Posted by admin on Nov 1, 2014 in |
In the present study, the antidiabetic and antioxidant effect of aqueous extract of Averrhoa bilimbi Linn (ABAE) fruits were evaluated. Diabetes mellitus was induced in male Sprague Dawley rats by a single intraperitoneal injection of streptozotocin (40 mg/kg body weight). Oral administration of aqueous extract of Averrhoa bilimbi Linn (ABAE) (50mg/kg body weight) and metformin (100 mg/kg body weight) to diabetic rats for 60 days significantly reduced the levels of blood glucose, lipids and lipid peroxidation, but increased the activities of plasma insulin and antioxidant enzymes, like catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase. The cytotoxicity of hepatic and renal tissue were ameliorated by treatment with aqueous extract of Averrhoa bilimbi Linn (ABAE) and metformin on histopathological examination. The Averrhoa bilimbi Linn (ABAE) aqueous fruit extract supplementation is useful in controlling the blood glucose level, improves the plasma insulin, lipid metabolism and is beneficial in preventing diabetic complications from lipid peroxidation and antioxidant systems in experimental diabetic rats; therefore, it could be useful for prevention or early treatment...
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Posted by admin on Nov 1, 2014 in |
Plants are the natural reservoir of many anticancer agents. Gardenia latifolia Ait. and Gardenia gummifera Linn. belonging to the family Rubiaceae. Gardenia Ellis. is a genus of 142 species, which occur in tropical and sub-tropical regions of Africa, South Asia, Australasia and oceania. The genus was named by Carl Linnaeus after Dr. Alexander Garden (1730-1791), a Scottish-born American naturalist. Both the plant leaves were extracted by ethanol, extracts were subjected to cytotoxic activity study against MCF-7 cell lines using the MTT assay. MTT assay was the technique utilized for cell survival determination. Measurements were performed and the concentration required for a 50% inhibition of viability (CTC50) was determined graphically. The concentration of ethanolic extract yields the value of CTC50 as 170.00±2.0 µg/ml and 200.00±1.6 µg/ml respectively for Gardenia latifolia Ait. and Gardenia gummifera Linn. The results showed that the Gardenia latifolia Ait. had potential cytotoxicity than the Gardenia gummifera Linn. against MCF-7cell...
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Posted by admin on Nov 1, 2014 in |
The phytochemical screening of the bark of Albizia lebbeck (L) showed positive test for tannin, alkaloid, flavonoid, terpenoid, phlabotannin, saponin, steroid and cardiac glycoside. In this article an attempt was made for biological studies (the antimicrobial activity, cytotoxicityand free radical-scavenging activity) of different extracts (hexane, methanol, ethyl acetate, water and butanol extract) of the bark of Albizia lebbeck. The antimicrobial sensitivity of the extracts was tested using the disc diffusion method. The cytotoxic effects of five extracts (hexane, methanol, ethyl acetate, water and butanol extract) of the bark of Albizia lebbbeck were carried out. Free radical scavenging activity of the bark of Albizia lebbeck was performed. All the extracts showed moderate anti microbial activity and gram positive bacteria were more sensitive than gram negative bacteria. Significant cytotoxic activity was noticed and hexane extract was found the most lethal to brine shrimp nauplii. This result revealed that the highest cytotoxic constituent may be non polar in nature. Good free radical scavenging activity was observed in all the extracts, and...
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Posted by admin on Nov 1, 2014 in |
The present paper deals with a novel approach in formulating and characterizing mucoadhesive buccal patches with the incorporation of herbal extract. In the present arena of Novel Drug Delivery System, delivery of drugs through buccal mucosa serves an easier method for utilization of drugs leading to reduction of dose frequencies and thereby tends to sustain the drug release. Buccal patches were prepared with herbal (Neem) extract with two polymers such as Methyl Cellulose and Hydroxy Propyl Methyl Cellulose in a respective solvent such as Ethanol with Propylene glycol as the plasticizer. Buccal patches were successfully formulated by solvent casting technique with several concentrations of polymers and those prepared patches were characterized in terms of film thickness, film weight, colour, surface texture, folding endurance, surface pH, swelling behaviour and percentage of moisture loss. Percentage of drug content in all patches was also determined and all patches showed their significant properties upon characterization and there was uniformity in drug content for all patches. In-vitro drug diffusion studies were carried out using...
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Posted by admin on Nov 1, 2014 in |
A facile synthesis of novel 2-amino-1,2-dihydroisoquinoline-3(4H)-one and their amide derivatives (6a-o) through sydnone intermediate (3) was derived from tetrahydroisoquinoline-3-carboxylic acid (1) and various substituted phenyl acrylic acid derivatives (5a-o) in short reaction time with good yield. The structure of all novel synthesized compounds was established based on Mass, 1H NMR, 13C NMR, IR spectral data and Single crystal X-ray study (6e). All the synthesized compounds were evaluated for their antimicrobial and antioxidant...
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