Posted by admin on Dec 31, 2023 in |
The objective of this research study is to assess the quality standards of various brands of Metformin hydrochloride tablets that are locally available in Hyderabad, India, by comparing and contrasting them with the brand available in the Jan Aushadhi stores in India (MET-3). Eight brands of Metformin tablets (500 mg) were selected and compared for their physical and chemical parameters as per the official method. The physiochemical equivalence of all tablet brands was assessed through evaluation of both official and non-official standards such as size, shape, uniformity of weight, friability, hardness, disintegration, assay, and dissolution rate. In contrast to the generic drug of metformin available at Jan Aushadhi Kendra (MET-3), the other seven brands of Metformin hydrochloride tablets have all met the requirements of the official I.P. specification regarding weight variation, friability, hardness, disintegration, assay, and dissolution rate. It was concluded that the generic drug of metformin available in Jan Aushadhi Kendra (MET-3), whose price is almost 70% less than the other seven brands of Metformin hydrochloride, is officially...
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Posted by admin on Dec 31, 2023 in |
Background: In the present era of quality accreditation, considering the quality of medical education is also very important, especially in developing countries. The present study was planned to understand the current state of medical education and explore medical students’ perception of their learning environment so that problem areas can be identified both at the institutional and curriculum level. Methods: DREEM tool was circulated to all willing participants from first to final-year MBBS students. Data was collected and analyzed using recent SPSS software. Descriptive statistics were used to calculate mean, standard deviation, and minimum and maximum values. One-way analysis of variance (ANOVA) was calculated, and p< 0.05 was considered to be significant. Results: An overall score of 111.76 (55.88%) out of 200 was obtained indicating ‘more positive than negative’. The overall mean score was 2.21±0.58, which is interpreted as an ‘educational aspect that could be enhanced’. Out of five domains, students’ perception of teachers scored the maximum (57.95 %) rating while students’ social self-perception scored the least (49.35 %). The relationship between...
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Posted by admin on Dec 31, 2023 in |
Metoprolol Succinate is an effective cardio-selective beta-1 blocker, that is used to treat acute disorders such as hypertension and cardiac diseases such as angina pectoris and cardiac heart failure (CHF). Oral route is the most convenient route for introducing different kind of drugs as it is preferred as the safest, cheaper & easiest route. Newly, researchers developed fast disintegrating tablets (FDT) with improved patient compliance. The main motto of this fast-disintegrating sublingual tablet is that is placed under the tongue &disintegrates rapidly within a short span of time in the presence of saliva. First-pass metabolism can be avoided by the sublingual route &the drug directly reaches into the systemic circulation. FDTs manage to overcome from hindrances such as dysphagia in pediatric, geriatric & unconscious patients. The FDTs were formed by different conc. Of super disintegrating agents such as crospovidone by direct compression method. The compatibility study of API & other excipients was studied & determined by DSC & FTIR techniques. The formulation was evaluated by studying various parameters such...
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Posted by admin on Dec 31, 2023 in |
Upgradation of conventional medications with additional therapeutic phytocompounds to combat emerging resistant pathogenic strains, is uptrend now-a-days. The current work investigates the precise in-vitro bactericidal efficacy of the methanolic extract of the unexplored seeds of a swampy weed, Hygrophila auriculata (K. Schum) Heine (MHA), Family – Acanthaceae against different uropathogens. It was observed that, 200µg of MHA has 20% of supplementary inhibitory effect on the antibiotic disc of Amoxicillin-clavulanic acid 30 against Enterococcus faecalis and Escherichia coli. Similarly, MHA treated Nitrofurantoin 300 disc shows 25%, 4.5% and 5% of supplementary inhibitory effect against E. faecalis, E. coli and Staphylococcus aureus, respectively. Ciprofloxacin 5 is supplemented by 2.8% and Streptomycin 10 by 4.5% against S. aureus. 39.28%, 42.39%, 53.36% and 90.4% of increased inhibition was recorded against E. faecalis, E. coli, Pseudomonas aeruginosa and S. aureus respectively in terms of cfu/mL, on treating with a higher concentration of MHA. Present study has noted a minimum inhibitory concentration of 2.5mg/mL of MHA each against E. coli, P. aeruginosa and 1.25mg/mL against...
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Posted by admin on Dec 31, 2023 in |
Introduction: Anxiety disorders are due to reduced serotonin or noradrenaline or GABA in the hippocampus. This study aims at investigating the anti-anxiety actions of verapamil. Materials and Methods: Swiss Albino mice of either sex were used. Group I – control recieved normal saline, Group II fluoxetine 20mg/Kg, Group III Verapamil (10mg/Kg), Group IV Verapamil (20mg/Kg) and Group V- Verapamil (10mg/Kg) and Fluoxetine. Each group had 5 mice. On day 9 of treatment mice were subjected to the marble burying test, light-dark exploration test, act photometer, and social interaction study. Results: Mean (sd) Locomotor activity in the control group was 267.6 (±61.77), 462.6 (± 58.2) with Verapamil 10mg, 561.8 (±33.33) with Verapamil 20mg. Verapamil significantly increased locomotion (P<0.001). The number of entries into light area was 57.20±11.78 in the control group, 85±11.26 with Verapamil (10mg/Kg) and 102.6±7.93 with Verapamil 20 mg/kg. Verapamil significantly increased the number of entries towards light as compared to control mice (P <0.001). The number of entries into dark area was 262.4±16.65 in the control group,...
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