Posted by admin on Jul 31, 2015 in |
Globally, more than 30 % of the onion peels arises at the retail and purchaser levels, of which the post-harvest and dealing out level wastages report for the major share. So, studies on the characterization of unutilized fractions of the onion peels specify their potential candidature for reprocessing. Maximum preservation of these phytochemicals during extraction requires optimised process parameter conditions. A microwave-assisted extraction (MAE) method was considered for extraction of total phenolics, total flavonoids and DPPH scavenging activity from onion peels. The total phenolic capacity (TPC), total flavonoids content (TFC) and antioxidant activity percentage of extracts at optimised MAE conditions. The influence of six main extraction parameters on the extraction was modelled by using a second-order regression equation. The optimal MAE conditions were 210W microwave power, 15min irradiation time and 40 mL/g solvent to material ratio. Under the MAE optimised conditions, the recovery of TPC was 94.34 mg gallic acid equivalent/g dry weight (DW), TFC was 45.61(mg/g) and free radical scavenging activity 92.25%.When bioactive phytochemicals extracted from onion skin...
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Posted by admin on Jul 31, 2015 in |
6-(2-Amino-3,5-substituted phenyl)-1,2,4-triazines were prepared by refluxing semicarbazones or thiosemicarbazones in presence of sodium hydroxide solution. 6-(3,5-Substituted-2-bromophenyl)-1,2,4-triazine derivatives and 6-(3,5-substituted-2-hydroxyphenyl)-1,2,4-triazine derivatives were prepared from 6-(2-amino-3,5-substituted phenyl)-1,2,4-triazine derivatives by sodium nitrite, hydrobromic acid, copper (I) bromide and sodium nitrite, sulfuric acid, respectively. The structures of the synthesized compounds were confirmed on the basis of their elemental analysis and spectral data (FT-IR and H1-NMR). Amongst synthesized compounds, some displayed significantly active profile against the electrically induced seizures at a dose of 30 mg/kg after 0.5 h. At the same dose level, one compound also showed activity after 4.0 h. Two compounds exhibited protection at dose level of 100 mg/kg after 0.5 h. At 4.0 h, two compounds persisted to reveal anti-MES protection at same dose, whereas two other compounds indicated to prevent seizure spread at a higher dose of 300 mg/kg after 4h. One compound displayed protection at 300 mg/kg after 0.5 h. The neurotoxicity screening data revealed that two compounds were exhibited neurotoxicity at a dose level of 300 mg/kg after...
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Posted by admin on Jul 31, 2015 in |
The number of patients with Diabetes mellitus is increasing rapidly both in developed and developing countries around the world. The existing medications especially synthetic drugs often fail to bring back normal glycemic control without complications. Numerous herbal medicines are widely explored as alternative medicine in diabetes. The objective of this work was to evaluate one such herbal extract of Benincasa hispida fruit for its anti-diabetic activity in experimentally induced diabetic rats. The extract at a dose of 200mg/kg/day and 400mg/kg/day was administered to streptozotocin induced diabetic animals for 15 consecutive days. Blood glucose levels, lipid profiles and body weight were measured for the evaluation of its anti-diabetic effect. The results of the study at both low and high dose of extract showed significant (p<0.01) decrease in blood glucose levels in diabetic rats. In addition, both the dose of extract also showed significant (p<0.05) decrease in serum triglyceride, VLDL levels, and an increase in HDL levels, though not significant. Only high dose of extract and glibenclamide treated group showed significant...
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Posted by admin on Jul 31, 2015 in |
Novel 1- Phenyl 1-H-Pyrazolo[3,4-d]Pyrimidine Derivatives were synthesized from the key intermediate chloro derivative (1).The conversion of chloro derivative(1) into 1,2,4 triazoles, 1,3,4 thiadiazoles and thiazoles was accomplished with the intermediacy of the ester(2) and hydrazide (3). Moreover triazole ring was annelated to the pyrazolopyrmidine core in two step reaction involving reaction with acid hydrazides followed by intramolecular cyclization in boiling glacial acetic acid Majority of the synthesized compounds showed variable antimicrobial activity on the hand tricyclic compounds(9a-b) were deprived from any antimicrobial activity against the tested micro-organisms. The hydrazine carbothioamide derivative (4) and 1,3,4 thiadiazole derivative (6) showed antimicrobial activity against Streptococcus pneumoniae and Bacillis subtilis comparable to ampicillin and a moderate antifungal activity against Asp. Fumigates and C....
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Posted by admin on Jul 31, 2015 in |
Present research work aims to develop venlafaxine hydrochloride gastro retentive tablets for prolonged release and increased gastric retention time. Venlafaxine is an antidepressant of the serotonin nor- epinephrine reuptake inhibitor (SNRI) class. Bioavailability is 45% following oral administration and half life is 5 hours. To study the effect of formulation variables on drug release and buoyancy properties of the sustained release venlafaxine hydrochloride gastro retentive floating drug delivery system, the floating matrix tablets of venlafaxine hydrochloride were prepared by bilayer tablet technology with sustained and floating layers. The different hydrophilic polymers for sustained release layer studied, were HPMC K 4M, HPMC K 15M, xanthan gum studied in order to obtain the desired sustained release up to 12 hrs and the effervescent component of floating layer was sodium bicarbonate along with HPMC K 100M. Drug compatibility with excipients was checked by FTIR studies. The formulation optimization batches were studied for physical parameters and floating behavior, dissolution studies and kinetics of drug release. Hardness of tablets was kept 6 kg/cm2. The effect...
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