Posted by admin on Jul 31, 2015 in |
Present research work aims to develop venlafaxine hydrochloride gastro retentive tablets for prolonged release and increased gastric retention time. Venlafaxine is an antidepressant of the serotonin nor- epinephrine reuptake inhibitor (SNRI) class. Bioavailability is 45% following oral administration and half life is 5 hours. To study the effect of formulation variables on drug release and buoyancy properties of the sustained release venlafaxine hydrochloride gastro retentive floating drug delivery system, the floating matrix tablets of venlafaxine hydrochloride were prepared by bilayer tablet technology with sustained and floating layers. The different hydrophilic polymers for sustained release layer studied, were HPMC K 4M, HPMC K 15M, xanthan gum studied in order to obtain the desired sustained release up to 12 hrs and the effervescent component of floating layer was sodium bicarbonate along with HPMC K 100M. Drug compatibility with excipients was checked by FTIR studies. The formulation optimization batches were studied for physical parameters and floating behavior, dissolution studies and kinetics of drug release. Hardness of tablets was kept 6 kg/cm2. The effect...
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Posted by admin on Jul 31, 2015 in |
In the recent days targeted drug delivery has gained more prominence for various advantages like site specific delivery and controlled release from the formulations. Amongst the plethora of avenues explored for targeted drug delivery, bioadhesive nanoparticles backed foremost attention offering local drug delivery and controlled drug release solving problems like tissue damage and drug wastage. Formulating nanoparticles with mucoadhesive polymers may provide a significant increase in the gastrointestinal residence time. Neostigmine bromide is a cholinesterase inhibitor used for the treatment of Myasthenia Gravis and is given by conventional routes like oral and intra venous. Bioadhesive nanoparticles of Neostigmine Bromide using synthetic and semi synthetic polymers like Carbopol, HPMC and ethyl cellulose were prepared by emulsification solvent evaporation method. The nanoparticles were characterized for their preformulation and post formulation parameters like compatibility, particle size, zeta potential, encapsulation efficiency, surface morphology, in vitro mucoadhesion, in vivo bioavailability, drug release and stability studies. Out of six, formulations F1 and F4 showed the best results for different evaluated parameters of nanoparticles. Entrapment efficiency...
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Posted by admin on Jul 31, 2015 in |
Bhasmas, the formulations, which can be prepared from metals, minerals or even some marine products, are being used in Ayurvedic system of medicine. Copper (Tamra) is one such metal, used to prepare a bhasma, called “Tamra Bhasma” (TB) which is claimed to cure various diseased conditions. Though bhasmas are prepared since centuries, the exact mechanism of conversion of metal to its bhasma, especially by the use of modern scientific tools is not established. Here is an attempt to prepare TB as per the text “Ayurved Sar Sangraha” and analyze the stepwise changes in terms of chemistry. TB was prepared from the copper wires. Steps involved in the preparation were shodhan, maran and post maran treatment. Raw materials, intermediates and finished product were analyzed as per Ayurvedic pharmacopeia. Modern scientific techniques such as XRD, XPS and SEM were employed to assess the changes taking place during the steps of preparation and thus characterization of the intermediates and finished drug was accomplished. Chronological study of TB preparation, showed that conversion of...
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Posted by admin on Jul 31, 2015 in |
Molluscs as a second largest phyla includes snails, slugs, clams, oysters, scallops, cuttlefish, squid and octopus. Present study revealed, diversity of molluscan fauna from three sites i.e Khanderajuri lake, Mhaishal lake and Krishna river in the period of January, 2011 to December, 2013. Among collected molluscs 10 species were identified from seven families i.e. Physidae, Lymnaeidae, Viviparidae, Corbiculidae, Thiaridae, Planorbidae and Littorinidae included in class Gastropods and Bivalve. Seasonal variations showed quantitative difference in gastropods, Quantity was observed to be minimum in mansoon season as compared to premansoon and postmansoon season. Physicochemical alterations were showed influence on the biodiversity at the various...
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Posted by admin on Jul 31, 2015 in |
The present work focuses on treatment of glaucoma by formulating ocular inserts of different polymeric combination and Betaxolol to enhance therapeutic effect through prolonging contact time with corneal surface, Betaxolol is a cardio selective (β1 adrenergic) receptor blocking agent. Ophthalmic betaxolol may be especially useful in the treatment of glaucoma in patient with pulmonary disease. Sustained drug therapies have more advantages than conventional. In the present study, an attempt was made to formulate sustained drug delivery system films for Betaxolol. In matrix type formulations for Betaxolol containing 10%, 12%, and 14% w/v of HPMCK4m and 14%, 16% and 18% w/v for Ethyl cellulose were Prepared by solvent casting method. And evaluated for their average weight variation, thickness, Drug content, In-vitro drug release and stability studies. An increase in average weight and thickness is due to increase in polymer concentration. IR spectral studies were performed to confirm the interaction of drug with excipients. IR spectrum revealed that there is no compatibility and no drug interaction. In vitro drug release Studies...
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