Posted by admin on Mar 30, 2015 in |
The present study was designed to investigate the effect of two different types of plasticizers, i.e., Triethyl citrate (TEC) and Acetyl tri butyl citrate on the in vitro release kinetics of Budesonide from sustained-release pellets during initial and stability conditions. Ethyl cellulose aqueous dispersion (Aqua coat ECD 30) is used as the release-retarding polymer. Both plasticizers were used at 10 % to 30% (w/w) of Aqua coat ECD 30. Sugar spheres #16/20 were used as core pellets. Dissolution study was performed by using USP apparatus II with sinker in 0.1 N HCl followed by 7.5 pH phosphate buffer. Trails planned with water insoluble plasticizer like acetyl tri butyl citrate showed comparative dissolution profile with innovator during initial condition but during accelerated stability conditions like 40ºC 75% RH for 6M dissolution profile was found to be on lower side when compared with innovator. Hence trails were planned with water soluble plasticizer like tri ethyl citrate showed comparable dissolution profile with innovator during initial and stability conditions. Different trails were planned...
Read More
Posted by admin on Mar 30, 2015 in |
Acetone extracts of the three medicinal plants Sida cardifolia, Phyllanthus amarus and Adathoda vasica were assessed for phytochemical components qualitatively and quantitatively and antioxidant activity. The results revealed that all the three contained alkaloids, carbohydrates, flavonoids, tannins, anthocyanins, steroids and phenols. Saponins were absent in all the three extracts. Sida cardifolia with 1.53mg and 7.09mg GA equivalent/g of extract powder showed maximum amount of Phenolics and flavonoids.The total sugars and proanthocyanidins was maximum in Phyllanthus amarus with 8.45ug glucose equivalent/g of extract powder and 10.84mg GA equivalent/g of extract powder. Tannin content was found to be high in Adathoda vasica with 11.07mg GA equivalent/g of extract powder. Sida cardifolia acetone leaf extract showed the highest reducing power activity, Free radical scavenging potential and inhibition of lipid...
Read More
Posted by admin on Mar 30, 2015 in |
Aim of this study was to compare bupivacaine heavy ( 0.5% ) 3ml with isobaric ropivacaine (0.75% ) 3ml, intrathecally in patients posted for lower abdominal and lower limb surgery for sensory and motor effects and hemodynamic stability. 100 patients aged 12 years or older (ASA grade I, II, III) scheduled for various lower abdominal and lower limb surgeries were randomly distributed in two groups. In group B (n= 50) 15 mg of hyperbaric bupivacaine (0.5%, 3ml) and in group R (n=50) 21.5 mg of isobaric ropivacaine (0.75%, 3ml) was given intrathecally. All observations were recorded and analyzed statistically by using unpaired t-test and P- value < 0.05 was considered significant. No statistically significant difference in onset of sensory blockade up to T10, onset of motor block (grade “I”), mean duration of analgesia and side effects was observed between both groups. Statistically significant difference in onset of motor blockade at grade “III” was observed between group B and R. Statistically significant mean duration of sensory and motor blockage was...
Read More
Posted by admin on Mar 30, 2015 in |
Ethnopharmacological relevance: A preliminary ethnobotanical survey of diabetic patients in Health Community Centre Sering, Medan, North Sumatera, Indonesia from 2010-2011 revealed Syzygium polyanthum (Wight) as the most commonly used herb in the traditional management of diabetes mellitus. Yet, no substantial pharmacological evidences are available to validate this claim. Material and methods: A survey on the traditional herbs used among 264 diabetic outpatients attending the Health Community Centre Sering, Medan, North Sumatera, Indonesia was carried out from January 2010-April 2011. The most commonly used herb was then extracted serially with petroleum ether (PEE), chloroform (CE), methanol (ME) and water (WE); and the extracts were used for detailed anti-diabetic evaluation in both non-diabetic rats (NDR) and streptozotocin-induced diabetic rats (SDR). Results: The most commonly used herb was Syzygium polyanthum (Wight) leaf. In NDR, the increasing on blood glucose levels (BGLs) of intraperitoneal glucose-loaded rats (1g/kg) were not significantly altered by PEE, CE, and ME (1 g/kg) within 120 minutes after glucose loading. However, the BGL in WE group was significantly altered...
Read More
Posted by admin on Mar 14, 2015 in |
Acute convulsive disorders are the most frequent neurological disorders in children which require emergency drug treatment. Immediate management of a convulsive episode is must as, delay can lead to status epilepticus, which is a significant cause of neurological morbidity and mortality among children. Benzodiazepines especially diazepam is often used as first line and routinely administered intravenously, but this is not a practical route in many peripheral health care facilities. Midazolam by buccal route is another upcoming mode of treatment in view of difficulties associated with securing an intravenous line in convulsing children with motor activity especially at peripheries, homes or even at schools. Being a developing country, malnourished group forms a significant number in our clinical practice so it was worthwhile to examine the issue of buccal midazolam’s safety and efficacy in this subset of malnourished children. It was a prospective double blind randomized control trial. Total 80 children who fulfilled the inclusion criteria were randomly allocated by a computer generated table. One group received buccal midazolam and the...
Read More
