Volume 15 (2024) - Issue 7, July
Review Articles
A REVIEW: DIFFERENT EXTRACTION TECHNIQUES ON PLANT ALKALOIDS
Natural products have achieved approval globally for assisting healthcare and also disease obstruction. Alkaloids are an important group of diversely distributed, chemically, biologically and commercially significant natural product which have various organic compounds that give different pharmacological activities. The most important and initial step in medicinal plant is extraction because the b...
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LOCUST BEAN GUM: A PROMISING MATERIAL IN ORAL DRUG DELIVERY SYSTEM
The increasing demand for natural polymers has fuelled substantial investment in research and development within the pharmaceutical and biotech sectors. Natural polymers, lauded for their biocompatibility, biodegradability, and safety, offer versatile advantages and among these, polysaccharides and proteins stand out. One class of natural polymers, gums, obtained primarily from plants, is gaining ...
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REVOLUTIONIZING PRODUCTION: THE ASTONISHING POWER OF PELLETS AND PELLETIZING TECHNOLOGY AND THEIR APPLICATION
In today's dynamic industrial landscape, the transformative potential of pellets and pelletizing technology stands as a beacon of innovation. Pellets, compacted forms of raw materials, have emerged as versatile solutions across diverse sectors, from agriculture to pharmaceuticals, offering enhanced efficiency and sustainability. The advent of advanced pelletizing technologies has further elevated ...
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NANOEMULSION: A CARRIER FOR DRUG DELIVERY
Researchers' interest in nanotechnology, and specifically nanoemulsions (NEs), has grown over time. NEs have a significant role in various sectors because of their droplet size is small and large surface area. The components, characteristics, creation, and applications are outlined in this review article. This article also discusses the benefits and drawbacks of nanoemulsion. High input energy and...
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REVIEW ON SCOPE AND APPLICATION OF POSTBIOTICS IN FOOD PRESERVATION
Food safety is at risk from several variables, including physical, chemical, and biological risks. In this context, biological risks are of utmost significance. The bacteria among them are crucial in producing food deterioration and food-borne illnesses. Additionally, a novel strategy has been applied in recent years that relies on pro-biotic and post-biotic to inhibit the increase of pathogenic m...
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PRONIOSOMAL DRUG DELIVERY SYSTEM- A REVIEW
Proniosomes are provesicular dried or anhydrous formulations that are composed using non-ionic surfactants and solvents. The non-ionic surfactant's hydrophilic portion orients outward to form a bilayer, while the hydrophobic portion moves inward. Medicines with hydrophilic properties are contained in vesicles, while hydrophobic drugs get embedded in proniosome bilayers. Proniosomes are physically ...
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MANAGEMENT OF GREEN PHARMACEUTICALS
Green Pharmacy represents a holistic approach to healthcare that emphasizes the importance of controlling the environmental contamination caused by pharmaceuticals. Also, Green Pharmacy prevents environmental contamination due to the API (active pharmaceutical ingredient) present in the medicines. Contamination of the environment by Active pharmaceutical ingredients can occur through various pathw...
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AFFORDABLE ARTIFICIAL INTELLIGENCE TOOLS IN CANCER DIAGNOSIS AND TREATMENT
Numerous genetic and epigenetic differences contribute to the complexity and multifaceted nature of the disease known as cancer. Artificial intelligence is opening up a lot of possibilities in the fight against cancer. AI-guided clinical care has the potential to significantly reduce health problems, particularly in low-resource countries. Numerous tools and applications of AI are being offered in...
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CAPPARIS ZEYLANICA LINN: A COMPREHENSIVE REVIEW
Capparis zeylanica Linn (Capparidaceae), commonly known as “wild caper” is a plant species found in tropical regions. It is known as culinary and medicinal uses. The abstract of a comprehensive study on this plant might discuss traditional uses, phyto-chemical composition. Also, future perspectives about plant: is a computational technique used to study the interaction between small molecules,...
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A REVIEW ON DIABETIC PERIPHERAL NEUROPATHY: PATHOPHYSIOLOGY, DIAGNOSIS AND PHARMACOTHERAPY
Diabetic Peripheral Neuropathy (DPN) is a prevalent and debilitating complication of diabetes mellitus, impacting the global well-being of millions. This review provides a concise overview of the key aspects related to DPN, including its pathophysiology, diagnostic approaches, and current pharmacotherapeutic interventions. The pathophysiology involves intricate mechanisms driven by hyperglycemia-i...
