linn., a member of the Malvaceae family also known as Portia tree, a plant commonly found in coastal and tropical regions of India. Its therapeutic properties have been recognized in ayurvedic medicine, which has been validated by modern scientific research. This paper highlights the chemical constituents and pharmacological profile of Thespesia populnea. The plant has shown rem...
363
331
CHRONOPHARMACOLOGICAL ASPECT ON IMPAIRMENT OF LIVER CIRCADIAN CLOCK AND HEPATIC DYSFUNCTION: A REVIEW
Hepatitis B, Diabetes, Alcoholic and Non-alcoholic Fatty Liver Disease, Cholangiocarcinoma, Cholangioleiomyopathies, and other risk factors for hepatic illness are all becoming more harmful nowadays. In animals, the dysfunction of melatonin levels and an unbalanced circadian rhythm can control physiological processes and cellular mechanisms during periods of rest and activity. The Suprachiasmatic ...
276
145
MEDICINAL IMPORTANCE OF TRADITIONAL INDIAN HERBAL PLANT OXALIS CORNICULATA: A REVIEW
Oxalis corniculata is a perennial weed which is found in both tropical and temperate climates, it grows in damp and shaded areas throughout the Himalayas and warmer regions of India. This herb, an invasive weed has a number of valuable secondary metabolites. Numerous research has demonstrated the advantages of Oxalis corniculata leaf extract. Its metabolite profile, phytochemical analysis and ther...
316
134
BACH FLOWER REMEDIES: NATURAL THERAPEUTIC FOR BALANCING EMOTIONS
Bach Flower Remedies were identified by Dr. Edward Bach who was a physician and homoeopath. His discovery and life history for these flower therapy to atone and cure emotions is stated. It affirms that factors like depression, anxiety, stress, anger etc. affects emotions and triggers diseases. The 38 flower remedies emphasize on Bach’s Philosophy of seven principle of causes and its healing stag...
284
117
A COMPREHENSIVE REVIEW ON NUTRITIONAL ASPECTS, CHEMICAL COMPOSITION AND PHARMACOLOGICAL ATTRIBUTES OF BLACK AND WHITE PEPPER
Indian spices and medicinal herbs are well known throughout the world. Both have many different physiological and pharmacological characteristics. The current biomedical research is mostly concentrated on finding chemicals extracted from natural sources that are pharmacologically efficient and have little to no side effects for application in food production and preventative medicine. Pepper (Pipe...
260
103
MULTIFACETED APPLICATION OF CURCUMIN IN TRADITIONAL HEALTHCARE SYSTEM
Curcumin, a substance produced from the root of the plant Curcuma longa, has been used for thousands of years in Ayurveda and traditional Chinese medicine to treat a variety of inflammatory disorders. Curcumin, the turmeric key ingredient responsible for this function, was discovered over two centuries ago. Curcumin exerts its effects via altering a number of crucial molecular targets, including t...
89
45
MEDICAL DEVICE REGULATIONS AND CURRENT CHALLENGES IN THE GROWTH OF MEDICAL DEVICES IN INDIA: AN OVERVIEW
Medical device, a device or instrument or apparatus or that is used to treat or prevent or diagnose or mitigate or cure the disease or to replace the structure of the body parts mimicking the natural function. The medical device sector started to grow rapidly in the last 8 years. Developed countries like the USA, European Union, and Japan concentrated on this sector to increase their production ca...
90
54
ACALYPHA INDICA: PHYTOCHEMICAL CONSTITUENTS, TRADITIONAL USES AND PHARMACOLOGICAL PROPERTIES: A REVIEW
Plants have been the major source of drugs in Ayurveda and other ancient system in world. The Ayurveda, Siddha, Unani, Homeopathy systems have evidenced the use of plants for various disorders. Medicinal constituents from plants playa vital role in traditional as well as western medicine. Acalypha indica L. belongs to family Euphorbiaceae and is a common weed found in Asia, including India, Pakist...
