Posted by admin on Mar 30, 2015 in |
The present study is an attempt to minimize the dosing frequency and to target the Metoprolol succinate to the colon. Drug loaded pellets are coated with pH independent Eudragit RS100 and further coated with pH dependent Eudragit S100 in R and D pan coater. 3 2 full factorial design is applied to study the effect of extent of Eudragit S100 coating %w/w (X1) and extent of Eudragit RS100 coating %w/w (X2) as independent variables on the dependent variables (responses) are Y1=Q5 (% released after lag time of 5h) and Y2=Q90 (90% of drug release within 12h). The formulation were further characterized by in vitro dissolution study, drug release kinetics and micromeritic properties. 32 factorial design reveals that coating level of both the coats play a significant role in drug release property of which coating level of Eudragit RS 100 was more significant after the tablet reaches colon. Design expert software gives D5 as optimized batch having 20% w/w Eudragit RS 100 and 30% w/w with S100 as the drug...
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Posted by admin on Mar 30, 2015 in |
Black pepper (Piper nigrum) is a spice vine crop and which was used as a food preservative and as an essential component in traditional medicines. Moreover it is used also as a spice for curry cooking. The fruits and leaves may be both contains the medicinal activities. First time our concentration on to the fruits only. The fruits were collected and normally dried in the sunlight. The dried fruit was then converted into powder material. Then the powder of black pepper was extracted with ethanol in a soxhlet’s apparatus. The concentrated filtrate was isolated by column chromatography using solvent system-benzene: ethyl acetate (3:1). Again, recrystallization was performed by benzene with a minimum volume of chloroform to give pale yellow crystals of MP. 128-129oC (Reported 130oC). The IR, 1HNR and mass spectra of the pure crystalline compound (A2) were recorded. The mass spectra shows molecular ion M+∙ 284.5 which indicates that the molecular weight of the compound A2 is equal to that of piperinemolecular weight...
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Posted by admin on Mar 30, 2015 in |
Aim: Bleomycin (BLM), a potent anticancer agent widely used in the treatment of cancer is an antibiotic isolated from Streptomyces verticillus. BLM has been reported to cause pulmonary fibrosis that limits the chemotherapeutic efficiency. The present study aims to evaluate the efficacy of the aqueous extract of pomegranate (Punica granatum) against BLM induced pulmotoxicity in rats. Methods: The experimental rats were divided to 5 groups. Aqueous extract of Punica granatum peel at 250 and 500 mg/kg, was administered to rats of group III and IV respectively. The rats were induced with BLM. Group I served as normal control and group II as BLM control. Vitamin C at 250 mg/kg b.wt was administered to group V rats. Results: Treatment with aqueous extract of Punica granatum peel (250 and 500 mg/kg, orally) proved to be protective against BLM induced pulmonary fibrosis by normalizing the levels of glycoproteins (hexose, hexosamine and sialic acid) and by improving the activity of antioxidant enzymes- superoxide dismutase (SOD) and catalase (CAT). The extract also enhanced pulmonary...
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Posted by admin on Mar 30, 2015 in |
The objective of this work was to use a full factorial design and response surface methodology to optimize and prepare fast disintegrating tablets of Itopride hydrochloride (ITOHCl). Tablets were prepared by direct compression technique and evaluated for their drug content, weight variation, hardness, friability, wetting, disintegration time, and in-vitro release. In addition, the optimum formulation was evaluated for taste, mouth feel and in-vivo disintegration time in human volunteers. A 32 full factorial design was employed to evaluate different variables affecting ITOHCl tablets. Furthermore, The response surface methodology was used to analyze the effect of the total amounts of superdisintegrant (SD, X1) and the percentage of sodium starch glycolate (% SSG) in the total amounts of superdisintegrant (SSG, X2) on the % friability (Y1), Disintegration time (Y2) and ITOHCl released after 10 mins (Y3). The increase in the (SD, X1) led to an increase in the % friability while an increase in % SSG led to a decrease in the % friability. The (SD, X1) were found to have a...
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Posted by admin on Mar 30, 2015 in |
Rheumatoid arthritis is one of the most serious medical problems leading to bone and cartilage destruction. The disease affects approximately 1% of the total world population. Mostly the women are affected. The pathogenesis of the disease is still not clearly understood. Free radicals and inflammatory molecules such as TNF-α, IL-1β etc have been recognized as major players in the progression of disease. Several herbal preparations have been reported to combat free radicals and relieve the sufferers of diseases such diabetes, atherosclerosis, asthma etc. Crocus sativus is considered as an anticonvulsant, antidepressant, antispasmodic and diaphoretic agent. Therefore, we planned this study to evaluate anti-inflammatory and antioxidant property of Crocus sativus extract (CSE) towards adjuvant induced arthritis. Arthritis was induced in mice by injecting Freund’s complete adjuvant. Three different doses of Crocus sativus extract (25, 50, 100mg/kg b.w.) were orally administered to the adjuvant induced arthritic mice for 47 days. We observed significant (p<0.05) reduction in TNF-α and IL-1β levels in the mice of CSE-2 and 3 group as compared to...
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