Posted by admin on Oct 31, 2023 in |
Carbamazepine (CBZ) has long been a therapeutic option for bipolar disorder. Carbamazepine used for the treatment of acute manic and mixed episodes associated with bipolar I disorder. In the present study bilayer tablet was developed to improve dosing convenience and decrease daily fluctuations in serum CBZ concentration, thereby lowering the incidence of adverse events. In bilayer tablet one layer provided the loading dose by immediate drug release and another layer provided maintenance dose up to 12 hrs by sustained release. The drug excipient compatibility study was carried out by FTIR and DSC techniques, there was no interaction found. Cross povidone was used as superdisintegrant in immediate release layer and controlled release fraction was formulated by using HPMC K 100 polymer. The prepared granules were evaluated for angle of repose, bulk density, tapped density and compressibility index which showed satisfactory result. The prepared bilayer tablets were evaluated for thickness, hardness, friability and in-vitro release studies. In-vitro dissolution study was carried out for 12 hours using USP dissolution apparatus I using...
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Posted by admin on Oct 31, 2023 in |
Background: Perception of pain and sleep disturbances are more prevalent in patients undergoing Dialysis. Assessing and determining the pain intensity and sleep disturbances help to establish the need for treatment, which is an important part of therapeutic intervention as they may affect the patient’s Quality of life (QOL). This study was aimed to assess pain intensity and sleep disturbances in patients undergoing Hemodialysis (HD) and Peritoneal Dialysis (PD). Methodology: This cross-sectional and observational study was conducted in the Department of Nephrology. 89 patients (49 HD and 40 PD) were enrolled into the study that were undergoing hemodialysis and peritoneal dialysis and were assessed for the pain intensity and sleep disturbances using McGill Pain Questionnaire (MPQ) and Pittsburgh Sleep Quality Index (PSQI) respectively. Results: 67.34% of HD patients and 77.5% of PD patients experienced moderate to severe chronic pain. Female patients aged above 40 years and elderly patients experienced more pain compared to other groups and pain was also observed increasing with the duration of dialysis. 57.14% of HD patients...
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Posted by admin on Oct 31, 2023 in |
Caffeine anhydrous is used as a stimulant to improve individual alertness and mental focus due to its ability of inhibiting the function of phosphodiesterase enzyme in the cells. Recent studies also discovered where caffeine reduced the risk of Parkinson’s disease by its inhibitory action on adenosine receptor. With the aim of masking the bitter taste of caffeine, increasing the compliance and convenience in elderly patients, and achieving better therapeutic purpose, the orally dissolving films (ODFs) were developed in this research. Six formulation of caffeine ODFs (CA1-CA6) with increasing caffeine concentrations, 5, 10, 15, 20, 25 and 30% w/v; were prepared by solvent casting method. All of the caffeine ODFs, CA1-CA5 (except CA6), exhibit good film forming capacity and were peelable. The in-vitro disintegration time for CA1-CA5 were in the range of United States Pharmacopoeia’s (USP) criteria (5-30s) and their surface pH is ~7, which suggested administration of ODF is not expected to cause irritation and...
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Posted by admin on Oct 31, 2023 in |
Introduction: Monoherbal or polyherbal formulation, which is used in Siddha medication, have a wide variety of phytochemical substances as primary and secondary metabolites, which show many pharmacological activities, including the anti-inflammatory effect. Materials and Methods: The anti-inflammatory activity of Kanduparangi chooranam (KC) was evaluated by using carrageenan-induced paw edema and carrageenan-induced pleurisy Wistar albino rat models. KCwas administered orally at doses such as 100 and 200 mg/kg BW, and it was compared with the standard drug indomethacin (10 mg/kg, body weight). The changes in % of inhibition of paw volume, level of pleural exudates and migratory leukocyte count were noted. Results: In the carrageenan-induced rat paw oedema model, the test drug KC was found to be the paw oedema volume at the dose of 100mg and 200 mg/kg, body weight was 61.94% and 63.05 %, respectively (p<0.001) whereas Indomethacin which had 65.83% paw volume inhibition. In the carrageenan-induced pleurisy rat models, the test drug KC was found to be values of the pleural exudates level at the dose of...
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Posted by admin on Oct 31, 2023 in |
Raphanus sativus L, belongs to the family Brassicaceae. Phytochemical analysis of its methanolic root extract revealed the presence of alkaloids, flavonoids, glycosides, tannin, phenolic compounds, triterpenoids and steroids. The antimicrobial activities and in-vitro Pharmacological activities like Antioxidant Activity and Anti-inflammatory activity of the root extract was assessed. Production of reactive oxygen species (ROS) causes various diseases and cellular anomalies in human beings. Antioxidants inhibit generation of reactive species, or scavenge them, or raise the levels of endogenous antioxidant defenses. In this study the radical scavenging ability different extracts of Raphanus sativus L. was undertaken. Results revealed that the root of Raphanus sativus L. has potent antioxidant ability. A good correlation was found to exist between concentration of extract and % inhibition of protein denaturation and free radicle damage. From different literature reports, root extract was found to be more potent antioxidant than the other parts of the plant. The extract had shown significant anti-bacterial activity against bacterium like Lactobacillus, Streptococcus aureus, Escherichia coli against standard Tetracycline by the determination...
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