Posted by admin on Aug 31, 2015 in |
Diclofenac sodium is a non-steroidal anti-inflammatory drug with wide use in the treatment of rheumatic diseases. Enteric-coated tablet form of this drug has been developed to prevent the gastric irritation problem encountered with its use and to improve its efficacy. The enteric film coat resists solution in gastric fluid and disintegrates and releases the medication in the intestines. Many brands of enteric coated tablets of diclofenac sodium are manufactured and sold in the market. However, there is a real concern that counterfeited drugs and drugs with poor pharmaceutical quality could enter the Libyan market. In this study, the physicochemical quality of four brands of diclofenac sodium 50 mg enteric-coated tablets was assessed and compared in terms of visual inspected characters, diameter, thickness, weight uniformity, hardness, friability, disintegration time, dissolution, and drug content. The brands compared were VoltarèneTM (brand A), Diclofenac NormonTM(Brand B), NeoflamTM (brand C), and DivonTM (brand D). As expected, brand A showed acceptable results considering it to be the original brand name drug. Brands B and D...
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Posted by admin on Aug 31, 2015 in |
The construction and electrochemical response characteristics of polyvinyl chloride (PVC) membrane sensors for determination of Tolterodine tartrate (TT) in presence of its oxidative degradation product are described. The sensors are based on the ion association complexes of TT cation with sodium tetraphenyl borate (TT-TPB) [sensor 1] or phosphomolybidic acid (TT-PMA) [sensor 2] counter anions as ion exchange sites in PVC matrix using dioctylphathalate (DOP) as plasticizer. The performance characteristics, sensitivity and selectivity of these electrodes in presence of TT oxidative degradation product were evaluated according to IUPAC recommendations. It reveals a fast, stable and linear response for TT over the concentration range 10-5-10-2 M with cationic slopes of 58.6 mV and 56.6 mV per concentration decade with sensors 1 and 2, respectively. The sensors are used for determination of TT, in pure form, in presence of its degradation product and in tablets. Validation of the method shows suitability of the proposed sensors for use in the quality control assessment of TT and for routine analysis as stability indicating method....
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Posted by admin on Aug 31, 2015 in |
The present study showcases a screening program for the hunt of potent antibacterial compounds from cyanobacteria. A total of 108 cyanobacterial samples, from different habitats of the Jabalpur town of Central India, were collected which finally yielded 20 unialgal cultures belonging to ten genera. Ethanolic extracts from seventeen out of twenty cyanobacterial dried masses showed potent antibacterial activity against five human pathogenic bacteria, which included three Gram negative and two Gram positive bacteria. The minimum inhibitory concentration ranged between 0.05 to 5µg dry weight equivalent for most of the cyanobacterial extracts. Extracts from Nostoc calcicola EBRS001 and Fischerella ambigua EBRS002 were the most potent against all tested...
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Posted by admin on Aug 31, 2015 in |
Objectives: To study the anti-convulsant potential of leaves of Psidium guajava Linn. in MES and PTZ induced convulsion in experimental animals. Materials and methods: The anticonvulsant potential of the ethanolic extracts of Psidium guajava Linn. (EEPG) were tested in the mice model of Maximal electroshock (MES) and Pentylenetetrazole (PTZ). In the MES model, seizures were induced by delivering electroshock of 50 mA for 0.2 seconds via a pair of transauricular electrodes using an electro-convulsiometer. In the PTZ model, seizures were induced by injecting 80 mg/kg i.p Pentylenetetrazole (PTZ). For MES model, parameters measured were – duration of hind limb tonic extension, total recovery time and percentage protection. For the PTZ model, parameters measured were –duration of onset of clonic convulsions, duration of clonic convulsions, percentage reduction of clonic phase, mortality percentage and seizure score. Results and Observation: The EEPG (200 mg/kg and 400 mg/kg) produced dose dependent anticonvulsant effect on MES induced seizures in albino mice, as suggested by reduction in the HLTE and total recovery time, and increase...
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Posted by admin on Aug 31, 2015 in |
The present study outlines a systematic approach for Formulation and Evaluation of Immediate release Tablets of Abacavir and Zidovudine tablet. Combination of anti retiro-viral creates multiple obstacles to HIV replication to keep the number of off springs low, reduce the possibility of superior mutations, decrease viral load and potentiate synergistic activity with one another, combining two drugs into one tablet reduces the number of individual medications1. To achieve this goal various prototype formulation trials were taken with varying compositions of diluents and disintegrant and evaluated with respect to their various quality control tests such as Thickness, hardness, weight variation, dissolution, disintegration, hardness and assay. The formula was finalized by comparing the In-vitro dissolution profile of all formulations with the respective individual marketed products. The in vitro release study was performed in 0.1N Hcl upto 60 min. Among all the formulations, formulation F6 release profile was good as compared to the other formulations. Forced degradation studies at 550C & Stability studies at 40±2ºC/75±5%RH (accelerated condition) for 1& 3 months indicated...
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