Posted by admin on Oct 31, 2023 in |
Dolutegravir, an integrase strand transfer inhibitor (INSTI), is a BCS class II, poorly soluble antiretroviral medication that has been licenced by the FDA for the treatment of HIV infections. DTG has a number of drawbacks, including limited oral bioavailability (16%), hepatotoxicity, and instability in an acidic environment. Due to the medication’s limited solubility, 84% of the dose is eliminated from the body after oral administration in an unaltered state. Lipid-based nanoparticles have been chosen for the current research study as a viable drug delivery technology to help with the aforementioned challenges. Melt emulsification sonication procedure was used with CAPMUL MCM EP, Glyceryl monostearate, TWEEN 80, SPAN 80, and other ingredients, a total of six formulations were created. The formulations’ particle size, polydispersity index, zeta potential, drug concentration, drug entrapment effectiveness, in-vitro release, and other factors were assessed. The prepared formulations demonstrated zeta potential of -11.78 to-26.6, in-vitro drug release of between 62 and 80.32 percent, and particle sizes varying from 155 to 205 nm. The best formulation, according to...
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Posted by admin on Oct 31, 2023 in |
Aging is defined as decreased maximal function and reserve capacity in all body, organs, resulting in an increased likelihood of disease and death. One of the reasons for Premature Aging is deficiency of Vitamin D3. The main aim of the research work is to develop and evaluate the Nanoparticle based Anti-aging cream of Vitamin D3 for Premature aging. Six formulations were prepared by Nano precipitation method using Poloxamer 407 as polymeric stabilizer. It was then incorporated into cream base. FT-IR studies were carried out to determine the drug-excipient compatibility. The prepared Nano-suspension was subjected to evaluations including particle size, zeta potential, drug entrapment efficiency and drug content. The formulated cream was tested for pH, Spreadability, Viscosity and in-vitro drug release. From the preliminary trial, F4 was found to be the best formulation. It was then fitted to Box-Behnken design with three independent variables including concentration of Stearic acid (X1), KOH (X2), Glycerine (X3) and two dependent variables – Spreadability (Y1) and In-vitro drug release (Y2). Among the 15 runs,...
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Posted by admin on Oct 31, 2023 in |
Background: Increased anxiety in patients undergoing caesarean delivery has a negative impact on fetus and mother. Music therapy can have beneficial effects. The aim of our study was to determine the effects of preoperative and intraoperative music therapy on anxiety, pain, patient satisfaction and postoperative nausea and vomiting in patients undergoing caesarean delivery under spinal anaesthesia. Methods: A prospective randomised study was conducted on 100 patients, 18–40 years of age, ASA Grade I–III posted for caesarean delivery under spinal anaesthesia. Patients were randomly divided into two groups (50 each). Group M patients listened to soothing meditative flute music, and Group C patients had no music but headphones until the end of the surgery. Observations were recorded and analysed statistically: mean blood pressure (MBP), heart rate (HR), visual analogue score (VAS) for pain, visual analogue score for anxiety (VASA), and patient satisfaction score (PSS). Results: Compared to Group C, HR and MBP in Group M started falling after 10 minutes of spinal anaesthesia, and the difference was significant (p<0.05). Compared...
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Posted by admin on Oct 31, 2023 in |
Introduction: Diabetic neuropathy occurs in about half of the individuals with long-standing diabetes manifested as polyneuropathy, mononeuropathy and autonomic neuropathy. There is evidence indicating the involvement of zinc in diabetes. Aim: To evaluate the effect of Zinc as add-on therapy in Diabetic Neuropathy on the basis of clinical signs and symptoms and glycaemic control. Materials and Methods: This prospective study was conducted in the Department of Pharmacology at Sarojini Naidu Medical College and associated Hospital Agra, Uttar Pradesh, India. A total of 105 patients of either type-1 or type-2 diabetes mellitus with complication of diabetic neuropathy were included and divided randomly into control and study groups of 52 and 53 patients each. Control group received standard anti-diabetic therapy plus Pregabalin 75 mg/day and Methylcobalamin 1500 mcg/day, while the participants of study group received standard anti-diabetic therapy plus Pregabalin 75 mg/day and Methylcobalamin 1500 mcg/day plus Zinc acetate 50mg/day as add-on therapy. Symptoms and signs of sensory-motor neuropathy, autonomic dysfunction and neuropathy were recorded at baseline and on subsequent follow...
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Posted by admin on Oct 31, 2023 in |
Annona squamosa (sugar apple) is commonly cultivated in tropical South America occasionally in southern Florida as well as in Jamaica, Puerto Rico, Barbados, and dry regions of Australia. It was growing in Indonesia early in the 17th century and has been widely adopted in southern China, tropical Africa, Egypt, and the lowlands of Palestine. This plant is a small well-branched tree or shrub that bears edible fruits called sugar-apples, species of the genus Annona and a member of the family Annonaceae is traditionally used for the treatment of epilepsy, dysentery, cardiac problem, warm infection, constipation, hemorrhage, antibacterial infection and also has anti-tumor activity. Especially the seeds have another important effect they are medically useful to show many therapeutic activities such as anticancer, and CNS depressant. Hence the present study was taken to test the antimicrobial activity of seeds of Annona squamosa and microbes such as Staphylococcus aureus and Salmonella typhi. The evaluation of the antimicrobial activity of the seed extracts of Annona squamosa was done with methanol using the...
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