Posted by admin on Nov 30, 2023 in |
Background: The WHO declared the coronavirus disease 2019 (COVID-19) outbreak as a global pandemic in March 2020. Since, no specific drugs are currently available for its treatment it is important to document the prescription patterns. Objectives: To evaluate the drug prescribing pattern and assess the disease progression in the patients hospitalized with COVID-19 in a tertiary care hospital. Methods: It is a retrospective study. Using electronic hospital database, we identified 2302 patients between May 2021 to August 2021. Analysis was done using Microsoft Excel 2007. Results: Out of 2302 patients, 1406 (61.1%) were males and 896 (38.9%) were females. Majority were severe 1001 (43.5 %) followed by mild 664 (28.84 %), moderate 555 (24.1%) and asymptomatic 82 (3.56 %). Majority occurred 853 (37.1%) between51-70 years with slight male preponderance 558 (39.69%). Common co-morbidities were hypertension 666 (28.93%) and diabetes mellitus 482 (20.94 %). Total drugs prescribed were 6,123. Average number of drugs per prescription was 2.66. Corticosteroids 1560 (67.77%) and oxygen 1556 (67.59%) were most commonly prescribed. Piperacillin/Tazobactam was...
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Posted by admin on Nov 30, 2023 in |
Plant products are of increasing interest in the search for new drugs and medicines in the treatment of diseases; and the discovery of new alternatives to existing commercially available drugs is an important area of this research due to pathogen resistance. The present investigation focused on the screening of anthelmintic potential of pet-ether, benzene, ethanol and aqueous extracts of the plant beet root (Beta vulgaris). The crude extract of the Beta vulgaris with pet ether, benzene, ethanol and aqueous were screened for anthelmintic activity against Indian adult earthworm Pheretima posthuma. The in-vitro anthelmintic activity was performed by using standard procedures. The comparison of the paralysis time and death time in different extracts with respect to the standard showed that the ethanol extract had most significant activity than petroleum ether; benzene and aqueous extract. The phyto-chemical constituents like flavanoids and alkaloids may be responsible for the activity. Finally our study conclude that Beta vulgaris has significant anti-helminthic activity and potential to develop as useful and safe alternative to the other...
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Posted by admin on Nov 30, 2023 in |
Bioactive compounds are secondary plant metabolites and are found in small amounts in plants, fruit, vegetables, and edible oils; they have health benefits and provide us an alternative search for drugs or medicines and followed by the minimum side effects. There are various bioactive assays for measuring the functional activities of bioactive compounds, such as phytochemical assays and anti-inflammatory assays and so on. The phytochemical research and in-vitro anti-inflammatory activity research on plants is considered an effective way to discover novel bioactive compounds with potential as drug leads. Ever since ancient times, plants have been used for treating several diseases. The present research aims to assess the anti-inflammatory impacts and the phytochemical makeup of several plant extracts. In this review, we compiled information on twelve distinct plant extracts that showed the highest levels of phytochemical activity and anti-inflammatory activity, and we offer additional research directions for these bioactive...
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Posted by admin on Nov 30, 2023 in |
A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and completely validated for the estimation of ellagic acid and ferulic acid in herbal formulation. Quantification was carried out with pre-coated silica gel aluminium plate G60F254 (10x10cm) as stationary phase, mobile phase consisting of Ethyl acetate: toluene: formic acid: methanol (3.5: 4:0.8:0.2 v/ v/ v) and scanned in Absorbance Reflectance mode at 275 nm using Camag TLC scanner 3 with WinCAT software. The Rf value of 0.31 for ellagic acid and 0.54 for ferulic acid was obtained. The proposed method has permitted the quantification of ellagic acid and ferulic acid over the linearity range of 100 to 1000 ng/spot, its percentage recovery was calculated along with intraday and inter day precision. The limit of quantification and the limit of detection were found to be 38.96ng/ spot and 12.85ng/ spot, respectively for ellagic acid and 42.28ng/spot and 27.66ng/spot, respectively for ferulic acid. The suggested method can be successfully used to estimate the drug content of many commercial...
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Posted by admin on Nov 30, 2023 in |
Multiple anatomical and physiological obstacles have always made ocular drug administration difficult. Different novel drug delivery systems, including nanogels, nanoparticles, liposomes, dendrimers, implants, contact lenses, nanosuspensions, microneedles, and in situ thermosensitive gels, have been developed to get around the barriers to improve ocular Bioavailability. For the encapsulation of visitor molecules, nanogel has become a flexible drug delivery technology in this aspect. Numerous techniques for the creation of nanogels have been developed over time, such as Concomitant polymerization and crosslinking, Separate polymerization and crosslinking, Micro templating/crosslinking, etc. In this work, Ofloxacin-loaded Nanostructured Lipid Carrier has been prepared with the help of Design expert software (Version 7.1.5) taking amount of liquid lipid, and homogenization speed as independent variables and particle size, spreadability coefficient, % entrapment efficiency as responses. Dynamic Light Scattering (DLS) was used for studying the particle size. The results confirmed the size of the NLC within the nano range (78.79- 648.4 nm). From the experiment, optimized product was found to be 78.79 nm with 66.2% drug entrapment efficiency and...
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