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NAVIGATING THE FUTURE OF MEDICINE: EXPLORING THE LATEST BREAKTHROUGHS IN THE PHARMACEUTICAL INDUSTRY FOR A BRIGHTER TOMORROW
The pharmaceutical industry is undergoing a significant transformation due to technological advancements, scientific breakthroughs and evolving healthcare needs, paving the way for more effective treatments and improved patient outcomes. AI and ML are revolutionizing drug discovery and development by analysing vast datasets, predicting drug interactions and accelerating the identification of poten...
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Research Articles
PRECLINICAL EVALUATION OF HYDROALCOHOLIC EXTRACT OF SIDA SPINOSA FOR ITS ANTI-ARTHRITIC ACTIVITY IN MICE
The present study aimed to evaluate the effect of hydroalcoholic extract of Sida spinosa L. (HYSS) in antigen induced rheumatoid arthritis in mice by intra articular administration of Bovine serum. Rheumatoid arthritis was induced by the mixture of antigen (Bovine serum albumin) and adjuvant (Imject alum) in 1:1 ratio on 1st, 7th and 21st day as an induction period. The mixture of antigen and adju...
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ANATOMICAL STUDIES OF ELAEOCARPUS SERRATUS LINN.
The medicinal plant Elaeocarpus serratus Linn., (Elaeocarpaceae) has been utilized in traditional medicine for various ailments. However, upon reviewing the literature, it was found that no anatomical work had been conducted on this plant. Therefore, our present study aimed to determine the macroscopic and microscopic characteristics of fresh leaf and stem of Elaeocarpus serratus. The macroscopic ...
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IN VITRO ANTIOXIDANT AND IN VIVO IMMUNOMODULATORY STUDY OF LEMON PEEL EXTRACT (STORG-FA) AND ITS BIOAVAILABILITY ASSESSMENT
Background: Natural bioactive compounds of plant origin have attracted comprehensive attention due to their multiple biological effects, including antioxidant and immunomodulatory activities. However, scientific underpinnings of these health benefits are inadequate. Objective: Present investigation was undertaken to evaluate the bioavailability, antioxidant, and Immunomodulatory activity of the he...
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NUTRITIONAL QUALITY UPGRADING OF INDIGENOUSLY DEVELOPED RICE MUTANT THROUGH EXPLORATION OF PHYTIC ACID AND AMYLOSE REGULATORY GENES
Phytic acid and amylose in rice food play an essential role in human health. The best-practiced approach is necessary for nutritional quality improvement of rice grain. The mutational breeding approach and chemical treatment are powerful methods to enhance rice quality by managing the concentration of phytic acid and amylose contents. The analysis of glycemic index and amylose contents is also sig...
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ATTENUATION OF NEPHROTOXICITY INDUCED WITH CISPLATIN IN HEK 293 CELL LINES BY SAGADEVI NEI
Sagadevi nei is a Siddha polyherbal formulation indicated for Neerkattu and Neersurukku. The main ingredient of the formulation is Vernonia cinerea, belonging to the family Fabaceae, which has been proven scientifically to exhibit renal tubular regrowth. Based on Literature, each ingredient of the mixture has nephroprotective, diuretic, antioxidant, and anti-inflammatory properties. Cisplatin is a...
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INHIBITION OF GROWTH OF BRUSHITE CRYSTALS USING KULITTH-YUSH WITH AND WITHOUT CITRIC ACID
The present study examined the potential of horsegram yush/ broth on preventing growth of calcium hydrogen phosphate dihydrate (Brushite) crystals in vitro. Crystal length was measured daily over a period of 11 days Two types of yush were tested (a) akruth yush made with only salt or (b) kruth yush with Trikatu consisting of equal proportions of long pepper (Piper longum), black pepper (Piper nigr...
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ETHANOLIC EXTRACTS OF CAESALPINIA BONDUCELLA LEAVES FOR ANTIDIABETIC ACTION IN ALBINO RATS
Further investigation into the mechanisms underlying the antidiabetic and antihyperlipidemic effects of Caesalpinia bonducella leaf extracts is warranted to elucidate its potential as a therapeutic agent for managing metabolic disorders such as hyperglycemia and hyperlipidemia. Future studies could explore the extract's impact on insulin sensitivity, glucose uptake in peripheral tissues, and its i...