90
45
BIBLIOMETRIC ANALYSIS OF LIQUID CRYSTALLINE NANOPARTICLES IN TRANSDERMAL DRUG DELIVERY AND THERAPEUTICS ADVANCES
This systematic review provides a comprehensive overview of recent advancements in liquid crystalline nanoparticles (LCNs) utilized for transdermal drug delivery systems. Recent literature indicates a surge in research emphasizing lipid carriers derived from glyceryl monooleate and monoolein. The inherent nanostructure of LCNs offers superior solubilization capacity for bioactive molecules and con...
76
44
A SYSTEMIC REVIEW ON THE PATHOGENESIS OF IBD, ALTERATIONS IN GUT MICROBIAL ECOLOGY OBSERVED IN IBD, ROLE OF CYTOKINES (TNF-, INF-, IL-1, IL-6, IL-4, IL-5, IL-10) IN IBD AND RECENT THERAPEUTIC STRATEGIES
Inflammatory bowel disease (IBD) is a chronic inflammatory illness of the gastrointestinal tract that consists of Crohn's disease and ulcerative colitis. The pathogenesis of IBD is multifactorial and involves a complex interplay between genetic, environmental, and immunological factors. A comprehensive literature search was conducted using relevant databases, such as PubMed, Scopus, and Web of Sci...
94
77
Research Articles
CHEMICAL CHARACTERISATION, EVALUATION OF ANTIOXIDANT ACTIVITY AND ACUTE TOXICITY OF POLAR EXTRACTS OF TABERNAEMONTANA CRASSA BENTH (FAMILY APOCYNACEAE)
Tabernaemontana crassa Benth, synonym Tabernaemontana jollyana Pietre ex Stapf, is a Central African pharmacopoeia plant whose stem bark is widely used in traditional medicine. The aim of this study was to evaluate the acute toxicity of aqueous extracts of this species. Preliminary phytochemical tests carried out on the different crude extracts of T. crassa revealed the following chemical groups: ...
250
142
MOLECULAR DOCKING AND MOLECULAR DYNAMIC SIMULATION STUDIES OF CHALCONE DERIVATIVES AS TOPOISOMERASE II INHIBITORS
Cancer is the uncontrolled growth of abnormal cells in the body. It is the second leading cause of death globally, accounting for an estimated 9.6 million deaths in 2018. Topoisomerases are important cellular targets especially in the treatment of human cancers. They are of two types mainly topoisomerase II alpha and beta. Some of the most powerful anticancer drugs used clinically such as etopos...
249
109
EFFECT OF STRYCHNOS POTATORUM LINN ON REPRODUCTIVE FUNCTION IN FEMALE DIABETIC RATS
Objective: During the reproductive years, diabetes has been associated with menstrual abnormalities, sexual dysfunction and increases infertility rates among females. Strychnos potatorum Linn (S. P. Linn) has been recognized as antidiabetic drug as an Ayurveda medicine. This study was done to estimate whether S. P. Linn can control diabetes and prevent diabetes related complication in the reproduc...
228
99
EVALUATION OF THE NEUROBEHAVIOURAL ACTIVITIES OF CRUDE LEAF EXTRACTS OF SARCOCEPHALUS LATIFOLIUS AND ITS EFFECT ON MICROANATOMY OF TEMPORAL LOBE OF ADULT WISTAR RATS
Sarcocephalus latifolius have a wide range of medicinal applications. This study evaluated the neurobehavioural activity of crude Leaf extract of Sarcocephalus latifolius on wistar rats and the effect on the histoarchitecture of the temporal lobe. Sixteen adult Wistar rats were divided into four groups of four rats each. Group A served as the negative control and received distilled water, B and ...
258
95
FORMULATION AND EVALUATION OF BI-LAYERED TABLET OF ATENOLOL AND HYDROCHLOROTHIAZIDE
The study focuses on creating and evaluating a specialized bilayer tablet for treating hypertension. It begins with in-depth preformulation analyses of key components like Atenolol, Hydrochlorothiazide, and various excipients. Special emphasis is placed on optimizing the powder blend's flow properties to facilitate tablet compression. A series of tests on resulting tablets (F1 to F8) assess weight...
