Posted by admin on Oct 31, 2023 in |
It appears that you have conducted a study on the preparation of Glipizide sustained-release tablets using different HPMC (hydroxypropyl methylcellulose) polymers of varying viscosity grades, specifically HPMCK 4M and HPMC K 15M, in different proportions. The concentration of the polymers was optimized using a simplex mixture design, with HPMC K4M, HPMC K15M and lactose as the components of the mixture. The tablets were prepared using the wet granulation method. According to your study, the prepared tablets exhibited polymeric synergism, which was confirmed through in-vitro dissolution testing. Both HPMC K4M and HPMC K15M showed a synergistic effect on the T50% drug release. However, HPMC K15M demonstrated a dominant effect compared to HPMC K4M due to its higher viscosity. It seems that the higher viscosity of HPMC K15M contributed to a more sustained drug release profile in the tablets. This finding suggests that HPMC K15M played a more significant role in controlling the release rate of Glipizide from the tablets, as compared to HPMC...
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Posted by admin on Oct 31, 2023 in |
Objectives: Fragmented micronucleus is a good prognostic indicator for monitoring and detecting chromosomal / genetic damage in human population. The objective of this study was to count the cells with presence of micronucleus in cervical pap smears in women with reproductive age group and to detect its predictive value. To substantiate the importance of Micronucleus evaluation in routine Pap smears evaluation for cervical cancer screening. Material and Method: In this study 750 cases, consisting of 200 smears of normal study, 200 smears of infective pathology with trichomonas, bacterial vaginosis and candida infection, 100 smears of ASCUS & ASC-H, 200 smears of squamous intraepithelial lesion (LSIL-100 & HSIL-100 ) and 50 smears of invasive carcinoma of women in reproductive women of age group were studied. The cervical smears of women with 20-45 years of age were included in the study. The study was conducted from Jan 2022 – Dec 2022 at Srinivasan Medical College and Hospital, Samayapuram, Trichy. Only routine papanicolaou-stained cervical smears were used. In each smear, the number...
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Posted by admin on Oct 31, 2023 in |
The aim of this study was to evaluate the antimicrobial and antibiofilm activity of silver nanoparticles of Azadirachta indica (AISNPs) against the pathogens isolated from effluent. Green synthesis approach was opted for the synthesis of the synthesis of AISNPs by using the ethanolic extract of Azadirachta indica which was added to 1mM solution of AgNO3. These synthesized nanoparticles were molecularly characterized by UV-Visible spectrophotometer, TEM, Zeta Sizer, Zeta Potential, XRD and FTIR respectively. Antimicrobial activity of the AISNPs was carried by well diffusion method on Muller Hinton Agar against biofilm-producing multi-drug resistant effluent pathogens, which were identified as E. coli, P. aeruginosa, S. aureus and K. pneumoniae. The zone of inhibition of AISNPs observed in case of E. coli was 16.08 mm, 18.65 mm against S. aureus, 10.46 mm against P. aeruginosa and 15.34 mm against K. pneumoniae. Antibiofilm activity of AISNPs demonstrated the decline of biofilm producing activity by 76% against P. aeruginosa, 74% against S. aureus, 60% against K. pneumoniae and 59% against E. coli respectively, indicating...
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Posted by admin on Oct 31, 2023 in |
A major susceptibility indicator for type 2 diabetes and cardiovascular diseases is obesity-related insulin resistance. Vascular endothelial cells strongly express the coreceptors for members of the transforming growth factor (TGF) superfamily, endocan and endoglin. Examining endocan and endoglin as potential indicators of cardiovascular complications in HFD rats with or without type 2 diabetes mellitus is the goal. The following four groups; normal diet-HFD, normal diet-STZ, and HFD-STZ were each comprised of eight wistar rats. Both types of type 2 DM groups had significantly higher levels of plasma glucose, insulin, glycosylated haemoglobin (HbA1c), and homeostatic model assessment (HOMA-IR) when compared to the control group (P <0.001). Comparing the HFD and HFDSTZ groups to the STZ and control Normal Diet groups, respectively, the serum lipid patterns in the HFD and HFD-STZ groups were drastically different levels were seen in comparison to the control group in all groups, but the HFD STZ- group had higher percentage change values. Both the HFD-STZ and the normal diet STZ groups had significantly higher levels of...
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Posted by admin on Oct 31, 2023 in |
Background: Epilepsy is a common and chronic neurological disorder. The prevalence of drug-resistant epilepsy (DRE) is reported as 25-30% among epileptic patients. So, there is a need of drugs for resistant epilepsy. Objective: To assess the effectiveness and tolerability of Lacosamide (LCM) as an add-on therapy in patients with Drug-Resistant Epilepsy in our patient population. Methods and Material: A total of 43 patients with Drug Resistant Epilepsy were screened, and 32 were included in the study based on inclusion and exclusion criteria and Lacosamide was added as an add-on therapy, and the patients were prospectively followed up for a minimum 3 months. Out of 32 patients, 25 had focal and the remaining 7 were having generalized epilepsy. The Lacosamide dosage used was between 4 – 12mg/kg/day. Seizure frequency, adverse effects, and tolerability were noted in the study participants. Results: Two patients lost follow-up. Hence 30 patients were taken for intension to treat analysis. Out of 30 patients with DRE, 11(36.6%), 25(83.3%) had seizure reduction of more than 90%, 50%...
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