Posted by admin on Apr 30, 2024 in |
Testicular toxicity has been associated with long-term paracetamol usage. Moringa oleifera is known to eliminate toxins from organs and restore functionality. This study seeks to ascertain the potency of moringa in ameliorating paracetamol-induced testicular toxicity. Forty nine (49) Sprague-Dawley rats were randomly assigned into seven (7) groups composed of 7 rats each treated for 5 weeks. One group served as the control, while 3 other groups were administered graded doses of paracetamol, then the other 3 groups were administered graded doses of paracetamol and 1600mg/kg of moringa extracts simultaneously. The animals were sacrificed 24 hours after the administration of last dose using anaesthesia. The testes and epididymis were harvested, while blood was obtained via ocular puncture. The moringa extract mitigated the paracetamol-induced dose-dependent decrease in sperm count and sperm morphology. Paracetamol toxicity on hormonal milieu was suppressed by the moringa extract treatment, yielding hormonal values closer to those obtained in the control group. The moringa extract treatment controlled the oxidative stress biomarkers as their values were not as variant...
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Posted by admin on Apr 30, 2024 in |
Objectives: To study potentiation of hypoglycaemic effect of Glimepiride with combination of Selenium, Zinc, Vitamin C and Vitamin E on Streptozotocin induced diabetic rats and to compare potentiating hypoglycaemic effect of above-mentioned drugs with that of standard diabetic control group. Methods: Study was carried out in Research Laboratory, Department of Pharmacology, BIMS, Belagavi. Albino rats weighing 200-250g were used. Streptozotocin was administered intraperitoneally for induction of type 2 diabetes. Each diabetic rat was fed orally with test drugs once daily for 21 days. Blood glucose levels were monitored on first day and at end of study. Results: Administration of glimepiride caused a decrease in blood glucose levels which is statistically significant (Group 2 vs 3, p=0.004).Combination of glimepiride, selenium, vitamin C and E decreased blood glucose levels to lower level than glimepiride alone (Group 3 vs 4, p = 0.016). Combination of glimepiride, zinc, vitamin C and E decreased blood glucose levels to lower level than glimepiride alone (Group 3 vs 5, p = 0.006). Combination of glimepiride, selenium,...
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Posted by admin on Apr 30, 2024 in |
Buccal drug delivery is the most suited route for local as well as systemic delivery of drugs. The purpose of this study was to develop and optimize formulations of mucoadhesive tablets of Cilnidipine with an objective to enhance therapeutic efficacy, bioavailability and was developed to administer into the unconscious and less-co-operative patients. Cilnidipine buccal tablets were prepared by direct compression method using various concentrations of mucoadhesive-polymers such as Carbopol and Hydroxyl propyl methylcellulose (HPMC) the Prepared Tablets were evaluated for their weight variation, Hardness, thickness, Friability, swelling-index, drug content uniformity and in-vitro release studies. The infra-red (IR) spectra showed no interaction, and Physico-chemical characteristics were found within the limit. Swelling index increases with increasing concentration of polymers. The formulation F8 showed a promising Bio adhesive strength and in-vitro drug release of 98.29% for 8 hrs thus can be selected as an optimized formulation of mucoadhesive buccal...
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Posted by admin on Apr 30, 2024 in |
Children under five years of age, with severe or cerebral malaria, cannot consume oral medication especially if they are vomiting or are unconscious. In such situations they are given an injectable drug until they can tolerate oral medication. The situation is bad in Sub-Saharan Africa, especially in rural areas as children are sometimes referred to the closest referral health care facility for proper management. The aim of this study was therefore to conduct a pilot study to estimate the bioavailability of lumefantrine (LF) when administered as a rectal enema, and compare it with a commercially available oral suspension, in rabbits. The study was conducted on six healthy rabbits in an open randomized, crossover three sequence, single dose study, where each rabbit received rectal and oral formulations. The oral formulation was administered under fed and fasted conditions. A two-week washout period was allowed between the experiments. LF was quantified in rabbit plasma using ultraperformance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). Results showed that the relative bioavailability of rectal LF was...
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Posted by admin on Apr 30, 2024 in |
The present study involves the formulation development and in-vitro evaluation of benidipine hydrochloride buccal tablets. Designed to prolong the time of release of drug and also to enhance the better bio-availability of the drug. Benidipine hydrochloride is a long-acting calcium channel blocker. It exerts its antiangial, antihypertensive action through blocking the influx of ca ions through voltage gated L-type ca channels to the pheripheral vascular smooth muscle cells, coronary smooth muscle cells and to the myocardial cells. And having biological half life 1-2 hrs, extensive protein binding need to formulate an dosage form. Benidipine hydrochloride buccal tablets were prepared by using direct compression method. Total eight formulations were prepared by using different polymers viz., Sodium alginate, Chitosan, Carbopol 934, HPMC, in various ratios. The nature of the polymer influences the physical and release characteristics of the buccal tablets. Preformulation studies were carried out before formulation design. Preformulation results showed good flow properties and all results are within specified limits. Compatibiity for drug and excipient was carried by FT-IR and...
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