Posted by admin on Oct 1, 2014 in |
Cosmetic applications of spices and herbs are well recognized. Apart from preservative and antimicrobial activities, spices display copious antioxidant activity. Inclusion of these antioxidants in topical supplements has proved to be effective against oxidative aging. However, food and contact allergy to most spices make it mandatory to screen for skin and eye irritation activities before cosmetic applications. In this report, we have aimed to compare ethanolic extracts of five seeds belonging to family Apiaceae (C. carvi, C. cyminum, C. sativum, T. ammi, A. graveolens) concerning their antioxidant activities, phenol and flavonoid content, in-vitro cytotoxicity, and eye irritation tests. Our investigation illustrates that C. carvi expresses the highest antioxidant activity among these. Further, the polyphenol content and antioxidant activity are positively correlated in all samples. In-vitro cytotoxic analysis on chick embryo fibroblasts and in-vitro eye irritation assays demonstrate 200µg/ml concentration of these extracts can be safely used for cosmetic...
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Posted by admin on Oct 1, 2014 in |
Objective: Modulation of the immune responses to alleviate the diseases has been of interest for many years. Thus, a real need exists to protect our immune systems and lead healthier lives. Hence the present study is aimed to evaluate the immunomodulatory activity of the Flavonoid of Kigelia africana (Family: Bignoniaceae). Methods: The assessment of immunomodulatory activity on cell-mediated and humoral mediated immunity were studied by Carbon clearance test; Cyclophosphamide induced neutropenia, Indirect Haemagglutination reaction, Neutrophil adhesion test, and effect on Serum immunoglobulin level. Results: Flavonoid of Kigelia africana was administered orally at a low dose and a high dose of 100mg/kg/day, po and 200 mg/kg/day, po respectively and Levamisole (2.5 mg/kg/day, po) was used as standard drug. Flavonoid of Kigelia africana in both doses showed a significant increase in the phagocytic index in carbon clearance assay, significant protection against Cyclophosphamide induced neutropenia. It also increased the circulating antibody titer in an indirect haemagglutination test and increased the adhesion of neutrophils in the neutrophil adhesion test. Hence, it was concluded...
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Posted by admin on Oct 1, 2014 in |
Objective: Scindapsus officinalis has been reported to have antioxidant, analgesic, anti-inflammatory, antibacterial, and antihistaminic activity. Peptic ulcer disease involves inflammation and oxidative stress. So, the present study was carried out to evaluate the potential of hydroalcoholic extract of Scindapsus officinalis fruits as an antiulcer agent. Materials and Methods: In this pharmacological study evaluation of the antiulcer effect of hydroalcoholic extract of Scindapsus officinalis fruits was performed by using pyloric ligation induced gastric ulcers model. Ranitidine (50 mg/kg p.o.) was used as standard. The preliminary phytochemical investigation, estimation of phenolic and flavonoid content and in-vitro antioxidant activity were also estimated. Results: The hydroalcoholic extract of Scindapsus officinalis fruits has a significant effect on scavenging free radicals as found in DPPH free radical scavenging assay and NO scavenging assay. In pylorus ligation induced ulcer model, the plant extract showed gastric ulcer healing effect and gastric antisecretory effect. The high dose of (500 mg/kg) of hydroalcoholic extract of Scindapsus officinalis fruits was more efficacious in reducing ulcer index. The result was supported...
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Posted by admin on Oct 1, 2014 in |
Novel Schiff base comprising 4-aminoantipyrine with Biginelli adducts of salicylaldehyde has been designed and synthesized. Solid metal complexes of this Schiff base with Ni(II), Zn(II), Cd(II) and Hg(II) metal ions were synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, ESI mass, IR, NMR, and UV-Vis spectral studies. From the data, it has been observed that the complexes had the composition of ML2 type, diamagnetic nature and a tetrahedral geometry around the metal ion except for Ni(II) complex which has square planar geometry. The Ligand and its complexes have been screened for their in-vitro antifungal and in-vitro antibacterial activities against the fungi i.e., Candida albicans, Aspergillus flavus, Penicillium spp., Aspergillus niger and Trichophyton and the gram-negative bacteria Escherichia coli, Vibrio spp., Pseudomonas aeroginosa, Vibrio para haemolytic, Salmonella spp., Aeromonas spp., Klebsiella spp., Proteus spp. and gram-positive bacteria Bacillus spp and Staphylococcus aureus. The in-vitro antimicrobial activities of these metal complexes found to be stronger than the...
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Posted by admin on Oct 1, 2014 in |
Quantitative Structure-Activity Relationship (QSAR) for tylophorine derivatives acting as Plasmodium kinases inhibitors has been developed. The proposed 2D-QSAR model was found to be statistically significant concerning training, cross-validation, and external validation. The contribution of carbon chains with aromatic and electronegative features are found to be the most important descriptors in predicting Plasmodium kinases inhibitory activity. Furthermore, a 3D-QSAR study using CoMFA and CoMSIA was carried out to investigate the molecular property determinants. The CoMFA model suggested that the favorable substitution of steric groups with electronegative properties at ring A. Furthermore, CoMSIA model indicated the possible role of H bond donor groups at 5 and 6 positions of ring A whereas H bond acceptors at 7 and 8 positions of ring A in enhancing the biological activities. The developed QSAR models can be used to discover new effective antimalarial leads for further development as antimalarial...
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