Posted by admin on Sep 30, 2015 in |
Uvaria afzelii Scott Elliot (Annonaceae) is an African traditional medicinal plant. In Ivory Coast, roots of the plant are commonly used as antiparasitic and against others ailments. During our previous investigation on the roots one 1-indanone derivative was obtained together with other compounds that showing interesting antiprotozoal activities. The aim of this study was to isolate other antiprotozoal compounds. The chloromethylenic extract of the roots was fractionated on silica and Sephadex® LH-20 gels columns chromatography. The new syncarpic acid derivative, bingervone (1), was isolated together with the known compounds, demethoxymatteucinol (2) and emorydone (3). The structures of these compounds were established by NMR, IR, UV and HRESIMS spectroscopic data. Bingervone (1) displayed weak antitrypanosomal activity against Trypanosoma brucei brucei trypomastigotes, with a LC100 value of 114.8 µM, and moderated antileishmanial activities against Leishmania donovani and L. major promastigotes, with IC50 values of 38.9 and 44.4 µM, respectively. These antileishmanial activities were in the range of reference drug...
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Posted by admin on Sep 30, 2015 in |
Hydrochlorothiazide (HCT) is a class IV drug which has limited solubility and permeability, for overcome this problems co-crystallization method is used. Co-crystallization is the process to enhance the physical properties of drug molecule especially the solubility. HCT belongs to diuretic category and Atenolol (ATL) belongs to Beta blocker category they are combined for use in tablet formulation. Co-crystallization was used to combine two drugs in single solid phase and thus to achieve new approach for combination therapy to treat hypertension. Using the new approach co-crystals of ATL with HCT was prepared. Co-crystallization of two drugs were carried out by using solvent evaporation and solution co-crystallization method. The saturation solubility was done to evaluate the solubility of co-crystals. Comparative drug release study was carried out between co-crystals and marketed formulation. The prepared co-crystals have shown several times faster release than marketed tablet and co-crystals were characterized by using DSC, FTIR and...
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Posted by admin on Sep 30, 2015 in |
Chenopodium ambrosioides Linn, member of the National List of Medicinal Plants of Interest to SUS (RENISUS), is used to treat different diseases and shows good potential to generate products of interest to the Brazilian Unified Health System “Sistema Único de Saúde” (SUS). However, the use of herbal derivatives implies the control of their quality and the evaluation of their toxicity. Pharmacopeial tests were performed aiming at the physicochemical and microbiological characterization of leaves and extract of C. ambrosioides. The toxicity of the extract was assessed using MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) and acute toxicity was assayed in mice. The results showed that the leaves and the extract presented acceptable pharmacopeial parameters and the preliminary phytochemical analysis showed the presence mainly of saponins, terpenes, phenols and tannins in the hydroethanolic extract of C. ambrosioides. The microbiological evaluation of the extract indicated no apparent growth of pathogenic microorganisms. Although the extract showed cytotoxicity at high concentration, no signs of acute oral toxicity could be observed at the tested doses. These results, besides the...
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Posted by admin on Sep 30, 2015 in |
A new potential allelochemical (A) m.f. C34H42O19, m.p 168-170 ◦C, [M]+ 754 (FABMS) along with two known compounds Scutellarin 7-O-β-D-glucopyranoside (B), Luteolin (C) were isolated from methanolic extract of the stems of Cassia Siamea Lam. The structure of a new allelochemical (A) was characterized as 3,7-dihydroxy-5,3′,4′-trimethoxyflavone-3-O-β-D-xylopyranosyl-7-O-α-L-rhamnopyranosyl(1→4)-O-α-L-arabinopyranoside, on the basis of extensive spectroscopic analysis, colour reactions and various chemical degradations. Compound A exhibited higher radical scavenging activity in the (DPPH) (1,1-diphenyl-2-picrylhydrazyl) assay...
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Posted by admin on Sep 30, 2015 in |
Anti-stress activity of hydro-alcoholic extract of Sauropus androgynous leaves was investigated against experimentally induced stress in rats using forced swimming endurance test and chronic cold restraint stress test. Acute toxicity study was performed and hydro-alcoholic extract of Sauropus androgynous leaves was found to be safe at a dose of 2000 mg/kg bodyweight. Two doses 200 mg/kg (SALE-200) and 400 mg/kg (SALE-400) of the extract was subjected to the evaluation of anti-stress activity. The parameters like cholesterol, triglycerides and corticosterone were estimated to determine the anti-stress activity. The animals pre-treated with SALE-200 and SALE-400 significantly restored the altered biochemical and physical parameters, when compared with stress control group. In addition the histopathology of the adrenal gland also confirmed the anti-stress activity of the extract as the SALE-400 treated groups showed significant recovery and SALE-200 treated groups showed moderately significant recovery of architecture of the adrenal gland. However, the maximum activity was observed at 400 mg/kg bodyweight. The findings of the present study concluded that the hydro alcoholic extract of Sauropus...
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