Posted by admin on Aug 31, 2015 in |
The present study showcases a screening program for the hunt of potent antibacterial compounds from cyanobacteria. A total of 108 cyanobacterial samples, from different habitats of the Jabalpur town of Central India, were collected which finally yielded 20 unialgal cultures belonging to ten genera. Ethanolic extracts from seventeen out of twenty cyanobacterial dried masses showed potent antibacterial activity against five human pathogenic bacteria, which included three Gram negative and two Gram positive bacteria. The minimum inhibitory concentration ranged between 0.05 to 5µg dry weight equivalent for most of the cyanobacterial extracts. Extracts from Nostoc calcicola EBRS001 and Fischerella ambigua EBRS002 were the most potent against all tested...
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Posted by admin on Aug 31, 2015 in |
Objectives: To study the anti-convulsant potential of leaves of Psidium guajava Linn. in MES and PTZ induced convulsion in experimental animals. Materials and methods: The anticonvulsant potential of the ethanolic extracts of Psidium guajava Linn. (EEPG) were tested in the mice model of Maximal electroshock (MES) and Pentylenetetrazole (PTZ). In the MES model, seizures were induced by delivering electroshock of 50 mA for 0.2 seconds via a pair of transauricular electrodes using an electro-convulsiometer. In the PTZ model, seizures were induced by injecting 80 mg/kg i.p Pentylenetetrazole (PTZ). For MES model, parameters measured were – duration of hind limb tonic extension, total recovery time and percentage protection. For the PTZ model, parameters measured were –duration of onset of clonic convulsions, duration of clonic convulsions, percentage reduction of clonic phase, mortality percentage and seizure score. Results and Observation: The EEPG (200 mg/kg and 400 mg/kg) produced dose dependent anticonvulsant effect on MES induced seizures in albino mice, as suggested by reduction in the HLTE and total recovery time, and increase...
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Posted by admin on Aug 31, 2015 in |
The present study outlines a systematic approach for Formulation and Evaluation of Immediate release Tablets of Abacavir and Zidovudine tablet. Combination of anti retiro-viral creates multiple obstacles to HIV replication to keep the number of off springs low, reduce the possibility of superior mutations, decrease viral load and potentiate synergistic activity with one another, combining two drugs into one tablet reduces the number of individual medications1. To achieve this goal various prototype formulation trials were taken with varying compositions of diluents and disintegrant and evaluated with respect to their various quality control tests such as Thickness, hardness, weight variation, dissolution, disintegration, hardness and assay. The formula was finalized by comparing the In-vitro dissolution profile of all formulations with the respective individual marketed products. The in vitro release study was performed in 0.1N Hcl upto 60 min. Among all the formulations, formulation F6 release profile was good as compared to the other formulations. Forced degradation studies at 550C & Stability studies at 40±2ºC/75±5%RH (accelerated condition) for 1& 3 months indicated...
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Posted by admin on Aug 31, 2015 in |
The present study focuses on the synthesis of ZnO nanoparticles by chemical method in alcohol base using three different capping agents-Thioglycerol, oleic acid and Triethanol amine (TEA). The effect of concentrations was analyzed for their effectiveness in particle growth and antibacterial activity. The antibacterial activity of ZnO nanoparticles using these capping agents at different concentrations was tested against six laboratory microorganisms namely Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, Proteus, and Klebsiella by agar well diffusion method. Zone of inhibitions produced by ZnO nanoparticles with different capping agents was tabulated. The quantitative measurement of zones of inhibition led to the conclusion that all the capping agents were effective in inhibiting growth of different organisms of which the maximum activity was shown by Thioglycerol, capped ZnO nanoparticles at a concentration of 0.12% against all...
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Posted by admin on Aug 31, 2015 in |
The work was aimed to develop an immediate release tablet formulation of Fenofibrate and Rosuvastatin in combination for better treatment as well as management of hypercholesterolemia and prevention of cardiovascular diseases. The target was also set to improve the dissolution profile of poorly soluble Fenofibrate. For manufacturing these immediate release combined formulation tablets, Hot-Melt Technology was used which helped in enhancing dissolution profile and moreover, here amino acids are used in conjunction with other excipients. In the developed formulation, the amino acids imparted its action as excipient by helping in the solubilization process which facilitated the release rate of Fenofibrate. The formulated tables were then investigated for hardness test, friability test, weight uniformity and dissolution test. The results showed that all tablets met the expected requirements for these tests and the release rate of fenofibrate also got improved giving an excellent dissolution profile for both fenofibrate and...
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