Posted by admin on Aug 1, 2014 in |
This study investigated the effects of arsenic on radish in the pot (green house experiment), result revealed that length, FW and DW of plant (EDP and leaf) was significantly (P < 0.05) affected at higher concentration of As (≥40ppm) treatment. Chl-a and Chl-b was significantly affected at >40ppm As treated plant compared with C*. TSS and Proline content in plant showed, increasing trend at increasing concentration of As treated plant. Ca, P and K content in plant was more after 30 DAS followed by 60DAS, P was significantly (P<0.05) more affected from 10 to 80ppm of As treated plant as compared to Ca and K. APX and CAT activities of As treated plant leaf showed increasing trends from C* and DAS. About 70 µg of As /g of DW of EDP accumulate after 60DAS at ≥ 40 to 80ppm, it was more than leaf. As uptake by the EDP was significantly more in 60DAS (R² = 0.810) than 30DAS (R² = 0.753) as compared with C*. BCFs was >1...
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Posted by admin on Aug 1, 2014 in |
The exposure to vibrations generated in oscillating/vibratory platform produces whole body vibration (WBV) exercises. The effect of the WBV in the concentrations of some biomarkers and his association between some substances has been investigated. Natural products have been used by the humans as food source and as medications. Coriandrum sativum (CS) is used for the treatment of diabetes and gastrointestinal complications. The aim of this study was evaluate if the WBV modify the effect of a CS on the biodistribution of Na99mTcO4 and in some biomarkers in Wistar rats. Rats were divided in: control group (CON) received of 0.9%NaCl solution (saline); treated group with 1.0 mL CS 8g/mL (COR); PLA were submitted to WBV (12 Hz) and also received 1.0 mL of saline; COR + PLA received 1.0 mL CS 8g/mL and were submitted to WBV. Na99mTcO4 was administrated via ocular plexus. After 10 min, sample of blood obtained from by cardiac puncture was used for biochemical analysis and organs isolated to determine %ATI/g. %ATI/g had a significant (p<0.05)...
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Posted by admin on Aug 1, 2014 in |
Ocimum gratissimum L. (O.G) has been used to treat various diseases since ancient time in India. This study investigated the antioxidant activity and phytochemical constituents in alcoholic extract ofO.G. The alcoholic extract of O.G. was screened for antioxidant potential through DPPH assay and phytochemical analysis was undertaken through qualitative and quantitative methods. Different concentrations of extract were analyzed and ascorbic acid was used as a standard antioxidant.IC50 and % inhibition were evaluated. O.G. was found to have potent antioxidant ability of 82.40% at 200 µg/ml concentration and IC50 value at 37.92 µg/ml concentration. A good correlation was found to exist between concentration of extract and % inhibition with r2=0.909. Phytochemical analysis revealed the presence of alkaloids, flavonoids, glycoside, tannin and phenolic compounds, triterpenoids and steroids, as well as 2.4 mg/g of photosynthetic pigments, 0.0003915 mg/g of ascorbic acid while 0.0910 mg/g of foliar phenol content was found to be present. These findings suggested that alcoholic extract of O.G. has potent antioxidant ability which could be the reason for its...
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Posted by admin on Aug 1, 2014 in |
Aim of present investigation was to develop self emulsifying drug delivery system of ibuprofen to enhance solubility, dissolution rate which may improve therapeutic performance and drug loading capacity so as to develop alternative to traditional oral formulations to improve bioavailability. In this study Labrafac, Tween 80 and PEG 200 were selected as oil, surfactant and co-surfactant respectively. Formulation development and screening was done based on results obtained from phase diagrams and characteristics of resultant microemulsions. The developed SEDDS were evaluated for droplet size analysis, zeta potential, polydispersibility index, viscosity, refractive index, % transmittance, drug content and in vitro diffusion profiles. All formulations of ibuprofen SEDDS showed globule size in micrometer range, good stability with no phase separation, creaming or cracking and rapidly formed emulsion which was clear. All formulations showed more than 90% of drug release within 30 min. The SEDDS showed improved dissolution rate compared to marketed product. Anti-inflammatory studies were conducted in Wistar strain male albino rats and ibuprofen SEDDS showed more significant activity than the marketed...
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Posted by admin on Aug 1, 2014 in |
The Gulf of Mannar, is a unique marine habitat with diverse of macroalgae. Macroalgae are primitive non flowering marine plants, which have rich sources of bioactive compounds (i.e., proteins, peptides, amino acid, polysaccharide, alkaloids etc). The selected red algaeGelidiela acerosa and Acanthophora spicifera collected from the Gulf of Mannar, southeast coast of India. In the present study, the anticancer potential of the methanol (crude) extract from G. acerosa and A. spicifera was tested for probable anticancer activity in Dalton’s Ascitic Lymphoma (DAL) cells. The cells were tested in Swiss albino mice. The results show that G. acerosa and A. spicifera algae extract were the most effective against DAL cells in mice respectively had significant anticancer activity and it might be a good candidate for further investigation in order to develop a natural compound as an anticancer agents, which can be utilized for the production of potential anticancer drug and novel pharmaceutical...
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