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DIFFERENTIAL SCANNING CALORIMETRY AND INFRARED SPECTROMETRY METHODS FOR THE QUANTIFICATION OF ETHAMBUTOL HYDROCHLORIDE IN ORAL DOSAGE FORMS
A new, simple, and sensitive differential scanning calorimetry and infrared spectrophotometric technique was developed to estimate ethambutol hydrochloride in tablet dosage form. In the first method the concentration range of ethambutol hydrochloride was discovered to be 0.5 mg to 2.0 mg using differential scanning calorimetry (DSC), with the peak region of an exothermic thermogram at 75.8 °C and...
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EFFECT OF PARTICLE SIZE ON YIELD OF PLANT EXTRACT
Plant extracts are in use in the form of decoctions and water infusions in Ayurvedic systems of medicine since ancient times. It is generally believed that particles finer in size, produce more amount of extract yield. However, there appears to be no uniformity in using powders of any particular particle size for extraction. Coarse and fine powders of different particle sizes have been observed ...
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COMPARATIVE STUDY OF LIGNOCAINE SUBTENONS ANESTHESIA VSPERIBULBAR ANESTHESIA IN MANUAL SMALL INCISION CATARACT SURGERY AND PHACOEMULSIFICATION
Aim: Comparison of safety and efficacy in subtenon anesthesia versus peribulbar anesthesia in manual small incision cataract surgery by randomized control trial. Setting and design: A prospective observational study was conducted among 150 patients undergoing MSICS at a tertiary care hospital and was grouped into two groups peribulbar anesthesia and subtenon anesthesia. Material and Method: After ...
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HPTLC FINGERPRINT PROFILE AND STANDARDIZATION OF CYAMOPSIS TETRA-GONOLOBA (L.) TAUB.
Cyamopsis tetragonoloba belongs to the family Fabaceae and has notable medicinal properties as it is used as a digestive aid. Guar Gum, which is a high molecular weight carbohydrate with multiple industrial applications, is also obtained from this plant. Methanolic extracts of C. tetragonoloba were obtained through reflux extraction to perform further experiments. Various experimental tests were c...
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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION STUDIES FOR SIMULTANEOUS ESTIMATION OF LULICONAZOLE AND EUGENOL USING UV SPECTROSCOPY
A simple, precise yet novel UV spectrophotometric method has been developed for the simultaneous estimation of luliconazole and eugenol. Two methods, namely the simultaneous equation method and the absorbance ratio method were tried for simultaneous analysis. Since the simultaneous equation method gave the best recovery; the simultaneous method was developed for the estimation of both drugs. The w...
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EXPLORING PARENTAL SELF-MEDICATION PRACTICES FOR PEDIATRIC CARE: A CROSS-SECTIONAL OBSERVATIONAL STUDY
The escalating use of medications among children presents a global concern, with self-medication by parents increasingly prevalent. This study investigates the prevalence of self-medication practices among parents of children aged 1 to 12. Methods: Over six months, 200 participants who self-medicated their sick children were enrolled. The study, conducted at King Koti District Hospital in Hyderaba...
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EXPLORATION AND ELUCIDATION OF THE PHYSICAL PROPERTIES OF HPMC BASED HERBAL TRANSDERMAL PATCHES, DEVELOPED FOR THE TREATMENT OF FUNGAL SKIN INFECTIONS
Fungal infections represent a significant global challenge within the realm of dermatology. The prevalence of fungal infections is notably high, affecting approximately 40 million individuals in developing and underdeveloped countries. Considering this, our study proposes a novel approach: transdermal drug delivery utilizing herbal formulations to enhance efficacy & minimize side effects in th...
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VARIABILITY IN VENOUS THROMBOEMBOLISM PROPHYLAXIS FOR INPATIENT MEDICAL PATIENTS: A DESCRIPTION OF DIFFERENCES IN PRACTICE ACROSS THE PRAIRIE PROVINCES
Background: Venous thromboembolism is the most common preventable cause of in-hospital mortality. Despite this, thromboprophylaxis practices vary related to order sets and special populations. Aim: To describe thromboprophylaxis strategies and awareness of institutional policies. Methods: Electronic survey of pharmacists having general medicine institutional practices within Alberta, Saskatchewan ...
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EVALUATION OF ANTIRETROVIRAL TDDS CONTAINING NATURAL PENETRATION ENHANCER
Aim: This study aims to explore the potential of transdermal drug administration as a viable alternative to conventional medication delivery systems. Specifically, the focus is on the development and evaluation of transdermal patches containing Lamivudine and Stavudine for the treatment of AIDS. The overarching objectives include extending drug release duration, reducing administration frequency, ...
