Posted by admin on Sep 30, 2023 in |
Carbamazepine (CBZ) has long been a therapeutic option for bipolar disorder. Carbamazepine is used to treat acute manic and mixed episodes associated with bipolar I disorder. In the present study, bilayer tablet was developed to improve dosing convenience and decrease daily fluctuations in serum CBZ concentration, thereby lowering the incidence of adverse events. In bilayer tablet one layer provides the loading dose by immediate drug release and another layer provides the maintenance dose up to 12 hrs by sustained release. The drug excipient compatibility study was carried out by FTIR and DSC techniques; there was no interaction found. Cross povidone was used as a superdisintegrant in the immediate release layer and controlled release fraction was formulated by using HPMC K 100 polymer. The prepared granules were evaluated for angle of repose, bulk density, tapped density, and compressibility index which showed satisfactory results. The prepared bilayer tablets were evaluated for thickness, hardness, friability and in-vitro release studies. In-vitro dissolution study was carried out for 12 hours using USP dissolution apparatus...
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Posted by admin on Sep 30, 2023 in |
Background: Traumatic brain injury has significant morbidity and mortality. Several prognostic markers have been evaluated to predict outcomes. ABG (arterial blood gas) analyzers are routinely available and predict the value of calcium, lactate and other electrolytes. We evaluated serum calcium and lactate as a prognostic markers in severe TBI. Methods: We prospectively studied 100 patients with severe TBI. Blood samples for calcium and lactate were taken following admission, day 3 and day 7 after trauma and the relationship with mortality and functional outcome was studied. The Glasgow Outcome Scale (GOS) was used to access functional outcomes. GOS≤3 was considered a poor outcome (Group I). GOS>3 was taken as a good outcome (Group II). Results: Mean age was 51 years. Most patients were males, 77% in Group I and 70% in Group II. Patients in the GOS≤3 group were significantly older than patients with a GOS score >3(p=0.007). Lactate levels were significantly higher in the GOS≤3 group on day 3 (p<0.0001) but no association on day 7. GOS and ionized...
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Posted by admin on Sep 30, 2023 in |
Diabetes mellitus is a group of disorders that speed up the metabolism of protein, fat, and carbohydrates. It has been forecasting rises in the incidence and prevalence of diabetes mellitus in recent years. Different plant parts have historically been used to treat diabetes mellitus. The Plant Gmelina arborea (lamiaceae) treats insecticidal, antidiuretic, anti-diabetic, anti-analgesic, and immunomodulatory activity. Basella rubra (Baellaeceae) is used as an Androgenic, diuretic, emollient, demulcent and anticonvulsant. Sphaeranthus indicus (Asteraceae) treats ananxiolytic, neuroleptic, antioxidant, anti-inflammatory, bronchodilatory, antihyperglycemic and hepatoprotective. The plants were processed, powdered and extracted with hydroalcoholic solvent. Maceration was processed for 72hrs, 48 hrs and 24 hrs. Solvents were filtered, distilled, and dried in a vacuum desiccator. Polyherbal formulations such as BSG, SBG, BGS were made by taking the required proportion of each powdered drugs. The in-vitro anti-oxidant and anti-diabetic potential of plant were determined by DPPH radical scavenging activity, Alpha-amylase and Alpha-glucosidase inhibition assay. The activity reported that hydroalcoholic extract of Gmelina arborea, Basella rubra, and Sphaeranthus indicus exhibits potent activity indose–dependent manner....
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Posted by admin on Sep 30, 2023 in |
2-(4-methyl piperazin-1-yl) acetohydrazide was synthesized. The combined practice of IR, 1H NMR, and mass spectrometry established the structure of the synthesized compound. Geometry optimization was performed using DFT at the B3LYP level, employing the basis set 6-31G (d, p). For the optimized structure, surfaces were created to study excited state properties such as electrostatic potential mapped density, highest occupied molecular orbital, lowest unoccupied molecular orbital, ionization energy, and electron affinity. Electric dipole moment, bond length, and angles were computed using the same basis set for the optimized structure. ADMET prediction revealed that the compound possesses the ability to cross the blood-brain barrier and is non-toxic. Further Molecular docking studies with Human Monoamine Oxidase A were carried out to predict the mono-amine inhibitory potential of the compound. The compound revealed better energy scores than the standard. The synthesized compound was evaluated from all aspects concerning essential structural features as well as interaction patterns against selected receptors to be an effective antidepressant. This study would provide an excellent platform to further...
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Posted by admin on Sep 30, 2023 in |
In this work, gel/na-alginate films containing curcumin were made using the straightforward procedure of mixing gel/na-alg solutions, followed by linking with glutaraldehyde solution. Glutaraldehyde was injected into the film solutions made at various proportions (A: G=25:75, 50:50, 75:25 and 10:90), and the resulting film’s mechanical, thermal, and swelling characteristics were evaluated. Gelatin and Sodium alginate were combined in a biocompatible wound dressing material that was effectively used in the biomedical areas. Several biochemical and molecular waterfalls, such as swelling, tissue growth, and the remodeling stage, identify the wound healing procedure. The natural bioactive ingredient curcumin, an anti-inflammatory, antioxidant, and tissue regeneration factor, was introduced in the film. Also, iron oxide nanoparticles are very appealing due to their non-poisonous properties in biomedical applications of biological systems. Composite film loaded with curcumin and iron nanoparticles using biopolymers of gel/na-alg with the help of a crosslinker (glutaraldehyde). The synthesized films are characterized by numerous techniques, including XRD, FTIR, SEM, and Thermo gravimetric analysis (TGA). The chemical studies also carried out were the welling...
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