268
133
FORMULATION AND EVALUATION OF EFFERVESCENT FLOATING TABLETS OF TIZANIDINE HYDROCHLORIDE USING COMBINATION OF POLYMERS
The present study was carried out with an objective of formulation and evaluation of effervescent floating tablets of Tizanidine hydrochloride using combination of polymers. The floating tablets were prepared using HPMC and Tara gum as a combination of polymers. The tablet was prepared by direct compression method. The effect of polymer concentration was evaluated for gastroretention and sustained...
70
49
CHEMICAL COMPOSITION, ANTIOXIDANT, ANTIBACTERIAL ACTIVITY OF ISOLATED OIL AND METHANOL EXTRACT OF TRIDAX PROCUMBENS L.
Tridax procumbens L. is an annual herb that has been used in Ayurveda, Unani, and traditional medicine in India to cure various microbial infections, skin diseases, bronchial disorders, and wound healing. The current study aims to investigate the chemical composition, antioxidant, and antibacterial activities of isolated oil (denoted as TPMG oil) from methanol extract using column chromatography. ...
76
48
FORMULATION AND EVALUATION OF FAST DISINTEGRATING TABLET OF LORATADINE BYUSINISABGOL MUCILAGE
Aim and Objective: The main aim of the research work is to formulate and evaluate fast disintegrating tablets of Loratadine by incorporating Ispaghula Mucilage as a Superdisintegrant. Materials and Methods: Tablets were produced utilizing the direct compression technique, incorporating three distinct synthetic superdisintegrants and a natural superdisintegrant (Ispaghula mucilage) at varying conce...
84
52
ISOLATION OF BIOSURFACTANT-PRODUCING BACTERIA FROM OIL-SPILLED SOIL AND CHARACTERIZATION OF THEIR SECRETED BIOSURFACTANTSIN PATHOGEN-INHIBITION AND OIL-EMULSIFICATION
Microbial bio-surfactants are surface-active amphiphilic molecules produced by bacteria, yeast and fungi. Biosurfactant-producing bacteria, often recoveredfrom oil-polluted sites, have significant role in microbial enhanced oil recovery (MEOR), environmental sustainability and pharmaceutical applications. The objective of the present study includes isolation, screening and selection of biosurfacta...
144
65
NITISINONE IN HUMAN PLASMA: UPLC-MS/MS ASSAY VALIDATION AND STABILITY STUDIES
A simple, precise, and rapid ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS method for determination of nitisinone in 20 µl human plasma was developed and validated. Nitisinone 6C13 was used as an internal standard (IS). Chromatographic analysis was performed on an Atlantis dC18 column (2.1 x 100 mm, 3 µm) using a mobile phase consisting of methanol and...
70
40
RP-HPLC BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF METFORMIN AND LEVOTHYROXINE IN HUMAN PLASMA- DRUG INTERACTION STUDIES
A simple, sensitive, robust and specific high performance liquid chromatographic (HPLC) method was developed and validated for the simultaneous determination metformin and levothyroxine in human plasma. In the current study, the analysis was performed on Phenomenex Luna 5µ C18 100A (250 x 4.6mm, 5 micron) column using acetonitrile: methanol: 0.03M phosphate buffer (pH 2- 3.5) 50:10:40 v/v/v as mo...
72
46
STABILITY STUDY OF NEWLY FORMULATED EMULSION WITH MARKETED FORMULATION
The aim of the article is to formulate and evaluate emulsion also perform comparative study with marketed formulation. Emulsion is a heterogeneous system consisting of at least one immiscible liquid dispersed in another in the form of droplets. Emulsion is prepared with castor oil and liquid paraffin. One marketed formulation was taken for comparison. Identification tests, evaluation tests and sta...
78
45
FORMULATION AND EVALUATION OF EFFERVESCENT GRANULES PREPARED BY USING MORINGA OLEIFERA (LAM) LEAF EXTRACT
Moringa oleifera leaves, have a high antioxidant content, which is beneficial for overcoming free radicals in the body. The leaves contents have the potential to be developed into a functional drink in the form of effervescent granules. The important aspects influencing the acceptability of granule is the type and ratio of the effervescent agent. In this study, citric acid and sodium bicarbonate w...
