Posted by admin on Nov 30, 2023 in |
Actinomycetes are biotechnologically important microorganism as they produce many secondary metabolites and natural pigments, including a dark-brown pigment melanin. Melanin is produced in melanocytes that provides pigmentation to skin. Although many roles have been attributed to melanic pigments, the main role in nature seems to be photoprotection damage. Melanin possesses anti- UV radiation property by absorbing the electromagnetic spectrum and preventing optical damage in the living organisms. Melanoma is a malignant of melanocytes that controls the pigment melanin in the skin. The aim of the present study is to isolate the melanin producing actinomycetes from the agricultural soil and to assay the cytotoxicity using murine B16 melanoma cell line and normal mouse L929 fibroblast cell line. The results showed that the melanin obtained from the actinomycetes showed good anticancer activity against murine B16 melanoma cell line and nontoxic against normal mouse L929 fibroblast cell line. Hence it can be used as a photoprotective...
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Posted by admin on Nov 30, 2023 in |
Introduction: Underreporting of adverse drug reactions (ADRs) in Pharmacovigilance programme of India (PvPI) may be due to lack of adequate knowledge, attitude and practice among healthcare professionals towards ADR reporting. Aim & Objective: Present study was planned to assess the knowledge, attitude and practices of ADR reporting amongst nursing staff of tertiary teaching hospital in Western Rural India. Methods: This was cross sectional, observational study in which about 527 Nursing staff from Tertiary teaching hospital in Western Rural India were participated. Study was conducted as per pre-validated google form questionnaire-based format to assess knowledge, attitude and practices of ADR reporting. Results: Out of total 527 nursing staff who filled the ADR survey questionnaire, 87.1% participants were aware of the term ADR and 82.5% were aware of the term Pharmacovigilance. Only 53.5% respondents have undergone training related to Pharmacovigilance & ADR reporting.54.8% nursing staff have faced ADR in a patient or themselves somewhere during their life time but only 46.5 % respondents have reported ADR. Most of nursing staff felt...
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Posted by admin on Nov 30, 2023 in |
Worldwide, glaucoma is the second most important cause of blindness and irreversible vision loss. Raised IOP (Intraocular Pressure) is not always a mark of glaucoma; it is a key risk factor and a cause of glaucomatous optic neuropathy. Herbal preparations have various active and inactive compounds which are not standardized likewise, Camellia sinensis and Areca catechu having various active constituents such as polyphenolic compounds, epigallocatechin-3-gallate, quercetin, etc which are having few therapeutic responses that are not yet reported. Aim is to study the pharmacological responses of drugs for Glaucoma. Drugs were authenticated by botanist of SUK. Camellia sinensis was extracted with ethanol, and Areca catechu was extracted using hydroalcohol by Soxhlet method. The extracted powder was analyzed by UV, FTIR, and phytochemical screening were carried out. Phytochemical test confirms the presence of phytoconstituents. The extract was administered by formulating an ocular film using polymers such as chitosan and HPMC. The film was evaluated for folding endurance, thickness, drug content uniformity, pH, eye irritancy test, sterility and In vitro drug...
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Posted by admin on Nov 30, 2023 in |
Ōrila is a well-known drug used in many Ayurvedic recipes in kerala. In most texts Ōrilais seen paired with Mūvilaand together they fare as components of the Daśamula. From very old Kerala commentaries of ancient Ayurvedic texts, Ōrila and Mūvila are seen as Malayalam translations of Pṛśniparṇī and Śālaparṇī respectively. In Kerala Pṛśniparṇīis often identified as Ōrila and its source here is Pleurolobus gangeticus (L) J. St.-Hil. However, in North India and in API, source plant of Pṛśniparṇīis Uraria picta (Jacq.) Desv. ex DC. Both belongs to the family Fabaceae where former is a stout herb or under shrub and the other is a small branched, perpetual herb. In the current globalized world where market have expanded, there are unconfirmed reports that other drug sources like Uraria pictaetc have begun appearing in Kerala herbal drug market in the name of Ōrila. So, decided to investigate the status of samples of Ōrila available in the Kerala herbal drug market and to check the quality and authenticity of the samples using...
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Posted by admin on Nov 30, 2023 in |
Background: The herbal drugs used in traditional medicine are proven more effective and safe compared to synthetic drugs for managing lifestyle diseases, including liver toxicity. Objective: The present investigation aimed to evaluate the hepatoprotective potentials of ethanol extract of Euphorbia heterophylla leaves against ethanol-induced liver damage in rats. Methodology: The acute oral toxicity study was conducted according to guidelines No 425 prescribed by OECD. The extract was proved safe up to 2000mg/kg. Ethanol-induced hepatotoxicity in rats model was used to assess the protective properties of ethanol extract of Euphorbia heterophylla. The serum, such as (AST), alkaline phosphatase (ALP), total bilirubin, direct bilirubin, albumin, total protein, ions was determined. And other parameters like clotting time, liver weight, liver histopathology, and liver antioxidant enzymes were also examined. Results: In toxic control animals treated with ethanol alone, there were variations in the parameters mentioned above. But in the animals treated with ethanol extract of Euphorbia heterophylla (EEEH) and standard drug silymarin, all the parameters were normal, possibly due to their beneficial property...
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