Posted by admin on Jan 31, 2015 in |
Solubility is the important parameter to design a dosage form; it is very difficult to formulate an insoluble drug in to final formulation. In This present study deals with the enhancement of solubility of poorly water soluble drug Meloxicam.: The liquisolid system is a novel technique for solubility enhancement and dissolution improvement of low soluble drugs. Liquisolid technique (powdered solution technology) is used to enhance the solubility parameter and dissolution rate of the drug. liquisolids were prepared by using non volatile solvents or hydrophobic carriers (like PEG 400, Tween 80, span 20) and their effect on dissolution of Meloxicam was studied. By using these solvents individually or in combination and find out the optimized formulation with good solubility.Based on the solubility studies the polyethylene glycol 400 (PEG400) is chosen as co solvent, Microcrystalline cellulose (MCC) used as carrier material and Aerosil used as coating material. In liquisolid system different nonvolatile or hydrophobic solvents are continuously added to the liquid until it convert in to a free flowing solid system...
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Posted by admin on Jan 31, 2015 in |
Boric acid is one of the widely used inorganic compound in pharmaceutical industry. We find its utilization as an antiseptic, in eye wash preparations, as an insecticidal, as a buffering agent etc. In this present work, a comparative study of the UV-Vis spectras of the boric acid solution in different solvents have been done. A variety of solvents like water, ethanol, methanol, glacial acetic acid, hexane, Tetrahydrofuran and 0.2M HCl solution have been employed for spectral analysis. When water was taken as a solvent, aqueous boric acid solution gave negative absorbance in complete range of UV-Vis analysis i.e. 1100nm to 190 nm. In contrary to this, when methanolic solution of boric acid was taken, positive absorbance in the complete range of spectrum was noticed. Purely on the basis of spectras obtained for boric acid solution in different solvents, best solvent out of those have been regarded as the most suitable solvent for carrying out the UV-Vis analysis for boric...
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Posted by admin on Jan 31, 2015 in |
Chloroxylon swietenia DC. belongs to the family Rutaceae / Meliaceae / Chloroxylaceae, is a medicinal and aromatic tree of dry deciduous forests. It is popularly known as Yellow wood, East Indian satin wood and Ceylon satin wood. The stem bark is credited for its effectiveness in the treatment of common cough and cold, it is also used as an astringent. Its pharmacognostic data for authentication of the crude drug is not available, hence, in the present study, macroscopical, microscopical, and preliminary phytochemical investigations of stem bark is undertaken. Powder microscopy revealed that Cork cells, Calcium oxalate crystals, Phloem parenchyma, medullary rays and thick walled phloem fibers were abundant. Anatomical studies showed the presence of phellem, phellogen, and phelloderm with abundant secondary phloem. The qualitative chemical tests of petroleum ether, chloroform, acetone, ethanol and water extracts of stem bark revealed the presence of carbohydrates, alkaloids, glycosides, flavonoids, phenolic compounds and...
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Posted by admin on Jan 31, 2015 in |
Adverse drug reactions are undesirable effects of drugs beyond its anticipated therapeutic uses occurring commonly in clinical practice. Although many of these ADRs are mild and disappear when the suspected drug is stopped or dose is reduced, some are more serious and last longer. Many studies have been published regarding hospital admission due to ADRs and it has been estimated that 2.9% to 5.6% of all hospital admissions are due to ADRs and 35% of the hospitalized patients experience an ADR during their hospital stay. Thus ADRs increase not only morbidity and mortality, but also add to the overall healthcare cost. In the present study a total of 1125 patients data were collected from six months study period. Out of 1125, 41 (3.64%) ADRs were identified. From among the 41patients, 22 (53.65%) were males and females were 19 (46.34%). This gender distribution percentage was compared with previous studies. The mean age of our study is 37.95±2.75 years and was compared with the previous similar studies. This study shows the...
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Posted by admin on Jan 31, 2015 in |
The immediate release tablet of antihypertensive drug Valsartan were prepared and evaluated to increase solubility and bioavailability of low soluble drug. The tablets were prepared by direct compression method using Surfactants such as Poloxamer 188, Sodium stearate, Sodium Lauryl Sulfate and Superdisintegrant such as Cross carmellose sodium were used in tablet formulation. The formulation were evaluated for various physical parameters, dissolution study and drug release profile. From all formulations the formulations F-C of batch B 3 i.e SLS-3 showed 98.04% drug release within 30 minutes, which was highest drug release than other batches. The optimized immediate release tablet of batch B 3i.e SLS-3 of formulation F-C showed no change in physical appearance, drug content or in dissolution pattern storage at 40± 20 C / 75 ± 5 % for 90 days. Finally it was concluded that batch B-3 containing formulation F-C i.e. SLS-3 shows highest drug...
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