Posted by admin on May 30, 2015 in |
A series of Baylis-Hillman derived N-cinnamyl substituted nitro methylene imidazole derivatives 4a-swere synthesizedfrom Baylis-Hillman acetates and nitro methylene imidazole compoundsand characterised by 1H NMR, IR, Mass and HRMS spectroscopy. Their insecticidal activities were evaluated against T. Castaneum and compared with a standard insecticide Permethrane. Preliminary biological activity tests showed that most of the compounds exhibited good insecticidal activity against T. Castaneum at 100µg/cm2 especially compounds 4b, 4g, 4i, 4l, 4n and 4r showed good insecticidal activity against T. castaneum, interestingly compound 4b with p-fluoro substitution displayed 75% activity. The structure-activity relationship showed that compounds with electron-with drawing substitutions like -F, -Br, -Cl, -NO2, -CF3 at the para position havinggood insecticidal activity and compounds with electron-with drawing groups like -F, -Br at the meta position have shown moderate activity.This work provides some hints for further structural modifications on the Baylis-Hillman derivatives and the enhancement of insecticidal...
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Posted by admin on May 30, 2015 in |
Felodipine is a member of the dihydropyridine class of calcium channel antagonists (calcium channel blockers) and is insoluble in water. To counter act above side effects, to enhance bioavailability of felodipine in blood stream and to make drug to more targeting, felodipine drug is being designed as nanosuspension formulation using hydroxyl propyl methyl cellulose and hydroxyl propyl cellulose as surfectants as well as rate controlling polymer. Drug polymers interactions were studied by FT-IR spectroscopy. Precipitation method has been used to prepare nanosuspension particles of poorly soluble drug. The prepared nanosuspensions were characterized for droplet size, pH, viscosity, polydispersity index, refractive index, surface morphology study by Scanning Electron Microscopy (SEM), drug content, percentage transmittance, zeta potential, in vitro skin permeation and drug release kinetic studies. The droplet size was in the ranges of 61.2±0.58 (F3) to 91.4±0.79 nm (F5). The polydispersity index of various felodipine nanosuspension formulations was in the ranges of 0.271±0.14 to 0.651±0.21. Most nanosuspension possesses a very low viscosity and, therefore, their application may be convenient. The...
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Posted by admin on May 30, 2015 in |
Present study describes wound healing activities of Ficus racemosa (Linn.) leaves extract on excision wound model of wistar albino rats. During the study, fresh plant materials after shade drying was used for the isolation of extract using soxhlet apparatus and percentage yield was obtained (3.50% in ethanol). Then, preliminary phytochemical screening of the extract was done and certain secondary metabolites viz. alkaloids, glycosides, tannin and flavonoid were confirmed in the Ficus racemosa extract. Then, thin layer and column chromatography of the extract was done and Rf value 0.12 and 0.84 were calculated and obtained fractions (FR-1 to FR-5) were tested on Wistar albino rats for wound healing activities. In the results of the present study, complete wound healing activity was found to be maximum 84.36% on day 17 when treated with mupirocin 5% ointment. Similarly, complete wound healing activity was found 81.30% on day 18th, by applying ethanolic extract of Ficus racemosa as compared to the control group i.e. 62.22% on day...
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Posted by admin on May 30, 2015 in |
Cissampelos pariera, an important medicinal plant was subjected to elicitation and bioconversion of precursors for the formation of Berberine, an important medicinal component. In vitro cultures of Cissampelos pariera, was successfully established using stem and leaf explants. MS Media fortified with IAA (2 mg/l) alone and MS media enriched with IAA (2mg/l) showed profuse callusing from leaf and stem explants respectively. Elicitation with yeast resulted in the highest percentage of berberine yield from leaf callus (0.055%). Elicitation with Bacillus subtilis showed the presence of 0.0294% berberine in leaf callus. Elicitation with Aspergillus niger showed the highest yield of 0.0019% from stem callus. Addition of precursor components Tryptophan and Phenylalanine did not increased the berberine from leaf callus. But addition of precursor components Tryptophan and Phenylalanine showed the bioconversion to 0.0019% and 0.0022% of berberine in stem callus. The study reports a standardized protocol for the efficient conversion of precursors to breberine and also to elicit the production using...
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Posted by admin on May 30, 2015 in |
Objective: To evaluate the antidepressant activity of chronic administration of Tramadol alone and when combined with Fluoxetine in low doses in albino mice. Methods: The antidepressant effect was determined by recording the immobility time in Despair Swim Test. The mice were randomized into seven groups, with six mice in each group. Group 1 mice were given normal saline (10 ml/kg) which served as control. Mice of groups 2, 3 and 4 received Tramadol in graded doses (10, 20 and 40 mg/kg). Fluoxetine (standard drug) was given to mice of groups 5 and 6. Tramadol and Fluoxetine in low doses (10ml/kg each) were co-administered to mice of group 7. All drugs were given intraperitoneally for 7 days and were subjected to despair swim test on the day 7 of drug administration. Results: Tramadol and Fluoxetine have shown significant antidepressant activity when compared to the control. There is dose dependant increase in antidepressant activity of Tramadol. The antidepressant of Tramadol 20 mg/kg was comparable to Fluoxetine 20 mg/kg. Tramadol potentiated the...
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