Posted by admin on Dec 31, 2023 in |
The present study evaluated the Anthelmintic activity of Ficus benghalensis bark extract against Indian earthworm Pheretima posthuma and compared it with the standard drug Albendazole. The results showed that the extract exhibited significant Anthelmintic activity, as evidenced by the time of paralysis and time of death of worms. The extract also contained various phytochemical constituents, including Phenolics, Terpenoids and Miscellaneous constituents. The findings of this study suggest that Ficus benghalensis bark extract may be a potential natural Anthelmintic agent. This activity was concentration dependent. As the concentration increases the extract produce maximal effect. Higher concentrations of ethanolic bark extract of Ficus benghalensis produce a paralytic effect much earlier and time taken for death was shorter. It shows maximum efficacy at 75 mg/ml concentration than the standard drug. Further studies are recommended to isolate and identify the active principles responsible for its activity. This could lead to the development of new drugs for the treatment of worm infections. The study provides valuable information on the medicinal properties of Ficus benghalensis...
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Posted by admin on Dec 31, 2023 in |
Introduction: Urolithiasis is one of the most common urologic diseases worldwide, with an estimated prevalence ranging from 1% to 13% across the globe. It’s increasing prevalence can be attributed to the westernization of lifestyle habits. The homoeopathic system of medicine offers a positive scope in the management of urolithiasis with hyperuricemia, prevent to undergo in surgical interventions and also prevents recurrence. Case Summary: The presented case involved a patient experiencing continuous severe pain in the right renal region for the past ten days, along with elevated uric acid levels. Bryophyllum pinnatum mother tincture was prescribed based on the acute presentation, followed by Lycopodium clavatum considering the chronic totality. This treatment approach resulted in a significant improvement in the patient’s presenting complaints. Objectively, the treatment led to a gradual decrease in serum uric acid levels, elimination the kidney calculus as observed in ultrasonography and reduced propensity for recurrent renal calculus formation. Additionally, the liver’s echo texture remained normal throughout the treatment. The modified Naranjo Criteria score (MONARCH) post treatment was...
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Posted by admin on Dec 31, 2023 in |
Background: Sodium fluoride (NaF) is an inorganic fluoride salt used for the treatment of dental caries topically. It is also used in water fluoridation to prevent tooth decay. It has been reported to be associated with a lot of harmful effects, including neurotoxic effects. The aim of our study was to evaluate the chronic effects of NaF on the models of cognition in adult mice. Methods: Forty mice were randomly divided into four equal groups. NaF was administered dissolved in drinking water. The control group was Group I and received distilled water. Oral NaF at doses of 10mg/L, 20mg/L and 30mg/L respectively was given to Group II, Group III, Group IV. The influence of fluoride exposure on cognition was assessed using forced alternation test and spontaneous alternation test using Y-Maze. Evaluation was done at baseline, at the end of one month, two months and three months of NaF administration. Statistical analysis was done with the help of the Wilcoxon Signed Rank Test (within the group), Kruskal Wallis Test (between-group)...
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Posted by admin on Dec 31, 2023 in |
The bio-active compounds present in Terminalia arjuna (Roxb. ExDC) have anti-oxidant, anti-proliferative, anti-obesity, anti-hyperglycemic, and lipid-lowering activity. In addition, it has cardioprotective, hepatoprotective, and renoprotective properties. The study evaluated in-vivo toxicity profile of the methanolic extract of Terminalia arjuna (META) bark on male albino Wistar rats before undertaking further investigation on the use of this extract as a potential therapeutic agent against such conditions. Animals were administered with 300 and 2000 mg/Kg b.w./day of META bark for 14 days; and 250, 500, and 1000 mg/Kg b.w./day of META bark for 28 days for acute and sub-acute toxicity respectively. The outcome of the acute toxicity study revealed no signs of mortality or general behavioral alteration in treatment groups in comparison to the control group. The sub-acute toxicity study revealed, there is no significant influence (p<0.05) of META bark in food consumption and percentage weight gain in the animals. No significant changes (p<0.05) in hematological parameters as well as in biochemical parameters were observed. Histopathological examination showed normal cellular architecture of...
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Posted by admin on Dec 31, 2023 in |
A quick and affordable analytical method validation for the determination of Ascomycin content in Tacrolimus API by HPLC UV-detector was developed with respect to the accuracy, precision, linearity, selectivity, robustness, limit of quantification, limit of detection, according to ICH guidelines. The extraction of samples was performed using HPLC –LC Solutions Chemstation system manufactured by WATERS by using X-TERRA, C18 (4.6 x 150mm, 3.0μm) in the Presence of mobile phases A&B composed of 6 ml orthophosphoric acid and Acetonitrile: Tert-butyl Methyl Ether (81:19) in the ratio of 4: 1 and 1: 4. The estimated samples were then analysed using an UV visible code 2487 manufactured by Waters. With a linear calibration curve spanning from the mean recovery of method precision and system precision 140765 and 142973 and %of relative standard density is found to be 0.30% and 0.87%. With retention time of Ascomycin 29.5mins and Tacrolimus 33.4 min. Column oven temperature of 60 0C at a flow rate of 1.5mL/min and wavelength is found at 220 nm the total run...
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