Posted by admin on Nov 30, 2023 in |
Objectives: The present study aims to develop a simple, precise, accurate, and reproducible spectrophotometric Second order derivative method for estimating Favipiravir in bulk and pharmaceutical dosage form. Method: Acetonitrile was used as an organic solvent. The maximum absorption of the drug was found to be at 323nm. The developed method was validated and applied for the estimation of Favipiravir by using a spectrophotometric second-order derivative. Results: The linearity was established in the 5 to 25µg/ml concentration range for favipiravir with a correlation coefficient (r2) of 0.9991, respectively. Percent recovery studies were obtained in the range of 99.55-101.25%. Both interday and intraday precision was found to be satisfactory. The limit of detection and quantitation were found to be 1.5µg/ml and 1.2µg/ml, respectively. The method was statistically validated according to ICH guidelines for linearity, accuracy, and precision. The relative standard deviation was found to be less than 2%. Conclusion: The proposed method is simple to use, affordable and cost-effective. It can be successfully applied to estimate favipiravir in bulk and pharmaceutical...
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Posted by admin on Nov 30, 2023 in |
An attempt was made to identify actinomycete strains of the South coastal region of Andhra Pradesh, India along with the study of their antimicrobial potential. Among the 50 actinomycete strains isolated, one strain (VLS-2) showed strong antimicrobial activity against Gram-positive and Gram-negative bacteria as well as fungi. It was identified as Kocuria assamensis based on morphological, biochemical, physiological as well as molecular characteristics. ISP-1 medium supplemented with sodium chloride @ 7% maintained at pH 7.0 supported the maximum yield of secondary metabolites by the strain when incubated at 35oC for six days. Production of antimicrobials by the strain varied significantly with different carbon and nitrogen sources. The present study reveals the potentiality of actinomycete strains isolated from South-coast of Andhra Pradesh, India which shows further scope to investigate their novel bioactive compounds by employing both natural product chemistry and modern biotechnological...
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Posted by admin on Nov 30, 2023 in |
Egyptians referred to aloe vera, a botanical remedy, as “the plant of immortality.” It helps with diabetes, hypertension, wound healing, and other medical conditions. Aloe vera gel extract and Clitoria ternatea watery, methanolic, and ethanolic extracts of plants was studied. A small sample of Aloe vera and Clitoria ternatea’s ethanolic, methanolic, and watery extracts were put through a phytochemical test to check alkaloids, tannins, carbohydrates, saponins, phenols, and flavonoids, and steroid and glycosides, as well as a physical chemical test to check the extractive value and ash value. The results of the phytochemical examination revealed phenols, steroids, glycosides, alkaloids, saponins, tannins, flavonoids, and tannins were all present. The findings of the current research support the use of plant species as traditional medicine for the treatment of numerous illnesses since they show that ethanolic, methanolic, and watery extracts of Aloe vera and Clitoria ternatea contain bioactive chemicals that have significant medicinal properties. The plant leaf extracts of Aloe vera and Clitoria ternatea demonstrated an abundance of phytochemicals as secondary metabolites...
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Posted by admin on Nov 30, 2023 in |
Background: The WHO declared the coronavirus disease 2019 (COVID-19) outbreak as a global pandemic in March 2020. Since, no specific drugs are currently available for its treatment it is important to document the prescription patterns. Objectives: To evaluate the drug prescribing pattern and assess the disease progression in the patients hospitalized with COVID-19 in a tertiary care hospital. Methods: It is a retrospective study. Using electronic hospital database, we identified 2302 patients between May 2021 to August 2021. Analysis was done using Microsoft Excel 2007. Results: Out of 2302 patients, 1406 (61.1%) were males and 896 (38.9%) were females. Majority were severe 1001 (43.5 %) followed by mild 664 (28.84 %), moderate 555 (24.1%) and asymptomatic 82 (3.56 %). Majority occurred 853 (37.1%) between51-70 years with slight male preponderance 558 (39.69%). Common co-morbidities were hypertension 666 (28.93%) and diabetes mellitus 482 (20.94 %). Total drugs prescribed were 6,123. Average number of drugs per prescription was 2.66. Corticosteroids 1560 (67.77%) and oxygen 1556 (67.59%) were most commonly prescribed. Piperacillin/Tazobactam was...
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Posted by admin on Nov 30, 2023 in |
Plant products are of increasing interest in the search for new drugs and medicines in the treatment of diseases; and the discovery of new alternatives to existing commercially available drugs is an important area of this research due to pathogen resistance. The present investigation focused on the screening of anthelmintic potential of pet-ether, benzene, ethanol and aqueous extracts of the plant beet root (Beta vulgaris). The crude extract of the Beta vulgaris with pet ether, benzene, ethanol and aqueous were screened for anthelmintic activity against Indian adult earthworm Pheretima posthuma. The in-vitro anthelmintic activity was performed by using standard procedures. The comparison of the paralysis time and death time in different extracts with respect to the standard showed that the ethanol extract had most significant activity than petroleum ether; benzene and aqueous extract. The phyto-chemical constituents like flavanoids and alkaloids may be responsible for the activity. Finally our study conclude that Beta vulgaris has significant anti-helminthic activity and potential to develop as useful and safe alternative to the other...
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