Posted by admin on Nov 1, 2014 in |
Context: Drug treatment during pregnancy presents a special concern. All drugs should not be avoided. A better knowledge of parameters that determine teratogenicity may allow the physicians gain confidence. Aims: This study was conducted to understand the drug utilization practices during pregnancy in women from rural areas and poor socioeconomic background; classify them according to US-FDA category for determining the teratogenic potential; to provide feedback and recommendations to the health care providers. Settings and Design: This was a retrospective cross-sectional study carried out at rural tertiary hospital. Methods and Material: Case record forms of 300 patients admitted to the obstetrics ward from September to November 2009 were analyzed for demographic details, drug prescriptions and drug utilization patterns. The teratogenic potential of drugs was analyzed according to US-FDA risk categories for drugs and medication. Statistical analysis used: Statistical software SPSS was used for analysis. Results: Maximum prescriptions happened in the second trimester of pregnancy. Vitamins, mineral and nutritional supplements were prescribed in almost 100% cases. The patients receiving more than...
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Posted by admin on Nov 1, 2014 in |
Medicinal plants contribute in human health care system. Most of the plants utilized by village peoples as a folk medicine. The effects of plant extracts on bacteria have been studied by a very large number of researchers in different part of the world. In this study antimicrobial activity of Acalypha indica were investicated against two strains of Human pathogenic bacteria. A total of 15 pus samples were collected from Namakkal private hospital, among that two strains were isolated as Staphylococcus aureus and Pseudomonas aeruginosa. Isolation and identification of bacterial isolates by using standared biochemical tests. The above isolated organisms were tested for their sensitivity towards the Acalypha indica medicinal plant leaves extract by disc diffusion and Agar well methods. In this study the highest antibacterial activity were observed in water extract of Acalypha indica than compared with acetone extract. Inhibitory effect of medicinal plant against Staphylococcus aureus in well diffusion is (17mm), and Psedomonas aeruginosa is (20mm) in water extract. In acetone extract 7mm, 9mm inhibitory zone showed by...
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Posted by admin on Nov 1, 2014 in |
Present investigation deals with the evaluation of the antimicrobial activity of extracts of Jatropha gossypifolia Linn., Sapium sebiferum (L.) Roxb., Kirganelia reticulata (Poir) Baill., Phyllanthus fraternus Webster and Pedilanthus tithymaloides (Linn.) Poit. against Escherichia coli, Proteus vulgaris, Staphylococcus aureus and Bacillus cereus and Trichophyton mentagrophytes and T. rubrum. The antibacterial activity was tested by the disc diffusion method and the antifungal (antidermatophytic) activity by the method of Abubacker et al. It was observed that only DMSO extracts of the leaves of K. reticulata and the flowers of P. tithymaloides inhibited the growth of P. vulgaris and S. aureus with MIC at 200 mg ml–1. The extracts did not inhibit the growth of T. mentagrophytes and T. rubrum. The phytochemical analysis of these extracts indicated that the tannin and saponin contents were highest in the leaves of K. reticulata (6.0 and 12.04 % respectively) whereas, the flavonoid and steroid and triterpenoid contents were highest in theflowers of P. tithymaloides (41.20 % and 46.74 %). The MIC values of extracted tannins...
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Posted by admin on Nov 1, 2014 in |
Diallyl Disulphide is an essential component of garlic which has numerous medicinal applications. Thus it was evaluated for its free radical scavenging potential. The compound was assayed for its ability to stabilize the erythrocyte membrane by osmotic fragility test and heat induced hemolysis assay. The thrombolytic potential was evaluated by the ability of the compound to dissolve the clot formed. The antioxidant studies were assessed by DPPH radical scavenging assay, ferric reducing antioxidant potential, Superoxide radical scavenging potential and Nitric oxide radical scavenging potential. The total antioxidant capacity was also estimated and the values were expressed in terms of Ascorbic acid equivalents. The results show a poor free radical scavenging potential and antioxidant capacity. However it has shown a moderate percentage in dissolution of clot implicating in thrombolytic potential. The compound has also shown a higher erythrocyte membrane stabilization by reducing the percentage of hemolysis in heat induced hemolytic assay than Ascorbic Acid. The results suggest that Diallyl Disulphide is a poor antioxidant but a potential anti-hemolytic in In-vitro...
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Posted by admin on Nov 1, 2014 in |
Two simple, sensitive and rapid spectrophotometric methods was developed for estimation of glibenclamide in pure and in pharmaceutical dosage forms. Method-A is a uv spectroscopic method with the absorption maxima at 276nm.Method-B is based on the oxidation/reduction of glibenclamide with iron (III) and chelation of iron with 3-methyl 2-benzothiozoline hydrazone(MBTH) to form green colored complex with absorption maxima at 630nm.Calibration curve was plotted. The assay was validated for the parameters like precision, accuracy, robustness, ruggedness, LOD and LOQ. The proposed methods can be useful for the routine analysis for the determination of glibenclamide in pharmaceutical dosage...
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