Posted by admin on Sep 30, 2015 in |
Anti-stress activity of hydro-alcoholic extract of Sauropus androgynous leaves was investigated against experimentally induced stress in rats using forced swimming endurance test and chronic cold restraint stress test. Acute toxicity study was performed and hydro-alcoholic extract of Sauropus androgynous leaves was found to be safe at a dose of 2000 mg/kg bodyweight. Two doses 200 mg/kg (SALE-200) and 400 mg/kg (SALE-400) of the extract was subjected to the evaluation of anti-stress activity. The parameters like cholesterol, triglycerides and corticosterone were estimated to determine the anti-stress activity. The animals pre-treated with SALE-200 and SALE-400 significantly restored the altered biochemical and physical parameters, when compared with stress control group. In addition the histopathology of the adrenal gland also confirmed the anti-stress activity of the extract as the SALE-400 treated groups showed significant recovery and SALE-200 treated groups showed moderately significant recovery of architecture of the adrenal gland. However, the maximum activity was observed at 400 mg/kg bodyweight. The findings of the present study concluded that the hydro alcoholic extract of Sauropus...
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Posted by admin on Sep 30, 2015 in |
Kawasaki Syndrome (KS) can be a widespread vasculitis affecting many systems, and some of the other recognized complications are discussed, including those affecting the skin, nervous system, gastrointestinal tract, musculo-skeletal system, kidneys, lungs, eyes and haematological effects. There is no specific diagnostic test or pathognomonic clinical features; those previously mentioned clinical criteria have been established to assist physicians in diagnosing Kawasaki disease (KD). We are reporting a case of 1 year 3 months child who has successfully relieved by the IgG and Aspirin therapy. A greater awareness on the part of paediatricians is now contributing to increased recognition of this entity even in India. We suggest that physicians should be cognizant of the fact that they must individualize every patient’s management to the best of their knowledge and judgment, rather than merely going by the...
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Posted by admin on Sep 30, 2015 in |
The radioprotective effect of Aloe vera was studied in liver of Swiss albino mice. Animals were divided into three groups. Animals of group I administered double distilled water only, group-II Aloe vera (drug) and control set of group III were given radiation only where as animals experimental set of group III were administered by Aloe vera + Radiation. Animals were given Aloe vera leaf extract orally 1000 mg/kg body weight/day for 15 consecutive days before radiation exposure (4.5 GY gamma-radiation).Biochemical parameters such as LPO, GSH, protein, glycogen and cholesterol were assessed at different intervals of post-irradiation i.e. day 1 and 30. Radiation treatment showed decrease in GSH content and an increase of LPO, protein, glycogen and cholesterol observed in control set animals, however the animals of experimental group i.e. Aloe vera and radiation combined group showed a significant increase in GSH content and decrease in LPO, protein, glycogen and cholesterol but values remained below normal. Results suggest that Aloe vera modulate the radiation induced biochemical alterations in Swiss albino...
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Posted by admin on Sep 30, 2015 in |
Oxidative stress contributes towards initiation and progression of hepatic damage in a variety of liver disorders (e.g. Hepatitis C, Hepatitis B, non alcoholic fatty liver disease amongst others). Hence, there is a great demand for the development of agents with potent antioxidant effect. There are various plant derived products which act as antioxidants. The aim of the present investigation is to evaluate the efficacy of Brassica oleracea extract as a hepatoprotective antioxidant. Brassica genus encompassing broccoli, cabbage, cauliflower and radish, have received much attention, due to their glucosinolate content. Glucosinolates are hydrolysed by the endogenous enzyme myrosinase and their degradation products are reported to have anticancer activity. The FRAP assay (ferric reducing ability of plasma) is a simple test that has been employed in this study to detect the free radical scavenging activity of Brassica oleracea extract. The present paper discusses the antioxidant and antibacterial activity of Brassica oleracea...
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Posted by admin on Sep 30, 2015 in |
The purpose of this research was to develop a drug-in-adhesive type transdermal drug delivery system containing drug, buflomedil hydrochloride, pressure sensitive adhesive (PSA), Duro-Tak 387-2052 by the solvent evaporation technique. Different concentrations of penetration enhancers; oleic acid and isopropyl myristate (IPM) were used to enhance the transdermal permeation of buflomedil hydrochloride. 3M Scotchpak TM 9723 polyester film was used as a backing membrane and 3M Scotchpak TM 1022 – Fluoropolymer Coated Polyester film was used as a release liner for the preparation of transdermal patches. FTIR and DSC studies were done to know any possible interaction between drug and polymer. Prepared drug-in-adhesive transdermal patches were physically evaluated with regards to thickness, weight variation, surface pH, folding endurance, moisture content and moisture uptake. The adhesion properties of the patches were very satisfactory. Also, the prepared patches showed good uniformity with regard to drug content. In vitro drug permeation studies of formulations were performed by using Franz diffusion cell through dialysis membrane. It was observed that the formulation containing 95% adhesive...
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