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STUDY OF PHYTOCHEMICAL AND ANTIMICROBIAL ACTIVITIES OF LIGUSTRUM SINENSE (LOUR.)
More attention on natural antimicrobials and antioxidants have increased. The medicinal plants production has high in Mediterranean region. WHO says many drugs can be obtained by using medicinal plants. Medicinal plants have many compounds of bioactive that gives more metabolic action on the human body. The congestive heart failure treatment and cardiac arrhythmia treatment can be treated by glyco...
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A STATISTICAL STUDY OF THE PREVALENCE OF CELIAC DISEASE IN ADULTS IN TWO SYRIAN GOVERNORATES (HOMS- TARTOUS) DURING THE PERIOD OF 2014-2022
Celiac disease is a multisystem immune based disorder that is triggered by the ingestion of gluten in genetically susceptible individuals. Our study was limited to a survey of the prevalence of Celiac disease in adult in two Syrian governorates (Homs and Tartous), Statistics were collected from hospitals and clinics of gastroenterologists and nutritionists, during the period of 2014-2022. 4000 cas...
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ENHANCING SOLUBILITY AND DISSOLUTION OF RESERPINE THROUGH OPTIMIZED SOLID DISPERSION AND FAST- DISSOLVING FILM FORMULATION: A QUALITY BY DESIGN APPROACH
This study aims to enhance the therapeutic effectiveness of reserpine, an essential anti-hypertensive agent, by addressing its poor solubility and dissolution properties. Employing a Quality by Design (QbD) methodology, the research systematically optimized the formulation using solid dispersion technology and fast-dissolving films. Characterization of reserpine included its physical properties, s...
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ETHNO-GYNECOLOGICAL KNOWLEDGE OF MEDICINAL PLANTS USED BY RURAL PEOPLE OF VILLAGES OF GURUGRAM DISTRICT, HARYANA INDIA
Ethnogynaecology is a young field of study that emphasize how indigenous people and local healers manage gynecological conditions in females. The goal of the current study was to record in-depth information about Ethnogynaecology in a previously unexplored region of Haryana. In the year 2022, a floristic and ethnomedicinal survey was conducted in Haryana, India in rural areas of Gurugram district....
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EXPLORING THE ANTI-INFLAMMATORY ACTIVITY OF FORMULATED AZADIRACHTA INDICA (NEEM) LOADED MICROSPONGES GEL
This research investigates the anti-inflammatory potential of Azadirachta indica-loaded microsponges gel, presenting a novel therapeutic approach. The microsponges gel, formulated with Azadirachta indica, aim to enhance drug delivery efficiency for improved anti-inflammatory effects. The microsponges gel is formulated using Carbopol 934P (1% w/v) to optimized encapsulated microsponge. Prepared for...
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IN-VITRO ANTIBACTERIAL ACTIVITY OF ARQE AJEEB ON ENTEROCOCCUS HIRAE, ESCHERICHIA COLI, PSEUDOMONAS AERUGINOSA, AND STREPTOCOCCUS MUTANS
The increased use of antibiotics and the rise of antibiotic resistance among microorganisms pose significant public health concerns. While several herbal drugs have been validated for their antimicrobial activity, identification of additional antimicrobial agents is necessary. The Unani system of medicine comprises numerous herbs and formulations used for treating various infections. Arq e Ajeeb (...
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BAY 11-7085 ANDSU-6656 ATTENUATES ALCOHOL DEPENDENCE INDUCED SPONTANEOUS WITHDRAWAL SYNDROME LIKE HYPERALGESIA, CONVULSION AND DEPRESSION IN MICE
The present study has been designed to investigate the effect of SU6656, a selective inhibitor of src kinase and BAY 11-7085, a selective nuclear factor kappa B inhibitor, as potential target in a mouse model of spontaneous alcohol dependence induced withdrawal syndrome. Our experimental protocol consisted of administration of Alcohol (2 g/kg, 10%, v/v, oral), once daily for 7 days. Assessment of ...
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A STABILITY-INDICATING HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF SELINEXOR AND BORTEZOMIB IN BULK AND PHARMACEUTICAL DOSAGE FORM
Symmetric peak and effective peak resolution in chromatography were achieved by adjusting the mobile phase's pH and amount of organic Phase. The retention time of 2.127 and 4.145 minutes was observed after the elution of Bortezomib and Selinexor respectively. To accurately measure both Selinexor and Bortezomib at the same time, an approach was developed with an optimal wavelength of 236nm. Selinex...
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