Posted by admin on Dec 1, 2014 in |
Diclofenac (DIC) is a widely used as an anti-inflammatory drug and it is used as the toxicant in hepatoprotective studies. In the present study, hepato-renal protective activity of Colchicine against DIC induced liver and kidney injury in albino rats was assessed. Animals were injected with Diclofenac sodium at the single dose of 150 mg/ kg body weight daily for 28 days. Oral administration of colchicine at a concentration of 10µg/kg b.w daily for 28 days showed a significant decrease in plasma AST, ALT and creatinine as well as hepatic and renal thiobarbituric acid reactive substances and hydroperoxides. The treatment also resulted in a significant increase in GSH, SOD, CAT and GPx in the liver and kidney of DIC treated rats. The results clearly suggest that the colchicine treated group may effectively normalize the impaired antioxidant status in DIC- induced liver and kidney injury than the vitamin C-treated groups. However, Colchicine rapid protective effects against lipid peroxidation by scavenging of free radicals reduce the risk of oxidative...
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Posted by admin on Dec 1, 2014 in |
The combination of Levodopa and Carbidopa is widely prescribed for Parkinson’s disease. Levodopa easily crosses the blood-brain barrier and presumably converted to dopamine in the brain. Carbidopa inhibits decarboxylation of peripheral Levodopa but not of Levodopa within the central nervous system as it does not cross the blood-brain barrier. The purpose of present work was to develop bilayer floating dosage form of Carbidopa and Levodopa to improve the delivery of the drug at optimal absorption site and to reduce the frequency of administration with improved patient compliance. Bilayer floating tablet were prepared by using Kollidon SR and hydroxypropyl methylcellulose (HPMC K15M) as matrixing agents and sodium bicarbonate as gas generating agent. The IR spectral studies and DSC thermogram showed no interaction between drug and other additives. Experimental design was used for optimizing the ratio of Kollidon SR: HPMC K15 (X1) and concentration of binder (X2). The optimized formulation (batch F3) showed zero order drug release with Non-Fickian or anomalous diffusion. The optimized formulation showed similarity in dissolution with theoretical...
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Posted by admin on Dec 1, 2014 in |
To develop a novel approach for the biological synthesis of silver nanoparticles using water extract of whole plant parts ofAdiantum capillus-veneris L. which has been proven to be active against human pathogenic bacteria such as Streptococcus pyogenes, Staphylococcus aereus, Escherichia coli and Klebsiella pneumonia. Characterization of nanoparticles was determined by using Ultra Violet-Visible (UV-Vis) spectrometry, Scanning Electron Microscopy (SEM), Energy Dispersive X-ray (EDX), X-ray Diffraction (XRD). The synthesis of nanoparticles was confirmed by the change of colour pale green to reddish brown. Further, a peak between 200nm to 2500nm wavelength was obtained on UV-VIS spectrometer which confirmed the biosynthesis of silver nanoparticles. SEM showed the formation of Silver nanoparticles with an average size of 25.71 nm-37.96 nm. X-ray diffraction analysis showed that the particles were crystalline in nature with cubic structure of the bulk silver with the broad peaks 380, 640, 670. It concluded that present study of A. capillus-veneriscan be good source for biological synthesis of silver nanoparticles which shows a good antibacterial activity of human pathogenic bacteria....
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Posted by admin on Dec 1, 2014 in |
Aim of the present study was to investigate the dose dependent effect of Aloe vera gel [5 mg, 10 mg, 15 mg of dry weight for 60 days each group] on Polycystic Ovarian Syndrome (PCOS) rat model. Charles Foster adult female (200-225 g weight) rats were treated orally with letrozole (non-steroidal aromatase inhibitor) at a dose of 0.5 mg/kg body weight daily for 21 days for PCOS model development, that were further treated orally daily with Aloe vera gel (AVG) at various doses of [5 mg, 10 mg, 15 mg of dry weight for 60 days. Parameters that were evaluated included glucose tolerance profile, estrus cyclicity, ovarian steroidogenic enzymes activities along with hormonal profile (Insulin, Progesterone, Testosterone, and Estradiol). Treatment of AVG daily at doses of 10 mg and 15 mg for 60 days in PCOS rat model demonstrated most beneficial effect by restoring the ovarian steroid status, by modulation of key steroidogenic activities, along with structural changes. This could be attributed to phyto-components present in the extract. The...
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Posted by admin on Dec 1, 2014 in |
The main purpose of this study was to evaluate hydrogel matrix systems of hydroxypropylmethylcellulose (HPMC) for oral release of poorly water-soluble drugs, by using triamcinolone (TR) as drug model. The influence of HPMC ratio (%) and compaction force (Kgf) on system performance were studied. Thus, several batches of tablets containing 10 mg of TR were prepared using distinct proportions of HPMC (30, 50 and 60 %; w/w), and characterized by: dimensions, weight, hardness, friability, disintegration time, swelling and dissolution. Regarding the dissolution profiles, several mathematical models were tested and the experimental data were fitted to a zero-order release. Additionally, the correlation between the swelling kinetics and the drug dissolution rate was established, suggesting the importance of the dependency of drug release from the swelling profile for all tested systems. However, there were not improvements for the system containing HPMC ratio higher than 30 % (w/w). To conclude, for the comparative evaluation of the system’s properties, the best technological conditions achieved were for the matrix produced under 7.5 kgf and...
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