82
54
ANTIBIOTIC MISUSE: A THREAT TO THE COMMUNITY
Lack of awareness about antibiotics use among healthcare practitioners can be a great threat to the community. There is a need to bring awareness among the healthcare providers and the pharmacists regarding the over the counter (OTC) medications list and indications of OTC medication prescribing and dispensing. Pharmacists are important members of the healthcare team and they play a major role in ...
81
45
ASSESSMENT OF FATIGUE IN DIALYSIS [PERITONEAL AND HEMODIALYSIS] AND NON- DIALYSIS PATIENTS OF CHRONIC KIDNEY DISEASE
Background: Fatigue is a common symptom in patients with advanced kidney disease, with implications for quality of life and clinical outcome. Fatigue is one of the most frequent complaints of dialysis patients and is associated with impaired health related quality of life (HRQOL). Aim: To monitor and measure the severity of fatigue in dialysis and non-dialysis patients of chronic kidney disease. M...
79
41
FORMULATION AND EVALUATION OF SOLID DISPERSION TABLET CONTAINING TINIDAZOLE
This study focused on the development and evaluation of solid dispersions of Tinidazole, aimed at creating a fast-release tablet formulation. The preparation involved using carriers such as PEG 4000 and HPMC. Solid dispersions were created using both solvent evaporation and fusion methods. The resulting solid dispersions exhibited desirable properties, appearing as fine and free-flowing powders. I...
76
43
AN EFFICIENT METHOD FOR ANTHER AND OVARY CULTURE IN ABELMOSCHUS ESCULENTUS (L.) MOENCH. IN-VITRO
Okra (Abelmoschus esculentus (L.) Moench.) is an important nutrient-rich vegetable crop also known as “lady’s finger”, widely grown in the tropics and sub-tropics mainly for its edible pods and is an alloploid. The haploid technique has been used in plant breeding for the improvements of plants and to develop new varieties in a relatively short time. Hence, we have optimized several factor...
71
63
POSTOPERATIVE PAIN MANAGEMENT BY FENTANYL VS DEXMEDETOMIDINE AS AN ADJUVANT WITH ROPIVACAINE BY TRANSVERSUS ABDOMINIS PLANE (TAP) BLOCK IN INFRA UMBILICAL SURGERIES UNDER SPINAL ANAESTHESIS: A COMPARATIVE STUDY
Introduction: The analgesia effect of anesthetic drugs namely Ropivacaine, can further be enhanced with adjuvants. For postoperative pain management in infra-umbilical surgeries, Ropivacaine with an adjuvant can be used through a Transversus Abdominis Plane (TAP) block, which is a simple and clinical anatomical landmark procedure, suitable in remote areas without advanced modern technical tools. A...
84
54
A PROSPECTIVE COMPARATIVE STUDY OF LETROZOLE AND CLOMIPHENE CITRATE IN OVULATION INDUCTION IN WOMEN HAVING PCOS
Introduction: Clomiphene citrate (CC) is the primary drug of choice for ovulation induction in PCOS but resistance to ovarian stimulation is frequent observation with CC. Letrozole (Let), an Aromatase Inhibitor (AI) induces folliculogenesis by releasing hypothalamo-pituitary axis from tonic inhibitory effect of estrogen. Aim: To compare the rate of folliculogenesis, number of follicle count, ovula...
67
51
COMPARATIVE STUDY BETWEEN RESULTS OF RETROGRADE INTRAMEDULLARY NAILING (RN) VS LOCKED PLATING (LP) IN TREATMENT OF DISTAL FEMUR FRACTURES: A PROSPECTIVE ANALYSIS
Introduction: Distal femoral fractures are among challenging orthopaedic injury constituting 0.4% of all fractures. Despite recent evaluation in operating techniques and surgical implants, debate continues around the choice of implant for various type of distal femur fractures. Method and Material: In prospective randomized study from 2020 to 2022, analysis of 40 patients was done out of which 20 ...
75
52