Posted by admin on Jan 31, 2024 in |
Objectives: Metabolic syndrome (MetS) is a cluster of several metabolic disorders including hyperglycemia, reduced high density lipoprotein cholesterol (HDL-C), raised triglyceride level in serum, hypertension and abdominal obesity. The independent risk factors of high sensitivity C-reactive protein (hs-CRP) levels may have a significant impact on evaluating the prevalence of MetS components in both men and women. Methods: The present study was conducted at Shri Ramkrishna Institute of Medical Sciences and Sanaka Hospital, Durgapur, West Bengal. The study includes 100 patients with MetS as a case and 100 healthy volunteers as a control. MetS was diagnosed according to international diabetes federation. Results: In our study the level of hs-CRP is high in metabolic syndrome patients (4.88 μg/ml) compared to control group is (1.699 μg/ml) A statistically highly significant difference was observed among two groups (p<0.000). Conclusions: The level of hs-CRP maybe used as a surrogate marker of chronic inflammation in metabolic syndrome patients and higher levels of the inflammatory marker hs-CRP are correlated with rise risk for development of cardiovascular...
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Posted by admin on Jan 31, 2024 in |
Antimicrobial resistance (AMR) emerged as a major challenge to public health and significantly impacting the global economy. Infections due to multi-drug resistant (MDR) bacteria are difficult to treat and cause financial burden on patients. Environment may serve as a genetic pool of several drug resistant genes and help bacteria to emerge as notorious superbugs. This study aimed to characterize MDR bacterial isolates from environmental samples and comparative analysis of MDR and multi-drug sensitive (MDS) strains for the expression of virulence factors. Twenty six (n=26) different environmental samples (water, soil, air and surface) were collected for the purpose. The antimicrobial susceptibility testing performed using 12 antibiotics belongs to six different antibiotic classes. The potential virulence factors were determined among MDR and MDS isolates. Thirty (n=30) bacterial isolates belong to 13 different genera (Staphylococcus spp., Enterococcus spp., Escherichia spp., Bacillus spp., Acinetobacter spp., Klebsiella spp., Pseudomonas spp., Shigella spp., Enterobacter spp., Citrobacter spp., Streptococcus spp., Streptobacillus spp. and Proteus spp.) were identified. All recovered isolates were susceptible to aminoglycosides. The most...
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Posted by admin on Jan 31, 2024 in |
Background: In this study, Embelia ribes fruit extract phospholipid complex (ERE-PC) was developed with an attempt to enhance the therapeutic effect by improving its dissolution profile and oral bioavailability. E. ribes, an ancient herb possesses anticancer, anti-fertility, antimicrobial and anti-diabetic activities. However, poor aqueous solubility of phytoconstituents of E. ribes, lowers the therapeutic effectiveness of the extract. Objective To prepare phytosomes of Embelia ribes fruit extract (ERE-PC) to improve in-vitro release profile and oral bioavailability. Method: ERE-PC were formulated by solvent evaporation technique using methanol as reaction mixture which aimed for its improved pharmacological activity. The complex formation was confirmed by FTIR, PXRD, DSC and microscopical studies. The prepared complex was evaluated for functional properties such as solubility, dissolution profile and in-vitro cytotoxic activity. Result: The data obtained from FTIR, DSC and microscopic studies confirmed the formation of phytosomal complex. Aqueous solubility of the extract significantly increased from 23.04 ± 0.0023μg/ml to 84.02 ± 0.0036μg/ml in ERE-PC. Particle size and zeta potential of optimized phytosome was found to be...
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Posted by admin on Jan 31, 2024 in |
Objective: To study the anti-arthritic effect of a Unani regimen comprising of Munḍij wa Mushil therapy along with Habb-e-Gul-e-Aak and to propose a safe and alternative therapy for RA. Materials and Methods: In this clinical trial, 30 diagnosed patients of RA fulfilling the inclusion and exclusion criteria were recruited and randomly distributed into two groups A&B with 20 patients in the test and 10 in the control groups, respectively. In Group A, Munḍij and Mushil therapy was given for 21 days once in the morning and then HGA for 28 days twice a day. Patients in Group B were treated with Hydroxychloroquine (HCQ) 200 mg twice a day for 49 days. All the patients were examined clinically before the treatment and follow-up was programmed 7th day, 21st day, 28th day, 42nd day, and 49th day. The efficacy was determined on subjective parameters as well as Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analog Scale (VAS). The biochemical and hematological investigations were conducted on baseline, 21st and,...
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Posted by admin on Jan 31, 2024 in |
Flurbiprofen (FP) is a phenyl alkanoic acid derivative and a family of non–steroidal anti-inflammatory drugs used in the treatment of arthritis. Flurbiprofen was formulated as a liposome using soya lecithin and cholesterol by thin film hydration method. It is then formulated as a stealth liposome to increase efficacy and reduce toxicity. Two polymers are used to prepare flurbiprofen as stealth liposomes i.e., PEG and PVP, and their effects are compared. The formulated liposomes and stealth liposomes were evaluated for various parameters like surface morphology, zeta potential, polydispersity index, drug content, percentage drug encapsulation, and in-vitro drug release. The optimized formulation (F2) containing a minimum concentration of cholesterol showed moderate stability and good entrapment efficiency. When compared to conventional liposomes, stealth liposomes showed more zeta potential values due to the effect of PEG 4000 and PVP K30.The zeta potential value demonstrated that stealth liposomes had enough charge to prevent liposome aggregation due to electric repulsion. The kinetic data analysis of formulations indicated that it fits the Higuchi model and follows...
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