Posted by admin on Mar 30, 2015 in |
Alstonia venenata a member of the family Apocynaceae, finds a prominent place in Ayurveda system of medicine and also among different tribal groups in India for a variety of diseases such as fever, epilepsy, malaria and a variety of skin diseases. A.venenata was studied to investigate the bioactive properties. Various plant parts like leaves, stem-bark, root-bark, flowers and fruits were extracted with a variety of solvents ranging from non-polar to polar and screened for bioactivity. Butanol and methanol extracts of all the parts alone were selected for antifungal testing. The tested organisms included human pathogens and laboratory contaminants/opportunistic fungi .They were Pencillium marniffi, Cyrptococcus sp., Candida sp., Epidermophyton sp., Microsporum sp., Fusarium sp., Pencillium sp., Aspergillus flavus, Aspergillus niger and Rhizopus sp. Different concentrations of the extracts dissolved in DMSO were incorporated in Sabouraud Dextrose Agar (SDA) and a final concentration of 50mg, 100mg and 125mg per ml of SDA was obtained for testing. The drug control used was Imidazole at a concentration of 100µg/ml of SDA. Butanol extracts...
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Posted by admin on Mar 30, 2015 in |
The present study discussed the nutritional content and quantification of eleven bioactive phenolic antioxidant contents in the water, methanol and acetone extracts of four different edible fruits viz. Musa acuminate (banana), Ananascomosus (pineapple), Psidiumguajava (guava) and Malusdomestica (apple) using HPLC-DAD. Nutritional analysis showed that the most moisture and fiber-containing fruit was guava where as banana had the lowest amount. On the other hand banana had the highest percentage of protein and carbohydrate whereas guava had the lowest percentage. The result showed that the antioxidant content determined by HPLC was varied in the water, methanol and acetone extracts of these fruits. According to the study, acetone was appeared as the most suitable extraction system of phenolic antioxidants present in these fruits, i.e. in the apple,(+) catechin hydrate was 486.80 ± 16.75, 28.64 ± 2.21and 0.0 ± 0.0 mg/100g of the extract; ellagic acid was 1735.14 ± 33.17, 33.44 ± 4.07 and 0.0 ± 0.0 mg/100g of the extract and (-) epicatechin was 138.02 ± 7.69, 6.78 ± 1.06 and 0.0...
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Posted by admin on Mar 30, 2015 in |
Leaves, rootstock, fruit and decoction of Lasia spinosa (Araceae) are used in folklore medicine for Gastrointestinal, Respiratory and Skin diseases. The intent of the present study was to evaluate the Antihyperlipidemic activity of methanolic leaves extract of Lasia spinosa and for its role in the prevention of hyperlipidemia induced pancreatitis in rats. The evaluation of the Antihyperlipidemic activity and the role of Lasia spinosa in the prevention of hyperlipidemia induced pancreatitis were done by means of Cholesterol 100 mg/kg body weight, p.o, induced hyperlipidemic model and Triton-X 100 (480 mg/kg, b.w; i.p.) induced hyperlipidemic model. The biochemical parameters such as Total Cholesterol, Triglycerides, LDL-C, HDL-C, VLDL-C, Serum Amylase, Serum Lipase and WBC Count were estimated to appraise its activity. A significant increase in the levels of biochemical and biological parameters was discerned in group 2 and a reversal in the extent was seen in the treated group of animals engaged in the study. The histopathological evaluations of Liver and Pancreas samples were in support of the obtained results. Based...
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Posted by admin on Mar 30, 2015 in |
The pulsatile drug delivery works upon the system that releases active pharmaceutical ingredient completely and rapidly after a desired lag time. This type of approach was advantageous for: Drugswith extensive first pass metabolism and biological tolerance. Locally absorbed or acting drugs to a specific site in the intestinal tract (e.g. colon). Adaptation of therapy according to chronopharmacological needs. The pH-dependent polymers in pulsatile drug delivery were insoluble at low pH levels but with increase in pH solubility of polymer increases. The objective of present study was to develop a pulsatile compression coated tablet. The system was developed into two steps: Firstly core tablet was prepared containing Nifidipine as API. Secondly core tablet was coated with polymer blend of Eudragit S100and Eudragit L100. The lag time was the time in which less than 10% of drug was released. From in vitro release study we had concluded that drug release at pH 6.8 was inversely proportional to the amount of polymer Eudragit L100, which might be due to pH-dependent solubility of...
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Posted by admin on Mar 30, 2015 in |
Bone marrow aspiration can determine the metastatic deposits, degree of cellularity and fibrosis readily. A retrospective analysis of bone marrow aspiration and biopsy, in children and adult patients with hematological anomalies, were performed in 674 cases for different indication of hematological abnormalities from January 2013 to March 2014. Cases were analyzed in detail regarding clinical, hematological examination and family history. The mean age of the patients was 38.03 years ranging from 2 years to 78 years. Among 674 cases, 58.16 percent cases were male and 41.84 percent were female with sex ratio of 1.4:1. The commonest clinical & physical symptoms were pallor (87.5%), followed by weakness & headache (47.9%) and fever (37.9%). The most frequent malignant hematological anomalies in children (99.9%) and adults (50.49%) were acute leukemia, followed by multiple myeloma (17.82%) in adults only. Normoblastic marrow represented highest number of cases both in children (21.43%) and in adults (20.86%) as non-malignant hematological disorder. Bone marrow examination helps to assess the spectrum of hematological disorder in both children &...
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