Posted by admin on Dec 31, 2015 in |
Seven parts of Pistacia atlantica were collected from Tlemcen in Algeria (fruits, leaves, buds, stems, roots internal and external trunk barks). Tannin content was determined and antioxidant activity of tannic extracts were measured using different assays: Total antioxidant capacity, 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power (FRAP) and β-carotene bleaching assay The results showed that the highest tannin contents were observed in roots(49.789±0.391 mg CE/g DM) and internal trunk barks (49.095±0.306 mg CE/g DM). Tannins extracted from leaves, roots and external trunk barks showed very good DPPH radical scavenging activity (IC50 of 0.124±0.001, 0.304±0.001 and 0.440±0.001 mg/mL), ferric reducing power (0.021±0.001, 0.154±0.001 and 0.170±0.005 mg/mL) and β-carotene bleaching inhibition (0.313±0.009, 0.094±0.006 and 0.131±0.002 mg/mL), respectively. Therefore, the results suggest that this plant with all its studied parts might be considered as a potential candidate of possible health-promoting functional...
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Posted by admin on Dec 31, 2015 in |
Since, the free radicals induced oxidative stress is posing threat present researchers are focusing on natural sources that could serve as antioxidants to combat the oxidative damage mediated diseases such as diabetes, atherosclerosis and cancer. In this context, present study was carried out to investigate the botanical characters, chemical composition and in vitro antioxidant potential of Jatropha gossypifolia L. so as to provide scientific evidences for the medicinal properties claimed on this plant. Microscopic studies were conducted on both entire leaf and leaf powder, the elemental composition of leaf powder was investigated. Extracts of J. gossypifolia leaf was prepared with hexane, chloroform, ethyl acetate, ethanol and water and screened for the detection of various phytochemicals and the major phytochemical compounds present were identified through HPTLC and GC-MS analysis. In vitro antioxidant activity of solvent extracts was evaluated through reducing power and DPPH radical scavenging assays. Phytochemical screening revealed the presence of phenols, flavones, glycosides, steroids, alkaloids and quinines in the ethanolic extract. Quantification of phytochemicals showed 3.35 mg/kg of...
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Posted by admin on Dec 31, 2015 in |
Salbutamol is a selective β2-adreno-receptor stimulant and is given four times daily in a dose of 2.4 mg orally to maintain therapeutic blood level. It is known to be absorbed in proximal parts of the small intestine. Prolonging gastric residence time is, therefore, beneficial to improve its bioavailability. Hence, seven in situ gelling liquid formulations were prepared using sodium alginate (SA) as gel forming agent and HPMC as viscosity enhancer. CaCO3 was incorporated as cross-linker and floating agent. Gelling capacity was evaluated based on a graded response which indicates rapidity of gelation and time taken by the gel to dissolve. All the formulations showed instant gelation but with regard to integrity, all formulations except the one with lowest SA level formed stiff gels maintaining integrity for at least 12 hr. With respect to floating behavior, all formulations except the one with the lowest SA level floated for more than 12 hr irrespective of their composition. Most of the formulations took less than 1 min to float but those with...
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Posted by admin on Dec 31, 2015 in |
The aim of present study was to examine the analgesic, neuropharmacological and cytotoxic effects of the methanolic extract of the barks of Dillenia indica Linn. The analgesic activity was evaluated for its central and peripheral pharmacological actions using tail-flick method and acetic acid-induced writhing test in mice respectively. The extract, at the dose of 100, 200 and 400 mg/kg body weight, produced a significant increase in pain threshold in tail-flick method in a dose dependent manner. In acetic acid-induced writhing test, the extract at 400 mg/kg dose showed a maximum of 46.0 % inhibition (p <0.001) of writhing reaction compared to the reference drug Diclofenac-Na (78.50%). The extract was also investigated for its neuropharmacological action using hole-cross and open field test. The extract displayed dose dependent suppression of motor activity and exploratory behavior in mice in the tested models. The results of the study indicate that the plant possesses strong analgesic potential which might be linked to inhibition of central mechanism of pain. However, studies are required on higher...
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Posted by admin on Dec 31, 2015 in |
A novel (N’, N”E, N’, N”E)- N’, N” – (2, 2′ – (propane-1,3-diylbis(sulfanediyl))bis(1-(4-chlorophenyl) ethan – 2 – yl – 1 -ylidene))bis(2-hydroxybenzohydrazide)(CAPSH) is identified as a sensitive and selective analytical reagent for the determination of trace levels of Co(II) in environmental samples like in food, water, synthetic samples and medicinal plants by spectrophotometry. CAPSH reacts with cobalt(II) at pH 7.0, in aqueous DMF to form orange colored 1:1 (Co-CAPSH) complex shows maximum absorbance (λmax) at 380nm. The color reaction is immediate and the absorbance remains constant for about 24h. The molar absorptivity coefficient and Sandell’s sensitivity are found to be 7.9×104 L.mol-1 cm-1 and 0.048μg cm-2 of cobalt(II) respectively. The linear regression coefficient is 0.9998 and standard deviation is 0.0050. The system obeys Beer`s law in the range of 00.059-0.59μg mL-1of cobalt(II). Large number of cations, anions and complexing agents do not interfere in this method. This method is successfully applied for the determination of cobalt(II) in environmental samples like food, water (potable and polluted), synthetic samples and medicinal...
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